WO1996004266A2 - Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung - Google Patents
Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung Download PDFInfo
- Publication number
- WO1996004266A2 WO1996004266A2 PCT/EP1995/002867 EP9502867W WO9604266A2 WO 1996004266 A2 WO1996004266 A2 WO 1996004266A2 EP 9502867 W EP9502867 W EP 9502867W WO 9604266 A2 WO9604266 A2 WO 9604266A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pyridin
- indol
- alkyl
- compounds
- fluorobenzyl
- Prior art date
Links
- 0 *c1n[n](Cc(cc2)ccc2F)c2ccccc12 Chemical compound *c1n[n](Cc(cc2)ccc2F)c2ccccc12 0.000 description 4
- NUKYPUAOHBNCPY-UHFFFAOYSA-N Nc1ccncc1 Chemical compound Nc1ccncc1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Definitions
- the drugs indomethacin and acemetacin have an N-substituted indole skeleton.
- Indomethacin is the prototype of compounds with
- the indazole derivative is the anti-inflammatory substance bendazac, the synthesis of the substance with the IUPAC name [(1-benzyl-1H-indazol-3-yl) oxy] acetic acid is described in US Pat. No. 3,470,194.
- DE-OS 42 25 756 and EP 392 317 describe benzimidazoles which are angiotensin antagonists, in particular angiotensin II antagonists.
- Colantti (Chim. Ther 6 (5), 367-79) describe indole derivatives which have coccidiostatic properties.
- EP 485 962 describes N-methyl indole derivatives as S 3 receptor antagonists.
- WO 88/5432 describes N-alkyl-substituted 3-indole
- Carboxylic acid derivatives as diuretics and cardiovascular substances are Carboxylic acid derivatives as diuretics and cardiovascular substances.
- WO 93/2062 also describes N-alkyl-substituted 3-indole carboxamides, the amide nitrogen of which
- Heterocycles such as the tetrazole ring and the substituted tetrazole ring, is substituted.
- EP 580 502 describes 3- (hydroxybenzylidenyl) indolin-2-one derivatives with anti-inflammatory, analgesic,
- the compounds which may exist as a mixture of E / Z isomers, inhibit LTB4 synthesis.
- the compounds have different substituents on the indole nitrogen, and on the 2-carbon atom of the indole ring there is a keto or a thioketo group.
- the object of the invention is to create new compounds
- the object of the invention therefore includes compounds of general formula 1
- R 1 hydrogen, (C 1 -C 6 ) alkyl, where the alkyl group can be straight-chain or branched and one or more times by halogen, phenyl, which in turn one or more times by halogen, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl,
- R 2 and R 3 may be the same or different and
- Halogen, benzyloxy, hydroxyl, furthermore R 2 and R 3 may be the nitro group, the amino group which may be substituted as described above, which
- W can be CH or N
- Y can be O or S
- X can be CH or N
- X furthermore, if Y stands for a single bond, such that the heterocycle is directly connected to the group - (CH) n -,
- Methylene group is bonded to the nitrogen atom of the group NR 5 R 7 of R 5 , and further applies that for the If R 6 and R 7 are hydrogen, this hydrogen is replaced,
- R 4 hydrogen, (C 1 -C 6 alkyl), where the alkyl group can be straight-chain or branched, (C 3 -C 7 )
- R 3 can be N- (C 1 -C 6 ) alkyl-2-pyrrolidinyl or the rest
- R 8 and R 9 can be different and as radicals R 8 and R 9 the meaning (C 1 -C 6 ) alkyl, where the alkyl group can be straight-chain or branched, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) alkoxy, NO 2 , NH 2 , ethoxycarbonylamino or may have phenoxycarbonylamino, furthermore R 6 and R 7 together with the N atom to which they are attached can form a piperazine skeleton of the formula 2 formula 2
- R 10 is the groups (C 1 -C 6 ) alkyl, where the alkyl group can be straight-chain or branched, (C 3 - C 7 ) cycloalkyl and phenyl, which with alkyl, alkoxy, halogen, the benzylhydryl and the bis-pF-benzhydryl group may be substituted, may furthermore
- R 5 is a 2- or 4-pyrimidinylamino ring
- 2-pyrimidinylamino ring can be substituted one or more times with methyl, or represent a 4-piperidylamino ring, where the N atom of the piperidine radical in each case with H, (C 1 -C 6 ) alkyl, the alkyl group being straight-chain or can be branched, (C 3 -C 7 ) cycloalkyl, aralkyl, phenyl or that substituted by the groups NH 2 , NO 2 , OCH 3 and NHCOOEt
