IL107386A - Benzimidazole-5-indole derivatives and pharmaceutical compositions containing them - Google Patents

Benzimidazole-5-indole derivatives and pharmaceutical compositions containing them

Info

Publication number
IL107386A
IL107386A IL10738693A IL10738693A IL107386A IL 107386 A IL107386 A IL 107386A IL 10738693 A IL10738693 A IL 10738693A IL 10738693 A IL10738693 A IL 10738693A IL 107386 A IL107386 A IL 107386A
Authority
IL
Israel
Prior art keywords
alkyl
aryl
indol
benzimidazole
ylmethyl
Prior art date
Application number
IL10738693A
Other languages
English (en)
Other versions
IL107386A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL107386A0 publication Critical patent/IL107386A0/xx
Publication of IL107386A publication Critical patent/IL107386A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
IL10738693A 1992-11-02 1993-10-25 Benzimidazole-5-indole derivatives and pharmaceutical compositions containing them IL107386A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97075892A 1992-11-02 1992-11-02

Publications (2)

Publication Number Publication Date
IL107386A0 IL107386A0 (en) 1994-01-25
IL107386A true IL107386A (en) 1999-03-12

Family

ID=25517470

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10738693A IL107386A (en) 1992-11-02 1993-10-25 Benzimidazole-5-indole derivatives and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US5886008A (cs)
EP (2) EP1094064A1 (cs)
JP (1) JP2788551B2 (cs)
KR (1) KR0163371B1 (cs)
CN (1) CN1051313C (cs)
AT (1) ATE202102T1 (cs)
AU (1) AU685066B2 (cs)
BR (1) BR9307348A (cs)
CA (2) CA2340999C (cs)
CZ (1) CZ283001B6 (cs)
DE (1) DE69330351T2 (cs)
DK (1) DK0666858T3 (cs)
EG (1) EG20396A (cs)
ES (1) ES2157224T3 (cs)
FI (2) FI111257B (cs)
GR (1) GR3036579T3 (cs)
HU (1) HU222235B1 (cs)
IL (1) IL107386A (cs)
MY (1) MY109696A (cs)
NO (1) NO309652B1 (cs)
NZ (1) NZ257059A (cs)
PL (1) PL176091B1 (cs)
PT (1) PT666858E (cs)
RU (1) RU2134266C1 (cs)
TW (1) TW251284B (cs)
WO (1) WO1994010171A1 (cs)
ZA (1) ZA938137B (cs)

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GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
AU686654B2 (en) * 1993-08-31 1998-02-12 Pfizer Inc. 5-arylindole derivatives
KR970701182A (ko) * 1994-02-10 1997-03-17 스피겔 알렌 제이 벤조다이아제핀 수용체 부위의 작용물질 및 길항물질로서의 5-헤테로아릴인돌 유도체(5-heteroarylindole derivatives as benzodiazepine receptor site agonists and antagonists)
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
KR19980703048A (ko) * 1995-03-20 1998-09-05 피터쥐.스트링거 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트
JPH11513666A (ja) * 1995-10-10 1999-11-24 イーライ・リリー・アンド・カンパニー Ｎ−［２−置換−３−（２−アミノエチル）−１ｈ−インドール−５−イル］−アミド：新規５−ｈｔ▲下１ｆ▼作動剤
EP0994877A1 (en) * 1997-07-03 2000-04-26 Du Pont Pharmaceuticals Company Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
AU4850199A (en) * 1998-06-30 2000-01-17 Eli Lilly And Company Pyrrolidine and pyrroline derivatives having effects on serotonin related systems
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
GB9819035D0 (en) * 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
EP1558586B1 (en) 2002-10-30 2011-03-30 Merck Sharp & Dohme Corp. Inhibitors of akt activity
US20040102360A1 (en) * 2002-10-30 2004-05-27 Barnett Stanley F. Combination therapy
US7332508B2 (en) 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
EP1620095A4 (en) 2003-04-24 2009-04-01 Merck & Co Inc HEMMER OF ACT ACTIVITY
DE10337184A1 (de) 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
EP1658289B1 (en) * 2003-08-21 2009-03-18 OSI Pharmaceuticals, Inc. 3-substituted imidazopyridine-derivatives as c-kit inhibitors
US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
SG149828A1 (en) 2003-10-03 2009-02-27 3M Innovative Properties Co Alkoxy substituted imidazoquinolines
CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
DE102004014304A1 (de) * 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
AU2006210392A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune response modifiers
RU2434863C2 (ru) * 2006-03-22 2011-11-27 Янссен Фармацевтика Н.В. Производные циклических алкиламинов в качестве ингибиторов взаимодействия между mdm2 и р53
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
DK2968220T3 (da) 2013-03-15 2021-06-14 Agenebio Inc Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
WO2016176463A1 (en) 2015-04-29 2016-11-03 Janssen Pharmaceutica Nv Indolone compounds and their use as ampa receptor modulators
BR112017023147B1 (pt) 2015-04-29 2024-04-30 Rapport Therapeutics, Inc Derivados de azabenzimidazóis, seus usos como moduladores do receptor de ampa e composições farmacêuticas
JP6804469B2 (ja) 2015-04-29 2020-12-23 ヤンセン ファーマシューティカ エヌ．ベー． ベンゾイミダゾロン及びベンゾチアゾロン化合物並びにａｍｐａ受容体調節因子としてのそれらの使用
CN107567452B (zh) 2015-04-29 2020-07-07 詹森药业有限公司 咪唑并哌嗪和吡唑并嘧啶以及它们作为ampa受体调节剂的用途
BR112017025031B1 (pt) 2015-05-22 2023-03-21 Agenebio, Inc Composições farmacêuticas de liberação prolongada de levetiracetam
EP3371169B1 (en) 2015-11-06 2019-07-17 H. Hoffnabb-La Roche Ag Indolin-2-one derivatives for use in the treatment of cns and related disorders
WO2017076842A1 (en) 2015-11-06 2017-05-11 F. Hoffmann-La Roche Ag Indolin-2-one derivatives
WO2017076932A1 (en) 2015-11-06 2017-05-11 F. Hoffmann-La Roche Ag Indolin-2-one derivatives useful in the treatment of cns diseases
JP6857662B2 (ja) 2015-11-06 2021-04-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ インドリン−２−オン誘導体
CN111822047B (zh) * 2020-07-17 2022-05-27 曲阜师范大学 一种磁性介孔聚合离子液体负载催化合成吲哚类衍生物的方法
WO2025104491A1 (en) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto
WO2025104490A1 (en) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto

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Also Published As

Publication number Publication date
ATE202102T1 (de) 2001-06-15
CA2340999A1 (en) 1994-05-11
FI934825A0 (fi) 1993-11-01
DE69330351T2 (de) 2001-09-20
CN1094727A (zh) 1994-11-09
AU5329494A (en) 1994-05-24
FI20002505A7 (fi) 2000-11-15
RU2134266C1 (ru) 1999-08-10
FI934825L (fi) 1994-05-03
KR950704313A (ko) 1995-11-17
PL308669A1 (en) 1995-08-21
CA2148380A1 (en) 1994-05-11
CA2148380C (en) 2001-08-14
EP0666858A1 (en) 1995-08-16
PT666858E (pt) 2001-09-28
AU685066B2 (en) 1998-01-15
ES2157224T3 (es) 2001-08-16
HUT66011A (en) 1994-08-29
WO1994010171A1 (en) 1994-05-11
DK0666858T3 (da) 2001-08-27
FI111257B (fi) 2003-06-30
NZ257059A (en) 1997-07-27
DE69330351D1 (de) 2001-07-19
US5886008A (en) 1999-03-23
ZA938137B (en) 1995-05-02
KR0163371B1 (ko) 1998-12-01
CN1051313C (zh) 2000-04-12
GR3036579T3 (en) 2001-12-31
NO951633D0 (no) 1995-04-28
NO309652B1 (no) 2001-03-05
JP2788551B2 (ja) 1998-08-20
BR9307348A (pt) 1999-05-11
CZ283001B6 (cs) 1997-12-17
PL176091B1 (pl) 1999-04-30
EP0666858B1 (en) 2001-06-13
JPH07508759A (ja) 1995-09-28
FI20002505L (fi) 2000-11-15
CA2340999C (en) 2005-01-04
EG20396A (en) 1999-02-28
MY109696A (en) 1997-04-30
CZ110895A3 (en) 1995-11-15
RU95109927A (ru) 1997-01-10
NO951633L (no) 1995-04-28
HU222235B1 (hu) 2003-05-28
IL107386A0 (en) 1994-01-25
TW251284B (cs) 1995-07-11
EP1094064A1 (en) 2001-04-25

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