ES2155447T3 - Aplicaciones farmaceuticas de peptidos-iones metalicos. - Google Patents
Aplicaciones farmaceuticas de peptidos-iones metalicos.Info
- Publication number
- ES2155447T3 ES2155447T3 ES93902846T ES93902846T ES2155447T3 ES 2155447 T3 ES2155447 T3 ES 2155447T3 ES 93902846 T ES93902846 T ES 93902846T ES 93902846 T ES93902846 T ES 93902846T ES 2155447 T3 ES2155447 T3 ES 2155447T3
- Authority
- ES
- Spain
- Prior art keywords
- useful metal
- medically useful
- ions
- peptides
- pharmaceutical applications
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
PEPTIDOS CONTENIENDO UN CAMPO DE FUNCION BIOLOGICA Y UN CAMPO DE FIJACION DE IONES METALICOS MEDICAMENTE UTILES, Y PROTEINAS CONTENIENDO ENLACES DE MONOSULFUROS O BISULFUROS, SE CLASIFICAN CON IONES METALICOS MEDICAMENTE UTILES PARA SU UTILIZACION USO EN LA DIAGNOSIS Y EL TRATAMIENTO DE UNA VARIEDAD DE ESTADOS PATOLOGICOS. LOS PEPTIDOS TIENEN LA SECUENCIA AMINOACIDA (R1) CONTENIENDO OPCIONALMENTE LA SECUENCIA IKVAV E YIGSR. EL CAMPO DE FIJACION DE IONES METALICOS MEDICAMENTE UTIL ES [Y1)N, [Y1 PARA CLASIFICAR LAS PROTEINAS CON IONES METALICOS MEDICAMENTE UTILES.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/816,476 US5346687A (en) | 1989-08-09 | 1992-01-03 | Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging |
US07/816,477 US5460785A (en) | 1989-08-09 | 1992-01-03 | Direct labeling of antibodies and other protein with metal ions |
US07/840,077 US5443816A (en) | 1990-08-08 | 1992-02-20 | Peptide-metal ion pharmaceutical preparation and method |
US07/998,820 US5738838A (en) | 1992-02-20 | 1992-12-30 | IKVAV peptide radiopharmaceutical applications |
US07/998,910 US5556609A (en) | 1992-02-20 | 1992-12-30 | YIGSR peptide radiopharmaceutical applications |
PCT/US1992/011334 WO1993012819A1 (en) | 1992-01-03 | 1992-12-31 | Protein- and peptide-metal ion pharmaceutical applications |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2155447T3 true ES2155447T3 (es) | 2001-05-16 |
Family
ID=27542230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93902846T Expired - Lifetime ES2155447T3 (es) | 1992-01-03 | 1992-12-31 | Aplicaciones farmaceuticas de peptidos-iones metalicos. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0629133B1 (es) |
AT (1) | ATE197767T1 (es) |
AU (1) | AU683833B2 (es) |
CA (1) | CA2127284C (es) |
DE (1) | DE69231586T2 (es) |
DK (1) | DK0629133T3 (es) |
ES (1) | ES2155447T3 (es) |
WO (1) | WO1993012819A1 (es) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
US5440015A (en) * | 1992-07-21 | 1995-08-08 | Glycomed Incorporated | Selectin peptide medicaments for treating disease |
DE4301871A1 (de) * | 1993-01-13 | 1994-07-14 | Diagnostikforschung Inst | Neue Mittel zur Diagnose von Gefäßerkrankungen |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
DE69426673T2 (de) * | 1993-06-23 | 2001-09-20 | Diatide Inc | Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung |
DE69529988T2 (de) * | 1994-05-02 | 2003-12-11 | Diatide Inc | Technetium-99m markierte bildformungsmittel |
US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
DE4425778A1 (de) * | 1994-07-13 | 1996-01-18 | Diagnostikforschung Inst | Komplexverbindungen zur Diagnose von Gefäßerkrankungen |
US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
WO1996040289A1 (en) * | 1995-06-07 | 1996-12-19 | Immunomedics, Inc. | Thiolation of peptides for radionuclide-based radiodetection and radiotherapy |
US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
US8038994B2 (en) | 1996-05-15 | 2011-10-18 | Quest Pharmatech Inc. | Combination therapy for treating disease |
NZ505174A (en) | 1996-05-15 | 2002-03-01 | Altarex Inc | Cancer antigens CA125 (multiple epitote) recognised by OC125, M11, B43.13, B27.1, where B43.13 is used as a binding agent to elicit host immune response as a vaccination method against cancer |
US6106804A (en) * | 1997-06-13 | 2000-08-22 | The University Of New Mexico | Arsenic-72 labeled compounds for tissue specific medical imaging |
US7060251B1 (en) | 1997-09-08 | 2006-06-13 | The General Hospital Corporation | Imaging agents for early detection and monitoring of cardiovascular plaque |
EP1011738A1 (en) * | 1997-09-08 | 2000-06-28 | The General Hospital Corporation | Imaging agents for early detection of cardiovascular plaque |
JP4199420B2 (ja) * | 1998-05-15 | 2008-12-17 | ジーイー・ヘルスケア・リミテッド | 標識化グルタミンおよびリジンアナログ |
US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
US6685914B1 (en) | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
PL207834B1 (pl) * | 2001-07-10 | 2011-02-28 | Ge Healthcare As | Związki na bazie peptydów, ich zastosowanie oraz zawierająca je kompozycja farmaceutyczna |
EP1411987A2 (en) * | 2001-07-31 | 2004-04-28 | Immunomedics, Inc. | Targeted polymeric delivery systems |
US7317104B2 (en) | 2003-06-13 | 2008-01-08 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
US7319149B2 (en) | 2003-06-13 | 2008-01-15 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
US7371364B2 (en) | 2003-08-15 | 2008-05-13 | Board Of Regents, The University Of Texas System | Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy |
WO2005084168A2 (en) | 2003-09-08 | 2005-09-15 | Proportional Technologies, Inc. | MINIATURIZED 62Zn/62Cu GENERATOR FOR HIGH CONCENTRATION CLINICAL DELIVERY OF 62Cu KIT FORMULATION FOR THE FACILE PREPARATION OF RADIOLABELED Cu-BIS(THIOSEMICARBAZONE) COMPOUNDS |
EP1729823B1 (en) | 2004-03-04 | 2009-11-04 | GE Healthcare AS | Conjugates of angiotensin peptidic analogues and chelating agents for diagnosis and therapy |
WO2007001339A2 (en) | 2004-08-17 | 2007-01-04 | Wake Forest University Health Sciences | Ambient stored blood plasma expanders |
US8920827B2 (en) | 2005-10-21 | 2014-12-30 | Wake Forest University Health Sciences | Keratin bioceramic compositions |
WO2007095151A2 (en) | 2006-02-10 | 2007-08-23 | Wake Forest University Health Sciences | Nerve regeneration employing keratin biomaterials |
WO2007098053A2 (en) | 2006-02-17 | 2007-08-30 | Wake Forest University Health Sciences | Coatings and biomedical implants formed from keratin biomaterials |
US8273702B2 (en) | 2006-02-17 | 2012-09-25 | Wake Forest University Health Sciences | Wound healing compositions containing keratin biomaterials |
US7909888B2 (en) | 2008-12-19 | 2011-03-22 | L'oreal | Process for dyeing or lightening human keratin fibers using an anhydrous composition and a monoethanolamine/basic amino acid mixture, and suitable device therefor |
EP2198843B1 (fr) | 2008-12-19 | 2017-09-13 | L'Oréal | Eclaircissement de fibres kératiniques humaines mettant en oeuvre une composition anhydre comprenant un melange monoethanolamine / acide amine basique et dispositif |
