MA23936A1 - Dimaleate de n,n-diethyl-8, 8-dipropyl-2-azaspiro (4,5) decane -2-propanamine - Google Patents

Dimaleate de n,n-diethyl-8, 8-dipropyl-2-azaspiro (4,5) decane -2-propanamine

Info

Publication number
MA23936A1
MA23936A1 MA24311A MA24311A MA23936A1 MA 23936 A1 MA23936 A1 MA 23936A1 MA 24311 A MA24311 A MA 24311A MA 24311 A MA24311 A MA 24311A MA 23936 A1 MA23936 A1 MA 23936A1
Authority
MA
Morocco
Prior art keywords
azaspiro
dipropyl
decane
diethyl
propanamine dimaleate
Prior art date
Application number
MA24311A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MA23936A1 publication Critical patent/MA23936A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
MA24311A 1995-07-13 1996-07-12 Dimaleate de n,n-diethyl-8, 8-dipropyl-2-azaspiro (4,5) decane -2-propanamine MA23936A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US113995P 1995-07-13 1995-07-13
US1606596P 1996-04-23 1996-04-23

Publications (1)

Publication Number Publication Date
MA23936A1 true MA23936A1 (fr) 1997-04-01

Family

ID=26668617

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24311A MA23936A1 (fr) 1995-07-13 1996-07-12 Dimaleate de n,n-diethyl-8, 8-dipropyl-2-azaspiro (4,5) decane -2-propanamine

Country Status (29)

Country Link
EP (1) EP0753512B1 (fr)
JP (1) JP3949750B2 (fr)
KR (1) KR100404832B1 (fr)
CN (1) CN1067378C (fr)
AR (1) AR003452A1 (fr)
AT (1) ATE164154T1 (fr)
AU (1) AU716256B2 (fr)
BG (1) BG62359B1 (fr)
CA (1) CA2181006C (fr)
CZ (1) CZ289617B6 (fr)
DE (1) DE69600189T2 (fr)
DK (1) DK0753512T3 (fr)
EA (1) EA000037B1 (fr)
ES (1) ES2113765T3 (fr)
HK (1) HK1010052A1 (fr)
HU (1) HU226691B1 (fr)
IL (1) IL118815A (fr)
MA (1) MA23936A1 (fr)
MX (1) MX9602767A (fr)
NO (1) NO306672B1 (fr)
NZ (1) NZ286951A (fr)
PL (1) PL191019B1 (fr)
RO (1) RO117376B1 (fr)
SG (1) SG43383A1 (fr)
SK (1) SK281254B6 (fr)
TR (1) TR199600579A2 (fr)
TW (1) TW419462B (fr)
UA (1) UA42749C2 (fr)
UY (1) UY24283A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100473645C (zh) * 2000-08-08 2009-04-01 第一制药株式会社 双环化合物的制备方法及其中间体
US20070015780A1 (en) * 2003-03-10 2007-01-18 Picker Donald H Method of treating cancer with azaspirane compositions
CN104119321B (zh) * 2013-04-28 2017-09-08 齐鲁制药有限公司 二氢吲哚酮衍生物的二马来酸盐及其多晶型物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3211397A1 (de) * 1982-03-27 1983-11-10 Hoechst Ag, 6230 Frankfurt Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
US4853409A (en) * 1988-04-13 1989-08-01 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
CA1336090C (fr) * 1988-08-31 1995-06-27 Isao Hayakawa Amines cycliques a substituant spiro de derives de la quinolone
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
GB9217116D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Also Published As

Publication number Publication date
CN1140710A (zh) 1997-01-22
TW419462B (en) 2001-01-21
EA000037B1 (ru) 1998-02-26
HUP9601918A2 (en) 1997-09-29
AU5945596A (en) 1997-01-23
SK88696A3 (en) 1997-06-04
BG100710A (bg) 1997-03-31
CA2181006A1 (fr) 1997-01-14
RO117376B1 (ro) 2002-02-28
HU9601918D0 (en) 1996-09-30
IL118815A0 (en) 1996-10-31
EA199600048A3 (ru) 1997-03-31
TR199600579A2 (tr) 1997-01-21
EP0753512A1 (fr) 1997-01-15
AR003452A1 (es) 1998-08-05
UY24283A1 (es) 2001-10-25
AU716256B2 (en) 2000-02-24
NO962931D0 (no) 1996-07-12
BG62359B1 (bg) 1999-09-30
ES2113765T3 (es) 1998-05-01
PL315191A1 (en) 1997-01-20
HU226691B1 (en) 2009-06-29
PL191019B1 (pl) 2006-03-31
JP3949750B2 (ja) 2007-07-25
CN1067378C (zh) 2001-06-20
SK281254B6 (sk) 2001-01-18
NO962931L (no) 1997-01-14
MX9602767A (es) 1998-01-31
CA2181006C (fr) 2007-04-03
UA42749C2 (uk) 2001-11-15
KR970069987A (ko) 1997-11-07
EP0753512B1 (fr) 1998-03-18
DE69600189D1 (de) 1998-04-23
EA199600048A2 (ru) 1996-12-30
DE69600189T2 (de) 1998-10-15
JPH09118618A (ja) 1997-05-06
IL118815A (en) 2000-06-29
ATE164154T1 (de) 1998-04-15
KR100404832B1 (ko) 2004-01-13
HK1010052A1 (en) 1999-06-11
SG43383A1 (en) 1997-10-17
DK0753512T3 (da) 1998-10-19
NZ286951A (en) 1998-02-26
CZ203696A3 (en) 1997-03-12
NO306672B1 (no) 1999-12-06
CZ289617B6 (cs) 2002-03-13
HUP9601918A3 (en) 1998-01-28

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