EG20224A - Process for preparing of indole derivatives and their use in treating migraine - Google Patents

Process for preparing of indole derivatives and their use in treating migraine

Info

Publication number
EG20224A
EG20224A EG61791A EG61791A EG20224A EG 20224 A EG20224 A EG 20224A EG 61791 A EG61791 A EG 61791A EG 61791 A EG61791 A EG 61791A EG 20224 A EG20224 A EG 20224A
Authority
EG
Egypt
Prior art keywords
aryl
alkyl
hydrogen
nr5r6
compounds
Prior art date
Application number
EG61791A
Other languages
English (en)
Inventor
John Eugene Macor
Martin James Wythes
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24393510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG20224(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of EG20224A publication Critical patent/EG20224A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Lasers (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EG61791A 1990-10-15 1991-10-14 Process for preparing of indole derivatives and their use in treating migraine EG20224A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59792890A 1990-10-15 1990-10-15

Publications (1)

Publication Number Publication Date
EG20224A true EG20224A (en) 1997-12-31

Family

ID=24393510

Family Applications (1)

Application Number Title Priority Date Filing Date
EG61791A EG20224A (en) 1990-10-15 1991-10-14 Process for preparing of indole derivatives and their use in treating migraine

Country Status (33)

Country Link
EP (1) EP0592438B1 (de)
JP (2) JP2575272B2 (de)
KR (1) KR0179053B1 (de)
CN (1) CN1039322C (de)
AT (1) ATE157361T1 (de)
AU (1) AU651637B2 (de)
BG (1) BG61975B1 (de)
BR (2) BR9106978A (de)
CA (1) CA2091562C (de)
DE (3) DE10299004I2 (de)
DK (1) DK0592438T5 (de)
EG (1) EG20224A (de)
ES (1) ES2104733T3 (de)
FI (1) FI105812B (de)
GR (1) GR3025087T3 (de)
HU (2) HU225055B1 (de)
IE (1) IE913555A1 (de)
IL (3) IL115117A (de)
LU (1) LU90902I2 (de)
MX (1) MX9101606A (de)
MY (1) MY111683A (de)
NL (1) NL300070I2 (de)
NO (3) NO305121B1 (de)
NZ (2) NZ240217A (de)
OA (1) OA09874A (de)
PL (3) PL168919B1 (de)
PT (1) PT99218B (de)
RO (1) RO111767B1 (de)
RU (1) RU2095360C1 (de)
SG (1) SG54270A1 (de)
WO (1) WO1992006973A1 (de)
YU (1) YU48088B (de)
ZA (1) ZA918156B (de)

Families Citing this family (72)

