DE69127468D1 - Indolderivate - Google Patents

Indolderivate

Info

Publication number
DE69127468D1
DE69127468D1 DE69127468T DE69127468T DE69127468D1 DE 69127468 D1 DE69127468 D1 DE 69127468D1 DE 69127468 T DE69127468 T DE 69127468T DE 69127468 T DE69127468 T DE 69127468T DE 69127468 D1 DE69127468 D1 DE 69127468D1
Authority
DE
Germany
Prior art keywords
aryl
alkyl
hydrogen
nr5r6
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69127468T
Other languages
English (en)
Other versions
DE69127468T2 (de
Inventor
John Macor
Martin James Wythes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24393510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69127468(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE69127468D1 publication Critical patent/DE69127468D1/de
Application granted granted Critical
Publication of DE69127468T2 publication Critical patent/DE69127468T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DE69127468T 1990-10-15 1991-10-08 Indolderivate Expired - Lifetime DE69127468T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59792890A 1990-10-15 1990-10-15
PCT/US1991/007194 WO1992006973A1 (en) 1990-10-15 1991-10-08 Indole derivatives

Publications (2)

Publication Number Publication Date
DE69127468D1 true DE69127468D1 (de) 1997-10-02
DE69127468T2 DE69127468T2 (de) 1998-01-02

Family

ID=24393510

Family Applications (3)

Application Number Title Priority Date Filing Date
DE9190141U Expired - Lifetime DE9190141U1 (de) 1990-10-15 1991-10-08
DE2002199004 Active DE10299004I2 (de) 1990-10-15 1991-10-08 Indolderivate
DE69127468T Expired - Lifetime DE69127468T2 (de) 1990-10-15 1991-10-08 Indolderivate

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE9190141U Expired - Lifetime DE9190141U1 (de) 1990-10-15 1991-10-08
DE2002199004 Active DE10299004I2 (de) 1990-10-15 1991-10-08 Indolderivate

Country Status (33)

Country Link
EP (1) EP0592438B1 (de)
JP (2) JP2575272B2 (de)
KR (1) KR0179053B1 (de)
CN (1) CN1039322C (de)
AT (1) ATE157361T1 (de)
AU (1) AU651637B2 (de)
BG (1) BG61975B1 (de)
BR (2) BR9106978A (de)
CA (1) CA2091562C (de)
DE (3) DE9190141U1 (de)
DK (1) DK0592438T5 (de)
EG (1) EG20224A (de)
ES (1) ES2104733T3 (de)
FI (1) FI105812B (de)
GR (1) GR3025087T3 (de)
HU (2) HU225055B1 (de)
IE (1) IE913555A1 (de)
IL (3) IL99701A (de)
LU (1) LU90902I2 (de)
MX (1) MX9101606A (de)
MY (1) MY111683A (de)
NL (1) NL300070I2 (de)
NO (3) NO305121B1 (de)
NZ (2) NZ240217A (de)
OA (1) OA09874A (de)
PL (3) PL168919B1 (de)
PT (1) PT99218B (de)
RO (1) RO111767B1 (de)
RU (1) RU2095360C1 (de)
SG (1) SG54270A1 (de)
WO (1) WO1992006973A1 (de)
YU (1) YU48088B (de)
ZA (1) ZA918156B (de)

Families Citing this family (72)