FR2940103B1 (fr) | 2008-12-19 | 2011-06-10 | Oreal | Procede de coloration eclaircissante de matieres keratiniques mettant en oeuvre une emulsion comprenant un colorant et un agent alcalin et une composition oxydante |
FR2940077B1 (fr) | 2008-12-19 | 2012-07-20 | Oreal | Procede de coloration eclaircissante de matieres keratiniques mettant en oeuvre une composition anhydre colorante comprenant un agent alcalin et une composition oxydante. |
JP5815205B2 (ja) | 2008-12-19 | 2015-11-17 | ロレアル | 有機アミン及び無機塩基の存在下で、淡色化し、あるいは淡色化直接染色し、あるいは酸化染色する方法、及びそのためのデバイス |
BRPI0907287B1 (pt) | 2008-12-19 | 2018-01-02 | L'oréal | "processo de clareamento ou de coloração das fibras queratínicas e dispositivo com vários comportamentos" |
JP5808077B2 (ja) | 2008-12-19 | 2015-11-10 | ロレアル | 無機塩基の存在下で着色または明色化する方法及びキット |
US7918902B2 (en) | 2008-12-19 | 2011-04-05 | L'oreal S.A. | Process for lightening or process for direct dyeing or oxidation dyeing of keratin fibers in the presence of at least one ammonium salt and device therefor |
WO2010093882A1 (en) | 2009-02-13 | 2010-08-19 | Wake Forest University Health Sciences | Keratin biomaterials for cell culture and methods of use |
FR2942704B1 (fr) | 2009-03-04 | 2011-09-02 | Oreal | Dispositif de distribution d'une composition tinctoriale pour les fibres keratiniques et procede associe. |
FR2949971B1 (fr) | 2009-09-17 | 2012-08-17 | Oreal | Procede d'eclaircissement ou de coloration en presence d'une composition anhydre particuliere et dispositif |
FR2951080B1 (fr) | 2009-10-13 | 2012-01-20 | Oreal | Composition comprenant un corps gras et un acide organophosphonique ou l'un de ses sels, procede de coloration ou d'eclaircissement la mettant en oeuvre et dispositifs |
FR2954121B1 (fr) | 2009-12-22 | 2016-03-25 | Oreal | Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties, comprenant un corps gras particulier et une reductone. |
FR2954101B1 (fr) | 2009-12-22 | 2012-05-11 | Oreal | Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties ou plus, comprenant une composition alcaline en emulsion inverse. |
FR2954160B1 (fr) | 2009-12-22 | 2012-03-30 | Oreal | Composition de coloration ou d'eclaircissement comprenant un corps gras et un polymere amphotere |
FR2954127B1 (fr) | 2009-12-22 | 2015-10-30 | Oreal | Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties, comprenant un corps gras et un agent sequestrant. |
WO2011076646A2 (en) | 2009-12-22 | 2011-06-30 | L'oreal | Agent for dyeing and/or bleaching keratin fibres, comprising an inverse emulsion comprising an oxidizing agent |
WO2011076647A2 (en) | 2009-12-22 | 2011-06-30 | L'oreal | Inverse emulsion for treating the hair comprising a particular fatty substance and an alkaline agent |
FR2954113B1 (fr) | 2009-12-22 | 2013-03-08 | Oreal | Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties ou plus, sous forme d'emulsion. |
FR2954161B1 (fr) | 2009-12-23 | 2012-03-02 | Oreal | Procede de coloration ou d'eclaircissement de fibres keratiniques en presence d'alcane(s) lineaire(s) volatil(s) et dispositif |
JP2013521313A (ja) | 2010-03-05 | 2013-06-10 | ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ | 制御送達系 |
