DE10299032I1 - 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1, 3-propandiol-Derivate - Google Patents

2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1, 3-propandiol-Derivate

Info

Publication number
DE10299032I1
DE10299032I1 DE2002199032 DE10299032C DE10299032I1 DE 10299032 I1 DE10299032 I1 DE 10299032I1 DE 2002199032 DE2002199032 DE 2002199032 DE 10299032 C DE10299032 C DE 10299032C DE 10299032 I1 DE10299032 I1 DE 10299032I1
Authority
DE
Germany
Prior art keywords
purin
dihydro
oxo
methoxy
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE2002199032
Other languages
English (en)
Other versions
DE10299032I2 (de
Inventor
John Nestor
Scott Womble
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23079211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10299032(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE10299032I1 publication Critical patent/DE10299032I1/de
Publication of DE10299032I2 publication Critical patent/DE10299032I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
DE2002199032 1994-07-28 1995-07-19 2-(2-Amino-1, 6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propandiol-Derivate Active DE10299032I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28189394A 1994-07-28 1994-07-28

Publications (2)

Publication Number Publication Date
DE10299032I1 true DE10299032I1 (de) 2003-01-23
DE10299032I2 DE10299032I2 (de) 2006-06-14

Family

ID=23079211

Family Applications (3)

Application Number Title Priority Date Filing Date
DE2002199032 Active DE10299032I2 (de) 1994-07-28 1995-07-19 2-(2-Amino-1, 6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propandiol-Derivate
DE69509173T Expired - Lifetime DE69509173T2 (de) 1994-07-28 1995-07-19 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propandiol-Derivate
DE0694547T Pending DE694547T1 (de) 1994-07-28 1995-07-19 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propandiol-Derivat

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69509173T Expired - Lifetime DE69509173T2 (de) 1994-07-28 1995-07-19 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propandiol-Derivate
DE0694547T Pending DE694547T1 (de) 1994-07-28 1995-07-19 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propandiol-Derivat

Country Status (33)

Country Link
EP (1) EP0694547B1 (de)
JP (1) JP3090305B2 (de)
KR (1) KR100358626B1 (de)
CN (1) CN1045089C (de)
AT (1) ATE179173T1 (de)
AU (1) AU697107B2 (de)
BR (1) BR9503468A (de)
CA (1) CA2154721C (de)
CO (1) CO4410181A1 (de)
CY (2) CY2180B1 (de)
CZ (1) CZ290511B6 (de)
DE (3) DE10299032I2 (de)
DK (1) DK0694547T3 (de)
ES (1) ES2083348T3 (de)
FI (1) FI112080B (de)
GR (2) GR960300021T1 (de)
HK (1) HK1012339A1 (de)
HU (1) HU216867B (de)
IL (1) IL114735A (de)
LU (1) LU91136I2 (de)
MA (1) MA23631A1 (de)
MY (1) MY114393A (de)
NL (1) NL300071I2 (de)
NO (2) NO312899B1 (de)
NZ (1) NZ272652A (de)
PE (1) PE32296A1 (de)
PL (1) PL180609B1 (de)
RU (1) RU2133749C1 (de)
SA (1) SA95160158B1 (de)
TR (1) TR199500895A2 (de)
TW (1) TW434242B (de)
UY (1) UY24006A1 (de)
ZA (1) ZA956228B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
WO1997027194A1 (en) * 1996-01-26 1997-07-31 F. Hoffmann-La Roche Ag Process for preparing purine derivatives
ATE222909T1 (de) * 1996-01-26 2002-09-15 Hoffmann La Roche Verfahren zur herstellung von purin-derivaten
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
CA2572577C (en) * 1997-02-10 2011-04-05 Medivir Ab Synthesis of acyclic nucleoside derivatives
US6184376B1 (en) 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
PT988304E (pt) * 1997-08-15 2001-10-31 Medivir Ab Analogos de nucleosidos tais como os antivirais que contem inibidores de transcritase reversa retroviral e de adn-polimerase do virus da hepatite b (hbv)
AU1711599A (en) * 1997-12-19 1999-07-12 Bristol-Myers Squibb Company Prodrugs of lobucavir and methods of use
WO1999051613A1 (en) * 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
KR20030015655A (ko) * 2001-08-17 2003-02-25 한미약품공업 주식회사 항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물
DE60328675D1 (de) * 2002-04-23 2009-09-17 Aventis Pharma Inc 3-(substitutierte amino)-1h-indole-2-carbonsäureester und 3-(substitutierte amino)-benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpression
AU2003273000A1 (en) 2002-10-16 2004-05-04 Takeda Pharmaceutical Company Limited Stable solid preparations
US20040224916A1 (en) 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
EP1660499A1 (de) * 2003-08-28 2006-05-31 Ranbaxy Laboratories Limited Amorphes valganciclovir hydrochlorid
JP5563735B2 (ja) 2004-06-16 2014-07-30 タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド Ｐｐｉ多回剤形
NZ553263A (en) * 2004-07-19 2010-06-25 Biocon Ltd Insulin-oligomer conjugates, formulations and uses thereof
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
CN102014638A (zh) 2007-10-12 2011-04-13 武田制药北美公司 与食物摄入无关的治疗胃肠病症的方法
EP2714691B1 (de) * 2011-05-31 2016-09-07 Pharmathen S.A. Verfahren zur herstellung von 2-amino-9- ((2-phenyl-1,3-dioxan-5-yloxy)methyl) (-1h-purin-6(9h) -on-verbindung zur herstellung von valganciclovir
KR102312533B1 (ko) 2021-02-24 2021-10-15 주식회사 이웅 자동 스패너

