ES2094653T3 - Derivados de indol como antagonistas de tipo 5-ht1 para uso en la migraña. - Google Patents
Derivados de indol como antagonistas de tipo 5-ht1 para uso en la migraña.Info
- Publication number
- ES2094653T3 ES2094653T3 ES94913573T ES94913573T ES2094653T3 ES 2094653 T3 ES2094653 T3 ES 2094653T3 ES 94913573 T ES94913573 T ES 94913573T ES 94913573 T ES94913573 T ES 94913573T ES 2094653 T3 ES2094653 T3 ES 2094653T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- sup
- alkyl
- alkylene
- cyclloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LOS COMPUESTOS DE LA FORMULA (I), LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS Y LOS SOLVATOS FARMACEUTICAMENTE ACEPTABLES (INCLUIDOS LOS HIDRATOS) DE CUALQUIER ESPECIE, EN LA QUE R{SUP,1} ES (A); (B); (C); (D); O CH{SUB,2}CH{SUB,2}NR{SUP,3}R{SUP,4} (E); R{SUP,2} ES R{SUP,5}R{SUP,6}C(OH)A O R{SUP,7}COA; R{SUP,3} ES H, ALQUILO C{SUB,1}-C{SUB,6}, ALQUILENO SUSTITUIDO, CICLOALQUILO C{SUB,3}C{SUB,7} OPCIONALMENTE SUSTITUIDO POR HO, ALQUENILO C{SUB,3}C{SUB,6} OPCIONALMENTE SUSTITUIDO POR ARILO, CICLOALQUENILO C{SUB,5}-C{SUB,7} O ALQUINILO C{SUB,3}-C{SUB,6}; R{SUP,4} ES H O ALQUILO C{SUB,1}-C{SUB,6}; R{SUP,5} Y R{SUP,6} SE SELECCIONAN CADA UNO, INDEPENDIENTEMENTE, DEL H, ALQUILO C{SUB,1}-C{SUB,6}, PERFLUORALQUILO C{SUB,1}-C{SUB,4} Y CICLOALQUILO C{SUB,3}C{SUB,7}, O JUNTO CON EL ATOMO DE CARBONO AL QUE SE ENCUENTRAN ENLAZADOS, FORMAN UN ANILLO HETEROCICLICO CARBOCICLICO U OPCIONAL DE 3 A 7 ELEMENTOS; R{SUP,7} ES ALQUILO C{SUB,1}-C{SUB,6}, ALQUILENO SUSTITUIDO, CICLOALQUILO C{SUB,3}-C{SUB,7} O ARILO; A ES UN ENLACE DIRECTO ALQUILENO C{SUB,1}-C{SUB,6} OPCIONALMENTE RAMIFICADO CON UN ALQUILO C{SUB,1}-C{SUB,4} O ALQUENILENO C{SUB,2}-C{SUB,6}; Y K ES 0, 1 O 2; SON AGONISTAS TIPO 5HT{SUB,1} SELECTIVOS UTILES PARA EL TRATAMIENTO DE LA MIGRAINA, DOLOR DE CABEZA LOCALIZADO, HEMICRANIA PAROXISMAL CRONICA Y DOLOR DE CABEZA ASOCIADOS A TRASTORNOS VASCULARES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939308360A GB9308360D0 (en) | 1993-04-22 | 1993-04-22 | Indoles |
GB939324433A GB9324433D0 (en) | 1993-11-27 | 1993-11-27 | Indoles |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2094653T3 true ES2094653T3 (es) | 1997-01-16 |
Family
ID=26302791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94913573T Expired - Lifetime ES2094653T3 (es) | 1993-04-22 | 1994-04-11 | Derivados de indol como antagonistas de tipo 5-ht1 para uso en la migraña. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5607960A (es) |
EP (1) | EP0695301B1 (es) |
JP (1) | JP2802169B2 (es) |
KR (1) | KR960701865A (es) |
CN (1) | CN1121348A (es) |
AT (1) | ATE144773T1 (es) |
AU (1) | AU6567094A (es) |
BR (1) | BR9406481A (es) |
CA (1) | CA2157397C (es) |
CZ (1) | CZ274595A3 (es) |
DE (1) | DE69400824T2 (es) |
DK (1) | DK0695301T3 (es) |
ES (1) | ES2094653T3 (es) |
FI (1) | FI954944A (es) |
GR (1) | GR3021804T3 (es) |
HU (1) | HUT73807A (es) |
IL (1) | IL109337A0 (es) |
NO (1) | NO954168D0 (es) |
NZ (1) | NZ265269A (es) |
PL (1) | PL311204A1 (es) |
WO (1) | WO1994024127A1 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5545644A (en) * | 1990-10-15 | 1996-08-13 | Pfizer Inc. | Indole derivatives |
US5607951A (en) * | 1990-10-15 | 1997-03-04 | Pfizer Inc | Indole derivatives |
US5559246A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc. | Indole derivatives |
US5559129A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc | Indole derivatives |
US5578612A (en) * | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
HUT75646A (en) * | 1993-08-31 | 1997-05-28 | Pfizer | 5-arylindole derivatives and pharmaceutical compositions containing them |
GB9417310D0 (en) | 1994-08-27 | 1994-10-19 | Pfizer Ltd | Therapeutic agents |
GB9420503D0 (en) * | 1994-10-11 | 1994-11-23 | Pfizer Ltd | Therapeutic agents |
GB9420529D0 (en) | 1994-10-12 | 1994-11-30 | Pfizer Ltd | Indoles |
CN1184425A (zh) * | 1995-03-20 | 1998-06-10 | 伊莱利利公司 | 5-取代-3-(1,2,3,6-四氢吡啶-4-基)-和3-(哌啶-4-基)-1h-吲哚:新型5-ht1f激动剂 |
US5872145A (en) * | 1996-08-16 | 1999-02-16 | Pozen, Inc. | Formulation of 5-HT agonist and NSAID for treatment of migraine |
US8022095B2 (en) | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
US6586458B1 (en) | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
WO1998011895A1 (en) * | 1996-09-18 | 1998-03-26 | Eli Lilly And Company | A method for the prevention of migraine |
JP2001504501A (ja) * | 1996-11-26 | 2001-04-03 | アレリックス バイオファーマスーティカルス インコーポレーテッド | 5−ht▲下1d▼レセプターのリガンドとしての5−シクロインドール化合物 |
US5856510A (en) * | 1996-12-16 | 1999-01-05 | Allelix Biopharmaceuticals Inc. | 5-alkenyl and 5-alkynyl indole compounds |
US5998462A (en) * | 1996-12-16 | 1999-12-07 | Allelix Biopharmaceuticals Inc. | 5-alkyl indole compounds |
GB9705035D0 (en) * | 1997-03-11 | 1997-04-30 | Pharmacia & Upjohn Spa | Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation |
EP0875513A1 (en) * | 1997-04-14 | 1998-11-04 | Eli Lilly And Company | Substituted heteroaromatic 5-HT 1F agonists |
DE69819903T2 (de) | 1997-08-09 | 2004-11-11 | Smithkline Beecham P.L.C., Brentford | Bicyclische verbindungen als liganden der 5-ht1 rezeptoren |
US6204274B1 (en) | 1998-04-29 | 2001-03-20 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
US6310066B1 (en) | 1998-04-29 | 2001-10-30 | American Home Products Corp. | Antipsychotic indolyl derivatives |
US6066637A (en) * | 1998-06-19 | 2000-05-23 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
WO2000000490A2 (en) * | 1998-06-26 | 2000-01-06 | Eli Lilly And Company | 5-ht1f agonists |
US5994352A (en) * | 1998-11-13 | 1999-11-30 | Pfizer Inc. | 5-arylindole derivatives |
AU2001281738B2 (en) * | 2000-07-21 | 2006-12-21 | H.Lundbeck A/S | Indole derivatives useful for the treatment of cns disorders |
US6489512B1 (en) * | 2002-06-21 | 2002-12-03 | Rhodia Chirex Inc. | Method for making aryl hydrazines and substituted indoles |
KR20050085472A (ko) * | 2002-12-10 | 2005-08-29 | 메르크 파텐트 게엠베하 | 인돌 유도체 및 5-ht 리간드로서의 이의 용도 |
WO2004056769A2 (en) * | 2002-12-20 | 2004-07-08 | Ciba Specialty Chemicals Holding Inc. | Synthesis of amines and intermediates for the synthesis thereof |
US7332183B2 (en) * | 2002-12-26 | 2008-02-19 | Pozen Inc. | Multilayer dosage forms containing NSAIDs and triptans |
AU2004247076A1 (en) * | 2003-06-06 | 2004-12-23 | Glaxo Group Limited | Composition comprising triptans and NSAIDs |
US20050245540A1 (en) * | 2003-12-09 | 2005-11-03 | Fujisawa Pharmaceutical Co., Ltd. | New methods |
WO2005066157A1 (en) * | 2004-01-02 | 2005-07-21 | Suven Life Sciences | 3-(pyrolidin-3-l) indoles as 5-ht6 receptor modulators |
GB0807772D0 (en) * | 2008-04-29 | 2008-06-04 | Lectus Therapeutics Ltd | Calcium ion modulators and uses thereof |
FR2953720B1 (fr) * | 2009-12-11 | 2012-05-11 | Oreal | Utilisation de derives de benzyloxy-ethylamines comme conservateur, |
CN104557957B (zh) * | 2013-10-09 | 2017-04-19 | 华东师范大学 | 螺‑氧化吲哚环氧乙烷衍生物的合成方法 |
AU2021215709A1 (en) * | 2020-02-04 | 2022-09-01 | Mindset Pharma Inc. | 3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8530507D0 (en) * | 1985-12-11 | 1986-01-22 | Glaxo Group Plc | Chemical compounds |
GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
AU651637B2 (en) * | 1990-10-15 | 1994-07-28 | Pfizer Inc. | Indole derivatives |
-
1994
- 1994-04-11 EP EP94913573A patent/EP0695301B1/en not_active Expired - Lifetime
- 1994-04-11 AT AT94913573T patent/ATE144773T1/de not_active IP Right Cessation
- 1994-04-11 AU AU65670/94A patent/AU6567094A/en not_active Abandoned
- 1994-04-11 CN CN94191850A patent/CN1121348A/zh active Pending
- 1994-04-11 HU HU9501920A patent/HUT73807A/hu unknown
- 1994-04-11 DK DK94913573.5T patent/DK0695301T3/da active
- 1994-04-11 ES ES94913573T patent/ES2094653T3/es not_active Expired - Lifetime
- 1994-04-11 NZ NZ265269A patent/NZ265269A/en unknown
- 1994-04-11 WO PCT/EP1994/001121 patent/WO1994024127A1/en not_active Application Discontinuation
- 1994-04-11 US US08/532,573 patent/US5607960A/en not_active Expired - Fee Related
- 1994-04-11 JP JP6522726A patent/JP2802169B2/ja not_active Expired - Fee Related
- 1994-04-11 PL PL94311204A patent/PL311204A1/xx unknown
- 1994-04-11 CA CA002157397A patent/CA2157397C/en not_active Expired - Fee Related
- 1994-04-11 BR BR9406481A patent/BR9406481A/pt not_active Application Discontinuation
- 1994-04-11 CZ CZ952745A patent/CZ274595A3/cs unknown
- 1994-04-11 DE DE69400824T patent/DE69400824T2/de not_active Expired - Fee Related
- 1994-04-11 KR KR1019950704623A patent/KR960701865A/ko not_active Application Discontinuation
- 1994-04-18 IL IL10933794A patent/IL109337A0/xx unknown
-
1995
- 1995-10-17 FI FI954944A patent/FI954944A/fi not_active Application Discontinuation
- 1995-10-19 NO NO954168A patent/NO954168D0/no unknown
-
1996
- 1996-11-28 GR GR960403195T patent/GR3021804T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69400824T2 (de) | 1997-03-13 |
CZ274595A3 (en) | 1996-03-13 |
NO954168L (no) | 1995-10-19 |
BR9406481A (pt) | 1996-01-09 |
JPH08507083A (ja) | 1996-07-30 |
DE69400824D1 (de) | 1996-12-05 |
HU9501920D0 (en) | 1995-09-28 |
DK0695301T3 (da) | 1996-12-09 |
EP0695301B1 (en) | 1996-10-30 |
FI954944A0 (fi) | 1995-10-17 |
ATE144773T1 (de) | 1996-11-15 |
US5607960A (en) | 1997-03-04 |
IL109337A0 (en) | 1994-07-31 |
NZ265269A (en) | 1996-09-25 |
NO954168D0 (no) | 1995-10-19 |
FI954944A (fi) | 1995-10-17 |
EP0695301A1 (en) | 1996-02-07 |
CN1121348A (zh) | 1996-04-24 |
PL311204A1 (en) | 1996-02-05 |
CA2157397A1 (en) | 1994-10-27 |
JP2802169B2 (ja) | 1998-09-24 |
CA2157397C (en) | 1999-07-06 |
WO1994024127A1 (en) | 1994-10-27 |
KR960701865A (ko) | 1996-03-28 |
GR3021804T3 (en) | 1997-02-28 |
HUT73807A (en) | 1996-09-30 |
AU6567094A (en) | 1994-11-08 |
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