US8545893B2 (en) | 2010-03-08 | 2013-10-01 | Wake Forest University Health Sciences | Keratin biomaterials for treatment of ischemia |
FR2958161B1 (fr) | 2010-04-02 | 2012-04-27 | Oreal | Procede de traitement des cheveux mettant en oeuvre une emulsion directe comprenant un agent oxydant et une emulsion directe contenant un agent alcalin |
FR2959127B1 (fr) | 2010-04-22 | 2016-01-01 | Oreal | Emulsion inverse pour le traitement des cheveux comprenant un solvant particulier |
FR2960773B1 (fr) | 2010-06-03 | 2015-12-11 | Oreal | Procedes de traitement cosmetique utilisant un revetement a base d'un polymere polyamide-polyether |
CA2818166C (en) | 2010-11-17 | 2019-04-30 | Wake Forest University Health Sciences | Keratin compositions for treatment of bone deficiency or injury |
US20140037626A1 (en) * | 2012-07-18 | 2014-02-06 | Echogen, Inc. | Metal Abstraction Peptide With Release of Metal |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO167124C (no) * | 1985-04-03 | 1991-10-09 | Du Pont Merck Pharma | Fremgangsmaate for fremstilling av et spormerket konjugat av metallthionein og biologisk aktivt molekyl. |
EP0210684A1 (en) * | 1985-07-31 | 1987-02-04 | MALLINCKRODT, INC.(a Missouri corporation) | Composition comprising a radioactive metal compound for radioassaying |
ATE52516T1 (de) * | 1986-05-28 | 1990-05-15 | Mallinckrodt Inc | Technetiumchelate fuer die bestimmung der nierenfunktion. |
DE3728599A1 (de) * | 1986-12-10 | 1988-06-23 | Hoechst Ag | Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz |
EP0354923B1 (en) * | 1987-04-02 | 1994-06-29 | Centocor, Inc. | Method for labelling antibodies with a metal ion |
US5128119A (en) * | 1989-06-12 | 1992-07-07 | Immunomedics, Inc. | Methods for technetium/rhenium labeling of f(ab1)2 fragments |
AU628357B2 (en) * | 1988-05-02 | 1992-09-17 | New England Deaconess Hospital Corporation | Synthetic peptides for arterial imaging |
US4917878A (en) * | 1988-05-02 | 1990-04-17 | Thomas Jefferson University | Novel use of a radiolabelled antibody against stage specific embryonic antigen for the detection of occult abscesses in mammals |
US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
MY106120A (en) * | 1988-12-05 | 1995-03-31 | Novartis Ag | Peptide derivatives. |
US5196510A (en) * | 1988-12-29 | 1993-03-23 | Cytogen Corporation | Molecular recognition units |
NZ314680A (en) * | 1989-05-09 | 2000-08-25 | Ortho Pharma Corp | Treating localised infection or inflammation with a therapeutically conjugated chemotactic peptide |
GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
EP0436005B1 (en) * | 1989-07-20 | 1995-03-29 | Sandoz Ltd. | Labeled polypeptide derivatives |
JP3070763B2 (ja) * | 1989-08-09 | 2000-07-31 | ロメッド インコーポレイティド | テクネチウムまたはレニウムでの抗体または他のタンパク質の直接放射能標識 |
US5277892A (en) * | 1990-08-08 | 1994-01-11 | Rhomed Incorporated | In vivo lymphocyte tagging |
ATE188387T1 (de) * | 1991-02-08 | 2000-01-15 | Diatide Inc | Technetium-99m markierte polypeptide zur bildformung |
-
1992
- 1992-12-31 WO PCT/US1992/011334 patent/WO1993012819A1/en active IP Right Grant
- 1992-12-31 DE DE69231586T patent/DE69231586T2/de not_active Revoked
- 1992-12-31 CA CA002127284A patent/CA2127284C/en not_active Expired - Fee Related
- 1992-12-31 ES ES93902846T patent/ES2155447T3/es not_active Expired - Lifetime
