WO1996004266A3 - Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung - Google Patents

Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung Download PDF

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Publication number
WO1996004266A3
WO1996004266A3 PCT/EP1995/002867 EP9502867W WO9604266A3 WO 1996004266 A3 WO1996004266 A3 WO 1996004266A3 EP 9502867 W EP9502867 W EP 9502867W WO 9604266 A3 WO9604266 A3 WO 9604266A3
Authority
WO
WIPO (PCT)
Prior art keywords
asthmatic
allergic
inflammatory
derivatives
pyridopyrrol
Prior art date
Application number
PCT/EP1995/002867
Other languages
English (en)
French (fr)
Other versions
WO1996004266A2 (de
Inventor
Guillaume Lebaut
Fabienne Fouchard
Bernhard Kutscher
Peter Emig
Ilona Fleischhauer
Juergen Schmidt
Stefan Szelenyi
Original Assignee
Asta Medica Ag
Guillaume Lebaut
Fabienne Fouchard
Bernhard Kutscher
Peter Emig
Ilona Fleischhauer
Juergen Schmidt
Stefan Szelenyi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19511916A external-priority patent/DE19511916A1/de
Application filed by Asta Medica Ag, Guillaume Lebaut, Fabienne Fouchard, Bernhard Kutscher, Peter Emig, Ilona Fleischhauer, Juergen Schmidt, Stefan Szelenyi filed Critical Asta Medica Ag
Priority to EP95927679A priority Critical patent/EP0775131A2/de
Priority to JP8506137A priority patent/JPH10503501A/ja
Priority to AU31626/95A priority patent/AU3162695A/en
Priority to US08/776,616 priority patent/US5965582A/en
Publication of WO1996004266A2 publication Critical patent/WO1996004266A2/de
Publication of WO1996004266A3 publication Critical patent/WO1996004266A3/de
Priority to NO970412A priority patent/NO970412L/no
Priority to FI971334A priority patent/FI971334A/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Die N-Benzylindol- und Benzopyrazol-Derivate der allgemeinen Formel (1) besitzen antiasthmatische, antiallergische, entzündungshemmende und immunmodulierende Wirkung und eignen sich zur Herstellung von Arzneimitteln.
PCT/EP1995/002867 1994-08-03 1995-07-20 Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung WO1996004266A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP95927679A EP0775131A2 (de) 1994-08-03 1995-07-20 Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung
JP8506137A JPH10503501A (ja) 1994-08-03 1995-07-20 抗喘息、抗アレルギー、抗炎症及び免疫修飾作用を有するインドール、インダゾール、ピリドピロール及びピリドピラゾール誘導体
AU31626/95A AU3162695A (en) 1994-08-03 1995-07-20 Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects
US08/776,616 US5965582A (en) 1994-08-03 1995-07-20 N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect
NO970412A NO970412L (no) 1994-08-03 1997-01-30 Indol-, indazol-, pyridopyrrol- og pyridopyrazolderivater med antiastmatisk, antiallergisk, anti-inflammatorisk og immunomodulerende virkning
FI971334A FI971334A (fi) 1994-08-03 1997-04-01 Indoli-, indatsoli-, pyridopyrroli- ja pyridopyratsolijohdannaiset, joilla on antiastmaattinen, antiallerginen, anti-inflammatorinen ja immunomoduloiva vaikutus

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4427393 1994-08-03
DEP4427393.2 1994-08-03
DE19511916.9 1995-03-31
DE19511916A DE19511916A1 (de) 1994-08-03 1995-03-31 Neue N-Benzylindol- und Benzopyrazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung

Publications (2)

Publication Number Publication Date
WO1996004266A2 WO1996004266A2 (de) 1996-02-15
WO1996004266A3 true WO1996004266A3 (de) 1996-05-17

Family

ID=25938901

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/002867 WO1996004266A2 (de) 1994-08-03 1995-07-20 Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung

Country Status (13)

Country Link
US (1) US5965582A (de)
EP (1) EP0775131A2 (de)
JP (1) JPH10503501A (de)
AU (1) AU3162695A (de)
CA (1) CA2195850A1 (de)
EG (1) EG21559A (de)
FI (1) FI971334A (de)
HR (1) HRP950435A2 (de)
IL (1) IL114795A (de)
NO (1) NO970412L (de)
TR (1) TR199500952A2 (de)
TW (1) TW434227B (de)
WO (1) WO1996004266A2 (de)

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US6673827B1 (en) 1999-06-29 2004-01-06 The Uab Research Foundation Methods of treating fungal infections with inhibitors of NAD synthetase enzyme
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US6362213B1 (en) 1999-12-23 2002-03-26 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
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DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
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Also Published As

Publication number Publication date
CA2195850A1 (en) 1996-02-15
NO970412L (no) 1997-02-27
IL114795A (en) 1999-11-30
AU3162695A (en) 1996-03-04
FI971334A0 (fi) 1997-04-01
HRP950435A2 (en) 1997-12-31
TR199500952A2 (tr) 1996-07-21
US5965582A (en) 1999-10-12
EG21559A (en) 2001-12-31
FI971334A (fi) 1997-04-01
WO1996004266A2 (de) 1996-02-15
JPH10503501A (ja) 1998-03-31
EP0775131A2 (de) 1997-05-28
IL114795A0 (en) 1995-12-08
TW434227B (en) 2001-05-16
NO970412D0 (no) 1997-01-30

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