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US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
AU671959B2 (en) * 1991-11-25 1996-09-19 Pfizer Inc. Indole derivatives
TW288010B (de) * 1992-03-05 1996-10-11 Pfizer
AU670579B2 (en) * 1992-04-07 1996-07-25 Pfizer Inc. Indole derivatives as 5-HT1 agonists
NZ251047A (en) * 1992-04-10 1996-09-25 Pfizer Acylaminoindole derivatives and medicaments
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
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GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (de) * 1992-11-02 1995-07-11 Pfizer
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1271352B (it) * 1993-04-08 1997-05-27 Boehringer Ingelheim Italia Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
PL311204A1 (en) * 1993-04-22 1996-02-05 Pfizer Res & Dev Indole derivatives as antagonists of 5-ht-like receptors for use in hemicrania
AP486A (en) * 1993-04-27 1996-04-16 Pfizer Indole derivatives.
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
HUT75646A (en) * 1993-08-31 1997-05-28 Pfizer 5-arylindole derivatives and pharmaceutical compositions containing them
AU3162695A (en) * 1994-08-03 1996-03-04 Asta Medica Aktiengesellschaft Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
DE69528288T2 (de) * 1994-10-12 2003-01-16 Pfizer Ltd Indolderivate zur behandlung von migräne
GB9420529D0 (en) * 1994-10-12 1994-11-30 Pfizer Ltd Indoles
AU726560B2 (en) * 1994-10-12 2000-11-09 Pfizer Research And Development Company, N.V./S.A. Use of indole derivatives for the treatment of various diseases
GB9424471D0 (en) * 1994-12-03 1995-01-18 Pfizer Ltd Treatment of emesis
EA001113B1 (ru) * 1995-03-20 2000-10-30 Эли Лилли Энд Компани 5-замещенные-3-(1,2,3,6-тетрагидропиридин-4-ил)- и 3-(пиперидин-4-ил)-1н-индолы и их фармацевтически приемлемые соли и сольваты, фармацевтическая композиция на их основе, способ активации рецепторов 5-нт1 и способ ингибирования нейронной белковой транссудации
GB9510223D0 (en) * 1995-05-20 1995-07-19 Pfizer Ltd Therapeutic agent
US5945118A (en) * 1995-09-29 1999-08-31 Pfizer Inc Indole derivative for the treatment of migraine
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
AU3170099A (en) * 1998-04-16 1999-11-08 Yamanouchi Pharmaceutical Co., Ltd. Remedies for obesity
GB9816556D0 (en) * 1998-07-30 1998-09-30 Pfizer Ltd Therapy
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
GB9825988D0 (en) 1998-11-27 1999-01-20 Pfizer Ltd Indole derivatives
GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
JP2000336074A (ja) 1999-03-24 2000-12-05 Sumitomo Chem Co Ltd ［２−（アリールスルホニル）エテニル］ベンゼン誘導体の製造方法
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
EP1207153A1 (de) * 1999-08-26 2002-05-22 Fujisawa Pharmaceutical Co., Ltd. Verfahren zur herstellung von indolderivaten oder ihren salzen
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
US20030166704A1 (en) 2000-12-20 2003-09-04 Pfizer Inc. New process
GB0031094D0 (en) * 2000-12-20 2001-01-31 Pfizer Ltd New Process
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
PT3168218T (pt) 2001-08-15 2019-01-11 Pharmacia & Upjohn Co Llc Um cristal compreendendo um sal de ácido l-málico de n-[2- (dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3h-indol- 3-ilideno)metil]-2,4-dimetil-1h-pirrol-3-carboxamida para utilização como um medicamento
US7132549B2 (en) 2003-05-30 2006-11-07 Pfizer Inc. Process
GB0312478D0 (en) * 2003-05-30 2003-07-09 Pfizer Ltd Improved process
CA2529528A1 (en) 2003-06-20 2004-12-29 Ronald Aung-Din Topical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
US7645786B2 (en) 2005-06-15 2010-01-12 Pfizer Inc. Substituted arylpyrazoles
BRPI0611798A2 (pt) 2005-06-15 2009-01-13 Pfizer Ltd compostos de arilpirazàis substituÍdos, sua composiÇço farmacÊutica e uso
WO2006079999A2 (en) * 2006-04-09 2006-08-03 Barth Frederik H Induction of a novel state of mind with a 5-ht2a agonist and a nmda antagonist
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EP2296652B1 (de) 2008-06-30 2017-11-08 Afgin Pharma, Llc Topische regionale neuroaffektive therapie
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IT1393700B1 (it) 2009-04-22 2012-05-08 F S I Fabbrica Italiana Sint Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
WO2011004391A2 (en) 2009-06-25 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of eletriptan and its salt thereof
WO2011024039A1 (en) * 2009-08-25 2011-03-03 Ramesh Babu Potluri Synthesis of novel 5-(2-(phenylsulfonyl)ethyl)-1h-indole derivatives
WO2011089614A1 (en) * 2010-01-19 2011-07-28 Sms Pharmaceuticals Limited PROCESS FOR PREPARING ELETRIPTAN HYDROBROMIDE HAVING α-FORM
CN102606426B (zh) * 2012-03-02 2014-05-21 王仲彦 踏步健身发电装置
WO2014063752A1 (en) 2012-10-26 2014-05-01 Synthon Bv Process for making crystalline form alpha of eletriptan hydrobromide
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺
US10716766B2 (en) 2015-03-02 2020-07-21 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
JP2019502761A (ja) 2016-01-21 2019-01-31 ラボラトリオス レヴィ エセエレ （（ｒ）−３−［（−１−メチルピロリジン−２−イル）メチル］−５−（２−フェニルスルホニルエチル）−１ｈ−インドールを作製する方法
CN106065008B (zh) * 2016-06-16 2018-06-05 黑龙江中医药大学 一种具有改善睡眠作用的吲哚-2-酰胺类化合物及其应用
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
TR201616365A1 (tr) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari
TR201619983A2 (tr) 2016-12-29 2018-07-23 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Di̇klofenak ve eletri̇ptanin farmasöti̇k formülasyonlari
KR102129947B1 (ko) 2018-06-08 2020-07-03 김종창 콘크리트 타설을 위한 입체형 와이어 메쉬
EP3766483A1 (de) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispergierbare pulverzusammensetzung mit einem triptan
CN114793420A (zh) 2020-01-22 2022-07-26 抗菌技术生物技术研究与发展股份有限公司 用于治疗脊髓损伤和改善运动功能的依来曲普坦氢溴酸盐
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Also Published As