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US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
BR9206810A (pt) * 1991-11-25 1995-10-31 Pfizer Derivados de indol
TW288010B (de) * 1992-03-05 1996-10-11 Pfizer
AU670579B2 (en) * 1992-04-07 1996-07-25 Pfizer Inc. Indole derivatives as 5-HT1 agonists
NZ251047A (en) * 1992-04-10 1996-09-25 Pfizer Acylaminoindole derivatives and medicaments
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (de) * 1992-11-02 1995-07-11 Pfizer
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1271352B (it) * 1993-04-08 1997-05-27 Boehringer Ingelheim Italia Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
US5607960A (en) * 1993-04-22 1997-03-04 Pfizer Inc. Indole derivatives as 5-HT1-like agonists for use in migraine
AP486A (en) * 1993-04-27 1996-04-16 Pfizer Indole derivatives.
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
DE69413240T2 (de) * 1993-08-31 1999-02-04 Pfizer 5-arylindolderivate
CA2195850A1 (en) * 1994-08-03 1996-02-15 Guillaume Lebaut Substituted indoles
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) * 1994-10-12 1994-11-30 Pfizer Ltd Indoles
CA2213241C (en) * 1994-10-12 2001-07-10 Pfizer Research And Development Company, N.V./S.A. Indole derivative for the treatment of migraine
AU726560B2 (en) * 1994-10-12 2000-11-09 Pfizer Research And Development Company, N.V./S.A. Use of indole derivatives for the treatment of various diseases
GB9424471D0 (en) * 1994-12-03 1995-01-18 Pfizer Ltd Treatment of emesis
WO1996029075A1 (en) * 1995-03-20 1996-09-26 Eli Lilly And Company 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists
GB9510223D0 (en) * 1995-05-20 1995-07-19 Pfizer Ltd Therapeutic agent
US5945118A (en) * 1995-09-29 1999-08-31 Pfizer Inc Indole derivative for the treatment of migraine
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
WO1999053956A1 (fr) * 1998-04-16 1999-10-28 Yamanouchi Pharmaceutical Co., Ltd. Remedes contre l'obesite
GB9816556D0 (en) * 1998-07-30 1998-09-30 Pfizer Ltd Therapy
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GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
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GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
US6515141B1 (en) * 1999-08-26 2003-02-04 Fujisawa Pharmaceutical Co., Ltd. Process for the preparation of indole derivatives or salts thereof
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
US20030166704A1 (en) 2000-12-20 2003-09-04 Pfizer Inc. New process
GB0031094D0 (en) * 2000-12-20 2001-01-31 Pfizer Ltd New Process
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
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GB0312478D0 (en) * 2003-05-30 2003-07-09 Pfizer Ltd Improved process
US7132549B2 (en) 2003-05-30 2006-11-07 Pfizer Inc. Process
EP1644004A4 (de) 2003-06-20 2010-10-06 Ronald Aung-Din Topische therapie zur behandlung von migräne, muskelzerrungen, muskelspasmus, spastizität und verwandten zuständen
JP4312256B2 (ja) 2005-06-15 2009-08-12 ファイザー・リミテッド 寄生生物に対して使用する置換アリールピラゾール
US7645786B2 (en) 2005-06-15 2010-01-12 Pfizer Inc. Substituted arylpyrazoles
WO2006079999A2 (en) * 2006-04-09 2006-08-03 Barth Frederik H Induction of a novel state of mind with a 5-ht2a agonist and a nmda antagonist
WO2009142771A2 (en) * 2008-05-22 2009-11-26 Plus Chemicals, S.A. Salts of (r)-5-(2-phenylsulphonylethenyl)-3-(n- methylpyrrolidin-2-ylmethyl)-1h-indole, 5-bromo-3-[(r)-1- methyl-pyrrolidin-2- ylmethyl]-1h-indole and of eletriptan
JP2011526889A (ja) 2008-06-30 2011-10-20 アフギン ファーマ，エルエルシー 局所局部的神経作用療法
EP2149573A1 (de) * 2008-08-01 2010-02-03 Laboratorios Del. Dr. Esteve, S.A. Substituierte Indolsulfonamidverbindungen, ihre Herstellung und ihre Verwendung als Medikamente
IT1393700B1 (it) * 2009-04-22 2012-05-08 F S I Fabbrica Italiana Sint Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
WO2011004391A2 (en) 2009-06-25 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of eletriptan and its salt thereof
WO2011024039A1 (en) * 2009-08-25 2011-03-03 Ramesh Babu Potluri Synthesis of novel 5-(2-(phenylsulfonyl)ethyl)-1h-indole derivatives
WO2011089614A1 (en) * 2010-01-19 2011-07-28 Sms Pharmaceuticals Limited PROCESS FOR PREPARING ELETRIPTAN HYDROBROMIDE HAVING α-FORM
CN102606426B (zh) * 2012-03-02 2014-05-21 王仲彦 踏步健身发电装置
WO2014063752A1 (en) 2012-10-26 2014-05-01 Synthon Bv Process for making crystalline form alpha of eletriptan hydrobromide
EP3610890A1 (de) 2012-11-14 2020-02-19 The Johns Hopkins University Verfahren und zusammensetzungen zur behandlung von schizophrenie
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
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WO2017125351A1 (en) 2016-01-21 2017-07-27 Laboratorios Lesvi Sl Process for preparing (( r)-3-[(-1-methylpyrrolidin-2-yl)methyl]-5-(2-phenylsulfonylethyl)-1h-indole
CN106065008B (zh) * 2016-06-16 2018-06-05 黑龙江中医药大学 一种具有改善睡眠作用的吲哚-2-酰胺类化合物及其应用
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
TR201616365A1 (tr) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari
TR201619983A2 (tr) 2016-12-29 2018-07-23 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Di̇klofenak ve eletri̇ptanin farmasöti̇k formülasyonlari
KR102129947B1 (ko) 2018-06-08 2020-07-03 김종창 콘크리트 타설을 위한 입체형 와이어 메쉬
EP3766483A1 (de) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispergierbare pulverzusammensetzung mit einem triptan
CN114793420A (zh) 2020-01-22 2022-07-26 抗菌技术生物技术研究与发展股份有限公司 用于治疗脊髓损伤和改善运动功能的依来曲普坦氢溴酸盐
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Also Published As

