ES8802522A1 - Un procedimiento para preparar nuevos derivados macrociclicos de lactona - Google Patents
Un procedimiento para preparar nuevos derivados macrociclicos de lactonaInfo
- Publication number
- ES8802522A1 ES8802522A1 ES557517A ES557517A ES8802522A1 ES 8802522 A1 ES8802522 A1 ES 8802522A1 ES 557517 A ES557517 A ES 557517A ES 557517 A ES557517 A ES 557517A ES 8802522 A1 ES8802522 A1 ES 8802522A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- preparation
- compounds
- macrolide antibiotics
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS MACROCICLICOS DE LACTONA DE FORMULA (I) Y SUS SALES, DONDE R1 ES UN GRUPO METILO, ETILO O ISOPROPILO, R2 Y R3 ATOMOS DE HIDROGENO Y OR4 UN GRUPO HIDROXI O UN GRUPO HIDROXILO SUSTITUIDO QUE TIENE HASTA 25 ATOMOS DE CARBONO. SE PREPARA UN COMPUESTO CORRESPONDIENTE, EN EL QUE R2 ES UN ATOMO O GRUPO HEMOLITICAMENTE REDUCIBLE, UTILIZANDO UN AGENTE REDUCTOR, EN UN DISOLVENTE ADECUADO, A UNA TEMPERATURA ENTRE 0 Y 200GC; Y OPCIONALMENTE, 1) SE ELIMINA EL GRUPO PROTECTOR DE UN COMPUESTO CORRESPONDIENTE EN EL QUE OR4 ES UN GRUPO HIDROXILO PROTEGIDO; 2) SE TRATA EL ACIDO CON UNA BASE O SE CONVIERTE UNA SAL DE UN ACIDO DE FORMULA (I); Y 3) SE HACE REACCIONAR UN COMPUESTO CORRESPONDIENTE, EN EL QUE OR4 ES UN GRUPO HIDROXILO, CON UN REACTIVO SUSTITUIDOR DE HIDROXILO EN LA PREPARACION DE UN COMPUESTO DE FORMULA (I) EN LA QUE OR4 ES UN GRUPO HIDROXILO SUSTITUIDO. TIENE APLICACION PARA PREPARAR COMPUESTOS ANTIBIOTICOS. *FORMULA*
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858510942A GB8510942D0 (en) | 1985-04-30 | 1985-04-30 | Chemical compounds |
GB858510943A GB8510943D0 (en) | 1985-04-30 | 1985-04-30 | Chemical compounds |
GB858510944A GB8510944D0 (en) | 1985-04-30 | 1985-04-30 | Chemical compounds |
GB868606103A GB8606103D0 (en) | 1986-03-12 | 1986-03-12 | Chemical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES557517A0 ES557517A0 (es) | 1988-07-16 |
ES8802522A1 true ES8802522A1 (es) | 1988-07-16 |
Family
ID=27449656
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES554444A Expired ES8802229A1 (es) | 1985-04-30 | 1986-04-28 | Un procedimiento para preparar nuevos derivados lactonicos macrociclicos. |
ES557517A Expired ES8802522A1 (es) | 1985-04-30 | 1987-04-30 | Un procedimiento para preparar nuevos derivados macrociclicos de lactona |
ES557774A Expired ES8900093A1 (es) | 1985-04-30 | 1987-10-30 | Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano |
ES557851A Expired ES9000023A1 (es) | 1985-04-30 | 1988-09-01 | Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES554444A Expired ES8802229A1 (es) | 1985-04-30 | 1986-04-28 | Un procedimiento para preparar nuevos derivados lactonicos macrociclicos. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES557774A Expired ES8900093A1 (es) | 1985-04-30 | 1987-10-30 | Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano |
ES557851A Expired ES9000023A1 (es) | 1985-04-30 | 1988-09-01 | Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano |
Country Status (25)
Country | Link |
---|---|
US (1) | US4978675A (es) |
JP (1) | JPH0819132B2 (es) |
KR (1) | KR930011282B1 (es) |
AT (1) | AT397095B (es) |
AU (1) | AU596586B2 (es) |
BE (1) | BE904709A (es) |
CA (1) | CA1335368C (es) |
CH (1) | CH675124A5 (es) |
DE (1) | DE3614549C2 (es) |
DK (1) | DK160992C (es) |
ES (4) | ES8802229A1 (es) |
FR (1) | FR2587344B1 (es) |
GB (1) | GB2176182B (es) |
GE (3) | GEP19971046B (es) |
HU (1) | HU200771B (es) |
IE (1) | IE59070B1 (es) |
IL (1) | IL78621A (es) |
LU (1) | LU86412A1 (es) |
LV (2) | LV10777B (es) |
NL (1) | NL193420C (es) |
NZ (1) | NZ215997A (es) |
PH (1) | PH23386A (es) |
PT (1) | PT82485B (es) |
RU (1) | RU2004545C1 (es) |
SE (1) | SE503571C2 (es) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3532794A1 (de) * | 1984-09-14 | 1986-04-17 | Glaxo Group Ltd., London | Antibiotika, verfahren zu deren herstellung und diese verbindungen enthaltende mittel |
ES8800986A1 (es) * | 1985-07-27 | 1987-12-01 | Pfizer | Un procedimiento para la produccion de un nuevo derivado de avermectina |
ATE119905T1 (de) * | 1985-09-13 | 1995-04-15 | American Cyanamid Co | Makrolide antibiotika und verfahren zu deren herstellung. |
GB8606108D0 (en) * | 1986-03-12 | 1986-04-16 | Glaxo Group Ltd | Chemical compounds |
GB8606123D0 (en) * | 1986-03-12 | 1986-04-16 | Glaxo Group Ltd | Chemical compounds |
US5336789A (en) * | 1986-03-12 | 1994-08-09 | American Cyanamid Company | Macrolide compounds |
NZ219576A (en) * | 1986-03-12 | 1989-01-06 | Glaxo Group Ltd | Milbemycin derivatives and pharmaceutical, veterinary, and pesticidal compositions |
NZ219575A (en) * | 1986-03-12 | 1990-04-26 | Glaxo Group Ltd | Phosphate, substituted alkoxy, or amino-carbonyloxy derivatives of milbemycin, and pesticidal compositions |
US5185456A (en) * | 1986-03-12 | 1993-02-09 | American Cyanamid Company | Macrolide compounds |
GR870397B (en) * | 1986-03-12 | 1987-07-10 | Glaxo Group Ltd | Macrolide compounds |
GB8613790D0 (en) * | 1986-06-06 | 1986-07-09 | Glaxo Group Ltd | Chemical compounds |
CA1296329C (en) * | 1986-06-06 | 1992-02-25 | Derek R. Sutherland | Macrolide compounds |
US5840704A (en) * | 1986-07-16 | 1998-11-24 | Pfizer Inc. | Antiparasitic agents and process for their preparation |
EP0254583B1 (en) * | 1986-07-24 | 1994-09-07 | Beecham Group Plc | Parasiticidal milbemycin derivatives, a process for their production, and compositions containing the same |
ES2058082T3 (es) * | 1986-09-12 | 1994-11-01 | American Cyanamid Co | Derivados 23-oxo (ceto) y 23-imino de compuestos ll-f28249. |
US5149832A (en) * | 1986-09-12 | 1992-09-22 | American Cyanamid Company | Mono and diacyl derivatives of ll-f28249 compounds |
EP0260537A1 (en) * | 1986-09-12 | 1988-03-23 | American Cyanamid Company | 13-Deoxy-23-oxo(keto) and 23-imino derivatives of 13-deoxy C-076-aglycone compounds |
US4916154A (en) * | 1986-09-12 | 1990-04-10 | American Cyanamid Company | 23-Imino derivatives of LL-F28249 compounds |
EP0262384B1 (en) * | 1986-09-12 | 1992-11-04 | American Cyanamid Company | 23-deoxy derivatives of ll-f28249 compounds |
US5525506A (en) * | 1987-01-23 | 1996-06-11 | Pfizer Inc. | Process for production of avermectins and cultures therefor |
US5234831A (en) * | 1987-01-23 | 1993-08-10 | Pfizer Inc | Cultures for production of B avermectins |
US5238848A (en) * | 1987-01-23 | 1993-08-24 | Pfizer Inc | Cultures for production of avermectins |
US4886829A (en) * | 1987-03-06 | 1989-12-12 | American Cyanamid Company | 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds |
US4886830A (en) * | 1987-03-06 | 1989-12-12 | American Cyanamid Company | Mono- and diepoxide derivatives of 23-deoxyl-LL-F28249 compounds |
US4956479A (en) * | 1987-03-06 | 1990-09-11 | American Cyanamid Company | 23-deoxy-27-chloro derivatives of LL-F28249 compounds |
US4806527A (en) * | 1987-03-16 | 1989-02-21 | Merck & Co., Inc. | Avermectin derivatives |
US4871719A (en) * | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
EP0285561A3 (de) * | 1987-03-27 | 1989-10-25 | Ciba-Geigy Ag | Parasitizide und insektizide Milbemycin-Derivate |
JPS6431776A (en) * | 1987-07-28 | 1989-02-02 | Sankyo Co | Novel macrolide compound and production thereof |
GB8721376D0 (en) * | 1987-09-11 | 1987-10-21 | Glaxo Group Ltd | Chemical compounds |