- R 5 also means the 3- or 4-
- Tetrahydropyridinylamino ring the N atom of which can be substituted by H, (C 1 -C 6 ) -alkyl, where the alkyl group can be straight-chain or branched, (C 3 -C 7 ) -cycloalkyl and aralkyl,
- Z can be O or S
- R 11 can have the same meaning as R 1 ,
- R 12 and R 13 may be the same or different and
- R 14 is benzyl, which is substituted one or more times by halogen, (C 1 -C 6 ) -alkyl, where the alkyl group can be straight-chain or branched, (C 1 -C 6 ) -alkoxy or benzyloxy, or the group
- 4-pyridylamino which may be substituted with an amino, nitro or (C 1 -C 4 ) alkoxycarbonyl and (C 1 -C 4 ) alkoxycarbonylamino, 4-quinolylamino which may be substituted with (C 1 -C 4 ) alkyl or
- the compounds according to the invention can also be present as acid addition salts, for example as salts of
- Mineral acids such as hydrochloric acid, sulfuric acid, phosphoric acid, salts of organic acids, such as
- straight-chain alkyl group means, for example, radicals such as methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, and "branched alkyl group” means radicals such as isopropyl or tert-but.l. Under the designation “alkyl groups” are both
- Cycloalkyl includes residues such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or
- halogen stands for fluorine, chlorine, bromine or iodine.
- alkoxy group represents radicals such as methoxy, ethoxy, propoxy, butoxy, isopropoxy, isobutoxy or pentoxy.
- the compounds according to the invention show a good activity in the pharmacological models for histamine release according to the following specification:
- Sprague-Dawley rats were killed against chicken egg white (HEW) by subcutaneous injection of 30 mg HEW along with
- the mast cells of the peritoneal and pleural cavity were isolated from these animals four weeks later.
- the cells were washed in Tris-Gel CM (the Tris-Gel CM buffer has the following composition: Tris 25 mmol / 1
- Murine T helper cells (D10.G4) were used as IL-4 / IL-5 producing cells. These cells were preincubated with the test substances for 30 minutes at 37 ° C.
- the cells were then stimulated at 37 ° C. by adding a monoclonal antibody against the T cell receptor domain CD3 (anti-CD3) to produce interleukins. After 16 hours, the cells were centrifuged off and the interleukins released were quantified in the cell supernatant using ELISAs for murine IL-4 or IL-5.
- anti-CD3 monoclonal antibody against the T cell receptor domain CD3
- guinea pigs Male guinea pigs (Pirbright White, 200-250 g, Charles River Wiga, Sulfeld) were actively sensitized using a s.c. Injection of ovalbumin (10 ⁇ g + 100 mg aluminum hydroxide) and boosted 2 weeks later. One week after the booster injection, the animals were exposed to an aerosol made from 0.5% ovalbumin solution for 30 seconds. 24 hours later, bronchoalveolar lavage (BAL) with 2 x 5 ml physiol.
- ovalbumin 10 ⁇ g + 100 mg aluminum hydroxide
- the lava fluid was pooled, centrifuged at 400 xg for 10 minutes and the cell pellet in 1 ml physiol.
- Eosinophil test kit from Becton-Dickinson were stained. Percent inhibition of eosinophilia in the lavage was calculated by using the number of eosinophils
- Substance-treated groups were compared with the eosinophil number of normal (non-challenged) and challenged, untreated control groups.
- the group sizes were 10 animals each.
- Test substances were given either prophylactically 2 hours before allergen challenge (-2h) or therapeutically 4 hours after challenge (+4 h). If the therapeutic
- DMSO dimethyl sulfoxide
- the indole carboxylic acid derivative is in a protic, dipolar aprotic or non-polar organic
- Solvents such as isopropanol, THF, DMSO, DMA, dioxane, toluene, DMF, N-methylpyrrolidone or
- Heteroaralkyl or aryl halide optionally with the addition of a catalyst such as Cu, is allowed to react for some time, for example 30 minutes to 3 hours, and maintains the temperature within a range from 0 ° C. to 120 ° C., preferably 30 ° C. to 80 ° ° C, especially at 50 ° C - 60 ° C. After the reaction has ended, the
- Reaction mixture added to the water, for example with diethyl ether dichloromethane, methyl tert. -butyl ether or tetrahydrofuran extracted and the organic phase obtained in each case with dried anhydrous sodium sulfate.