Publication number Publication date
SG54270A1 (en) 1998-11-16
IL99701A0 (en) 1992-08-18
PT99218A (pt) 1992-09-30
BG97632A (bg) 1994-03-31
AU651637B2 (en) 1994-07-28
YU165391A (sh) 1994-01-20
CN1039322C (zh) 1998-07-29
ATE157361T1 (de) 1997-09-15
KR0179053B1 (ko) 1999-03-20
JP2575272B2 (ja) 1997-01-22
LU90902I2 (fr) 2002-06-26
NZ270675A (en) 1997-07-27
ZA918156B (en) 1993-04-14
HUT64326A (en) 1993-12-28
JPH05507288A (ja) 1993-10-21
CA2091562A1 (en) 1992-04-16
BR1100080A (pt) 2000-06-06
YU48088B (sh) 1997-01-08
NO931378D0 (no) 1993-04-14
NL300070I2 (nl) 2002-03-01
ES2104733T3 (es) 1997-10-16
DE10299004I2 (de) 2006-03-16
HU9301098D0 (en) 1993-07-28
NZ240217A (en) 1995-05-26
JPH093063A (ja) 1997-01-07
DE69127468D1 (de) 1997-10-02
PL170330B1 (pl) 1996-11-29
DK0592438T5 (da) 1999-12-06
BG61975B1 (bg) 1998-11-30
RO111767B1 (ro) 1997-01-30
DK0592438T3 (da) 1997-09-29
FI931667A0 (fi) 1993-04-14
GR3025087T3 (en) 1998-01-30
EP0592438A1 (de) 1994-04-20
IL115117A0 (en) 1995-12-08
NO305121B1 (no) 1999-04-06
DE69127468T2 (de) 1998-01-02
NO985607D0 (no) 1998-12-01
OA09874A (en) 1994-09-15
FI931667A (fi) 1993-04-14
NO2001019I1 (no) 2001-12-03
MX9101606A (es) 1992-06-05
JP2677777B2 (ja) 1997-11-17
FI105812B (fi) 2000-10-13
DE9190141U1 (de) 1993-07-15
PL169987B1 (en) 1996-09-30
IL115117A (en) 1996-11-14
CA2091562C (en) 2001-03-27
MY111683A (en) 2000-11-30
NL300070I1 (nl) 2002-02-01
PL168919B1 (pl) 1996-05-31
CN1062529A (zh) 1992-07-08
RU2095360C1 (ru) 1997-11-10
AU8950491A (en) 1992-05-20
IE913555A1 (en) 1992-04-22
NO931378L (no) 1993-04-14
IL99701A (en) 1996-10-31
BR9106978A (pt) 1993-09-28
NO985607L (no) 1998-12-01
PT99218B (pt) 1999-04-30
HU225055B1 (en) 2006-05-29
EP0592438B1 (de) 1997-08-27
DE10299004I1 (de) 2002-05-08
WO1992006973A1 (en) 1992-04-30

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