EA199600048A3 - N,n-диэтил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанамин дималеат, фармацевтическая композиция на его основе и способ индуцирования иммуномодуляции - Google Patents

N,n-диэтил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанамин дималеат, фармацевтическая композиция на его основе и способ индуцирования иммуномодуляции

Info

Publication number
EA199600048A3
EA199600048A3 EA199600048A EA199600048A EA199600048A3 EA 199600048 A3 EA199600048 A3 EA 199600048A3 EA 199600048 A EA199600048 A EA 199600048A EA 199600048 A EA199600048 A EA 199600048A EA 199600048 A3 EA199600048 A3 EA 199600048A3
Authority
EA
Eurasian Patent Office
Prior art keywords
azaspiro
diethyl
8dipropyl
decane
dimaleate salt
Prior art date
Application number
EA199600048A
Other languages
English (en)
Other versions
EA199600048A2 (ru
EA000037B1 (ru
Inventor
Раймонд Э. Дэггер
Каролин В. Грэди
Original Assignee
Смитклайн Бичем Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичем Корпорейшн filed Critical Смитклайн Бичем Корпорейшн
Publication of EA199600048A2 publication Critical patent/EA199600048A2/ru
Publication of EA199600048A3 publication Critical patent/EA199600048A3/ru
Publication of EA000037B1 publication Critical patent/EA000037B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems

Abstract

Изобретение относится к дималеатной соли N,N-диэтил-8,8-дипропил-2-азаспиро [4.5]декан-2-пропанамина и к фармацевтической композиции на ее основе, используемой как иммуномодулирующее средство, в частности, для лечения ревматоидного артрита.
EA199600048A 1995-07-13 1996-07-12 N,n-диэтил-8,8-дипропил-2-азаспиро{4,5}декан-2-пропанамин дималеат, фармацевтическая композиция на его основе и способ индуцирования иммуномодуляции EA000037B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US113995P 1995-07-13 1995-07-13
US1606596P 1996-04-23 1996-04-23

Publications (3)

Publication Number Publication Date
EA199600048A2 EA199600048A2 (ru) 1996-12-30
EA199600048A3 true EA199600048A3 (ru) 1997-03-31
EA000037B1 EA000037B1 (ru) 1998-02-26

Family

ID=26668617

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199600048A EA000037B1 (ru) 1995-07-13 1996-07-12 N,n-диэтил-8,8-дипропил-2-азаспиро{4,5}декан-2-пропанамин дималеат, фармацевтическая композиция на его основе и способ индуцирования иммуномодуляции

Country Status (29)

Country Link
EP (1) EP0753512B1 (ru)
JP (1) JP3949750B2 (ru)
KR (1) KR100404832B1 (ru)
CN (1) CN1067378C (ru)
AR (1) AR003452A1 (ru)
AT (1) ATE164154T1 (ru)
AU (1) AU716256B2 (ru)
BG (1) BG62359B1 (ru)
CA (1) CA2181006C (ru)
CZ (1) CZ289617B6 (ru)
DE (1) DE69600189T2 (ru)
DK (1) DK0753512T3 (ru)
EA (1) EA000037B1 (ru)
ES (1) ES2113765T3 (ru)
HK (1) HK1010052A1 (ru)
HU (1) HU226691B1 (ru)
IL (1) IL118815A (ru)
MA (1) MA23936A1 (ru)
MX (1) MX9602767A (ru)
NO (1) NO306672B1 (ru)
NZ (1) NZ286951A (ru)
PL (1) PL191019B1 (ru)
RO (1) RO117376B1 (ru)
SG (1) SG43383A1 (ru)
SK (1) SK281254B6 (ru)
TR (1) TR199600579A2 (ru)
TW (1) TW419462B (ru)
UA (1) UA42749C2 (ru)
UY (1) UY24283A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5052729B2 (ja) * 2000-08-08 2012-10-17 第一三共株式会社 双環化合物の製造方法およびその中間体
TW200505438A (en) * 2003-03-10 2005-02-16 Callisto Pharmaceuticals Inc Method of treating cancer with azaspirane compositions
CN104119321B (zh) * 2013-04-28 2017-09-08 齐鲁制药有限公司 二氢吲哚酮衍生物的二马来酸盐及其多晶型物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3211397A1 (de) * 1982-03-27 1983-11-10 Hoechst Ag, 6230 Frankfurt Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
US4853409A (en) * 1988-04-13 1989-08-01 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
GB9217116D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Also Published As

Publication number Publication date
MA23936A1 (fr) 1997-04-01
HK1010052A1 (en) 1999-06-11
HU9601918D0 (en) 1996-09-30
CN1140710A (zh) 1997-01-22
AU716256B2 (en) 2000-02-24
EA199600048A2 (ru) 1996-12-30
NO962931D0 (no) 1996-07-12
BG100710A (bg) 1997-03-31
DE69600189T2 (de) 1998-10-15
HUP9601918A3 (en) 1998-01-28
CA2181006C (en) 2007-04-03
AR003452A1 (es) 1998-08-05
UY24283A1 (es) 2001-10-25
AU5945596A (en) 1997-01-23
JP3949750B2 (ja) 2007-07-25
TR199600579A2 (tr) 1997-01-21
ATE164154T1 (de) 1998-04-15
EP0753512B1 (en) 1998-03-18
MX9602767A (es) 1998-01-31
IL118815A0 (en) 1996-10-31
SK281254B6 (sk) 2001-01-18
HU226691B1 (en) 2009-06-29
KR100404832B1 (ko) 2004-01-13
SG43383A1 (en) 1997-10-17
EP0753512A1 (en) 1997-01-15
PL191019B1 (pl) 2006-03-31
CA2181006A1 (en) 1997-01-14
DK0753512T3 (da) 1998-10-19
JPH09118618A (ja) 1997-05-06
DE69600189D1 (de) 1998-04-23
PL315191A1 (en) 1997-01-20
NO306672B1 (no) 1999-12-06
CZ203696A3 (en) 1997-03-12
EA000037B1 (ru) 1998-02-26
BG62359B1 (bg) 1999-09-30
RO117376B1 (ro) 2002-02-28
SK88696A3 (en) 1997-06-04
HUP9601918A2 (en) 1997-09-29
CN1067378C (zh) 2001-06-20
NZ286951A (en) 1998-02-26
NO962931L (no) 1997-01-14
IL118815A (en) 2000-06-29
ES2113765T3 (es) 1998-05-01
UA42749C2 (ru) 2001-11-15
KR970069987A (ko) 1997-11-07
CZ289617B6 (cs) 2002-03-13
TW419462B (en) 2001-01-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU