FI103967B1 - Förfarande för framställning av tetrahydrokarbazolderivat - Google Patents

Förfarande för framställning av tetrahydrokarbazolderivat

Info

Publication number
FI103967B1
FI103967B1 FI935842A FI935842A FI103967B1 FI 103967 B1 FI103967 B1 FI 103967B1 FI 935842 A FI935842 A FI 935842A FI 935842 A FI935842 A FI 935842A FI 103967 B1 FI103967 B1 FI 103967B1
Authority
FI
Finland
Prior art keywords
preparation
tetrahydrocarbazole derivatives
tetrahydrocarbazole
derivatives
Prior art date
Application number
FI935842A
Other languages
English (en)
Finnish (fi)
Other versions
FI935842A0 (fi
FI935842A (fi
FI103967B (sv
Inventor
Francis David King
Laramie Mary Gaster
Alberto Julio Kaumann
Rodney Christopher Young
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI103967(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of FI935842A0 publication Critical patent/FI935842A0/fi
Publication of FI935842A publication Critical patent/FI935842A/fi
Application granted granted Critical
Publication of FI103967B1 publication Critical patent/FI103967B1/sv
Publication of FI103967B publication Critical patent/FI103967B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI935842A 1991-06-26 1993-12-23 Förfarande för framställning av tetrahydrokarbazolderivat FI103967B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9113802 1991-06-26
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
US08/167,846 US5464864A (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists
PCT/GB1992/001082 WO1993000086A1 (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5ht1 receptor agonists
GB9201082 1992-06-17
US16784693 1993-12-23

Publications (4)

Publication Number Publication Date
FI935842A0 FI935842A0 (fi) 1993-12-23
FI935842A FI935842A (fi) 1993-12-23
FI103967B1 true FI103967B1 (sv) 1999-10-29
FI103967B FI103967B (sv) 1999-10-29

Family

ID=10697363

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935842A FI103967B (sv) 1991-06-26 1993-12-23 Förfarande för framställning av tetrahydrokarbazolderivat

Country Status (35)

Country Link
US (2) US5464864A (sv)
EP (1) EP0591280B1 (sv)
JP (1) JP3261502B2 (sv)
KR (1) KR100251571B1 (sv)
CN (1) CN1034072C (sv)
AP (1) AP344A (sv)
AT (1) ATE170746T1 (sv)
BR (2) BR9206237A (sv)
CA (1) CA2113726C (sv)
CZ (3) CZ282327B6 (sv)
DE (2) DE69226953T2 (sv)
DK (1) DK0591280T3 (sv)
FI (1) FI103967B (sv)
GB (1) GB9113802D0 (sv)
HK (1) HK1014669A1 (sv)
HU (1) HU218907B (sv)
IE (1) IE922062A1 (sv)
IL (4) IL117104A (sv)
LU (1) LU90939I2 (sv)
MA (1) MA22563A1 (sv)
MX (1) MX9203444A (sv)
NL (1) NL300103I2 (sv)
NO (2) NO304774B1 (sv)
NZ (1) NZ243288A (sv)
PL (3) PL169392B1 (sv)
PT (1) PT100620B (sv)
RU (1) RU2137474C1 (sv)
SA (1) SA92130141B1 (sv)
SG (1) SG47877A1 (sv)
SI (1) SI9200125B (sv)
SK (3) SK280905B6 (sv)
TW (1) TW214544B (sv)
UA (1) UA41254C2 (sv)
WO (1) WO1993000086A1 (sv)
ZA (1) ZA924658B (sv)

Families Citing this family (37)

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GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
DE69610793T2 (de) * 1995-06-23 2001-05-03 Eli Lilly And Co., Indianapolis 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
BR0312176A (pt) 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmaceutica, uso de um composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso, processo para a preparação de um composto, novo intermediario e processo para a preparação de um novo intermediario
DK1537113T5 (da) 2002-06-21 2011-01-10 Suven Life Sciences Ltd Arylalkylindoler med serotoninreceptoraffinitet anvendelige som terapeutiske midler, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
EP1567492B1 (en) 2002-11-28 2013-05-22 Suven Life Sciences Limited N-arylsulfonyl-3-aminoalkoxyindoles
SI1581492T1 (sl) 2002-11-28 2008-12-31 Suven Life Sciences Ltd N-arilsulfonil-3-substituirani indoli, ki imajo afiniteto za serotoninski receptor, postopek za njihovo pripravo in farmacevtski sestavek, ki jih vsebuje
DK1581538T3 (da) 2002-12-18 2007-06-25 Suven Life Sciences Ltd Tetracykliske 3-substituerede indoler med serotoninreceptoraffinitet
SI2051962T1 (sl) * 2006-08-07 2012-02-29 Actelion Pharmaceuticals Ltd Derivati (3-amino-1,2,3,4-tetrahidro-9h-karbazol-9-il)-ocetne kisline
PL2124556T3 (pl) 2006-10-09 2015-02-27 Charleston Laboratories Inc Kompozycje farmaceutyczne
JP5825757B2 (ja) 2007-02-11 2015-12-02 マップ・ファーマシューティカルズ・インコーポレイテッド 副作用プロファイルを最小限にしながら片頭痛の迅速な緩和を可能にするｄｈｅの治療上の投与方法
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
CA3066426A1 (en) 2008-01-09 2009-07-16 Charleston Laboratories, Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
EP2451274B1 (en) 2009-07-08 2017-10-04 Charleston Laboratories, Inc. Pharmaceutical compositions
WO2011050140A1 (en) 2009-10-22 2011-04-28 Blue Fury Consulting, L.L.C. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
EP3628325A1 (en) 2011-07-22 2020-04-01 The University of Chicago Treatments for migraine and related disorders
EP2935280A4 (en) 2012-12-21 2016-05-25 Map Pharmaceuticals Inc 8'-HYDROXY-DIHYDROERGOTAMINE COMPOUNDS AND COMPOSITIONS
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) * 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
CA3055170A1 (en) 2016-03-04 2017-09-08 Charleston Laboratories, Inc. Pharmaceutical compositions
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) * 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Also Published As

