ES8900093A1 - Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano - Google Patents

Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano

Info

Publication number
ES8900093A1
ES8900093A1 ES557774A ES557774A ES8900093A1 ES 8900093 A1 ES8900093 A1 ES 8900093A1 ES 557774 A ES557774 A ES 557774A ES 557774 A ES557774 A ES 557774A ES 8900093 A1 ES8900093 A1 ES 8900093A1
Authority
ES
Spain
Prior art keywords
group
preparation
compounds
macrolide antibiotics
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557774A
Other languages
English (en)
Other versions
ES557774A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858510944A external-priority patent/GB8510944D0/en
Priority claimed from GB858510943A external-priority patent/GB8510943D0/en
Priority claimed from GB858510942A external-priority patent/GB8510942D0/en
Priority claimed from GB868606103A external-priority patent/GB8606103D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8900093A1 publication Critical patent/ES8900093A1/es
Publication of ES557774A0 publication Critical patent/ES557774A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LOS COMPUESTOS ANALOGOS 23-CETONA, 23-DESOXI Y 23-HIDROXILO O HIDROXILO SUSTITUIDO DE LOS ANTIBIOTICOS S 541 QUE TIENEN UN GRUPO HIDROXILO O HIDROXILO SUSTITUIDO EN LA POSICION 5, DE FORMULA GENERAL (I), SE PREPARAN ETERIFICANDO UN COMPUESTO CORRESPONDIENTE EN EL QUE R7 ES UN ATOMO DE HIDROGENO, CON UN REACTIVO R7Y DONDE Y ES UN GRUPO ELIMINABLE (COMO UN ATOMO DE HALOGENO, UN GRUPO HIDROCARBILSULFONILOXI O HALOALCANOILOXI). ESTOS COMPUESTOS SON UTILES COMO ANTIBIOTICOS Y/O COMO COMPUESTOS INTERMEDIOS PARA LA PREPARACION DE OTROS COMPUESTOS ACTIVOS Y/O EN EL AISLAMIENTO Y LA PURIFICACION DE COMPUESTOS ANTIBIOTICOS S 541. EN CUANTO A SU ACTIVIDAD ANTIBIOTICA PUEDEN UTILIZARSE POR SU ACTIVIDAD ANTI-ECTOPARASITOS Y ANTI-ENDOPARASITOS QUE INFECTAN A SERES HUMANOS Y A DIVERSIDAD DE ANIMALES. PUEDEN FORMULARSE PARA ADMINISTRACION DE CUALQUIER MANERA CONVENIENTE PARA USO EN VETERINARIA O MEDICINA HUMANA. *FORMULA*
ES557774A 1985-04-30 1987-10-30 Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano Expired ES8900093A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB858510944A GB8510944D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB858510943A GB8510943D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB858510942A GB8510942D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB868606103A GB8606103D0 (en) 1986-03-12 1986-03-12 Chemical compounds

Publications (2)

Publication Number Publication Date
ES8900093A1 true ES8900093A1 (es) 1988-12-01
ES557774A0 ES557774A0 (es) 1988-12-01

Family

ID=27449656

Family Applications (4)

Application Number Title Priority Date Filing Date
ES554444A Expired ES8802229A1 (es) 1985-04-30 1986-04-28 Un procedimiento para preparar nuevos derivados lactonicos macrociclicos.
ES557517A Expired ES8802522A1 (es) 1985-04-30 1987-04-30 Un procedimiento para preparar nuevos derivados macrociclicos de lactona
ES557774A Expired ES8900093A1 (es) 1985-04-30 1987-10-30 Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano
ES557851A Expired ES9000023A1 (es) 1985-04-30 1988-09-01 Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES554444A Expired ES8802229A1 (es) 1985-04-30 1986-04-28 Un procedimiento para preparar nuevos derivados lactonicos macrociclicos.
ES557517A Expired ES8802522A1 (es) 1985-04-30 1987-04-30 Un procedimiento para preparar nuevos derivados macrociclicos de lactona

