BR9406481A - Derivados de indol como agonistas do tipo 5-HT1 para utilização na enxaqueca - Google Patents
Derivados de indol como agonistas do tipo 5-HT1 para utilização na enxaquecaInfo
- Publication number
- BR9406481A BR9406481A BR9406481A BR9406481A BR9406481A BR 9406481 A BR9406481 A BR 9406481A BR 9406481 A BR9406481 A BR 9406481A BR 9406481 A BR9406481 A BR 9406481A BR 9406481 A BR9406481 A BR 9406481A
- Authority
- BR
- Brazil
- Prior art keywords
- migraine
- pct
- indole derivatives
- date oct
- type agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939308360A GB9308360D0 (en) | 1993-04-22 | 1993-04-22 | Indoles |
| GB939324433A GB9324433D0 (en) | 1993-11-27 | 1993-11-27 | Indoles |
| PCT/EP1994/001121 WO1994024127A1 (en) | 1993-04-22 | 1994-04-11 | Indole derivatives as 5-h1-like agonists for use in migraine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9406481A true BR9406481A (pt) | 1996-01-09 |
Family
ID=26302791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9406481A BR9406481A (pt) | 1993-04-22 | 1994-04-11 | Derivados de indol como agonistas do tipo 5-HT1 para utilização na enxaqueca |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5607960A (pt) |
| EP (1) | EP0695301B1 (pt) |
| JP (1) | JP2802169B2 (pt) |
| KR (1) | KR960701865A (pt) |
| CN (1) | CN1121348A (pt) |
| AT (1) | ATE144773T1 (pt) |
| AU (1) | AU6567094A (pt) |
| BR (1) | BR9406481A (pt) |
| CA (1) | CA2157397C (pt) |
| CZ (1) | CZ274595A3 (pt) |
| DE (1) | DE69400824T2 (pt) |
| DK (1) | DK0695301T3 (pt) |
| ES (1) | ES2094653T3 (pt) |
| FI (1) | FI954944A (pt) |
| GR (1) | GR3021804T3 (pt) |
| HU (1) | HUT73807A (pt) |
| IL (1) | IL109337A0 (pt) |
| NO (1) | NO954168D0 (pt) |
| NZ (1) | NZ265269A (pt) |
| PL (1) | PL311204A1 (pt) |
| WO (1) | WO1994024127A1 (pt) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5607951A (en) * | 1990-10-15 | 1997-03-04 | Pfizer Inc | Indole derivatives |
| US5578612A (en) * | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| US5559129A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc | Indole derivatives |
| US5559246A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc. | Indole derivatives |
| US5545644A (en) * | 1990-10-15 | 1996-08-13 | Pfizer Inc. | Indole derivatives |
| DK0716649T3 (da) * | 1993-08-31 | 1999-02-08 | Pfizer | 5-Arylindolderivater |
| GB9417310D0 (en) | 1994-08-27 | 1994-10-19 | Pfizer Ltd | Therapeutic agents |
| GB9420503D0 (en) * | 1994-10-11 | 1994-11-23 | Pfizer Ltd | Therapeutic agents |
| GB9420529D0 (en) | 1994-10-12 | 1994-11-30 | Pfizer Ltd | Indoles |
| KR19980703048A (ko) * | 1995-03-20 | 1998-09-05 | 피터쥐.스트링거 | 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트 |
| US6586458B1 (en) | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| US8022095B2 (en) | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| US5872145A (en) * | 1996-08-16 | 1999-02-16 | Pozen, Inc. | Formulation of 5-HT agonist and NSAID for treatment of migraine |
| WO1998011895A1 (en) * | 1996-09-18 | 1998-03-26 | Eli Lilly And Company | A method for the prevention of migraine |
| CN1289479C (zh) * | 1996-11-26 | 2006-12-13 | Nps艾里利克斯有限公司 | 作为5－ht1d受体配位体的5－环吲哚化合物 |
| US5998462A (en) * | 1996-12-16 | 1999-12-07 | Allelix Biopharmaceuticals Inc. | 5-alkyl indole compounds |
| US5856510A (en) * | 1996-12-16 | 1999-01-05 | Allelix Biopharmaceuticals Inc. | 5-alkenyl and 5-alkynyl indole compounds |
| GB9705035D0 (en) * | 1997-03-11 | 1997-04-30 | Pharmacia & Upjohn Spa | Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation |
| EP0875513A1 (en) * | 1997-04-14 | 1998-11-04 | Eli Lilly And Company | Substituted heteroaromatic 5-HT 1F agonists |
| WO1999007700A1 (en) * | 1997-08-09 | 1999-02-18 | Smithkline Beecham Plc | Bicyclic compounds as ligands for 5-ht1 receptors |
| US6310066B1 (en) | 1998-04-29 | 2001-10-30 | American Home Products Corp. | Antipsychotic indolyl derivatives |
| US6204274B1 (en) | 1998-04-29 | 2001-03-20 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| US6066637A (en) * | 1998-06-19 | 2000-05-23 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| WO2000000490A2 (en) * | 1998-06-26 | 2000-01-06 | Eli Lilly And Company | 5-ht1f agonists |
