WO1990006949A3 - Derives de peptides - Google Patents

Derives de peptides Download PDF

Info

Publication number
WO1990006949A3
WO1990006949A3 PCT/EP1989/001448 EP8901448W WO9006949A3 WO 1990006949 A3 WO1990006949 A3 WO 1990006949A3 EP 8901448 W EP8901448 W EP 8901448W WO 9006949 A3 WO9006949 A3 WO 9006949A3
Authority
WO
WIPO (PCT)
Prior art keywords
somatostatin
peptide derivatives
detectable element
amino group
group
Prior art date
Application number
PCT/EP1989/001448
Other languages
English (en)
Other versions
WO1990006949A2 (fr
Inventor
Rainer Albert
Eric P Krenning
Steven W J Lamberts
Janos Pless
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to DE3991505A priority Critical patent/DE3991505B4/de
Priority to DE893991505T priority patent/DE3991505T1/de
Publication of WO1990006949A2 publication Critical patent/WO1990006949A2/fr
Publication of WO1990006949A3 publication Critical patent/WO1990006949A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

On forme un complexe de peptides de somatostatine portant au moins un groupe de chélation destiné à un élément détectable, ledit groupe de chélation étant lié à un groupe amino dudit peptide, et ledit groupe amino n'ayant pas d'affinité de liaison vis-à-vis de récepteurs de somatostatine, sous forme libre ou de sel, avec un élément détectable, lesquels sont utiles comme produit pharmaceutique, par exemple comme produit radiopharmaceutique pour l'imagerie in vivo de tumeurs à réaction positive aux récepteurs de somatostatine, ou en thérapie.
PCT/EP1989/001448 1988-12-05 1989-11-30 Derives de peptides WO1990006949A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE3991505A DE3991505B4 (de) 1988-12-05 1989-11-30 Somatostatinpeptide, deren Analoga oder Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
DE893991505T DE3991505T1 (de) 1988-12-05 1989-11-30 Peptidderivate

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8828364.3 1988-12-05
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB8916115.2 1989-07-13
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds
GB8916761.3 1989-07-21

Publications (2)

Publication Number Publication Date
WO1990006949A2 WO1990006949A2 (fr) 1990-06-28
WO1990006949A3 true WO1990006949A3 (fr) 1990-07-26

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1989/001448 WO1990006949A2 (fr) 1988-12-05 1989-11-30 Derives de peptides

Country Status (24)

Country Link
JP (2) JP2726320B2 (fr)
KR (1) KR0156541B1 (fr)
AT (1) AT403476B (fr)
AU (1) AU633859B2 (fr)
BE (1) BE1002296A5 (fr)
CA (1) CA2004532C (fr)
CH (1) CH678329A5 (fr)
DE (1) DE3991505B4 (fr)
DK (1) DK175338B1 (fr)
ES (1) ES2023533A6 (fr)
FI (1) FI102540B1 (fr)
FR (1) FR2639947B1 (fr)
GB (1) GB2225579B (fr)
HK (1) HK189995A (fr)
HU (2) HUT53375A (fr)
IE (1) IE62091B1 (fr)
IL (1) IL92534A (fr)
LU (1) LU87633A1 (fr)
MY (1) MY106120A (fr)
NL (1) NL194828C (fr)
PT (1) PT92487B (fr)
SA (1) SA96160495B1 (fr)
SE (1) SE508799C2 (fr)
WO (1) WO1990006949A2 (fr)

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DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
JPH05506254A (ja) * 1991-02-08 1993-09-16 バイオメジャー，インコーポレイテッド 良性および悪性増殖性皮膚病の治療方法
WO1992021383A1 (fr) * 1991-06-03 1992-12-10 Mallinckrodt Medical, Inc. Derives de somatostatine radiomarques, leur preparation et utilisation
DK0600992T3 (da) * 1991-08-29 2000-10-09 Mallinckrodt Medical Inc Anvendelse af gentissyre eller gentisylalkohol til stabilisering af radiomærkede peptider og proteiner
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
DE69231586T2 (de) * 1992-01-03 2001-07-19 Rhomed Inc Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
DE69330494T2 (de) * 1992-02-05 2002-03-28 Mallinckrodt Inc Radioaktiv markierte somatostatin
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
AU3967593A (en) * 1992-03-25 1993-10-21 Mallinckrodt Medical, Inc. Method of intraoperatively detecting and locating tumoral tissues
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
CA2113121A1 (fr) * 1993-01-12 1994-07-13 Rainer Albert Peptides
CA2154667A1 (fr) * 1993-02-02 1994-08-18 Linda M. Gustavson Biodistribution dirigee de petites molecules
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
DE69426673T2 (de) * 1993-06-23 2001-09-20 Diatide Inc Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung
CA2190727C (fr) * 1994-05-19 2006-07-18 Sudhakar Kasina Ligands d'atomes donneurs d'azote et de soufre pontes et substitues par amines aromatiques, utilises en imagerie
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181A (fi) * 1996-12-20 1998-06-21 Map Medical Technologies Oy Polyalkoholi-peptidijohdannaiset
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
BR0209074A (pt) * 2001-04-23 2004-08-10 Mallinckrodt Inc Derivados de octreotìdeos glicosilados radioativos marcadores com tc e re
WO2005018682A2 (fr) 2003-08-20 2005-03-03 The Regents Of The University Of California Analogues de somatostatine a activite inhibitrice de liberation d'hormone de croissance
WO2005027981A1 (fr) * 2003-09-17 2005-03-31 Board Of Regents, The University Of Texas System Imagerie de cellules beta cibles du pancreas fondee sur un mecanisme, et therapie associee
EP2067786A1 (fr) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Nouveaux analogues non sélectifs de somatostatine
EP2922578B1 (fr) 2012-11-21 2018-12-12 Serene, Llc Composés de liaison de récepteur somatostatine comprenant l'isotope de l'etain 117m

