HUT64326A - Process for production indole derivatives and pharmaceutical preparations containing these compounds - Google Patents

Process for production indole derivatives and pharmaceutical preparations containing these compounds

Info

Publication number
HUT64326A
HUT64326A HU9301098A HU109893A HUT64326A HU T64326 A HUT64326 A HU T64326A HU 9301098 A HU9301098 A HU 9301098A HU 109893 A HU109893 A HU 109893A HU T64326 A HUT64326 A HU T64326A
Authority
HU
Hungary
Prior art keywords
aryl
alkyl
hydrogen
compounds
nr5r6
Prior art date
Application number
HU9301098A
Other languages
English (en)
Other versions
HU9301098D0 (en
Inventor
John Eugene Macor
Martin James Wythes
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24393510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUT64326(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of HU9301098D0 publication Critical patent/HU9301098D0/hu
Publication of HUT64326A publication Critical patent/HUT64326A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Lasers (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU9301098A 1990-10-15 1991-10-08 Process for production indole derivatives and pharmaceutical preparations containing these compounds HUT64326A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59792890A 1990-10-15 1990-10-15

Publications (2)

Publication Number Publication Date
HU9301098D0 HU9301098D0 (en) 1993-07-28
HUT64326A true HUT64326A (en) 1993-12-28

Family

ID=24393510

Family Applications (2)

Application Number Title Priority Date Filing Date
HU9301098A HU225055B1 (en) 1990-10-15 1991-10-08 Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds
HU9301098A HUT64326A (en) 1990-10-15 1991-10-08 Process for production indole derivatives and pharmaceutical preparations containing these compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU9301098A HU225055B1 (en) 1990-10-15 1991-10-08 Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds

Country Status (33)

Country Link
EP (1) EP0592438B1 (hu)
JP (2) JP2575272B2 (hu)
KR (1) KR0179053B1 (hu)
CN (1) CN1039322C (hu)
AT (1) ATE157361T1 (hu)
AU (1) AU651637B2 (hu)
BG (1) BG61975B1 (hu)
BR (2) BR9106978A (hu)
CA (1) CA2091562C (hu)
DE (3) DE10299004I2 (hu)
DK (1) DK0592438T5 (hu)
EG (1) EG20224A (hu)
ES (1) ES2104733T3 (hu)
FI (1) FI105812B (hu)
GR (1) GR3025087T3 (hu)
HU (2) HU225055B1 (hu)
IE (1) IE913555A1 (hu)
IL (3) IL115117A (hu)
LU (1) LU90902I2 (hu)
MX (1) MX9101606A (hu)
MY (1) MY111683A (hu)
NL (1) NL300070I2 (hu)
NO (3) NO305121B1 (hu)
NZ (2) NZ240217A (hu)
OA (1) OA09874A (hu)
PL (3) PL168919B1 (hu)
PT (1) PT99218B (hu)
RO (1) RO111767B1 (hu)
RU (1) RU2095360C1 (hu)
SG (1) SG54270A1 (hu)
WO (1) WO1992006973A1 (hu)
YU (1) YU48088B (hu)
ZA (1) ZA918156B (hu)

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US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
CA2124206C (en) * 1991-11-25 2001-02-27 John Eugene Macor Indole derivatives
TW288010B (hu) * 1992-03-05 1996-10-11 Pfizer
RU2101283C1 (ru) * 1992-04-07 1998-01-10 Пфайзер Инк. Производные индола или их фармацевтически приемлемые соли
AU670270B2 (en) * 1992-04-10 1996-07-11 Pfizer Inc. Acylaminoindole derivatives as 5-HT1 agonists
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GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (hu) * 1992-11-02 1995-07-11 Pfizer
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1271352B (it) * 1993-04-08 1997-05-27 Boehringer Ingelheim Italia Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
HUT73807A (en) * 1993-04-22 1996-09-30 Pfizer Res & Dev 5-ht1-like indole derivatives and pharmaceutical compositions containing them
AP486A (en) * 1993-04-27 1996-04-16 Pfizer Indole derivatives.
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
CN1129933A (zh) * 1993-08-31 1996-08-28 辉瑞大药厂 5-芳基吲哚衍生物
WO1996004266A2 (de) * 1994-08-03 1996-02-15 Asta Medica Aktiengesellschaft Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
AU726560B2 (en) * 1994-10-12 2000-11-09 Pfizer Research And Development Company, N.V./S.A. Use of indole derivatives for the treatment of various diseases
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
ES2181791T3 (es) * 1994-10-12 2003-03-01 Pfizer Res & Dev Derivados de indol para el tratamiento de la migraña.
GB9424471D0 (en) * 1994-12-03 1995-01-18 Pfizer Ltd Treatment of emesis
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GB9510223D0 (en) * 1995-05-20 1995-07-19 Pfizer Ltd Therapeutic agent
US5945118A (en) * 1995-09-29 1999-08-31 Pfizer Inc Indole derivative for the treatment of migraine
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
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AU3170099A (en) * 1998-04-16 1999-11-08 Yamanouchi Pharmaceutical Co., Ltd. Remedies for obesity
GB9816556D0 (en) * 1998-07-30 1998-09-30 Pfizer Ltd Therapy
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
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GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
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GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
AU6476700A (en) * 1999-08-26 2001-03-26 Fujisawa Pharmaceutical Co., Ltd. Process for the preparation of indole derivatives or salts thereof
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
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US20030166704A1 (en) 2000-12-20 2003-09-04 Pfizer Inc. New process
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US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
EP2332934B1 (en) 2001-08-15 2017-03-01 Pharmacia & Upjohn Company LLC Processes for the preparation of crystals including a malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indole-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide.
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US7132549B2 (en) 2003-05-30 2006-11-07 Pfizer Inc. Process
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CN102606426B (zh) * 2012-03-02 2014-05-21 王仲彦 踏步健身发电装置
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JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺
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US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
WO2017125351A1 (en) 2016-01-21 2017-07-27 Laboratorios Lesvi Sl Process for preparing (( r)-3-[(-1-methylpyrrolidin-2-yl)methyl]-5-(2-phenylsulfonylethyl)-1h-indole
CN106065008B (zh) * 2016-06-16 2018-06-05 黑龙江中医药大学 一种具有改善睡眠作用的吲哚-2-酰胺类化合物及其应用
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
TR201616365A1 (tr) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari
TR201619983A2 (tr) 2016-12-29 2018-07-23 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Di̇klofenak ve eletri̇ptanin farmasöti̇k formülasyonlari
KR102129947B1 (ko) 2018-06-08 2020-07-03 김종창 콘크리트 타설을 위한 입체형 와이어 메쉬
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan
CN114793420A (zh) 2020-01-22 2022-07-26 抗菌技术生物技术研究与发展股份有限公司 用于治疗脊髓损伤和改善运动功能的依来曲普坦氢溴酸盐
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Also Published As

Publication number Publication date
NL300070I1 (nl) 2002-02-01
NO931378D0 (no) 1993-04-14
HU9301098D0 (en) 1993-07-28
AU8950491A (en) 1992-05-20
NZ270675A (en) 1997-07-27
FI105812B (fi) 2000-10-13
NO931378L (no) 1993-04-14
DK0592438T5 (da) 1999-12-06
HU225055B1 (en) 2006-05-29
NO305121B1 (no) 1999-04-06
EP0592438B1 (en) 1997-08-27
CN1039322C (zh) 1998-07-29
DK0592438T3 (da) 1997-09-29
EP0592438A1 (en) 1994-04-20
BG97632A (bg) 1994-03-31
JPH05507288A (ja) 1993-10-21
CA2091562A1 (en) 1992-04-16
RO111767B1 (ro) 1997-01-30
KR0179053B1 (ko) 1999-03-20
OA09874A (en) 1994-09-15
DE10299004I2 (de) 2006-03-16
ATE157361T1 (de) 1997-09-15
DE9190141U1 (de) 1993-07-15
NO985607L (no) 1998-12-01
IL99701A0 (en) 1992-08-18
FI931667A0 (fi) 1993-04-14
GR3025087T3 (en) 1998-01-30
RU2095360C1 (ru) 1997-11-10
DE69127468T2 (de) 1998-01-02
IL115117A (en) 1996-11-14
PL170330B1 (pl) 1996-11-29
BG61975B1 (bg) 1998-11-30
NZ240217A (en) 1995-05-26
LU90902I2 (fr) 2002-06-26
PT99218B (pt) 1999-04-30
MX9101606A (es) 1992-06-05
MY111683A (en) 2000-11-30
IL99701A (en) 1996-10-31
PT99218A (pt) 1992-09-30
CN1062529A (zh) 1992-07-08
YU165391A (sh) 1994-01-20
EG20224A (en) 1997-12-31
WO1992006973A1 (en) 1992-04-30
ES2104733T3 (es) 1997-10-16
CA2091562C (en) 2001-03-27
JP2677777B2 (ja) 1997-11-17
SG54270A1 (en) 1998-11-16
JP2575272B2 (ja) 1997-01-22
PL168919B1 (pl) 1996-05-31
NO985607D0 (no) 1998-12-01
YU48088B (sh) 1997-01-08
DE10299004I1 (de) 2002-05-08
IE913555A1 (en) 1992-04-22
PL169987B1 (en) 1996-09-30
JPH093063A (ja) 1997-01-07
NO2001019I1 (no) 2001-12-03
IL115117A0 (en) 1995-12-08
ZA918156B (en) 1993-04-14
DE69127468D1 (de) 1997-10-02
AU651637B2 (en) 1994-07-28
NL300070I2 (nl) 2002-03-01
BR1100080A (pt) 2000-06-06
BR9106978A (pt) 1993-09-28
FI931667A7 (fi) 1993-04-14

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