DE69600189D1 - N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decan-2-propan-amin Dimaleatsalz - Google Patents

N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decan-2-propan-amin Dimaleatsalz

Info

Publication number
DE69600189D1
DE69600189D1 DE69600189T DE69600189T DE69600189D1 DE 69600189 D1 DE69600189 D1 DE 69600189D1 DE 69600189 T DE69600189 T DE 69600189T DE 69600189 T DE69600189 T DE 69600189T DE 69600189 D1 DE69600189 D1 DE 69600189D1
Authority
DE
Germany
Prior art keywords
azaspiro
dipropyl
decane
propane
diethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69600189T
Other languages
English (en)
Other versions
DE69600189T2 (de
Inventor
Raymond E Dagger
Carolyn W Grady
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anormed Inc
Original Assignee
Anormed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anormed Inc filed Critical Anormed Inc
Application granted granted Critical
Publication of DE69600189D1 publication Critical patent/DE69600189D1/de
Publication of DE69600189T2 publication Critical patent/DE69600189T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69600189T 1995-07-13 1996-07-11 N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decan-2-propan-amin Dimaleatsalz Expired - Fee Related DE69600189T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US113995P 1995-07-13 1995-07-13
US1606596P 1996-04-23 1996-04-23

Publications (2)

Publication Number Publication Date
DE69600189D1 true DE69600189D1 (de) 1998-04-23
DE69600189T2 DE69600189T2 (de) 1998-10-15

Family

ID=26668617

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69600189T Expired - Fee Related DE69600189T2 (de) 1995-07-13 1996-07-11 N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decan-2-propan-amin Dimaleatsalz

Country Status (29)

Country Link
EP (1) EP0753512B1 (de)
JP (1) JP3949750B2 (de)
KR (1) KR100404832B1 (de)
CN (1) CN1067378C (de)
AR (1) AR003452A1 (de)
AT (1) ATE164154T1 (de)
AU (1) AU716256B2 (de)
BG (1) BG62359B1 (de)
CA (1) CA2181006C (de)
CZ (1) CZ289617B6 (de)
DE (1) DE69600189T2 (de)
DK (1) DK0753512T3 (de)
EA (1) EA000037B1 (de)
ES (1) ES2113765T3 (de)
HK (1) HK1010052A1 (de)
HU (1) HU226691B1 (de)
IL (1) IL118815A (de)
MA (1) MA23936A1 (de)
MX (1) MX9602767A (de)
NO (1) NO306672B1 (de)
NZ (1) NZ286951A (de)
PL (1) PL191019B1 (de)
RO (1) RO117376B1 (de)
SG (1) SG43383A1 (de)
SK (1) SK281254B6 (de)
TR (1) TR199600579A2 (de)
TW (1) TW419462B (de)
UA (1) UA42749C2 (de)
UY (1) UY24283A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100473645C (zh) * 2000-08-08 2009-04-01 第一制药株式会社 双环化合物的制备方法及其中间体
TW200505438A (en) * 2003-03-10 2005-02-16 Callisto Pharmaceuticals Inc Method of treating cancer with azaspirane compositions
CN104119321B (zh) * 2013-04-28 2017-09-08 齐鲁制药有限公司 二氢吲哚酮衍生物的二马来酸盐及其多晶型物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3211397A1 (de) * 1982-03-27 1983-11-10 Hoechst Ag, 6230 Frankfurt Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
US4853409A (en) * 1988-04-13 1989-08-01 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
GB9217116D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Also Published As

Publication number Publication date
BG100710A (bg) 1997-03-31
MA23936A1 (fr) 1997-04-01
CZ203696A3 (en) 1997-03-12
HU9601918D0 (en) 1996-09-30
EA000037B1 (ru) 1998-02-26
CN1067378C (zh) 2001-06-20
CA2181006C (en) 2007-04-03
UA42749C2 (uk) 2001-11-15
SK88696A3 (en) 1997-06-04
RO117376B1 (ro) 2002-02-28
DE69600189T2 (de) 1998-10-15
MX9602767A (es) 1998-01-31
ES2113765T3 (es) 1998-05-01
EP0753512B1 (de) 1998-03-18
IL118815A0 (en) 1996-10-31
SK281254B6 (sk) 2001-01-18
TR199600579A2 (tr) 1997-01-21
NZ286951A (en) 1998-02-26
PL191019B1 (pl) 2006-03-31
CZ289617B6 (cs) 2002-03-13
CA2181006A1 (en) 1997-01-14
HUP9601918A2 (en) 1997-09-29
EP0753512A1 (de) 1997-01-15
HU226691B1 (en) 2009-06-29
JP3949750B2 (ja) 2007-07-25
UY24283A1 (es) 2001-10-25
BG62359B1 (bg) 1999-09-30
NO306672B1 (no) 1999-12-06
EA199600048A3 (ru) 1997-03-31
HUP9601918A3 (en) 1998-01-28
AU5945596A (en) 1997-01-23
AU716256B2 (en) 2000-02-24
ATE164154T1 (de) 1998-04-15
NO962931L (no) 1997-01-14
EA199600048A2 (ru) 1996-12-30
DK0753512T3 (da) 1998-10-19
HK1010052A1 (en) 1999-06-11
SG43383A1 (en) 1997-10-17
PL315191A1 (en) 1997-01-20
KR970069987A (ko) 1997-11-07
JPH09118618A (ja) 1997-05-06
TW419462B (en) 2001-01-21
AR003452A1 (es) 1998-08-05
IL118815A (en) 2000-06-29
CN1140710A (zh) 1997-01-22
NO962931D0 (no) 1996-07-12
KR100404832B1 (ko) 2004-01-13

Similar Documents

Publication Publication Date Title
NL300214I1 (nl) Chinazolinederivaten.
IS4963A (is) Setnar 6,5-heteró-bísýklískar afleiður
TR199501724A2 (tr) Sizdirmazlik saglayici düzen.
DE69636353D1 (de) Datenübetragungsvorrichtung.
SV1996000005A (es) Quinazolinonas bisustituidas en 2,8
FI950715A0 (fi) Ytmikromekanisk, symmetrisk tryckskillnadsgivare
TR199600883A2 (tr) Pürin-6-on türevleri.
TR27961A (tr) Sübstitüe edilmis 1,2,3,4 -tetrahidro-5-nitro-pirimidinler.
DE69814441D1 (de) 6,11-verbrückte erythromycinderivate
MA26503A1 (fr) Derives de 5'-desoxy-cytidine.
BR9609884A (pt) N-aril- 1,2,4-triazolin-5-onas
TR199600715A2 (tr) Kefalosforin türevleri.
DE69618634D1 (de) 1,4-benzodioxin-derivate
NO960499D0 (no) Antineurodegenerativt virksomme 10-aminoalifatyldibenz[b,fÅoksepiner
DK0874814T3 (da) 25-hydroxy-16-en-26,27-bishomo-cholecalciferoler
TR199600064A2 (tr) 4-amino-benzoilguanidin-türevleri.
DE69600189T2 (de) N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decan-2-propan-amin Dimaleatsalz
TR199700219A3 (tr) 1,25-Dihidroksi-16, 22, 23-Trisdihidro-kolkalsiferol türevleri.
ES1032571Y (es) Gafa,
AU6637096A (en) N,n-dimethyl-8,8-dipropyl-2-azaspiro{4,5}decane-2-propanamin e dimaleate
BR9610047A (pt) 1,3,4-oxadiazolin-2-onas
ES1030601Y (es) Radiador-convector, perfeccionado.
ES1031381Y (es) Estuche-jabonera de bolsillo.
FI950956A0 (fi) Luftkabel, saosom haengspiralkabel
FI952416A0 (fi) Distributionsanordning foer vaetska, speciellt tvaettvaetska foer vindrutor

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8339 Ceased/non-payment of the annual fee