FI101676B1 - Parannettu menetelmä stabiilin mikrohelmikoostumuksen valmistamiseksi - Google Patents

Parannettu menetelmä stabiilin mikrohelmikoostumuksen valmistamiseksi

Info

Publication number
FI101676B1
FI101676B1 FI911531A FI911531A FI101676B1 FI 101676 B1 FI101676 B1 FI 101676B1 FI 911531 A FI911531 A FI 911531A FI 911531 A FI911531 A FI 911531A FI 101676 B1 FI101676 B1 FI 101676B1
Authority
FI
Finland
Prior art keywords
producing
improved process
microsphere composition
stable microsphere
stable
Prior art date
Application number
FI911531A
Other languages
English (en)
Swedish (sv)
Other versions
FI911531A0 (fi
FI911531A (fi
FI101676B (fi
Inventor
William Steber
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FI911531A0 publication Critical patent/FI911531A0/fi
Publication of FI911531A publication Critical patent/FI911531A/fi
Application granted granted Critical
Publication of FI101676B1 publication Critical patent/FI101676B1/fi
Publication of FI101676B publication Critical patent/FI101676B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
FI911531A 1990-03-30 1991-03-28 Parannettu menetelmä stabiilin mikrohelmikoostumuksen valmistamiseksi FI101676B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/502,382 US5213810A (en) 1990-03-30 1990-03-30 Stable compositions for parenteral administration and method of making same
US50238290 1990-03-30

Publications (4)

Publication Number Publication Date
FI911531A0 FI911531A0 (fi) 1991-03-28
FI911531A FI911531A (fi) 1991-10-01
FI101676B1 true FI101676B1 (fi) 1998-08-14
FI101676B FI101676B (fi) 1998-08-14

Family

ID=23997559

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911531A FI101676B (fi) 1990-03-30 1991-03-28 Parannettu menetelmä stabiilin mikrohelmikoostumuksen valmistamiseksi

Country Status (29)

Country Link
US (1) US5213810A (fi)
EP (1) EP0448930B1 (fi)
JP (1) JP2966564B2 (fi)
KR (1) KR0159778B1 (fi)
CN (1) CN1063941C (fi)
AR (1) AR248085A1 (fi)
AT (1) ATE106240T1 (fi)
AU (1) AU641994B2 (fi)
BG (1) BG60850B1 (fi)
CA (1) CA2039491C (fi)
CZ (1) CZ283053B6 (fi)
DE (1) DE69102176T2 (fi)
DK (1) DK0448930T3 (fi)
ES (1) ES2054380T3 (fi)
FI (1) FI101676B (fi)
HK (1) HK1000004A1 (fi)
HU (1) HU219584B (fi)
IE (1) IE65970B1 (fi)
IL (1) IL97145A (fi)
MX (1) MX172602B (fi)
NO (1) NO300717B1 (fi)
NZ (1) NZ237509A (fi)
PL (1) PL167692B1 (fi)
PT (1) PT97160B (fi)
RO (1) RO106191B1 (fi)
RU (1) RU2011377C1 (fi)
SK (1) SK279461B6 (fi)
YU (1) YU47650B (fi)
ZA (1) ZA912398B (fi)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0525307B1 (en) * 1991-07-23 1996-03-06 American Cyanamid Company Stable compositions for parenteral administration and their use
AU6029694A (en) * 1993-01-19 1994-08-15 Pharmacia P-L Biochemicals, Inc. Storage and delivery of purified protein reagents with carrier wax
US5599660A (en) * 1993-01-19 1997-02-04 Pharmacia Biotech Inc. Method and preparation for sequential delivery of wax-embedded, inactivated biological and chemical reagents
US5683720A (en) * 1994-10-28 1997-11-04 Fuisz Technologies Ltd. Liquiflash particles and method of making same
US6083430A (en) * 1994-10-28 2000-07-04 Fuisz Technologies Ltd. Method of preparing a dosage unit by direct tableting and product therefrom
AU9496798A (en) 1997-09-19 1999-04-05 Shire Laboratories, Inc. Solid solution beadlet
AU2002300572B2 (en) * 1997-09-19 2004-11-25 Shire Laboratories, Inc. Solid Solution Beadlet
US6117452A (en) * 1998-08-12 2000-09-12 Fuisz Technologies Ltd. Fatty ester combinations
CA2369594A1 (en) * 1999-05-07 2000-11-16 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
KR20020011985A (ko) * 1999-05-07 2002-02-09 파르마솔 게엠베하 액상 및 고체상 지질 혼합물에 기초한 지질입자들 및 그의제조방법
PT1187601E (pt) * 1999-06-07 2005-11-30 Altana Pharma Ag Nova forma de preparacao e a administracao compreendendo um inibidor da bomba de protoes instavel em meio acido
WO2001080831A2 (en) 2000-04-27 2001-11-01 Verion Inc. Zero order release and temperature-controlled microcapsules and process for the preparation thereof
DE60125176T3 (de) * 2000-06-26 2015-07-23 Dsm Ip Assets B.V. Verbesserte Verfahren zum Hinzufügen mehrfach gesättigter Fettsäuren in Milch
CA2423484A1 (en) 2000-09-27 2002-04-04 Verion Inc. Instant water dissolvable encapsulate and process
ES2304371T3 (es) * 2000-10-10 2008-10-16 Wyeth Holdings Corporation Composiciones estables para administracion parenteral.
FR2852843B1 (fr) 2003-03-24 2008-05-23 Karim Ioualalen Systeme galenique permettant le masquage du gout
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
AU2004294813A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
BRPI0416534A (pt) * 2003-12-04 2007-01-09 Pfizer Prod Inc composições multiparticuladas com estabilidade melhorada
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
RU2006119453A (ru) * 2003-12-04 2007-12-20 Пфайзер Продактс Инк. (Us) Получение посредством основанных на применении жидкостей способов лекарственные формы азитромицина с большим количеством частиц
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
ATE399536T1 (de) * 2003-12-04 2008-07-15 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US8221809B2 (en) * 2006-06-22 2012-07-17 Martek Biosciences Corporation Encapsulated labile compound compositions and methods of making the same
DK2049081T3 (da) 2006-08-09 2013-02-25 Intarcia Therapeutics Inc Osmotiske leveringssystemer og stempelarrangementer
ES2402172T3 (es) 2007-04-23 2013-04-29 Intarcia Therapeutics, Inc Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
EP3685837A1 (en) * 2008-09-04 2020-07-29 Amylin Pharmaceuticals, LLC Sustained release formulations using non-aqueous carriers
JP5494957B2 (ja) 2009-06-11 2014-05-21 株式会社リコー 静電荷像現像用トナー、現像剤、画像形成方法及び画像形成装置
CN107638562B (zh) 2009-09-28 2022-12-02 精达制药公司 基本稳态药物递送的快速建立和/或终止
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9364549B2 (en) * 2011-11-30 2016-06-14 Andreas Voigt Hydrophobic drug-delivery material, method for manufacturing thereof and methods for delivery of a drug-delivery composition
US20160151286A1 (en) * 2013-05-29 2016-06-02 Therakine Biodelivery Gmbh Hydrophilic Microparticles, Drug-Delivery Material, Method For Manufacturing Thereof And Methods For Delivery of A Drug-Delivery Composition
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
BR112018073511A2 (pt) 2016-05-16 2019-03-26 Intarcia Therapeutics, Inc. polipeptídeos seletivos do receptor de glucagon e métodos de uso dos mesmos
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
MX2019008006A (es) 2017-01-03 2019-08-29 Intarcia Therapeutics Inc Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco.
MX2021010043A (es) * 2019-02-21 2022-07-19 Chromadex Inc Uso de nicotinamida ribósido, ácido nicotinico ribósido, compuestos de nicotinil ribósido reducido y derivados de compuestos de nicotinil ribósido en formulaciones.