| US5994352A (en) * | 1998-11-13 | 1999-11-30 | Pfizer Inc. | 5-arylindole derivatives |
| CN1264838C (zh) | 2000-07-21 | 2006-07-19 | H·隆德贝克有限公司 | 用于治疗中枢神经系统疾病的吲哚衍生物 |
| US6489512B1 (en) | 2002-06-21 | 2002-12-03 | Rhodia Chirex Inc. | Method for making aryl hydrazines and substituted indoles |
| PL375350A1 (en) * | 2002-12-10 | 2005-11-28 | Merck Patent Gmbh | Indol derivatives and their use as 5-ht ligands |
| CN1729174B (zh) * | 2002-12-20 | 2015-10-21 | 西巴特殊化学品控股有限公司 | 胺的合成以及用于合成胺的中间体 |
| EP1575566B1 (en) * | 2002-12-26 | 2012-02-22 | Pozen, Inc. | Multilayer dosage forms containing naproxen and triptans |
| WO2004110492A2 (en) * | 2003-06-06 | 2004-12-23 | Glaxo Group Limited | Composition comprising triptans and nsaids |
| US20050245540A1 (en) * | 2003-12-09 | 2005-11-03 | Fujisawa Pharmaceutical Co., Ltd. | New methods |
| WO2005066157A1 (en) * | 2004-01-02 | 2005-07-21 | Suven Life Sciences | 3-(pyrolidin-3-l) indoles as 5-ht6 receptor modulators |
| GB0807772D0 (en) * | 2008-04-29 | 2008-06-04 | Lectus Therapeutics Ltd | Calcium ion modulators and uses thereof |
| FR2953720B1 (fr) * | 2009-12-11 | 2012-05-11 | Oreal | Utilisation de derives de benzyloxy-ethylamines comme conservateur, |
| CN104557957B (zh) * | 2013-10-09 | 2017-04-19 | 华东师范大学 | 螺‑氧化吲哚环氧乙烷衍生物的合成方法 |
| KR20220137085A (ko) * | 2020-02-04 | 2022-10-11 | 마인드셋 파마 인크. | Cns 장애의 치료를 위한 세로토닌성 사이키델릭 작용제로서의 3-피롤리딘-인돌 유도체 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8530507D0 (en) * | 1985-12-11 | 1986-01-22 | Glaxo Group Plc | Chemical compounds |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| HU225055B1 (en) * | 1990-10-15 | 2006-05-29 | Pfizer | Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds |
-
1994
- 1994-04-11 DE DE69400824T patent/DE69400824T2/de not_active Expired - Fee Related
- 1994-04-11 HU HU9501920A patent/HUT73807A/hu unknown
- 1994-04-11 CN CN94191850A patent/CN1121348A/zh active Pending
- 1994-04-11 BR BR9406481A patent/BR9406481A/pt not_active Application Discontinuation
- 1994-04-11 EP EP94913573A patent/EP0695301B1/en not_active Expired - Lifetime
- 1994-04-11 AT AT94913573T patent/ATE144773T1/de not_active IP Right Cessation
- 1994-04-11 AU AU65670/94A patent/AU6567094A/en not_active Abandoned
- 1994-04-11 NZ NZ265269A patent/NZ265269A/en unknown
- 1994-04-11 CA CA002157397A patent/CA2157397C/en not_active Expired - Fee Related
- 1994-04-11 JP JP6522726A patent/JP2802169B2/ja not_active Expired - Fee Related
- 1994-04-11 CZ CZ952745A patent/CZ274595A3/cs unknown
- 1994-04-11 WO PCT/EP1994/001121 patent/WO1994024127A1/en not_active Application Discontinuation
- 1994-04-11 US US08/532,573 patent/US5607960A/en not_active Expired - Fee Related
- 1994-04-11 ES ES94913573T patent/ES2094653T3/es not_active Expired - Lifetime
- 1994-04-11 KR KR1019950704623A patent/KR960701865A/ko not_active Application Discontinuation
- 1994-04-11 PL PL94311204A patent/PL311204A1/xx unknown
- 1994-04-11 DK DK94913573.5T patent/DK0695301T3/da active
- 1994-04-18 IL IL10933794A patent/IL109337A0/xx unknown
-
1995
- 1995-10-17 FI FI954944A patent/FI954944A/fi not_active Application Discontinuation
- 1995-10-19 NO NO954168A patent/NO954168D0/no unknown
-
1996
- 1996-11-28 GR GR960403195T patent/GR3021804T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3021804T3 (en) | 1997-02-28 |
| DE69400824T2 (de) | 1997-03-13 |
| CN1121348A (zh) | 1996-04-24 |
| AU6567094A (en) | 1994-11-08 |
| ES2094653T3 (es) | 1997-01-16 |
| CZ274595A3 (en) | 1996-03-13 |
| FI954944A0 (fi) | 1995-10-17 |
| DK0695301T3 (da) | 1996-12-09 |
| HU9501920D0 (en) | 1995-09-28 |
| NZ265269A (en) | 1996-09-25 |
| NO954168L (no) | 1995-10-19 |
| DE69400824D1 (de) | 1996-12-05 |
| PL311204A1 (en) | 1996-02-05 |
| EP0695301B1 (en) | 1996-10-30 |
| US5607960A (en) | 1997-03-04 |
| CA2157397A1 (en) | 1994-10-27 |
| CA2157397C (en) | 1999-07-06 |
| FI954944A (fi) | 1995-10-17 |
| NO954168D0 (no) | 1995-10-19 |
| WO1994024127A1 (en) | 1994-10-27 |
| JP2802169B2 (ja) | 1998-09-24 |
| KR960701865A (ko) | 1996-03-28 |
| JPH08507083A (ja) | 1996-07-30 |
| IL109337A0 (en) | 1994-07-31 |
| HUT73807A (en) | 1996-09-30 |
| ATE144773T1 (de) | 1996-11-15 |
| EP0695301A1 (en) | 1996-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal |