DE69227458D1 - Tryptamin analoga, ihre herstellung und anwendung als 5-ht1-artige rezeptoren oder 5-ht2 rezeptor agonisten - Google Patents

Tryptamin analoga, ihre herstellung und anwendung als 5-ht1-artige rezeptoren oder 5-ht2 rezeptor agonisten

Info

Publication number
DE69227458D1
DE69227458D1 DE69227458T DE69227458T DE69227458D1 DE 69227458 D1 DE69227458 D1 DE 69227458D1 DE 69227458 T DE69227458 T DE 69227458T DE 69227458 T DE69227458 T DE 69227458T DE 69227458 D1 DE69227458 D1 DE 69227458D1
Authority
DE
Germany
Prior art keywords
pct
receptors
production
date
receptor agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69227458T
Other languages
English (en)
Other versions
DE69227458T2 (de
Inventor
Lawrence Kruse
Rodney Christopher Young
Alberto Julio Kaumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919113385A external-priority patent/GB9113385D0/en
Priority claimed from GB919113382A external-priority patent/GB9113382D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69227458D1 publication Critical patent/DE69227458D1/de
Application granted granted Critical
Publication of DE69227458T2 publication Critical patent/DE69227458T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69227458T 1991-06-21 1992-06-17 Tryptamin analoga, ihre herstellung und anwendung als 5-ht1-artige rezeptoren oder 5-ht2 rezeptor agonisten Expired - Fee Related DE69227458T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919113385A GB9113385D0 (en) 1991-06-21 1991-06-21 Compounds
GB919113382A GB9113382D0 (en) 1991-06-21 1991-06-21 Compounds
PCT/GB1992/001089 WO1993000333A1 (en) 1991-06-21 1992-06-17 Tryptamine analogues, their synthesis and their use as 5-ht1-like or 5-ht2 receptor agonists

Publications (2)

Publication Number Publication Date
DE69227458D1 true DE69227458D1 (de) 1998-12-03
DE69227458T2 DE69227458T2 (de) 1999-04-29

Family

ID=26299103

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69227458T Expired - Fee Related DE69227458T2 (de) 1991-06-21 1992-06-17 Tryptamin analoga, ihre herstellung und anwendung als 5-ht1-artige rezeptoren oder 5-ht2 rezeptor agonisten

Country Status (13)

Country Link
US (1) US5571833A (de)
EP (1) EP0593513B1 (de)
JP (1) JPH06508354A (de)
AT (1) ATE172723T1 (de)
AU (1) AU1928892A (de)
CA (1) CA2110574A1 (de)
DE (1) DE69227458T2 (de)
DK (1) DK0593513T3 (de)
IE (1) IE921993A1 (de)
MX (1) MX9203050A (de)
PT (1) PT100603A (de)
TW (1) TW217407B (de)
WO (1) WO1993000333A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9226532D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5496957A (en) * 1993-09-01 1996-03-05 Virginia Commonwealth University Tryptamine analogs with 5-HT1D selectivity
CA2147991A1 (en) * 1993-09-01 1995-03-09 Richard A. Glennon Tryptamine analogs with 5-ht1d selectivity
US5504101A (en) * 1994-05-06 1996-04-02 Allelix Biopharmaceuticals, Inc. 5-HT-1D receptor ligands
CA2207201A1 (en) * 1994-12-06 1996-06-13 Caroline Henry Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
JP2002526443A (ja) 1998-09-18 2002-08-20 アルコン ラボラトリーズ， インコーポレーテッド 緑内障治療用セロトニン作動性５ｈｔ２作用物質
EP1132389A1 (de) * 2000-03-06 2001-09-12 Vernalis Research Limited Neue Azaindolyl-Derivate für die Behandlung von Fettleibigheit
AU2001216035A1 (en) * 2000-03-17 2001-10-03 Alcon Universal Ltd. 5-hydroxy indole derivatives for treating glaucoma
US7005443B1 (en) * 2000-03-17 2006-02-28 Alcon, Inc. 5-Hydroxy indazole derivatives for treating glaucoma
US6660870B1 (en) 2000-03-17 2003-12-09 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
US7012090B1 (en) 2000-03-17 2006-03-14 Alcon, Inc. Pyranoindoles for treating glaucoma
US6806285B1 (en) 2000-03-17 2004-10-19 Alcon, Inc. 5-Hydroxyl indole derivatives for treating glaucoma
US6956036B1 (en) 2000-03-17 2005-10-18 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
WO2004098807A1 (en) * 2000-11-21 2004-11-18 Barsplice Products, Inc. Method of making steel couplers for joining concrete reinforcing bars
WO2002079153A1 (en) * 2001-03-28 2002-10-10 Biocatalytics, Inc. Method for producing tryptamine derivatives
CA2447156A1 (en) * 2001-06-01 2002-12-12 Alcon, Inc. Novel fused indazoles and indoles and their use for the treatment of glaucoma
CN1512879A (zh) * 2001-06-01 2004-07-14 �Ƹ��� 新的芳氨基丙烷类似物及其用于治疗青光眼的用途
CA2447480A1 (en) * 2001-06-01 2002-12-12 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
US6884816B2 (en) * 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
AU2002364711A1 (en) * 2001-12-14 2003-06-30 Alcon, Inc. Substituted 5-hydroxy-indole compounds for the treatment of glaucoma
TW593302B (en) * 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
PL375564A1 (en) * 2002-08-30 2005-11-28 Alcon, Inc. Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma
WO2004054572A2 (en) * 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
JP4897221B2 (ja) 2002-12-20 2012-03-14 チバ ホールディング インコーポレーテッド アミン類の合成及びその合成のための中間体
US7476687B2 (en) * 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
WO2005058911A2 (en) * 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) * 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US20060073172A1 (en) * 2004-10-01 2006-04-06 Schneider L W Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure
WO2006062839A1 (en) * 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma
JP5868980B2 (ja) * 2010-09-14 2016-02-24 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ トリプタミン誘導体、その製造方法および胃疾患についての使用
WO2018204354A1 (en) * 2017-05-01 2018-11-08 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods to reduce pathogenesis
PL3873883T3 (pl) * 2019-11-07 2023-05-08 Small Pharma Ltd Sposób syntezy
US11773062B2 (en) 2021-03-22 2023-10-03 Small Pharma Ltd Deuterated compounds
KR20230092878A (ko) * 2020-09-04 2023-06-26 길가메쉬 파마슈티컬스, 인코포레이티드 아제티디닐 트립타민 및 정신 질환 치료 방법
US11697638B2 (en) 2021-09-08 2023-07-11 Small Pharma Ltd 5-methoxy-N,N-dimethyltryptamine crystalline forms

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5883671A (ja) * 1981-11-11 1983-05-19 Mitsui Toatsu Chem Inc トリプタミン誘導体の製造法
WO1990005721A1 (en) * 1988-11-14 1990-05-31 The Upjohn Company Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents

Also Published As

Publication number Publication date
PT100603A (pt) 1993-08-31
US5571833A (en) 1996-11-05
ATE172723T1 (de) 1998-11-15
CA2110574A1 (en) 1993-01-07
EP0593513A1 (de) 1994-04-27
IE921993A1 (en) 1992-12-30
DE69227458T2 (de) 1999-04-29
EP0593513B1 (de) 1998-10-28
DK0593513T3 (da) 1999-07-05
TW217407B (de) 1993-12-11
JPH06508354A (ja) 1994-09-22
AU1928892A (en) 1993-01-25
MX9203050A (es) 1993-07-01
WO1993000333A1 (en) 1993-01-07

Similar Documents

Publication Publication Date Title
DE69227458D1 (de) Tryptamin analoga, ihre herstellung und anwendung als 5-ht1-artige rezeptoren oder 5-ht2 rezeptor agonisten
DK0687268T3 (da) Spiroazacykliske derivater som substans P-antagonister
NO963639D0 (no) Sublingual eller buckal farmasöytisk blanding
PT804252E (pt) Agentes queladores metalicos que contem monoaminas diamidas e tiois
MY132229A (en) Indole derivatives as 5-ht receptor antagonist
DE69132141D1 (de) Neuroprotective indolone und verwandte derivate
PH22960A (en) 2-pyrimidinyl-1-piperazine derivatives
MY129189A (en) Prostaglandin agonists and their use to treat bone disorders
ATE423769T1 (de) Fluor- und sulfonylaminohaltige, 3,6- disubstituierte azabicyclo 3.1.0 hexanderivate als muscarinrezeptorantagonisten
LV12568A (en) Morpholine and thiomorpholine tachykinin receptor antagonists
UA27776C2 (uk) Похідні хінуклідину та їх фармацевтично прийнятні солі, що є антагоністами речовини р у ссавців, фармацевтична композиція, що має антагоністичну дію на речовину р у ссавців
DK0641328T3 (da) Broforbundne, azabicykliske derivater som substans P-antagonister
MX9203053A (es) Derivados de aza nor bornano.
UA34416C2 (uk) Похідні хроману, активні стосовно 5-нт рецептора, спосіб їх одержання та проміжні сполуки
KR100310277B1 (ko) 뼈 형성 촉진용 저분자량 하이알루론산의 제조
ATE293448T1 (de) Benzo(d)azepin-derivative als 5-ht6-rezeptor- antagonisten
PE34297A1 (es) Ligandos especificos del neuropeptido y1
UA39866C2 (uk) Похідні індолу, проміжні сполуки, фармацевтична композиція та спосіб лікування
TW200509933A (en) Therapeutic agents
AU2284001A (en) Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone
MX9403088A (es) Composiciones farmaceuticas que contienen deriva- dos de indol y metodos de uso.
PH27326A (en) Substituted cyclohexenes as central nervous system agents
UA48962C2 (uk) Біциклічні антагоністи тахікінінів, фармацевтична композиція та спосіб лікування
PE26198A1 (es) Compuestos farmaceuticos
ECSP972049A (es) Derivados de lactama

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee