FI105812B - Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi Download PDF

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Publication number
FI105812B
FI105812B FI931667A FI931667A FI105812B FI 105812 B FI105812 B FI 105812B FI 931667 A FI931667 A FI 931667A FI 931667 A FI931667 A FI 931667A FI 105812 B FI105812 B FI 105812B
Authority
FI
Finland
Prior art keywords
alkyl
indole
aryl
ylmethyl
hydrogen
Prior art date
Application number
FI931667A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI931667A (fi
FI931667A0 (fi
Inventor
Martin James Wythes
John Eugene Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24393510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI105812(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of FI931667A publication Critical patent/FI931667A/fi
Publication of FI931667A0 publication Critical patent/FI931667A0/fi
Application granted granted Critical
Publication of FI105812B publication Critical patent/FI105812B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Lasers (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI931667A 1990-10-15 1993-04-14 Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi FI105812B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US59792890A 1990-10-15 1990-10-15
US59792890 1990-10-15
US9107194 1991-10-08
PCT/US1991/007194 WO1992006973A1 (fr) 1990-10-15 1991-10-08 Derives d'indole

Publications (3)

Publication Number Publication Date
FI931667A FI931667A (fi) 1993-04-14
FI931667A0 FI931667A0 (fi) 1993-04-14
FI105812B true FI105812B (fi) 2000-10-13

Family

ID=24393510

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931667A FI105812B (fi) 1990-10-15 1993-04-14 Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi

Country Status (33)

Country Link
EP (1) EP0592438B1 (fr)
JP (2) JP2575272B2 (fr)
KR (1) KR0179053B1 (fr)
CN (1) CN1039322C (fr)
AT (1) ATE157361T1 (fr)
AU (1) AU651637B2 (fr)
BG (1) BG61975B1 (fr)
BR (2) BR9106978A (fr)
CA (1) CA2091562C (fr)
DE (3) DE10299004I2 (fr)
DK (1) DK0592438T5 (fr)
EG (1) EG20224A (fr)
ES (1) ES2104733T3 (fr)
FI (1) FI105812B (fr)
GR (1) GR3025087T3 (fr)
HU (2) HU225055B1 (fr)
IE (1) IE913555A1 (fr)
IL (3) IL115117A (fr)
LU (1) LU90902I2 (fr)
MX (1) MX9101606A (fr)
MY (1) MY111683A (fr)
NL (1) NL300070I2 (fr)
NO (3) NO305121B1 (fr)
NZ (2) NZ240217A (fr)
OA (1) OA09874A (fr)
PL (3) PL169987B1 (fr)
PT (1) PT99218B (fr)
RO (1) RO111767B1 (fr)
RU (1) RU2095360C1 (fr)
SG (1) SG54270A1 (fr)
WO (1) WO1992006973A1 (fr)
YU (1) YU48088B (fr)
ZA (1) ZA918156B (fr)

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* Cited by examiner, † Cited by third party
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US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
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TW288010B (fr) * 1992-03-05 1996-10-11 Pfizer
KR0179072B1 (ko) * 1992-04-07 1999-03-20 알렌 제이. 스피겔 5-ht1 작동약으로서의 인돌 유도체
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
KR0179074B1 (ko) * 1992-04-10 1999-03-20 알렌 제이. 스피겔 5-ht1 작용물질로서의 아실아미노인돌 유도체
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (fr) * 1992-11-02 1995-07-11 Pfizer
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IT1271352B (it) * 1993-04-08 1997-05-27 Boehringer Ingelheim Italia Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
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AP486A (en) * 1993-04-27 1996-04-16 Pfizer Indole derivatives.
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
ATE170836T1 (de) * 1993-08-31 1998-09-15 Pfizer 5-arylindolderivate
WO1996004266A2 (fr) * 1994-08-03 1996-02-15 Asta Medica Aktiengesellschaft Derives d'indol, d'indazol, de pyridopyrrol et de pyridopyrazol a effet antiasthmatique, antiallergique, anti-inflammatoire et immunomodulateur
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AU726560B2 (en) * 1994-10-12 2000-11-09 Pfizer Research And Development Company, N.V./S.A. Use of indole derivatives for the treatment of various diseases
CA2213241C (fr) * 1994-10-12 2001-07-10 Pfizer Research And Development Company, N.V./S.A. Derive indole destine au traitement de la migraine
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GB9510223D0 (en) * 1995-05-20 1995-07-19 Pfizer Ltd Therapeutic agent
US5945118A (en) * 1995-09-29 1999-08-31 Pfizer Inc Indole derivative for the treatment of migraine
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
WO1999053956A1 (fr) * 1998-04-16 1999-10-28 Yamanouchi Pharmaceutical Co., Ltd. Remedes contre l'obesite
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US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
GB9825988D0 (en) 1998-11-27 1999-01-20 Pfizer Ltd Indole derivatives
GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
JP2000336074A (ja) 1999-03-24 2000-12-05 Sumitomo Chem Co Ltd ［２−（アリールスルホニル）エテニル］ベンゼン誘導体の製造方法
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GB9923314D0 (en) 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
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US20030166704A1 (en) 2000-12-20 2003-09-04 Pfizer Inc. New process
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
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US20070065463A1 (en) 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
ATE456557T1 (de) 2005-06-15 2010-02-15 Pfizer Ltd Substituierte arylpyrazole zur verwendung gegen parasiten
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US20090299077A1 (en) * 2008-05-22 2009-12-03 Vinod Kumar Kansal Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan
US8592424B2 (en) 2008-06-30 2013-11-26 Afgin Pharma Llc Topical regional neuro-affective therapy
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IT1393700B1 (it) 2009-04-22 2012-05-08 F S I Fabbrica Italiana Sint Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
WO2011004391A2 (fr) 2009-06-25 2011-01-13 Matrix Laboratories Ltd Procédé amélioré d'élaboration d'élétriptane et son sel correspondant
WO2011024039A1 (fr) * 2009-08-25 2011-03-03 Ramesh Babu Potluri Synthèse de nouveaux dérivés 5-(2-(phénylsulfonyl)éthyl)-1h-indole
WO2011089614A1 (fr) * 2010-01-19 2011-07-28 Sms Pharmaceuticals Limited Procédé de préparation de bromhydrate d'élétriptan ayant une forme α
CN102606426B (zh) * 2012-03-02 2014-05-21 王仲彦 踏步健身发电装置
WO2014063752A1 (fr) 2012-10-26 2014-05-01 Synthon Bv Procédé de production de la forme cristalline alpha du bromhydrure d'élétriptan
WO2014078568A1 (fr) 2012-11-14 2014-05-22 The Johns Hopkins University Méthodes et compositions pour le traitement de la schizophrénie
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US20160256410A1 (en) 2015-03-02 2016-09-08 Afgin Pharma, Llc Topical regional neuro-affective therapy in mammals with cannabinoids
JP2019502761A (ja) 2016-01-21 2019-01-31 ラボラトリオス レヴィ エセエレ （（ｒ）−３−［（−１−メチルピロリジン−２−イル）メチル］−５−（２−フェニルスルホニルエチル）−１ｈ−インドールを作製する方法
CN106065008B (zh) * 2016-06-16 2018-06-05 黑龙江中医药大学 一种具有改善睡眠作用的吲哚-2-酰胺类化合物及其应用
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
TR201616365A1 (tr) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari
TR201619983A2 (tr) 2016-12-29 2018-07-23 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Di̇klofenak ve eletri̇ptanin farmasöti̇k formülasyonlari
KR102129947B1 (ko) 2018-06-08 2020-07-03 김종창 콘크리트 타설을 위한 입체형 와이어 메쉬
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WO2023150547A2 (fr) * 2022-02-01 2023-08-10 Caamtech, Inc. Composés psychédéliques et leurs utilisations thérapeutiques

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Also Published As

Publication number Publication date
YU48088B (sh) 1997-01-08
BG61975B1 (bg) 1998-11-30
LU90902I2 (fr) 2002-06-26
PL168919B1 (pl) 1996-05-31
CN1039322C (zh) 1998-07-29
RO111767B1 (ro) 1997-01-30
JPH093063A (ja) 1997-01-07
CA2091562C (fr) 2001-03-27
CA2091562A1 (fr) 1992-04-16
BR9106978A (pt) 1993-09-28
ES2104733T3 (es) 1997-10-16
NO931378L (no) 1993-04-14
NZ270675A (en) 1997-07-27
DE10299004I1 (de) 2002-05-08
DE69127468D1 (de) 1997-10-02
NO2001019I1 (no) 2001-12-03
EG20224A (en) 1997-12-31
WO1992006973A1 (fr) 1992-04-30
DE10299004I2 (de) 2006-03-16
PT99218B (pt) 1999-04-30
NO305121B1 (no) 1999-04-06
IL99701A (en) 1996-10-31
HU9301098D0 (en) 1993-07-28
OA09874A (en) 1994-09-15
JP2575272B2 (ja) 1997-01-22
IL99701A0 (en) 1992-08-18
FI931667A (fi) 1993-04-14
RU2095360C1 (ru) 1997-11-10
DE69127468T2 (de) 1998-01-02
SG54270A1 (en) 1998-11-16
IL115117A (en) 1996-11-14
EP0592438A1 (fr) 1994-04-20
FI931667A0 (fi) 1993-04-14
GR3025087T3 (en) 1998-01-30
ATE157361T1 (de) 1997-09-15
PT99218A (pt) 1992-09-30
CN1062529A (zh) 1992-07-08
BR1100080A (pt) 2000-06-06
JP2677777B2 (ja) 1997-11-17
JPH05507288A (ja) 1993-10-21
NO985607L (no) 1998-12-01
NO985607D0 (no) 1998-12-01
IE913555A1 (en) 1992-04-22
YU165391A (sh) 1994-01-20
EP0592438B1 (fr) 1997-08-27
PL170330B1 (pl) 1996-11-29
AU8950491A (en) 1992-05-20
PL169987B1 (en) 1996-09-30
DK0592438T5 (da) 1999-12-06
MX9101606A (es) 1992-06-05
NL300070I2 (nl) 2002-03-01
NO931378D0 (no) 1993-04-14
DE9190141U1 (de) 1993-07-15
AU651637B2 (en) 1994-07-28
ZA918156B (en) 1993-04-14
MY111683A (en) 2000-11-30
KR0179053B1 (ko) 1999-03-20
HUT64326A (en) 1993-12-28
NL300070I1 (nl) 2002-02-01
IL115117A0 (en) 1995-12-08
BG97632A (bg) 1994-03-31
DK0592438T3 (da) 1997-09-29
HU225055B1 (en) 2006-05-29
NZ240217A (en) 1995-05-26

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