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557851A Expired ES9000023A1 (es) 1985-04-30 1988-09-01 Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano

Country Status (25)

Country Link
US (1) US4978675A (es)
JP (1) JPH0819132B2 (es)
KR (1) KR930011282B1 (es)
AT (1) AT397095B (es)
AU (1) AU596586B2 (es)
BE (1) BE904709A (es)
CA (1) CA1335368C (es)
CH (1) CH675124A5 (es)
DE (1) DE3614549C2 (es)
DK (1) DK160992C (es)
ES (4) ES8802229A1 (es)
FR (1) FR2587344B1 (es)
GB (1) GB2176182B (es)
GE (3) GEP19971046B (es)
HU (1) HU200771B (es)
IE (1) IE59070B1 (es)
IL (1) IL78621A (es)
LU (1) LU86412A1 (es)
LV (2) LV10777B (es)
NL (1) NL193420C (es)
NZ (1) NZ215997A (es)
PH (1) PH23386A (es)
PT (1) PT82485B (es)
RU (1) RU2004545C1 (es)
SE (1) SE503571C2 (es)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59394B1 (en) * 1984-09-14 1994-02-23 American Cyanamid Co Antibiotic compounds and their preparation
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
IE67373B1 (en) * 1985-09-13 1996-03-20 American Cyanamid Co Macrolide antibiotics and their preparation
US5185456A (en) * 1986-03-12 1993-02-09 American Cyanamid Company Macrolide compounds
US5336789A (en) * 1986-03-12 1994-08-09 American Cyanamid Company Macrolide compounds
GB8606108D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
GB8606123D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
ES2004384A6 (es) * 1986-03-12 1989-01-01 Glaxo Group Ltd Procedimiento para preparar compuestos antibioticos macrolidos y metodo para combatir plagas con ellos.
NZ219575A (en) * 1986-03-12 1990-04-26 Glaxo Group Ltd Phosphate, substituted alkoxy, or amino-carbonyloxy derivatives of milbemycin, and pesticidal compositions
CA1296328C (en) * 1986-03-12 1992-02-25 Derek R. Sutherland Macrolide compounds
CA1296329C (en) * 1986-06-06 1992-02-25 Derek R. Sutherland Macrolide compounds
GB8613790D0 (en) * 1986-06-06 1986-07-09 Glaxo Group Ltd Chemical compounds
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
JP2587241B2 (ja) * 1986-07-24 1997-03-05 ビ−チヤム・グル−プ・ピ−エルシ− 新規化合物、その製法及びそれを含む医薬組成物
EP0260537A1 (en) * 1986-09-12 1988-03-23 American Cyanamid Company 13-Deoxy-23-oxo(keto) and 23-imino derivatives of 13-deoxy C-076-aglycone compounds
ES2055695T3 (es) * 1986-09-12 1994-09-01 American Cyanamid Co Derivados 23-desoxi de compuestos ll-f28249.
ES2058082T3 (es) * 1986-09-12 1994-11-01 American Cyanamid Co Derivados 23-oxo (ceto) y 23-imino de compuestos ll-f28249.
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
US5149832A (en) * 1986-09-12 1992-09-22 American Cyanamid Company Mono and diacyl derivatives of ll-f28249 compounds
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US4956479A (en) * 1987-03-06 1990-09-11 American Cyanamid Company 23-deoxy-27-chloro derivatives of LL-F28249 compounds
US4886830A (en) * 1987-03-06 1989-12-12 American Cyanamid Company Mono- and diepoxide derivatives of 23-deoxyl-LL-F28249 compounds
US4886829A (en) * 1987-03-06 1989-12-12 American Cyanamid Company 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
US4871719A (en) * 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
EP0285561A3 (de) * 1987-03-27 1989-10-25 Ciba-Geigy Ag Parasitizide und insektizide Milbemycin-Derivate
JPS6431776A (en) * 1987-07-28 1989-02-02 Sankyo Co Novel macrolide compound and production thereof
GB8721376D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721375D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721378D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721373D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
JPH01156981A (ja) * 1987-09-11 1989-06-20 American Cyanamid Co マクロライド化合物の製法
GB8721377D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721647D0 (en) * 1987-09-15 1987-10-21 Pfizer Ltd Antiparasitic agents
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
EP0316124B1 (en) * 1987-11-09 1993-04-07 Pfizer Inc. Ethylated avermectins
GB8726384D0 (en) * 1987-11-11 1987-12-16 Coopers Animal Health Veterinary treatment
GB8726730D0 (en) * 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
GB8801908D0 (en) * 1988-01-28 1988-02-24 Glaxo Group Ltd Chemical compounds
GB8804440D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Antiparasitic agents
GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8811037D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
JP2629047B2 (ja) * 1988-05-10 1997-07-09 アメリカン・サイアナミツド・カンパニー マクロライド化合物
GB8813150D0 (en) * 1988-06-03 1988-07-06 American Cyanamid Co Chemical compounds
GB8813760D0 (en) * 1988-06-10 1988-07-13 American Cyanamid Co Chemical process
US5428034A (en) * 1988-09-02 1995-06-27 Sankyo Co., Ltd. Milbemycin derivatives, their preparation and their use
US6001822A (en) * 1989-04-11 1999-12-14 Pfizer Inc. Antiparasitic formulations
EP0393890B1 (en) * 1989-04-11 1992-08-12 Pfizer Limited Injectable compositions containing 25-cyclohexyl-avermectin b1
NZ234802A (en) * 1989-08-14 1992-11-25 Merck & Co Inc Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals
US5055486A (en) * 1989-12-22 1991-10-08 American Cyanamid Company 13-alkyl-23-imino derivative of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents
US4988824A (en) * 1989-09-11 1991-01-29 Maulding Donald R Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds
JP2622197B2 (ja) * 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
US5290804A (en) * 1991-05-01 1994-03-01 Merck & Co., Inc. Anthelmintic milbemycin analogs of novel microorganisms
EP0535734B1 (en) * 1991-09-30 1999-06-02 Merck & Co. Inc. Long acting injectable formulations containing hydrogenated castor oil
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
DE19534366C2 (de) * 1995-09-15 2000-08-17 Asta Medica Ag Verfahren zur Herstellung von 2,3,4,6-Tetra-O-benzyl-D-glucopyranose und 2,3,4,6-Tetra-O-allyl-D-glucopyranose
CA2211949A1 (en) * 1997-07-21 1999-01-29 David Farley Johnson Nonaqueous compositions for parenteral administration
EP1197215B1 (en) 2000-10-10 2006-03-22 Wyeth Anthelmintic compositions
NZ552040A (en) * 2006-12-13 2009-04-30 Bomac Research Ltd Veterinary formulation comprising an anthelmintic compound and glyceryl acetate
WO2012028556A1 (en) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Macrocyclic lactones and their use and their combinations with other active substances
DE102010064245A1 (de) 2010-12-28 2012-06-28 Bayer Animal Health Gmbh Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
US4550160A (en) * 1979-08-13 1985-10-29 Merck & Co., Inc. Processes for the interconversion of C-076 compounds
JPS5632481A (en) * 1979-08-23 1981-04-01 Sankyo Co Ltd Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
US4457920A (en) * 1981-09-03 1984-07-03 Merck & Co., Inc. 4a-Substituted avermectin compounds
US4423209A (en) * 1982-02-26 1983-12-27 Merck & Co., Inc. Processes for the interconversion of avermectin compounds
JPS59108785A (ja) * 1982-11-25 1984-06-23 Sankyo Co Ltd ミルベマイシン類の５−オキシム誘導体
JPS60126289A (ja) * 1983-11-14 1985-07-05 Sankyo Co Ltd ミルベマイシン類の５−カ−ボネ−ト誘導体
DK165119C (da) * 1984-06-05 1993-03-01 American Cyanamid Co Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling
IE59394B1 (en) * 1984-09-14 1994-02-23 American Cyanamid Co Antibiotic compounds and their preparation
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina

Also Published As

Publication number Publication date
NZ215997A (en) 1989-06-28
LV10777B (en) 1996-04-20
RU2004545C1 (ru) 1993-12-15
GEP19971046B (en) 1997-11-26
NL193420C (nl) 1999-10-04
ES8802522A1 (es) 1988-07-16
ES557517A0 (es) 1988-07-16
IE59070B1 (en) 1993-12-15
AU5676786A (en) 1986-11-06
CH675124A5 (es) 1990-08-31
GEP19970833B (en) 1997-02-10
DK160992C (da) 1991-11-11
ES557851A0 (es) 1990-05-01
FR2587344A1 (fr) 1987-03-20
IL78621A0 (en) 1986-08-31
PT82485A (en) 1986-05-01
BE904709A (fr) 1986-10-30
AU596586B2 (en) 1990-05-10
ES8802229A1 (es) 1988-04-16
IL78621A (en) 1991-06-30
GB8610631D0 (en) 1986-06-04
LV10777A (lv) 1995-08-20
FR2587344B1 (fr) 1991-04-05
DE3614549C2 (de) 1998-03-12
GEP20001917B (en) 2000-01-05
HU200771B (en) 1990-08-28
IE861127L (en) 1986-10-30
LV10314B (en) 1995-08-20
ES9000023A1 (es) 1990-05-01
JPS61280496A (ja) 1986-12-11
KR860008205A (ko) 1986-11-14
ATA115486A (de) 1993-06-15
CA1335368C (en) 1995-04-25
DK196586D0 (da) 1986-04-29
NL193420B (nl) 1999-06-01
PT82485B (pt) 1988-03-03
LU86412A1 (fr) 1986-11-05
ES554444A0 (es) 1988-04-16
ES557774A0 (es) 1988-12-01
GB2176182A (en) 1986-12-17
KR930011282B1 (ko) 1993-11-29
SE8601998L (sv) 1986-10-31
JPH0819132B2 (ja) 1996-02-28
GB2176182B (en) 1989-02-01
DE3614549A1 (de) 1987-01-02
LV10314A (lv) 1994-10-20
SE8601998D0 (sv) 1986-04-29
PH23386A (en) 1989-07-26
SE503571C2 (sv) 1996-07-08
NL8601103A (nl) 1986-11-17
HUT46012A (en) 1988-09-28
US4978675A (en) 1990-12-18
AT397095B (de) 1994-01-25
DK160992B (da) 1991-05-13
DK196586A (da) 1986-10-31

Similar Documents

Publication Publication Date Title
ES8802229A1 (es) Un procedimiento para preparar nuevos derivados lactonicos macrociclicos.
EP0215654A3 (en) Macrolide antibiotics and their preparation
ES2006479A6 (es) Un procedimiento para preparar nuevos derivados de antibioticos macrolidos
IE870627L (en) Macrolide compounds
SE8703032D0 (es)
AU522721B2 (en) Arolylureas
AU6990987A (en) Macrolide compounds
IE890259L (en) Macrolide compounds
AU2208888A (en) Macrolide compounds
AU1669288A (en) Antidiabetic composition comprising 7-thiaprostaglandin e1 or its derivative
IE46118L (en) Triazolidine diones
AU2208488A (en) Macrolide compounds
ES8506011A1 (es) Procedimiento para la obtencion de un derivado de tetrahidrobenzotiazol
AU631792B2 (en) S541 macrolide derivative compounds
MD1026G2 (ro) Compuşi macrolidici
FI943596A (fi) Menetelmä terapeuttisesti käytt¦kelpoisten makrolidiyhdisteiden valmistamiseksi