FI111257B - Menetelmä terapeuttisesti käyttökelpoisten 5-aryyli-indolijohdannaisten valmistamiseksi sekä uudet välituoteyhdisteet - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten 5-aryyli-indolijohdannaisten valmistamiseksi sekä uudet välituoteyhdisteet Download PDFInfo
- Publication number
- FI111257B FI111257B FI934825A FI934825A FI111257B FI 111257 B FI111257 B FI 111257B FI 934825 A FI934825 A FI 934825A FI 934825 A FI934825 A FI 934825A FI 111257 B FI111257 B FI 111257B
- Authority
- FI
- Finland
- Prior art keywords
- ylmethyl
- indol
- formula
- compound
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97075892A | 1992-11-02 | 1992-11-02 | |
| US97075892 | 1992-11-02 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI934825A0 FI934825A0 (fi) | 1993-11-01 |
| FI934825L FI934825L (fi) | 1994-05-03 |
| FI111257B true FI111257B (fi) | 2003-06-30 |
Family
ID=25517470
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI934825A FI111257B (fi) | 1992-11-02 | 1993-11-01 | Menetelmä terapeuttisesti käyttökelpoisten 5-aryyli-indolijohdannaisten valmistamiseksi sekä uudet välituoteyhdisteet |
| FI20002505A FI20002505L (fi) | 1992-11-02 | 2000-11-15 | 5-aryyli-indolijohdannaisia |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI20002505A FI20002505L (fi) | 1992-11-02 | 2000-11-15 | 5-aryyli-indolijohdannaisia |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5886008A (cs) |
| EP (2) | EP0666858B1 (cs) |
| JP (1) | JP2788551B2 (cs) |
| KR (1) | KR0163371B1 (cs) |
| CN (1) | CN1051313C (cs) |
| AT (1) | ATE202102T1 (cs) |
| AU (1) | AU685066B2 (cs) |
| BR (1) | BR9307348A (cs) |
| CA (2) | CA2340999C (cs) |
| CZ (1) | CZ283001B6 (cs) |
| DE (1) | DE69330351T2 (cs) |
| DK (1) | DK0666858T3 (cs) |
| EG (1) | EG20396A (cs) |
| ES (1) | ES2157224T3 (cs) |
| FI (2) | FI111257B (cs) |
| GR (1) | GR3036579T3 (cs) |
| HU (1) | HU222235B1 (cs) |
| IL (1) | IL107386A (cs) |
| MY (1) | MY109696A (cs) |
| NO (1) | NO309652B1 (cs) |
| NZ (1) | NZ257059A (cs) |
| PL (1) | PL176091B1 (cs) |
| PT (1) | PT666858E (cs) |
| RU (1) | RU2134266C1 (cs) |
| TW (1) | TW251284B (cs) |
| WO (1) | WO1994010171A1 (cs) |
| ZA (1) | ZA938137B (cs) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| HUT75646A (en) * | 1993-08-31 | 1997-05-28 | Pfizer | 5-arylindole derivatives and pharmaceutical compositions containing them |
| JP2829788B2 (ja) * | 1994-02-10 | 1998-12-02 | ファイザー インク． | ベンゾジアゼピン受容体部位アゴニスト及びアンタゴニストとしての５−ヘテロアリールインドール誘導体 |
| GB9420529D0 (en) | 1994-10-12 | 1994-11-30 | Pfizer Ltd | Indoles |
| EA001113B1 (ru) * | 1995-03-20 | 2000-10-30 | Эли Лилли Энд Компани | 5-замещенные-3-(1,2,3,6-тетрагидропиридин-4-ил)- и 3-(пиперидин-4-ил)-1н-индолы и их фармацевтически приемлемые соли и сольваты, фармацевтическая композиция на их основе, способ активации рецепторов 5-нт1 и способ ингибирования нейронной белковой транссудации |
| CA2234166A1 (en) * | 1995-10-10 | 1997-04-17 | Patric James Hahn | N-¬2-substituted-3-(2-aminoethyl)-1h-indol-5-yl|-amides: new 5-ht1f agonists |
| NZ502642A (en) * | 1997-07-03 | 2002-06-28 | Du Pont Pharm Co | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders |
| US6465484B1 (en) | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| WO2000000196A1 (en) * | 1998-06-30 | 2000-01-06 | Eli Lilly And Company | Pyrrolidine and pyrroline derivatives having effects on serotonin related systems |
| US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
| GB9819035D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
| US5994352A (en) * | 1998-11-13 | 1999-11-30 | Pfizer Inc. | 5-arylindole derivatives |
| PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| US20040102360A1 (en) * | 2002-10-30 | 2004-05-27 | Barnett Stanley F. | Combination therapy |
| WO2004041162A2 (en) | 2002-10-30 | 2004-05-21 | Merck & Co., Inc. | Inhibitors of akt activity |
| US7332508B2 (en) * | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
| AU2004233827B2 (en) | 2003-04-24 | 2009-05-28 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
| DE10337184A1 (de) | 2003-08-13 | 2005-03-10 | Gruenenthal Gmbh | Substituierte 3-Pyrrolidin-Indol-Derivate |
| AU2004268950A1 (en) * | 2003-08-21 | 2005-03-10 | Osi Pharmaceuticals, Inc. | N3-substituted imidazopyridine-derivatives as c-kit inhibitors |
| US7442709B2 (en) * | 2003-08-21 | 2008-10-28 | Osi Pharmaceuticals, Inc. | N3-substituted imidazopyridine c-Kit inhibitors |
| BRPI0414856A (pt) | 2003-10-03 | 2006-11-21 | 3M Innovative Properties Co | imidazoquinolinas alcóxi-substituìdas |
| NZ547467A (en) | 2003-11-25 | 2010-06-25 | 3M Innovative Properties Co | Substituted imidazo ring system and methods |
| DE102004014304A1 (de) | 2004-03-22 | 2005-10-06 | Grünenthal GmbH | Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen |
| JP2008530022A (ja) | 2005-02-04 | 2008-08-07 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 免疫反応調節物質を含む水性ゲル処方物 |
| BRPI0709077A2 (pt) * | 2006-03-22 | 2012-04-10 | Janssen Pharmaceutica Nv | derivados de alquilaminas cìclicas como inibidores da interação entre mdm2 e p53 |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| CA2904767C (en) | 2013-03-15 | 2022-06-21 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
| EP2968237A4 (en) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
| RS61688B1 (sr) * | 2015-04-29 | 2021-05-31 | Janssen Pharmaceutica Nv | Azabenzimidazoli i njihiova upotreba kao modulatori ampa receptora |
| MX373652B (es) | 2015-04-29 | 2020-04-02 | Janssen Pharmaceutica Nv | Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa. |
| KR20170141767A (ko) | 2015-04-29 | 2017-12-26 | 얀센 파마슈티카 엔.브이. | 벤즈이미다졸론 및 벤조티아졸론 화합물 및 ampa 수용체 조절제로서의 이들의 용도 |
| CN107750250B (zh) | 2015-04-29 | 2021-09-07 | 詹森药业有限公司 | 吲哚酮化合物及其作为ampa受体调节剂的用途 |
| US10925834B2 (en) | 2015-05-22 | 2021-02-23 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| CN108137555B (zh) | 2015-11-06 | 2021-02-19 | 豪夫迈·罗氏有限公司 | 可用于治疗cns疾病的二氢吲哚-2-酮衍生物 |
| CR20180255A (es) | 2015-11-06 | 2018-06-22 | Hoffmann La Roche | Derivados de indolin-2-ona |
| WO2017076931A1 (en) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives for use in the treatment of cns and related disorders |
| EP3371174B1 (en) | 2015-11-06 | 2021-03-17 | H. Hoffnabb-La Roche Ag | Indolin-2-one derivatives |
| CN111822047B (zh) * | 2020-07-17 | 2022-05-27 | 曲阜师范大学 | 一种磁性介孔聚合离子液体负载催化合成吲哚类衍生物的方法 |
| WO2025104491A1 (en) * | 2023-11-14 | 2025-05-22 | Mindset Pharma Inc. | Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto |
| WO2025104490A1 (en) * | 2023-11-14 | 2025-05-22 | Mindset Pharma Inc. | Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
| ZA815541B (en) * | 1980-08-12 | 1983-03-30 | Glaxo Group Ltd | Heterocyclic compounds |
| US4983622A (en) * | 1984-02-06 | 1991-01-08 | Eli Lilly And Company | 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles |
| GB8600397D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| GB8724912D0 (en) * | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
| GB8819024D0 (en) * | 1988-08-10 | 1988-09-14 | Glaxo Group Ltd | Chemical compounds |
| IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| US5340838A (en) * | 1990-05-04 | 1994-08-23 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines |
| CA2042295A1 (fr) * | 1990-05-15 | 1991-11-16 | Jacques Chauveau | Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant |
| KR100215627B1 (ko) * | 1990-06-07 | 1999-08-16 | 레슬리 제인 에드워즈 | 치료용 헤테로사이클 화합물 |
| DK158590D0 (da) * | 1990-07-02 | 1990-07-02 | Lundbeck & Co As H | Indolderivater |
| RO111767B1 (ro) * | 1990-10-15 | 1997-01-30 | Pfizer | Derivati de indol, procedee si intermediari pentru prepararea acestora, compozitii farmaceutice si metoda pentru tratarea unor afectiuni |
| SK278998B6 (sk) * | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
| FR2672602B1 (fr) * | 1991-02-12 | 1993-06-04 | Centre Nat Rech Scient | Composes derives des beta-carbolines ligands du recepteur des benzodiazepines ayant un effet agoniste inverse et antagoniste vis-a-vis des benzodiazepines et medicaments les contenant. |
| US5229401A (en) * | 1991-09-23 | 1993-07-20 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino benzo[b]thiophene compounds |
| US5187159A (en) * | 1991-10-07 | 1993-02-16 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a substituted 1,3-benzodioxole or 1,3-benzodithiole |
| GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| US5378846A (en) * | 1993-06-11 | 1995-01-03 | Russian-American Institute For New Drug Development | 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives |
-
1993
- 1993-10-16 TW TW082108604A patent/TW251284B/zh active
- 1993-10-19 AU AU53294/94A patent/AU685066B2/en not_active Ceased
- 1993-10-19 EP EP93923389A patent/EP0666858B1/en not_active Expired - Lifetime
- 1993-10-19 RU RU95109927/04A patent/RU2134266C1/ru not_active IP Right Cessation
- 1993-10-19 DK DK93923389T patent/DK0666858T3/da active
- 1993-10-19 CZ CZ951108A patent/CZ283001B6/cs not_active IP Right Cessation
- 1993-10-19 DE DE69330351T patent/DE69330351T2/de not_active Expired - Fee Related
- 1993-10-19 US US08/424,357 patent/US5886008A/en not_active Expired - Fee Related
- 1993-10-19 JP JP6511101A patent/JP2788551B2/ja not_active Expired - Lifetime
- 1993-10-19 CA CA002340999A patent/CA2340999C/en not_active Expired - Fee Related
- 1993-10-19 KR KR1019950701729A patent/KR0163371B1/ko not_active Expired - Fee Related
- 1993-10-19 ES ES93923389T patent/ES2157224T3/es not_active Expired - Lifetime
- 1993-10-19 CA CA002148380A patent/CA2148380C/en not_active Expired - Fee Related
- 1993-10-19 BR BR9307348A patent/BR9307348A/pt not_active Application Discontinuation
- 1993-10-19 AT AT93923389T patent/ATE202102T1/de not_active IP Right Cessation
- 1993-10-19 WO PCT/US1993/009790 patent/WO1994010171A1/en active IP Right Grant
- 1993-10-19 NZ NZ257059A patent/NZ257059A/en unknown
- 1993-10-19 PT PT93923389T patent/PT666858E/pt unknown
- 1993-10-19 EP EP00124422A patent/EP1094064A1/en not_active Withdrawn
- 1993-10-25 IL IL10738693A patent/IL107386A/en not_active IP Right Cessation
- 1993-11-01 FI FI934825A patent/FI111257B/fi not_active IP Right Cessation
- 1993-11-01 MY MYPI93002280A patent/MY109696A/en unknown
- 1993-11-01 CN CN93120716A patent/CN1051313C/zh not_active Expired - Fee Related
- 1993-11-01 ZA ZA938137A patent/ZA938137B/xx unknown
- 1993-11-02 HU HU9303118A patent/HU222235B1/hu not_active IP Right Cessation
- 1993-11-02 EG EG69793A patent/EG20396A/xx active
-
1995
- 1995-04-28 NO NO951633A patent/NO309652B1/no not_active IP Right Cessation
- 1995-05-01 PL PL93308669A patent/PL176091B1/pl unknown
-
2000
- 2000-11-15 FI FI20002505A patent/FI20002505L/fi unknown
-
2001
- 2001-09-11 GR GR20010401436T patent/GR3036579T3/el not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed | ||
| MA | Patent expired |