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150844A2 (fr) * 1984-01-30 1985-08-07 Enzo Biochem, Inc. Méthode pour le marquage radioactif d'agents diagnostiques et thérapeutiques contenant un groupe de chélation
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
EP0233619A1 (fr) * 1986-02-14 1987-08-26 Nihon Medi-Physics Co., Ltd. Composés aminés de haut poids moléculaire et leur utilisation
EP0247866A1 (fr) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Agents de couplage pour la préparation de protéines marquées par la radioactivité
EP0248506A1 (fr) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Marquage de molécules de support par les ions métalliques
WO1989004666A1 (fr) * 1987-11-18 1989-06-01 The Administrators Of The Tulane Educational Fund Traitement du cancer avec de la somatostatine et avec des analogues de celle-ci

Family Cites Families (8)

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CA1222691A (fr) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Methode de preparation de proteines marquees par un radionucleide, notamment des anticorps ou des fragments d'anticorps
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3522638A1 (de) * 1985-06-25 1987-01-08 Diamalt Ag Neue somatostatin-derivate
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
CH679045A5 (fr) * 1987-06-29 1991-12-13 Sandoz Ag
BE1003762A3 (fr) * 1988-11-11 1992-06-09 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150844A2 (fr) * 1984-01-30 1985-08-07 Enzo Biochem, Inc. Méthode pour le marquage radioactif d'agents diagnostiques et thérapeutiques contenant un groupe de chélation
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
EP0233619A1 (fr) * 1986-02-14 1987-08-26 Nihon Medi-Physics Co., Ltd. Composés aminés de haut poids moléculaire et leur utilisation
EP0248506A1 (fr) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Marquage de molécules de support par les ions métalliques
EP0247866A1 (fr) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Agents de couplage pour la préparation de protéines marquées par la radioactivité
WO1989004666A1 (fr) * 1987-11-18 1989-06-01 The Administrators Of The Tulane Educational Fund Traitement du cancer avec de la somatostatine et avec des analogues de celle-ci

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Life Sciences, Vol. 43, No. 5, 1988 J.E. Taylor et al: "High affinity binding of (125I-Tyr11)somatostatin-14 to human small cell lung carcinoma (NCI-H69) ", *

Also Published As

Publication number Publication date
HK189995A (en) 1995-12-29
FI102540B (fi) 1998-12-31
FI102540B1 (fi) 1998-12-31
HUT53375A (en) 1990-10-28
CA2004532C (fr) 2000-02-22
HU896359D0 (en) 1990-02-28
ES2023533A6 (es) 1992-01-16
GB8927255D0 (en) 1990-01-31
CA2004532A1 (fr) 1990-06-05
GB2225579B (en) 1993-03-17
LU87633A1 (fr) 1991-09-18
JP2726320B2 (ja) 1998-03-11
DK612689A (da) 1990-06-06
DK175338B1 (da) 2004-08-30
AU633859B2 (en) 1993-02-11
PT92487A (pt) 1990-06-29
JP3686503B2 (ja) 2005-08-24
NL8902981A (nl) 1990-07-02
HU211468A9 (en) 1995-11-28
KR900009697A (ko) 1990-07-05
BE1002296A5 (fr) 1990-11-20
SE8904087D0 (sv) 1989-12-04
GB2225579A (en) 1990-06-06
MY106120A (en) 1995-03-31
SE8904087L (sv) 1991-06-05
JPH02184698A (ja) 1990-07-19
FR2639947B1 (fr) 1995-04-21
CH678329A5 (fr) 1991-08-30
KR0156541B1 (ko) 1998-10-15
ATA901789A (de) 1997-07-15
PT92487B (pt) 1996-01-31
SA96160495B1 (ar) 2006-08-23
IL92534A (en) 1994-06-24
SE508799C2 (sv) 1998-11-09
WO1990006949A2 (fr) 1990-06-28
IE62091B1 (en) 1994-12-14
NL194828B (nl) 2002-12-02
NL194828C (nl) 2003-04-03
FR2639947A1 (fr) 1990-06-08
DE3991505B4 (de) 2006-04-20
AT403476B (de) 1998-02-25
IE893866L (en) 1990-06-05
DK612689D0 (da) 1989-12-05
AU4587189A (en) 1990-06-14
FI895809A0 (fi) 1989-12-04
JPH1095737A (ja) 1998-04-14

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