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
FI91959C (fi) * 1984-12-12 1994-09-12 Syntex Inc Menetelmä valmistaa alkoksimetyylieetteri- ja alkoksimetyyliesterijohdoksia
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
JP2788084B2 (ja) * 1988-12-19 1998-08-20 ザ ウエルカム フアウンデーシヨン リミテツド 抗ウイルス化合物

Also Published As

Publication number Publication date
KR960004345A (ko) 1996-02-23
FI953592A0 (fi) 1995-07-27
PE32296A1 (es) 1996-08-07
RU95113148A (ru) 1997-06-27
JPH0841061A (ja) 1996-02-13
IL114735A0 (en) 1995-11-27
EP0694547B1 (de) 1999-04-21
CY2004003I1 (el) 2009-11-04
HU9502238D0 (en) 1995-09-28
EP0694547A3 (de) 1996-06-05
CA2154721A1 (en) 1996-01-29
EP0694547A2 (de) 1996-01-31
FI953592A (fi) 1996-01-29
RU2133749C1 (ru) 1999-07-27
SA95160158B1 (ar) 2006-05-20
IL114735A (en) 1998-06-15
MY114393A (en) 2002-10-31
ATE179173T1 (de) 1999-05-15
PL309812A1 (en) 1996-02-05
DK0694547T3 (da) 2000-01-03
DE10299032I2 (de) 2006-06-14
FI112080B (fi) 2003-10-31
CZ193995A3 (en) 1996-02-14
NO952977L (no) 1996-01-29
BR9503468A (pt) 1996-02-27
CO4410181A1 (es) 1997-01-09
JP3090305B2 (ja) 2000-09-18
MA23631A1 (fr) 1996-04-01
CN1122804A (zh) 1996-05-22
CA2154721C (en) 2001-01-02
DE694547T1 (de) 1996-10-24
DE69509173D1 (de) 1999-05-27
NO952977D0 (no) 1995-07-27
KR100358626B1 (ko) 2003-01-14
TR199500895A2 (tr) 1996-06-21
CZ290511B6 (cs) 2002-08-14
NO312899B1 (no) 2002-07-15
NL300071I1 (nl) 2002-02-01
PL180609B1 (pl) 2001-03-30
AU2719595A (en) 1996-02-08
UY24006A1 (es) 2001-07-31
ES2083348T1 (es) 1996-04-16
GR960300021T1 (en) 1996-04-30
ZA956228B (en) 1996-02-22
TW434242B (en) 2001-05-16
AU697107B2 (en) 1998-09-24
ES2083348T3 (es) 1999-08-01
CN1045089C (zh) 1999-09-15
NO2003001I2 (no) 2007-06-11
HU216867B (hu) 1999-09-28
CY2004003I2 (el) 2009-11-04
GR3030678T3 (en) 1999-11-30
HUT73246A (en) 1996-07-29
LU91136I2 (fr) 2005-07-06
DE69509173T2 (de) 1999-10-21
HK1012339A1 (en) 1999-07-30
NL300071I2 (nl) 2002-03-01
NZ272652A (en) 1996-12-20
CY2180B1 (en) 2002-08-23

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