FI102540B - Kelatoivan ryhmän sisältäviä somatostatiinipeptidijohdannaisia diagnos tista käyttöä varten - Google Patents

Kelatoivan ryhmän sisältäviä somatostatiinipeptidijohdannaisia diagnos tista käyttöä varten Download PDF

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Publication number
FI102540B
FI102540B FI895809A FI895809A FI102540B FI 102540 B FI102540 B FI 102540B FI 895809 A FI895809 A FI 895809A FI 895809 A FI895809 A FI 895809A FI 102540 B FI102540 B FI 102540B
Authority
FI
Finland
Prior art keywords
cys
group
trp
phe
lys
Prior art date
Application number
FI895809A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI102540B1 (fi
FI895809A0 (fi
Inventor
Rainer Albert
Eric P Krenning
Steven W J Lamberts
Janos Pless
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of FI895809A0 publication Critical patent/FI895809A0/fi
Priority to FI943306A priority Critical patent/FI101967B/fi
Application granted granted Critical
Publication of FI102540B1 publication Critical patent/FI102540B1/fi
Publication of FI102540B publication Critical patent/FI102540B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI895809A 1988-12-05 1989-12-04 Kelatoivan ryhmän sisältäviä somatostatiinipeptidijohdannaisia diagnos tista käyttöä varten FI102540B (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI943306A FI101967B (fi) 1988-12-05 1994-07-11 Menetelmä farmaseuttisesti käyttökelpoisen radionuklidin kanssa komple ksoidun ligandin valmistamiseksi

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB8828364 1988-12-05
GB8916115 1989-07-13
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds
GB8916761 1989-07-21

Publications (3)

Publication Number Publication Date
FI895809A0 FI895809A0 (fi) 1989-12-04
FI102540B1 FI102540B1 (fi) 1998-12-31
FI102540B true FI102540B (fi) 1998-12-31

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
FI895809A FI102540B (fi) 1988-12-05 1989-12-04 Kelatoivan ryhmän sisältäviä somatostatiinipeptidijohdannaisia diagnos tista käyttöä varten

Country Status (24)

Country Link
JP (2) JP2726320B2 (fr)
KR (1) KR0156541B1 (fr)
AT (1) AT403476B (fr)
AU (1) AU633859B2 (fr)
BE (1) BE1002296A5 (fr)
CA (1) CA2004532C (fr)
CH (1) CH678329A5 (fr)
DE (1) DE3991505B4 (fr)
DK (1) DK175338B1 (fr)
ES (1) ES2023533A6 (fr)
FI (1) FI102540B (fr)
FR (1) FR2639947B1 (fr)
GB (1) GB2225579B (fr)
HK (1) HK189995A (fr)
HU (2) HUT53375A (fr)
IE (1) IE62091B1 (fr)
IL (1) IL92534A (fr)
LU (1) LU87633A1 (fr)
MY (1) MY106120A (fr)
NL (1) NL194828C (fr)
PT (1) PT92487B (fr)
SA (1) SA96160495B1 (fr)
SE (1) SE508799C2 (fr)
WO (1) WO1990006949A2 (fr)

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AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
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US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
ATE181240T1 (de) * 1991-02-08 1999-07-15 Biomeasure Inc Verwendung von somatostatinanalogen zur behandlung von melanomen
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
JPH06508357A (ja) * 1991-06-03 1994-09-22 マリンクロッド・メディカル・インコーポレイテッド 標識ポリペプチド、その製造法および使用
WO1993004702A1 (fr) * 1991-08-29 1993-03-18 Mallinckrodt Medical, Inc. Utilisation de l'acide gentisique ou de l'alcool gentisyle pour stabiliser des peptides et proteines radiomarques
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
ES2155447T3 (es) * 1992-01-03 2001-05-16 Rhomed Inc Aplicaciones farmaceuticas de peptidos-iones metalicos.
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
DE69330494T2 (de) * 1992-02-05 2002-03-28 Mallinckrodt Inc Radioaktiv markierte somatostatin
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
AU3967593A (en) * 1992-03-25 1993-10-21 Mallinckrodt Medical, Inc. Method of intraoperatively detecting and locating tumoral tissues
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
IL108308A0 (en) * 1993-01-12 1994-04-12 Sandoz Ag Polypeptides, their production and pharmaceutical compositions containing them
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
EP0683676A4 (fr) * 1993-02-02 1998-09-30 Neorx Corp Biodistribution dirigee des petites molecules.
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
ES2158897T3 (es) * 1993-06-23 2001-09-16 Diatide Inc Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos.
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
CA2190727C (fr) * 1994-05-19 2006-07-18 Sudhakar Kasina Ligands d'atomes donneurs d'azote et de soufre pontes et substitues par amines aromatiques, utilises en imagerie
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181A (fi) 1996-12-20 1998-06-21 Map Medical Technologies Oy Polyalkoholi-peptidijohdannaiset
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
CZ20032872A3 (cs) 2001-04-23 2005-01-12 Mallinckrodt Inc. Peptický ligand, který váže receptor somatostatinu
CN100475271C (zh) 2003-08-20 2009-04-08 加利福尼亚大学董事会 具有抑制生长激素释放活性的促生长素抑制素类似物
EP2474328A3 (fr) * 2003-09-17 2012-07-18 Board Of Regents, The University Of Texas System Imagerie de cellule béta pancréatique ciblée à base de mécanisme et thérapie
EP2067786A1 (fr) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Nouveaux analogues non sélectifs de somatostatine
EP2922578B1 (fr) 2012-11-21 2018-12-12 Serene, Llc Composés de liaison de récepteur somatostatine comprenant l'isotope de l'etain 117m

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CA1222691A (fr) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Methode de preparation de proteines marquees par un radionucleide, notamment des anticorps ou des fragments d'anticorps
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3522638A1 (de) * 1985-06-25 1987-01-08 Diamalt Ag Neue somatostatin-derivate
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
DK172629B1 (da) * 1986-02-14 1999-03-22 Nihon Mediphysics Co Ltd Reaktive højmolekylære forbindelser med mindst én fri aminogruppe, højmolekylære forbindelser kombineret med et fysiologisk
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
CH679045A5 (fr) * 1987-06-29 1991-12-13 Sandoz Ag
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
FR2638968B1 (fr) * 1988-11-11 1994-10-07 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives

Also Published As

Publication number Publication date
WO1990006949A3 (fr) 1990-07-26
CH678329A5 (fr) 1991-08-30
SA96160495B1 (ar) 2006-08-23
FR2639947B1 (fr) 1995-04-21
IE62091B1 (en) 1994-12-14
WO1990006949A2 (fr) 1990-06-28
PT92487B (pt) 1996-01-31
GB8927255D0 (en) 1990-01-31
SE8904087L (sv) 1991-06-05
GB2225579B (en) 1993-03-17
FI102540B1 (fi) 1998-12-31
DK612689A (da) 1990-06-06
JPH1095737A (ja) 1998-04-14
HK189995A (en) 1995-12-29
AT403476B (de) 1998-02-25
KR0156541B1 (ko) 1998-10-15
DK612689D0 (da) 1989-12-05
GB2225579A (en) 1990-06-06
CA2004532A1 (fr) 1990-06-05
HU211468A9 (en) 1995-11-28
FR2639947A1 (fr) 1990-06-08
LU87633A1 (fr) 1991-09-18
SE8904087D0 (sv) 1989-12-04
KR900009697A (ko) 1990-07-05
NL194828B (nl) 2002-12-02
JPH02184698A (ja) 1990-07-19
DK175338B1 (da) 2004-08-30
NL194828C (nl) 2003-04-03
AU633859B2 (en) 1993-02-11
IE893866L (en) 1990-06-05
FI895809A0 (fi) 1989-12-04
IL92534A (en) 1994-06-24
ATA901789A (de) 1997-07-15
PT92487A (pt) 1990-06-29
NL8902981A (nl) 1990-07-02
HUT53375A (en) 1990-10-28
CA2004532C (fr) 2000-02-22
BE1002296A5 (fr) 1990-11-20
JP3686503B2 (ja) 2005-08-24
DE3991505B4 (de) 2006-04-20
ES2023533A6 (es) 1992-01-16
AU4587189A (en) 1990-06-14
HU896359D0 (en) 1990-02-28
JP2726320B2 (ja) 1998-03-11
MY106120A (en) 1995-03-31
SE508799C2 (sv) 1998-11-09

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Legal Events

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GB Transfer or assigment of application

Owner name: NOVARTIS AG

FG Patent granted

Owner name: NOVARTIS AG