Publication number Publication date
CA2091562A1 (en) 1992-04-16
CN1062529A (zh) 1992-07-08
YU48088B (sh) 1997-01-08
NO931378L (no) 1993-04-14
FI105812B (fi) 2000-10-13
CN1039322C (zh) 1998-07-29
BR1100080A (pt) 2000-06-06
NL300070I1 (nl) 2002-02-01
EP0592438A1 (de) 1994-04-20
BG61975B1 (bg) 1998-11-30
PL169987B1 (en) 1996-09-30
NZ270675A (en) 1997-07-27
ATE157361T1 (de) 1997-09-15
RU2095360C1 (ru) 1997-11-10
WO1992006973A1 (en) 1992-04-30
MY111683A (en) 2000-11-30
BG97632A (bg) 1994-03-31
PL170330B1 (pl) 1996-11-29
NO985607L (no) 1998-12-01
IL99701A0 (en) 1992-08-18
NZ240217A (en) 1995-05-26
HU9301098D0 (en) 1993-07-28
JP2677777B2 (ja) 1997-11-17
AU651637B2 (en) 1994-07-28
NL300070I2 (nl) 2002-03-01
LU90902I2 (fr) 2002-06-26
RO111767B1 (ro) 1997-01-30
JP2575272B2 (ja) 1997-01-22
NO305121B1 (no) 1999-04-06
PT99218A (pt) 1992-09-30
ES2104733T3 (es) 1997-10-16
DK0592438T5 (da) 1999-12-06
ZA918156B (en) 1993-04-14
DK0592438T3 (da) 1997-09-29
YU165391A (sh) 1994-01-20
AU8950491A (en) 1992-05-20
FI931667A0 (fi) 1993-04-14
GR3025087T3 (en) 1998-01-30
FI931667A (fi) 1993-04-14
IE913555A1 (en) 1992-04-22
KR0179053B1 (ko) 1999-03-20
NO985607D0 (no) 1998-12-01
DE10299004I2 (de) 2006-03-16
IL99701A (en) 1996-10-31
PT99218B (pt) 1999-04-30
EP0592438B1 (de) 1997-08-27
DE69127468T2 (de) 1998-01-02
BR9106978A (pt) 1993-09-28
MX9101606A (es) 1992-06-05
DE9190141U1 (de) 1993-07-15
CA2091562C (en) 2001-03-27
JPH093063A (ja) 1997-01-07
DE10299004I1 (de) 2002-05-08
HU225055B1 (en) 2006-05-29
SG54270A1 (en) 1998-11-16
JPH05507288A (ja) 1993-10-21
OA09874A (en) 1994-09-15
IL115117A0 (en) 1995-12-08
NO931378D0 (no) 1993-04-14
PL168919B1 (pl) 1996-05-31
HUT64326A (en) 1993-12-28
IL115117A (en) 1996-11-14
EG20224A (en) 1997-12-31
NO2001019I1 (no) 2001-12-03

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