Publication number Publication date
SI9200125A (en) 1992-12-31
CA2113726A1 (en) 1993-01-07
WO1993000086A1 (en) 1993-01-07
SA92130141B1 (ar) 2005-12-18
EP0591280B1 (en) 1998-09-09
PL171034B1 (en) 1997-02-28
PL169410B1 (pl) 1996-07-31
NL300103I1 (nl) 2002-12-02
JP3261502B2 (ja) 2002-03-04
NO934800L (no) 1993-12-23
ZA924658B (en) 1993-12-24
US5637611A (en) 1997-06-10
AP9200403A0 (en) 1992-07-31
NO304774B1 (no) 1999-02-15
HK1014669A1 (en) 1999-09-30
CZ282061B6 (cs) 1997-05-14
HUT68961A (en) 1995-08-28
NO2005011I1 (no) 2005-05-18
PT100620A (pt) 1993-09-30
SK280906B6 (sk) 2000-09-12
FI935842A0 (fi) 1993-12-23
FI935842A (fi) 1993-12-23
CZ282083B6 (cs) 1997-05-14
AU1977592A (en) 1993-01-25
IL117105A (en) 1998-01-04
IL117104A (en) 1997-09-30
IL117104A0 (en) 1996-06-18
EP0591280A1 (en) 1994-04-13
IL117105A0 (en) 1996-06-18
IL102322A0 (en) 1993-01-14
RU2137474C1 (ru) 1999-09-20
SK280907B6 (sk) 2000-09-12
BR9206237A (pt) 1995-04-11
AP344A (en) 1994-07-05
FI103967B (sv) 1999-10-29
PL169392B1 (pl) 1996-07-31
LU90939I2 (fr) 2002-09-24
CZ150696A3 (en) 1997-06-11
DK0591280T3 (da) 1999-02-15
US5464864A (en) 1995-11-07
CZ150596A3 (en) 1997-05-14
CN1034072C (zh) 1997-02-19
NO934800D0 (no) 1993-12-23
NL300103I2 (nl) 2003-02-03
SI9200125B (en) 2001-12-31
AU652842B2 (en) 1994-09-08
GB9113802D0 (en) 1991-08-14
TW214544B (sv) 1993-10-11
IE922062A1 (en) 1992-12-30
CN1069726A (zh) 1993-03-10
BR1100460A (pt) 2000-07-18
NO2005011I2 (no) 2008-02-11
KR100251571B1 (ko) 2000-07-01
MX9203444A (es) 1993-12-01
UA41254C2 (uk) 2001-09-17
DE69226953D1 (de) 1998-10-15
DE10299042I1 (de) 2003-02-20
CZ286193A3 (en) 1994-07-13
NZ243288A (en) 1994-09-27
SK131993A3 (en) 1994-06-08
ATE170746T1 (de) 1998-09-15
IL102322A (en) 1997-09-30
SG47877A1 (en) 1998-04-17
SK280905B6 (sk) 2000-09-12
JPH06508827A (ja) 1994-10-06
MA22563A1 (fr) 1992-12-31
DE10299042I2 (de) 2005-02-03
DE69226953T2 (de) 1999-05-12
CZ282327B6 (cs) 1997-06-11
HU218907B (hu) 2000-12-28
CA2113726C (en) 2008-02-19
PT100620B (pt) 1999-01-29

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Legal Events

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SPCF Supplementary protection certificate application filed

Spc suppl protection certif: L20020003

SPCF Supplementary protection certificate application filed

Spc suppl protection certif: L20020015

SPCG Supplementary protection certificate granted

Spc suppl protection certif: NUMBER:213

MA Patent expired