DK0593513T3 - Tryptaminanaloger, deres syntese og deres anvendelse som 5-HT,-lignende eller 5-HT2-receptoragonister - Google Patents

Tryptaminanaloger, deres syntese og deres anvendelse som 5-HT,-lignende eller 5-HT2-receptoragonister

Info

Publication number
DK0593513T3
DK0593513T3 DK92912269T DK92912269T DK0593513T3 DK 0593513 T3 DK0593513 T3 DK 0593513T3 DK 92912269 T DK92912269 T DK 92912269T DK 92912269 T DK92912269 T DK 92912269T DK 0593513 T3 DK0593513 T3 DK 0593513T3
Authority
DK
Denmark
Prior art keywords
pct
date
synthesis
receptor agonists
sec
Prior art date
Application number
DK92912269T
Other languages
English (en)
Inventor
Lawrence Ivan C O Smithk Kruse
Rodney Christopher Young
Alberto Julio Kaumann
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919113382A external-priority patent/GB9113382D0/en
Priority claimed from GB919113385A external-priority patent/GB9113385D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of DK0593513T3 publication Critical patent/DK0593513T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK92912269T 1991-06-21 1992-06-17 Tryptaminanaloger, deres syntese og deres anvendelse som 5-HT,-lignende eller 5-HT2-receptoragonister DK0593513T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919113382A GB9113382D0 (en) 1991-06-21 1991-06-21 Compounds
GB919113385A GB9113385D0 (en) 1991-06-21 1991-06-21 Compounds
PCT/GB1992/001089 WO1993000333A1 (en) 1991-06-21 1992-06-17 Tryptamine analogues, their synthesis and their use as 5-ht1-like or 5-ht2 receptor agonists

Publications (1)

Publication Number Publication Date
DK0593513T3 true DK0593513T3 (da) 1999-07-05

Family

ID=26299103

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92912269T DK0593513T3 (da) 1991-06-21 1992-06-17 Tryptaminanaloger, deres syntese og deres anvendelse som 5-HT,-lignende eller 5-HT2-receptoragonister

Country Status (13)

Country Link
US (1) US5571833A (da)
EP (1) EP0593513B1 (da)
JP (1) JPH06508354A (da)
AT (1) ATE172723T1 (da)
AU (1) AU1928892A (da)
CA (1) CA2110574A1 (da)
DE (1) DE69227458T2 (da)
DK (1) DK0593513T3 (da)
IE (1) IE921993A1 (da)
MX (1) MX9203050A (da)
PT (1) PT100603A (da)
TW (1) TW217407B (da)
WO (1) WO1993000333A1 (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9226532D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5496957A (en) * 1993-09-01 1996-03-05 Virginia Commonwealth University Tryptamine analogs with 5-HT1D selectivity
ATE167471T1 (de) * 1993-09-01 1998-07-15 Allelix Biopharma Tryptamin analoge mit 5-ht1d selektivität
US5504101A (en) * 1994-05-06 1996-04-02 Allelix Biopharmaceuticals, Inc. 5-HT-1D receptor ligands
EP0796258A1 (en) * 1994-12-06 1997-09-24 MERCK SHARP & DOHME LTD. Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
EP1112106B1 (en) 1998-09-18 2005-11-23 Alcon Manufacturing Ltd. Serotonergic 5ht2 agonists for treating glaucoma
EP1132389A1 (en) * 2000-03-06 2001-09-12 Vernalis Research Limited New aza-indolyl derivatives for the treatment of obesity
US6806285B1 (en) 2000-03-17 2004-10-19 Alcon, Inc. 5-Hydroxyl indole derivatives for treating glaucoma
US6660870B1 (en) 2000-03-17 2003-12-09 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
US6956036B1 (en) 2000-03-17 2005-10-18 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
US7012090B1 (en) 2000-03-17 2006-03-14 Alcon, Inc. Pyranoindoles for treating glaucoma
US7005443B1 (en) * 2000-03-17 2006-02-28 Alcon, Inc. 5-Hydroxy indazole derivatives for treating glaucoma
AU2001216035A1 (en) * 2000-03-17 2001-10-03 Alcon Universal Ltd. 5-hydroxy indole derivatives for treating glaucoma
WO2004098807A1 (en) * 2000-11-21 2004-11-18 Barsplice Products, Inc. Method of making steel couplers for joining concrete reinforcing bars
WO2002079153A1 (en) * 2001-03-28 2002-10-10 Biocatalytics, Inc. Method for producing tryptamine derivatives
EP1392269A1 (en) * 2001-06-01 2004-03-03 Alcon, Inc. Novel arylaminopropane analogues and their use for the treatment of glaucoma
DK1392292T3 (da) * 2001-06-01 2006-05-29 Alcon Inc Pyranoindazoler og deres anvendelse til behandling af glaukom
JP2004532887A (ja) * 2001-06-01 2004-10-28 アルコン，インコーポレイテッド 新規な融合インダゾールおよびインドールおよび緑内障治療へのこれらの使用
US6884816B2 (en) 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
AU2002364711A1 (en) * 2001-12-14 2003-06-30 Alcon, Inc. Substituted 5-hydroxy-indole compounds for the treatment of glaucoma
TW593302B (en) * 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
PL375564A1 (en) * 2002-08-30 2005-11-28 Alcon, Inc. Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma
JP2006511556A (ja) * 2002-12-13 2006-04-06 アルコン，インコーポレイテッド 新規のベンゾピラン類似体及び緑内障の治療のためのそれらの使用
EP1572647B1 (en) 2002-12-20 2016-09-21 Basf Se Synthesis of amines and intermediates for the synthesis thereof
WO2005053688A1 (en) * 2003-11-26 2005-06-16 Alcon, Inc. Substituted furo[2,3-g] indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
WO2005058911A2 (en) * 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) * 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US20060073172A1 (en) * 2004-10-01 2006-04-06 Schneider L W Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure
US7425572B2 (en) * 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma
WO2012035406A1 (en) * 2010-09-14 2012-03-22 Council Of Scientific & Industrial Research Tryptamine derivatives, their preparation and their use in gastropathy
US20200078335A1 (en) * 2017-05-01 2020-03-12 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods to reduce pathogenesis
GB201907871D0 (en) 2019-06-03 2019-07-17 Small Pharma Ltd Therapeutic compositions
MX2022005399A (es) * 2019-11-07 2022-07-05 Small Pharma Ltd Compuestos.
US11773062B2 (en) 2021-03-22 2023-10-03 Small Pharma Ltd Deuterated compounds
IL301066A (en) * 2020-09-04 2023-05-01 Gilgamesh Pharmaceuticals Inc Azetidinyl tryptamines and methods for the treatment of psychiatric disorders
US20240059653A1 (en) * 2020-12-31 2024-02-22 1280225 B.C. Ltd. Method of synthesizing indole compounds
US11697638B2 (en) 2021-09-08 2023-07-11 Small Pharma Ltd 5-methoxy-N,N-dimethyltryptamine crystalline forms
WO2024138007A2 (en) * 2022-12-21 2024-06-27 Caamtech, Inc. Tryptamine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5883671A (ja) * 1981-11-11 1983-05-19 Mitsui Toatsu Chem Inc トリプタミン誘導体の製造法
JPH04501722A (ja) * 1988-11-14 1992-03-26 ジ・アップジョン・カンパニー 抗―糖尿病、抗―肥満症および抗―アテローム性動脈硬化症薬として有用なα―アミノ―インドール―３―酢酸

Also Published As

Publication number Publication date
JPH06508354A (ja) 1994-09-22
ATE172723T1 (de) 1998-11-15
MX9203050A (es) 1993-07-01
DE69227458T2 (de) 1999-04-29
AU1928892A (en) 1993-01-25
EP0593513B1 (en) 1998-10-28
DE69227458D1 (de) 1998-12-03
EP0593513A1 (en) 1994-04-27
IE921993A1 (en) 1992-12-30
TW217407B (da) 1993-12-11
WO1993000333A1 (en) 1993-01-07
US5571833A (en) 1996-11-05
CA2110574A1 (en) 1993-01-07
PT100603A (pt) 1993-08-31

Similar Documents

Publication Publication Date Title
DK0593513T3 (da) Tryptaminanaloger, deres syntese og deres anvendelse som 5-HT,-lignende eller 5-HT2-receptoragonister
DK0687268T3 (da) Spiroazacykliske derivater som substans P-antagonister
FI954944A0 (fi) Indolijohdannaisia 5-HT1-kaltaisina agonisteina käytettäväksi migreenin hoitoon
DK0687251T3 (da) 1,3-dihydroindol-2-on-derivater, der er substitueret i 3-stillingen med en nitrogengruppe, til anvendelse som vasopressin- og/eller ocytocin-agonister og/eller -antagonister
NO20021751L (no) Purinderivater
BG106569A (en) Purine derivatives
DK31092D0 (da) 2-pyrimidinyl-1-piperazin-derivater, deres fremstilling og anvendelse
DE69132141D1 (de) Neuroprotective indolone und verwandte derivate
MY132229A (en) Indole derivatives as 5-ht receptor antagonist
CO4910163A1 (es) Prevencion de la perdida y restauracion de la masa osea por determinados agonistas de prostaglandinas
MY129189A (en) Prostaglandin agonists and their use to treat bone disorders
ATE331726T1 (de) Adenine-derivate
DK0641328T3 (da) Broforbundne, azabicykliske derivater som substans P-antagonister
BR0215212A (pt) Ativador de carboxamida ou sulfonamida de glicoquinase, composto, composição farmacêutica, e, uso de um composto
NO20061981L (no) Arylindenopyridiner og arylindenopyridiner og deres anvendelse som adenosin A2A reseptoragonist
NO20050664L (no) 2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer
EP0354777A3 (en) 3-(4-piperidine)-5-(2-sulfonylaminoethyl) indole derivatives
DK0773943T3 (da) Forbindelser, der er anvendelige som antiproliferative midler og garft-inhibitorer
HK1074843A1 (en) Tetracyclic arylsulfonyl indoles having serotonin receptor affinity
HK1074842A1 (en) Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
NO943261L (no) Indolderivater som 5-HT, agonister
NO963331L (no) 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
NO991589L (no) Nye 3-,5- og/eller 6-substituerte analoger av swainsonin, fremgangsmÕter for deres fremstilling og deres anvendelse som terapeutiske midler
ECSP972049A (es) Derivados de lactama