ES2001782A6 - Un procedimiento para preparar derivados de bencimidazol - Google Patents

Un procedimiento para preparar derivados de bencimidazol

Info

Publication number
ES2001782A6
ES2001782A6 ES8601773A ES8601773A ES2001782A6 ES 2001782 A6 ES2001782 A6 ES 2001782A6 ES 8601773 A ES8601773 A ES 8601773A ES 8601773 A ES8601773 A ES 8601773A ES 2001782 A6 ES2001782 A6 ES 2001782A6
Authority
ES
Spain
Prior art keywords
radical
hydrogen atom
benzimidazole derivatives
alkyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601773A
Other languages
English (en)
Inventor
Philippe Manoury
Jean Binet
Gerard Defosse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES2001782A6 publication Critical patent/ES2001782A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR DERIVADOS DE BENCIMIDAZOL DE FORMULA DONDE X ES CH O N, R1, R2 Y R4 SON HIDROGENO O UN RADICAL ORGANICO Y R3 ES HIDROGENO O HIDROXI, EVENTUALMENTE EN FORMA DE TAUTOMEROS CUANDO R3 ES OH, EN EL QUE SE HACE REACCIONAR UN COMPUESTO DE FORMULA CON UNA (R2)(R)AMINO-4-PIPERIDINA DE FORMULA: DONDE R2 ES H O ALQUILO (C1-4) Y R ES HIDROGENO, ALCOXICARBONILO (C1-4) O EL GRUPO (R3=H U OH, , R4=H O ALQUILO (C1-4) Y, CUANDO R ES H, SE INTRODUCE EN UN SEGUNDO TIEMPO EL GRUPO PIRIMIDILO O, CUANDO R ES EL GRUPO ALCOXICARBONILO (C1-4), SE ELIMINA ESTE GRUPO POR HIDROLISIS Y LUEGO SE INTRODUCE EL GRUPO PIRIMIDILO. LOS COMPUESTOS OBTENIDOS SON UTILES EN TERAPEUTICA, ESPECIALMENTE PARA EL TRATAMIENTO DE ALERGIAS.
ES8601773A 1985-09-11 1986-09-10 Un procedimiento para preparar derivados de bencimidazol Expired ES2001782A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8513453A FR2587029B1 (fr) 1985-09-11 1985-09-11 Derives de benzimidazole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ES2001782A6 true ES2001782A6 (es) 1988-06-16

Family

ID=9322797

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601773A Expired ES2001782A6 (es) 1985-09-11 1986-09-10 Un procedimiento para preparar derivados de bencimidazol

Country Status (25)

Country Link
US (2) US4820710A (es)
EP (1) EP0217700B1 (es)
JP (1) JPS6261979A (es)
KR (1) KR930001411B1 (es)
AR (1) AR243187A1 (es)
AT (1) ATE103603T1 (es)
AU (1) AU582894B2 (es)
CA (1) CA1272486A (es)
CS (1) CS357991A3 (es)
DE (2) DE3689748T2 (es)
DK (1) DK170594B1 (es)
ES (1) ES2001782A6 (es)
FI (1) FI87210C (es)
FR (1) FR2587029B1 (es)
GR (1) GR862318B (es)
HK (1) HK1005592A1 (es)
HU (1) HU196597B (es)
IE (1) IE61607B1 (es)
IL (1) IL79992A (es)
LU (1) LU90085I2 (es)
NL (1) NL970029I2 (es)
NO (2) NO167026C (es)
NZ (1) NZ217537A (es)
PT (1) PT83355B (es)
ZA (1) ZA866901B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005096692A2 (es) * 2004-04-06 2005-10-20 Ragactives, S.L. Formas cristalinas de mizolastina, procedimientos para su obtención y composiciones farmacéuticas que las contienen

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2618435B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
FR2637595B1 (fr) * 1988-10-11 1990-11-30 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
JPH02294758A (ja) * 1989-05-09 1990-12-05 Nec Corp 計算機使用時間管理方式
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
FR2666582B1 (fr) * 1990-09-07 1994-09-02 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique.
FR2693194B1 (fr) * 1992-07-03 1994-09-23 Synthelabo Dérivés d'alcanecarboxamide, leur préparation et leur application thérapeutique.
FR2745500B1 (fr) * 1996-03-04 1998-04-03 Synthelabo Formulations pharmaceutiques a liberation prolongee contenant de la mizolastine
JPH10101564A (ja) * 1996-09-27 1998-04-21 Mitsubishi Chem Corp 鼻炎予防及び／又は治療剤
US6369235B1 (en) 1997-02-25 2002-04-09 The United States Of America As Represented By The Department Of Health And Human Services Substituted benzimidazoles, and methods of use thereof, for the inhibition of HIV reverse transcription and for the treatment of HIV infection
FR2762214B1 (fr) * 1997-04-17 2000-10-06 Synthelabo Utilisation de la mizolastine pour la preparation d'un medicament destine au traitement de l'inflammation
EP0958820A1 (en) * 1998-05-19 1999-11-24 Sanofi-Synthelabo Use of an imidazol derivative for the manufacture of a medicament for treating auto-immunodiseases
ES2208098B1 (es) * 2002-10-02 2005-10-16 Ragactives, S.L. Procedimiento e intermedios para la obtencion de derivados de 1-(1h-bencimidazol-2-il)-4-(2-aminopirimidin) piperidina.
CN1886380B (zh) * 2003-09-30 2010-12-22 詹森药业有限公司 苯并咪唑化合物
CA2766033C (en) * 2009-06-25 2016-09-20 Alkermes, Inc. Prodrugs of nh-acidic compounds
AU2010266018B2 (en) 2009-06-25 2014-01-09 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
CN102140076A (zh) * 2010-02-03 2011-08-03 辽宁本源制药有限公司 咪唑斯汀中间体的制备
ES2715562T3 (es) 2011-12-15 2019-06-04 Alkermes Pharma Ireland Ltd Profármacos de compuestos de amina secundaria
JP7384812B2 (ja) 2018-03-05 2023-11-21 アルカームス ファーマ アイルランド リミテッド アリピプラゾール投与戦略
WO2020210597A1 (en) * 2019-04-11 2020-10-15 Amgen Inc. Benzimidazole derivatives and their uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281005A (en) * 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
EP0144101B1 (en) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005096692A2 (es) * 2004-04-06 2005-10-20 Ragactives, S.L. Formas cristalinas de mizolastina, procedimientos para su obtención y composiciones farmacéuticas que las contienen
WO2005096692A3 (es) * 2004-04-06 2005-11-17 Ragactives Sl Formas cristalinas de mizolastina, procedimientos para su obtención y composiciones farmacéuticas que las contienen
ES2245227A1 (es) * 2004-04-06 2005-12-16 Ragactives, S.L. Formas cristalinas de mizolastina, procedimientos para su obtencion y composiciones farmaceuticas que las contienen.

Also Published As

Publication number Publication date
IE61607B1 (en) 1994-11-16
HUT41771A (en) 1987-05-28
ZA866901B (en) 1987-04-29
FI863661A0 (fi) 1986-09-10
NO863608L (no) 1987-03-12
NO863608D0 (no) 1986-09-10
DK431586D0 (da) 1986-09-10
ATE103603T1 (de) 1994-04-15
DK170594B1 (da) 1995-11-06
FI863661A (fi) 1987-03-12
EP0217700A1 (fr) 1987-04-08
JPH0460596B2 (es) 1992-09-28
AU6255286A (en) 1987-03-12
NZ217537A (en) 1988-11-29
FI87210B (fi) 1992-08-31
NO167026C (no) 1991-09-25
FR2587029A1 (fr) 1987-03-13
JPS6261979A (ja) 1987-03-18
DK431586A (da) 1987-03-12
GR862318B (en) 1987-01-19
PT83355A (fr) 1986-10-01
HU196597B (en) 1988-12-28
NL970029I1 (nl) 1997-10-01
KR870003100A (ko) 1987-04-15
HK1005592A1 (en) 1999-01-15
EP0217700B1 (fr) 1994-03-30
PT83355B (pt) 1989-05-12
US4912219A (en) 1990-03-27
AR243187A1 (es) 1993-07-30
CA1272486A (en) 1990-08-07
AU582894B2 (en) 1989-04-13
FI87210C (fi) 1992-12-10
US4820710A (en) 1989-04-11
NO2001017I1 (no) 2001-11-05
DE3689748D1 (de) 1994-05-05
DE3689748T2 (de) 1994-08-11
NL970029I2 (nl) 1998-04-01
LU90085I2 (fr) 1997-09-25
FR2587029B1 (fr) 1987-10-30
DE19775081I2 (de) 2002-08-29
CS357991A3 (en) 1992-06-17
NO167026B (no) 1991-06-17
IL79992A (en) 1990-07-12
IL79992A0 (en) 1986-12-31
IE862416L (en) 1987-03-11
KR930001411B1 (ko) 1993-02-27

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Legal Events

Date Code Title Description
SPCF Request for supplementary protection certificate filed

Free format text: MIZOLEN

Spc suppl protection certif: C9800018

SPCG Supplementary protection certificate granted

Free format text: MIZOLEN

Spc suppl protection certif: C9800018

Expiry date: 20101121

FD1A Patent lapsed

Effective date: 20100528