- the organic phase is concentrated in vac. one, crystallizes the
- the N-substituted indolecarboxylic acid ester obtained according to the above regulation (1st stage) is dissolved in ethanol and IN sodium hydroxide solution is added.
- the saponification reaction is carried out between 20 ° and 100 ° C., preferably between 40 ° C. and 80 ° C., in particular between 50 ° C. and 60 ° C. After 1-2 hours, the mixture is cooled to room temperature, acidified with hydrochloric acid or concentrated and concentrated
- the acid obtained according to the above procedure (2nd stage) is dissolved in anhydrous tetrahydrofuran.
- Dicyclohexylcarbodiimide is added as the condensing agent and then the substituted primary or secondary amine is added.
- the urea formed is filtered.
- the residue is recrystallized or purified chromatographically on silica gel.
- a solvent e.g. a mixture of dichloromethane and ethanol (95: 5, vol / vol) use.
- Condensation reaction in stage 3 can be as Condensing agents can also be used diisopropylcarbodiimide (DIC).
- DIC diisopropylcarbodiimide
- the condensation reaction of stage 3 can also be carried out using triphenylphoshin and bromotrichloromethane in THF at a temperature of 30-70 ° C. instead of using DCC / THF or DIC / TMF.
- the combinations carbonyldiimidazole in anhydrous THF at a temperature of 0 ° C to 60 ° C, preferably at a temperature of 10 ° C - 30 ° C, especially at 25 ° C were used for the condensation reaction (stage 3). Also used for the condensation reaction in stage 3
- dicyclohexylcarbodiimide or diisopropylcarbodiimide solvent anhydrous tetrahydrofuran
- the final stage D 23714 is made from D 23720 by
- the indol-3-ylcarboxamide is placed in a reflux condenser under a nitrogen atmosphere in an anhydrous organic solvent, such as, for example, diethyl ether, THF, dioxane or toluene. After adding 2-5 times,
- reducing agent such as lithium aluminum hydride
- the base obtained above is in an organic solvent, preferably an alcohol such as methanol, ethanol or isopropanol or not in one
- protic solvents such as ethyl acetate or
- Table 2 below are from the general formula 1 and the substituents YG, W, X, R 1 , R 2 and R 3 , the
- N- (3-nitro-6-methoxy-pyridin-2-yl) -1,2,3,4-tetrahydro- ⁇ -carboline 200 ml of acetonitrile and 3.01 g of K 2 CO 3 are added to a flask. It is cooled with an ice-salt mixture and 2.5 g (14.5 mmol) of 1,2,3,4-tetr1hydro-ß-carboline and 2.71 g (14.5 mmol) of 2-chloro-3-nitro are added -6-methoxypyridine too. Under Stirring is allowed to come to room temperature and heated to reflux temperature for 2 hours. Then i.Vak.
- N- (3-ethoxycarbonylamino-6-methoxypyridin-2-yl) -1,2,3,4-tetrahydro- ⁇ -carboline In a three-necked flask with 200 ml of anhydrous ethanol, 4 g (12.3 mmol) of N- (3-nitro-6-methoxy-pyridin-2-yl) -1,2,3,4-tetrahydro- ⁇ -carboline. 2 g of sodium borohydride and 0.5 g of palladium-carbon are added under a nitrogen atmosphere. With further nitrogen gassing, the mixture is heated to boiling for 2 hours. The mixture is then cooled to 10 ° C. and 4.07 g (37 mmol) are left
- Tryptamine hydrochloride is dissolved in water in a flask while heating. Glyoxylic acid monohydrate and a solution of an inorganic base such as NaOH, KOH, LiOH or Ba (OH) 2 are added. After the reaction, the precipitate formed is filtered off and washed. Then the precipitate is heated in an inorganic acid such as
- Hydrochloric acid or sulfuric acid are additionally conc.
- Alkali hydrogen carbonates in an organic solvent such as acetonitrile, propionitrile, THF, diethyl ether or
- the dichloromethane extracts are dried with anhydrous sodium sulfate, filtered and concentrated. The residue is purified by column chromatography on silica gel. Eluent: dichloromethane / ethanol 95: 5 (v / v). Recrystallization of the compound is absolute. Ethanol performed.
