DE3689748T2 - Benzimidazolderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung. - Google Patents

Benzimidazolderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung.

Info

Publication number
DE3689748T2
DE3689748T2 DE3689748T DE3689748T DE3689748T2 DE 3689748 T2 DE3689748 T2 DE 3689748T2 DE 3689748 T DE3689748 T DE 3689748T DE 3689748 T DE3689748 T DE 3689748T DE 3689748 T2 DE3689748 T2 DE 3689748T2
Authority
DE
Germany
Prior art keywords
preparation
therapeutic use
benzimidazole derivatives
benzimidazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3689748T
Other languages
English (en)
Other versions
DE3689748D1 (de
Inventor
Philippe Manoury
Jean Binet
Gerard Defosse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Application granted granted Critical
Publication of DE3689748D1 publication Critical patent/DE3689748D1/de
Publication of DE3689748T2 publication Critical patent/DE3689748T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE3689748T 1985-09-11 1986-09-02 Benzimidazolderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung. Expired - Lifetime DE3689748T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8513453A FR2587029B1 (fr) 1985-09-11 1985-09-11 Derives de benzimidazole, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
DE3689748D1 DE3689748D1 (de) 1994-05-05
DE3689748T2 true DE3689748T2 (de) 1994-08-11

Family

ID=9322797

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3689748T Expired - Lifetime DE3689748T2 (de) 1985-09-11 1986-09-02 Benzimidazolderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung.
DE1997175081 Active DE19775081I2 (de) 1985-09-11 1986-09-02 Benzimidazolderivate Verfahren zu deren Herstellung und deren therapeutische Anwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1997175081 Active DE19775081I2 (de) 1985-09-11 1986-09-02 Benzimidazolderivate Verfahren zu deren Herstellung und deren therapeutische Anwendung

Country Status (25)

Country Link
US (2) US4820710A (de)
EP (1) EP0217700B1 (de)
JP (1) JPS6261979A (de)
KR (1) KR930001411B1 (de)
AR (1) AR243187A1 (de)
AT (1) ATE103603T1 (de)
AU (1) AU582894B2 (de)
CA (1) CA1272486A (de)
CS (1) CS357991A3 (de)
DE (2) DE3689748T2 (de)
DK (1) DK170594B1 (de)
ES (1) ES2001782A6 (de)
FI (1) FI87210C (de)
FR (1) FR2587029B1 (de)
GR (1) GR862318B (de)
HK (1) HK1005592A1 (de)
HU (1) HU196597B (de)
IE (1) IE61607B1 (de)
IL (1) IL79992A (de)
LU (1) LU90085I2 (de)
NL (1) NL970029I2 (de)
NO (2) NO167026C (de)
NZ (1) NZ217537A (de)
PT (1) PT83355B (de)
ZA (1) ZA866901B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2618435B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
FR2637595B1 (fr) * 1988-10-11 1990-11-30 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
JPH02294758A (ja) * 1989-05-09 1990-12-05 Nec Corp 計算機使用時間管理方式
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
FR2666582B1 (fr) * 1990-09-07 1994-09-02 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique.
FR2693194B1 (fr) * 1992-07-03 1994-09-23 Synthelabo Dérivés d'alcanecarboxamide, leur préparation et leur application thérapeutique.
FR2745500B1 (fr) * 1996-03-04 1998-04-03 Synthelabo Formulations pharmaceutiques a liberation prolongee contenant de la mizolastine
JPH10101564A (ja) * 1996-09-27 1998-04-21 Mitsubishi Chem Corp 鼻炎予防及び／又は治療剤
EP0963371B1 (de) 1997-02-25 2003-05-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Substituierte benzimidazole als nicht-nucleoside reverse transcriptase inhibitore
FR2762214B1 (fr) * 1997-04-17 2000-10-06 Synthelabo Utilisation de la mizolastine pour la preparation d'un medicament destine au traitement de l'inflammation
EP0958820A1 (de) * 1998-05-19 1999-11-24 Sanofi-Synthelabo Verwendung von einem Imidazolderivat zur Herstellung eines Arzneimittels zur Behandlung von Autoimmunerkrankungen
ES2208098B1 (es) * 2002-10-02 2005-10-16 Ragactives, S.L. Procedimiento e intermedios para la obtencion de derivados de 1-(1h-bencimidazol-2-il)-4-(2-aminopirimidin) piperidina.
US7432378B2 (en) * 2003-09-30 2008-10-07 Janssen Pharmaceutica, N.V. Benzoimidazole compounds
ES2245227B1 (es) * 2004-04-06 2007-03-01 Ragactives, S.L. Formas cristalinas de mizolastina, procedimientos para su obtencion y composiciones farmaceuticas que las contienen.
JP5732453B2 (ja) * 2009-06-25 2015-06-10 アルカーメス ファーマ アイルランド リミテッド Ｎｈ酸性化合物のプロドラッグ
EP4124616A1 (de) 2009-06-25 2023-02-01 Alkermes Pharma Ireland Limited Heterocyclische verbindungen zur behandlung von neurologischen und psychologischen erkrankungen
CN102140076A (zh) * 2010-02-03 2011-08-03 辽宁本源制药有限公司 咪唑斯汀中间体的制备
AU2012351747B2 (en) 2011-12-15 2016-05-12 Alkermes Pharma Ireland Limited Prodrugs of secondary amine compounds
EP3761983A1 (de) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Dosierstrategie für aripiprazol
WO2020210597A1 (en) * 2019-04-11 2020-10-15 Amgen Inc. Benzimidazole derivatives and their uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281005A (en) * 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
DE3484096D1 (de) * 1983-11-30 1991-03-14 Janssen Pharmaceutica Nv Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine.
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives

Also Published As

Publication number Publication date
JPS6261979A (ja) 1987-03-18
AU582894B2 (en) 1989-04-13
PT83355A (fr) 1986-10-01
PT83355B (pt) 1989-05-12
US4912219A (en) 1990-03-27
DK431586D0 (da) 1986-09-10
LU90085I2 (fr) 1997-09-25
DK170594B1 (da) 1995-11-06
AR243187A1 (es) 1993-07-30
CA1272486A (en) 1990-08-07
IE862416L (en) 1987-03-11
NO863608D0 (no) 1986-09-10
IL79992A0 (en) 1986-12-31
IL79992A (en) 1990-07-12
HUT41771A (en) 1987-05-28
NL970029I1 (nl) 1997-10-01
EP0217700A1 (de) 1987-04-08
FI87210C (fi) 1992-12-10
FI87210B (fi) 1992-08-31
FR2587029A1 (fr) 1987-03-13
NO863608L (no) 1987-03-12
JPH0460596B2 (de) 1992-09-28
HU196597B (en) 1988-12-28
DE3689748D1 (de) 1994-05-05
NZ217537A (en) 1988-11-29
DK431586A (da) 1987-03-12
NL970029I2 (nl) 1998-04-01
FI863661A0 (fi) 1986-09-10
KR930001411B1 (ko) 1993-02-27
NO167026C (no) 1991-09-25
DE19775081I2 (de) 2002-08-29
CS357991A3 (en) 1992-06-17
NO2001017I1 (no) 2001-11-05
EP0217700B1 (de) 1994-03-30
FR2587029B1 (fr) 1987-10-30
KR870003100A (ko) 1987-04-15
US4820710A (en) 1989-04-11
GR862318B (en) 1987-01-19
ZA866901B (en) 1987-04-29
FI863661A (fi) 1987-03-12
ES2001782A6 (es) 1988-06-16
IE61607B1 (en) 1994-11-16
AU6255286A (en) 1987-03-12
HK1005592A1 (en) 1999-01-15
ATE103603T1 (de) 1994-04-15
NO167026B (no) 1991-06-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: MIZOLASTIN; REGISTRATION NO/DATE: 37218.00.00, 19970428

Spc suppl protection certif: 197 75 081

Filing date: 19970912

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

V457 Spc granted

Free format text: PRODUCT NAME: MIZOLASTIN; REGISTRATION NO/DATE: 37218.00.00, 19970428

Spc suppl protection certif: 197 75 081

Filing date: 19970912

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR

V464 Spc expired

Free format text: PRODUCT NAME: MIZOLASTIN; REGISTRATION NO/DATE: 37218.00.00, 19970428

Spc suppl protection certif: 197 75 081

Filing date: 19970912

R081 Change of applicant/patentee

Owner name: SANOFI-AVENTIS, FR

Free format text: FORMER OWNER: SANOFI-AVENTIS, PARIS, FR

Spc suppl protection certif: 19775081

Filing date: 19970912

Expiry date: 20060903

Extension date: 20101121

Owner name: SANOFI-AVENTIS, 174, AVENUE DE FRANCE, 75635 P, FR

Free format text: FORMER OWNER: SANOFI-AVENTIS, PARIS, FR

Spc suppl protection certif: 19775081

Filing date: 19970912

Expiry date: 20060903

Extension date: 20101121

R082 Change of representative

Free format text: PRODUCT NAME: MIZOLLEN (WIRKSTOFF: MIZOLASTIN) IN ALLEN DEM SCHUTZ DES GRUNDPATENTS UNTERLIEGENDEN FORMEN; NAT. REGISTRATION NO/DATE: 37218.00.00 19970428; FIRST REGISTRATION: GROSSBRITANNIEN PL 049 69/0026 19951121

Spc suppl protection certif: 19775081

Filing date: 19970912

Expiry date: 20060903

Representative=s name: TER MEER STEINMEISTER & PARTNER PATENTANWAELTE, DE

Extension date: 20101121