UY24283A1 - N,n-dietil-8,8-dipropil-2-azaspiro(4.5)decano-2-propanamin dimaleato - Google Patents
N,n-dietil-8,8-dipropil-2-azaspiro(4.5)decano-2-propanamin dimaleatoInfo
- Publication number
- UY24283A1 UY24283A1 UY24283A UY24283A UY24283A1 UY 24283 A1 UY24283 A1 UY 24283A1 UY 24283 A UY24283 A UY 24283A UY 24283 A UY24283 A UY 24283A UY 24283 A1 UY24283 A1 UY 24283A1
- Authority
- UY
- Uruguay
- Prior art keywords
- propanamin
- azaspiro
- decane
- diethyl
- dimaleate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a un un agente inmunomodulatorio, la sal de N,N-dietil-8,8- dipropil-2-azaspiro [4.5] decano-2-propanamin-dimaleato. El compuesto está representado por la fórmula (I). El compuesto de esta invención es útil como agente inmunomodulatorio, particularmente en el tratamiento de la artritis reumatoidea.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US113995P | 1995-07-13 | 1995-07-13 | |
US1606596P | 1996-04-23 | 1996-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY24283A1 true UY24283A1 (es) | 2001-10-25 |
Family
ID=26668617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY24283A UY24283A1 (es) | 1995-07-13 | 1996-07-15 | N,n-dietil-8,8-dipropil-2-azaspiro(4.5)decano-2-propanamin dimaleato |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP0753512B1 (es) |
JP (1) | JP3949750B2 (es) |
KR (1) | KR100404832B1 (es) |
CN (1) | CN1067378C (es) |
AR (1) | AR003452A1 (es) |
AT (1) | ATE164154T1 (es) |
AU (1) | AU716256B2 (es) |
BG (1) | BG62359B1 (es) |
CA (1) | CA2181006C (es) |
CZ (1) | CZ289617B6 (es) |
DE (1) | DE69600189T2 (es) |
DK (1) | DK0753512T3 (es) |
EA (1) | EA000037B1 (es) |
ES (1) | ES2113765T3 (es) |
HK (1) | HK1010052A1 (es) |
HU (1) | HU226691B1 (es) |
IL (1) | IL118815A (es) |
MA (1) | MA23936A1 (es) |
MX (1) | MX9602767A (es) |
NO (1) | NO306672B1 (es) |
NZ (1) | NZ286951A (es) |
PL (1) | PL191019B1 (es) |
RO (1) | RO117376B1 (es) |
SG (1) | SG43383A1 (es) |
SK (1) | SK281254B6 (es) |
TR (1) | TR199600579A2 (es) |
TW (1) | TW419462B (es) |
UA (1) | UA42749C2 (es) |
UY (1) | UY24283A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1310487B1 (en) * | 2000-08-08 | 2007-01-03 | Daiichi Pharmaceutical Co., Ltd. | Processes for preparation of bicyclic compounds and intermediates therefor |
WO2004080408A2 (en) * | 2003-03-10 | 2004-09-23 | Callisto Pharmaceuticals, Inc. | Method of treating cancer with azaspirane compositions |
CN104119321B (zh) * | 2013-04-28 | 2017-09-08 | 齐鲁制药有限公司 | 二氢吲哚酮衍生物的二马来酸盐及其多晶型物 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3211397A1 (de) * | 1982-03-27 | 1983-11-10 | Hoechst Ag, 6230 Frankfurt | Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
US4430335A (en) * | 1983-02-09 | 1984-02-07 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted 1-azaspiro[4,5]decanes and their analgesic compositions |
US4963557A (en) * | 1987-09-28 | 1990-10-16 | Smithkline Beecham Corporation | Immunomodulatory azaspiranes |
US4853409A (en) * | 1988-04-13 | 1989-08-01 | Pfizer Inc. | 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function |
CA1336090C (en) * | 1988-08-31 | 1995-06-27 | Isao Hayakawa | Spiro-substituted cyclic amines of quinolone derivatives |
PT100566B (pt) * | 1991-06-07 | 1999-06-30 | Smithkline Beecham Corp | Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso |
GB9122735D0 (en) * | 1991-10-25 | 1991-12-11 | Smithkline Beecham Corp | Methods |
GB9217116D0 (en) * | 1992-08-13 | 1992-09-23 | Smithkline Beecham Corp | Methods |
US5506232A (en) * | 1994-03-28 | 1996-04-09 | Boehringer Mannheim Italia S.P.A. | 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt |
-
1996
- 1996-07-08 SK SK886-96A patent/SK281254B6/sk unknown
- 1996-07-08 IL IL11881596A patent/IL118815A/xx not_active IP Right Cessation
- 1996-07-08 SG SG1996010235A patent/SG43383A1/en unknown
- 1996-07-08 NZ NZ286951A patent/NZ286951A/en not_active IP Right Cessation
- 1996-07-08 BG BG100710A patent/BG62359B1/bg unknown
- 1996-07-09 CZ CZ19962036A patent/CZ289617B6/cs not_active IP Right Cessation
- 1996-07-09 UA UA96072764A patent/UA42749C2/uk unknown
- 1996-07-10 TW TW085108324A patent/TW419462B/zh not_active IP Right Cessation
- 1996-07-10 PL PL315191A patent/PL191019B1/pl not_active IP Right Cessation
- 1996-07-11 KR KR1019960028016A patent/KR100404832B1/ko not_active IP Right Cessation
- 1996-07-11 AR ARP960103537A patent/AR003452A1/es active IP Right Grant
- 1996-07-11 AU AU59455/96A patent/AU716256B2/en not_active Ceased
- 1996-07-11 CA CA002181006A patent/CA2181006C/en not_active Expired - Fee Related
- 1996-07-11 RO RO96-01426A patent/RO117376B1/ro unknown
- 1996-07-11 EP EP96201943A patent/EP0753512B1/en not_active Expired - Lifetime
- 1996-07-11 AT AT96201943T patent/ATE164154T1/de not_active IP Right Cessation
- 1996-07-11 DK DK96201943T patent/DK0753512T3/da active
- 1996-07-11 ES ES96201943T patent/ES2113765T3/es not_active Expired - Lifetime
- 1996-07-11 DE DE69600189T patent/DE69600189T2/de not_active Expired - Fee Related
- 1996-07-12 MX MX9602767A patent/MX9602767A/es unknown
- 1996-07-12 MA MA24311A patent/MA23936A1/fr unknown
- 1996-07-12 NO NO962931A patent/NO306672B1/no not_active IP Right Cessation
- 1996-07-12 HU HU9601918A patent/HU226691B1/hu not_active IP Right Cessation
- 1996-07-12 EA EA199600048A patent/EA000037B1/ru not_active IP Right Cessation
- 1996-07-12 JP JP18305896A patent/JP3949750B2/ja not_active Expired - Fee Related
- 1996-07-12 CN CN96110820A patent/CN1067378C/zh not_active Expired - Fee Related
- 1996-07-12 TR TR96/00579A patent/TR199600579A2/xx unknown
- 1996-07-15 UY UY24283A patent/UY24283A1/es unknown
-
1998
- 1998-09-18 HK HK98110743A patent/HK1010052A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ABAN | Application deemed to be withdrawn (no publication fee paid) |
Effective date: 20090526 |