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3147187A (en) * 1962-09-10 1964-09-01 Don Hall Lab Sustained release pharmaceutical
CH637297A5 (fr) * 1978-12-05 1983-07-29 Nestle Sa Microbille comprenant un microorganisme et son procede de fabrication.
JPS56140915A (en) * 1980-04-07 1981-11-04 Yamanouchi Pharmaceut Co Ltd Pharmaceutical preparation for solid drug
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
DE3024416C2 (de) * 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
US4666839A (en) * 1982-12-01 1987-05-19 Amgen Methods and materials for obtaining microbial expression of polypeptides including bovine prolactin
US4452775A (en) * 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US4603044A (en) * 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4568536A (en) * 1985-02-08 1986-02-04 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4755387A (en) * 1985-03-21 1988-07-05 The Procter & Gamble Company Therapeutic particles
DE3527356A1 (de) * 1985-07-31 1987-02-05 Degussa Verfahren zur verbesserung der fruchtbarkeit von haustieren
SE462894B (sv) * 1985-10-28 1990-09-17 Biogram Ab Mikrokapslar, foerfarande foer framstaellning daerav samt anvaendning
US4837381A (en) * 1986-08-11 1989-06-06 American Cyanamid Company Compositions for parenteral administration and their use
US4911928A (en) * 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles

Also Published As

Publication number Publication date
ZA912398B (en) 1992-01-29
KR0159778B1 (ko) 1998-12-01
BG60850B1 (bg) 1996-05-31
CA2039491A1 (en) 1991-10-01
FI911531A0 (fi) 1991-03-28
AR248085A1 (es) 1995-06-30
CZ283053B6 (cs) 1997-12-17
IE65970B1 (en) 1995-11-29
EP0448930B1 (en) 1994-06-01
MX172602B (es) 1993-01-03
HU911054D0 (en) 1991-10-28
CN1055293A (zh) 1991-10-16
AU7397291A (en) 1991-10-03
PT97160A (pt) 1991-11-29
ATE106240T1 (de) 1994-06-15
HUT59834A (en) 1992-07-28
CA2039491C (en) 2001-09-04
KR910016322A (ko) 1991-11-05
FI911531A (fi) 1991-10-01
JPH04221319A (ja) 1992-08-11
AU641994B2 (en) 1993-10-07
IL97145A (en) 1996-06-18
NO300717B1 (no) 1997-07-14
RO106191B1 (ro) 1993-03-31
RU2011377C1 (ru) 1994-04-30
DE69102176T2 (de) 1995-01-05
CN1063941C (zh) 2001-04-04
IL97145A0 (en) 1992-05-25
YU47650B (sh) 1995-12-04
FI101676B (fi) 1998-08-14
IE911041A1 (en) 1991-10-09
SK279461B6 (sk) 1998-11-04
EP0448930A1 (en) 1991-10-02
DE69102176D1 (de) 1994-07-07
NZ237509A (en) 1993-04-28
JP2966564B2 (ja) 1999-10-25
HU219584B (hu) 2001-05-28
PL289657A1 (en) 1992-01-13
HK1000004A1 (en) 1997-10-03
YU57091A (sh) 1994-01-20
DK0448930T3 (da) 1994-06-20
ES2054380T3 (es) 1994-08-01
US5213810A (en) 1993-05-25
NO911228D0 (no) 1991-03-26
PL167692B1 (en) 1995-10-31
PT97160B (pt) 1998-07-31
NO911228L (no) 1991-10-01
BG93923A (bg) 1993-12-24

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