- 1992-12-31 AU AU34272/93A patent/AU683833B2/en not_active Ceased
- 1992-12-31 DK DK93902846T patent/DK0629133T3/da active
- 1992-12-31 EP EP93902846A patent/EP0629133B1/en not_active Revoked
- 1992-12-31 AT AT93902846T patent/ATE197767T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2127284C (en) | 2002-02-05 |
ATE197767T1 (de) | 2000-12-15 |
DE69231586D1 (de) | 2001-01-04 |
EP0629133A4 (en) | 1995-02-01 |
WO1993012819A1 (en) | 1993-07-08 |
AU683833B2 (en) | 1997-11-27 |
CA2127284A1 (en) | 1993-07-08 |
EP0629133B1 (en) | 2000-11-29 |
DE69231586T2 (de) | 2001-07-19 |
AU3427293A (en) | 1993-07-28 |
EP0629133A1 (en) | 1994-12-21 |
DK0629133T3 (da) | 2001-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2155447T3 (es) | Aplicaciones farmaceuticas de peptidos-iones metalicos. | |
EA199700239A1 (ru) | Ингибиторы тромбина, основанные на аминокислотной последовательности гирудина | |
NL300168I2 (nl) | Tweewaardige metaalzouten van 2-N,N-di(cararboxymethyl)amino-3-cyaan-4-carboxymethyl-5-thiofeencarbonzuur, werkwijze voor de bereiding ervan en deze bevattende farmaceutische preparaten. | |
ATE172879T1 (de) | Direkte radioetikettierung von antikörpern und sonstigen proteinen mittels technetium oder rhenium | |
EA200100721A1 (ru) | Производное габапентина для предупреждения и лечения висцеральной боли | |
DE69635959D1 (de) | Behandlung negativer und kognitiver symptome der schizophrenie mit antagonisten der glycinaufnahme | |
ES2177789T3 (es) | Peptidos antagonistas de lhrh. | |
DE69807679D1 (de) | Zusammensetzungen aus konjugaten des stabilen, aktiven, menschlichen ob proteins mit der fc kette von immunoglobulinen und damit zusammenhängende verfahren | |
DE60024092D1 (de) | Citrullin-enthaltende fibrin-derivate und ihre verwendung zur diagnose und behandlung von rheumatischer arthritis | |
ES2182054T3 (es) | Derivados de oxazol, su produccion y uso. | |
SE8901552D0 (sv) | Acid addition salts of amidated or glycine, their preparation and use | |
DE69012901T2 (de) | Hämoregulierende Peptide. | |
KR930002373A (ko) | 헥사펩티드 | |
KR960000921A (ko) | 칼시토닌 유도체 및 그 용도 | |
ES2057572T3 (es) | Agentes de reconocimiento. | |
EA199900755A1 (ru) | Производное хинолин-2-карбоновой кислоты и его применение в качестве антагониста возбуждающих аминокислот | |
BR0308095A (pt) | Teste para anticorpos anti-ingap | |
EA200001252A1 (ru) | КОМПОЗИЦИЯ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА-β-1A(IFN-β-1A) ЧЕЛОВЕКА | |
BR9608147A (pt) | Método para descontaminação microbiana de plaquetas sanguìneas. | |
RU95105249A (ru) | Гидрохлорид ng монометил-l-аргинина, способы его получения, способ получения фармацевтического препарата и способ лечения | |
DE69113437T2 (de) | Therapeutische Mittel für diabetisches Gangrän. | |
EA199600048A3 (ru) | N,n-диэтил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанамин дималеат, фармацевтическая композиция на его основе и способ индуцирования иммуномодуляции | |
SE8506094D0 (sv) | New antibacterial agents and intermediates therefor | |
KR950023647A (ko) | 생물학적 활성을 나타내는 폴리펩티드 | |
BR9101544A (pt) | Processo de preparacao de uma composicao contendo hexetidina ou seus derivados ou sais e sua utilizacao |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 629133 Country of ref document: ES |