- the 2- (1-methylindol-3-yl) isopropylamii used, for example, for the end compound D 23202 can be synthesized according to the following reaction route:
- Lithium aluminum hydride slowly destroyed by adding 150 ml of ice water and the resulting mixture with
- Benzyl-1H-indazol-3-yl) oxyacetic acid ethyl ester are mixed with sodium hydroxide solution at 50 ° C in a solvent mixture
- Triphenylphosphine added and then a solution of 5.1 g (29 mmol) of diethyl azodicarboxylate in 10 ml
- a solution of the amine is added dropwise at room temperature to a solution of the indazole derivative in an organic solvent, such as THF, dioxane, DMF or DMA.
- an organic solvent such as THF, dioxane, DMF or DMA.
- the mixture is stirred briefly before triphenylphosphine and azodicarboxylic acid ester in THF are added.
- the mixture is stirred and the solvent is stripped off after the end of the reaction. The cleaning is done via
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Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8506137A JPH10503501A (ja) | 1994-08-03 | 1995-07-20 | 抗喘息、抗アレルギー、抗炎症及び免疫修飾作用を有するインドール、インダゾール、ピリドピロール及びピリドピラゾール誘導体 |
AU31626/95A AU3162695A (en) | 1994-08-03 | 1995-07-20 | Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects |
US08/776,616 US5965582A (en) | 1994-08-03 | 1995-07-20 | N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect |
EP95927679A EP0775131A2 (de) | 1994-08-03 | 1995-07-20 | Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung |
NO970412A NO970412L (no) | 1994-08-03 | 1997-01-30 | Indol-, indazol-, pyridopyrrol- og pyridopyrazolderivater med antiastmatisk, antiallergisk, anti-inflammatorisk og immunomodulerende virkning |
FI971334A FI971334A0 (fi) | 1994-08-03 | 1997-04-01 | Indoli-, indatsoli-, pyridopyrroli- ja pyridopyratsolijohdannaiset, joilla on antiastmaattinen, antiallerginen, anti-inflammatorinen ja immunomoduloiva vaikutus |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4427393 | 1994-08-03 | ||
DEP4427393.2 | 1994-08-03 | ||
DE19511916.9 | 1995-03-31 | ||
DE19511916A DE19511916A1 (de) | 1994-08-03 | 1995-03-31 | Neue N-Benzylindol- und Benzopyrazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung |
Publications (2)
Publication Number | Publication Date |
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WO1996004266A2 true WO1996004266A2 (de) | 1996-02-15 |
WO1996004266A3 WO1996004266A3 (de) | 1996-05-17 |
Family
ID=25938901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1995/002867 WO1996004266A2 (de) | 1994-08-03 | 1995-07-20 | Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung |
Country Status (13)
Country | Link |
---|---|
US (1) | US5965582A (de) |
EP (1) | EP0775131A2 (de) |
JP (1) | JPH10503501A (de) |
AU (1) | AU3162695A (de) |
CA (1) | CA2195850A1 (de) |
EG (1) | EG21559A (de) |
FI (1) | FI971334A0 (de) |
HR (1) | HRP950435A2 (de) |
IL (1) | IL114795A (de) |
NO (1) | NO970412L (de) |
TR (1) | TR199500952A2 (de) |
TW (1) | TW434227B (de) |
WO (1) | WO1996004266A2 (de) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US5965582A (en) * | 1994-08-03 | 1999-10-12 | Asta Medica Aktiengesellschaft | N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect |
WO1999058503A1 (de) * | 1998-05-11 | 1999-11-18 | Arzneimittelwerk Dresden Gmbh | Neue 1,5- und 3-o-substituierte 1h-indazole mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver wirkung, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
EP0737685B1 (de) * | 1995-04-14 | 2000-07-19 | Adir Et Compagnie | Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
WO2001056988A1 (fr) * | 2000-02-01 | 2001-08-09 | Kirin Beer Kabushiki Kaisha | Composes contenant de l'azote et possedant une activite d'inhibition des kinases, et medicaments comprenant ces composes |
US7202237B2 (en) * | 1997-11-05 | 2007-04-10 | Neurosearch A/S | Pyridylether derivatives, their preparation and use |
EP2049520A2 (de) * | 2006-08-07 | 2009-04-22 | Ironwood Pharmaceuticals, Inc. | Indolverbindungen |
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DE69918799D1 (de) | 1998-01-14 | 2004-08-26 | Uab Res Foundation Birmingham | Verfahren zur herstellung und screening von inhibitoren des bakteriellen nad synthetase enzyms, verbindungen daraus und methoden zur behandlung bakterieller und mikrobieller infektionen mit diesen inhibitoren |
US6861448B2 (en) * | 1998-01-14 | 2005-03-01 | Virtual Drug Development, Inc. | NAD synthetase inhibitors and uses thereof |
US6673827B1 (en) | 1999-06-29 | 2004-01-06 | The Uab Research Foundation | Methods of treating fungal infections with inhibitors of NAD synthetase enzyme |
ATE330955T1 (de) | 1998-04-28 | 2006-07-15 | Elbion Ag | Indolderivate und deren verwendung als inhibitoren der phosphodiesterase 4. |
US6362213B1 (en) | 1999-12-23 | 2002-03-26 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
DE10037310A1 (de) * | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
CA2460347A1 (en) * | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 3-glyoxlylamideindoles for treating cancer |
SE0200356D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
SE0200411D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
US20040048866A1 (en) * | 2002-03-08 | 2004-03-11 | Teodozyj Kolasa | Indazole derivatives that are activators of soluble guanylate cyclase |
US20050089559A1 (en) * | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
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US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
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US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
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AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
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US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
JP7169008B2 (ja) * | 2018-04-26 | 2022-11-10 | エーディーティー ファーマシューティカルズ,エルエルシー | 抗がんインデン、インダン、アザインデン、アザインダン、医薬組成物および使用 |
WO2022211518A1 (ko) * | 2021-04-02 | 2022-10-06 | 파렌키마바이오텍 주식회사 | 신규 화합물 및 이의 건선, 천식 또는 전신홍반루푸스의 치료 용도 |
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- 1995-07-20 JP JP8506137A patent/JPH10503501A/ja active Pending
- 1995-07-20 WO PCT/EP1995/002867 patent/WO1996004266A2/de not_active Application Discontinuation
- 1995-07-20 EP EP95927679A patent/EP0775131A2/de not_active Withdrawn
- 1995-07-20 CA CA002195850A patent/CA2195850A1/en not_active Abandoned
- 1995-07-26 TW TW084107752A patent/TW434227B/zh not_active IP Right Cessation
- 1995-08-01 IL IL11479595A patent/IL114795A/xx not_active IP Right Cessation
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US5965582A (en) * | 1994-08-03 | 1999-10-12 | Asta Medica Aktiengesellschaft | N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect |
EP0737685B1 (de) * | 1995-04-14 | 2000-07-19 | Adir Et Compagnie | Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
US7202237B2 (en) * | 1997-11-05 | 2007-04-10 | Neurosearch A/S | Pyridylether derivatives, their preparation and use |
WO1999058503A1 (de) * | 1998-05-11 | 1999-11-18 | Arzneimittelwerk Dresden Gmbh | Neue 1,5- und 3-o-substituierte 1h-indazole mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver wirkung, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US6166023A (en) * | 1998-05-11 | 2000-12-26 | Arzneimittelwerk Dresden Gmbh | 1,5- and 3-O-substituted 1H-indazoles having anti-asthmatic, anti-allergic, anti-inflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments |
WO2001056988A1 (fr) * | 2000-02-01 | 2001-08-09 | Kirin Beer Kabushiki Kaisha | Composes contenant de l'azote et possedant une activite d'inhibition des kinases, et medicaments comprenant ces composes |
US7217722B2 (en) | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
EP2049520A2 (de) * | 2006-08-07 | 2009-04-22 | Ironwood Pharmaceuticals, Inc. | Indolverbindungen |
EP2049520A4 (de) * | 2006-08-07 | 2011-01-05 | Ironwood Pharmaceuticals Inc | Indolverbindungen |
EP2610244A1 (de) * | 2006-08-07 | 2013-07-03 | Ironwood Pharmaceuticals, Inc. | Indolverbindungen |
Also Published As
Publication number | Publication date |
---|---|
AU3162695A (en) | 1996-03-04 |
WO1996004266A3 (de) | 1996-05-17 |
EG21559A (en) | 2001-12-31 |
CA2195850A1 (en) | 1996-02-15 |
NO970412L (no) | 1997-02-27 |
TR199500952A2 (tr) | 1996-07-21 |
IL114795A0 (en) | 1995-12-08 |
IL114795A (en) | 1999-11-30 |
JPH10503501A (ja) | 1998-03-31 |
HRP950435A2 (en) | 1997-12-31 |
FI971334A (fi) | 1997-04-01 |
TW434227B (en) | 2001-05-16 |
FI971334A0 (fi) | 1997-04-01 |
NO970412D0 (no) | 1997-01-30 |
US5965582A (en) | 1999-10-12 |
EP0775131A2 (de) | 1997-05-28 |
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