GB8721373D0 (en) * | 1987-09-11 | 1987-10-21 | Glaxo Group Ltd | Chemical process |
GB8721378D0 (en) * | 1987-09-11 | 1987-10-21 | Glaxo Group Ltd | Chemical process |
GB8721375D0 (en) * | 1987-09-11 | 1987-10-21 | Glaxo Group Ltd | Chemical process |
EP0307219B1 (en) * | 1987-09-11 | 1992-07-15 | American Cyanamid Company | Process for the preparation of macrolide compounds |
GB8721377D0 (en) * | 1987-09-11 | 1987-10-21 | Glaxo Group Ltd | Chemical compounds |
GB8721647D0 (en) * | 1987-09-15 | 1987-10-21 | Pfizer Ltd | Antiparasitic agents |
US5240850A (en) * | 1987-10-23 | 1993-08-31 | Pfizer Inc. | Cultures for production of avermectin aglycones |
DE3880088T2 (de) * | 1987-11-09 | 1993-07-22 | Pfizer | Ethylierte avermectine. |
GB8726384D0 (en) * | 1987-11-11 | 1987-12-16 | Coopers Animal Health | Veterinary treatment |
GB8726730D0 (en) | 1987-11-14 | 1987-12-16 | Pfizer Ltd | Antiparasitic agents |
GB8801908D0 (en) * | 1988-01-28 | 1988-02-24 | Glaxo Group Ltd | Chemical compounds |
GB8804440D0 (en) * | 1988-02-25 | 1988-03-23 | Pfizer Ltd | Antiparasitic agents |
HU9203978D0 (en) * | 1988-05-10 | 1993-04-28 | American Cyanamid Co | Method for producing macrolidic compounds and preparatives containing them qs active substance by means of fermentation |
GB8811037D0 (en) * | 1988-05-10 | 1988-06-15 | Glaxo Group Ltd | Chemical compounds |
GB8811036D0 (en) * | 1988-05-10 | 1988-06-15 | Glaxo Group Ltd | Chemical compounds |
GB8813150D0 (en) * | 1988-06-03 | 1988-07-06 | American Cyanamid Co | Chemical compounds |
GB8813760D0 (en) * | 1988-06-10 | 1988-07-13 | American Cyanamid Co | Chemical process |
US5428034A (en) * | 1988-09-02 | 1995-06-27 | Sankyo Co., Ltd. | Milbemycin derivatives, their preparation and their use |
DK0393890T3 (da) * | 1989-04-11 | 1992-09-28 | Pfizer | Injicerbart præparat indeholdende 25-cyclohexyl-avermectin B1 |
US6001822A (en) * | 1989-04-11 | 1999-12-14 | Pfizer Inc. | Antiparasitic formulations |
NZ234802A (en) * | 1989-08-14 | 1992-11-25 | Merck & Co Inc | Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals |
US4988824A (en) * | 1989-09-11 | 1991-01-29 | Maulding Donald R | Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds |
US5055486A (en) * | 1989-12-22 | 1991-10-08 | American Cyanamid Company | 13-alkyl-23-imino derivative of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents |
JP2622197B2 (ja) * | 1990-03-01 | 1997-06-18 | 三共株式会社 | 13−エーテル置換ミルベマイシン誘導体 |
US5290804A (en) * | 1991-05-01 | 1994-03-01 | Merck & Co., Inc. | Anthelmintic milbemycin analogs of novel microorganisms |
DE69229318T2 (de) * | 1991-09-30 | 1999-11-18 | Merck & Co Inc | Hydrierte Rizinusöl-enthaltende injizierbare Formulierungen mit verlängerter Wirkstoffabgabe |
US6103504A (en) * | 1992-03-25 | 2000-08-15 | Pfizer Inc. | Process for production of avermectins and cultures therefor |
DE19534366C2 (de) * | 1995-09-15 | 2000-08-17 | Asta Medica Ag | Verfahren zur Herstellung von 2,3,4,6-Tetra-O-benzyl-D-glucopyranose und 2,3,4,6-Tetra-O-allyl-D-glucopyranose |
CA2211949A1 (en) * | 1997-07-21 | 1999-01-29 | David Farley Johnson | Nonaqueous compositions for parenteral administration |
ATE320812T1 (de) | 2000-10-10 | 2006-04-15 | Wyeth Corp | Anthelmintika |
NZ552040A (en) * | 2006-12-13 | 2009-04-30 | Bomac Research Ltd | Veterinary formulation comprising an anthelmintic compound and glyceryl acetate |
WO2012028556A1 (en) | 2010-08-31 | 2012-03-08 | Bayer Animal Health Gmbh | Macrocyclic lactones and their use and their combinations with other active substances |
DE102010064245A1 (de) | 2010-12-28 | 2012-06-28 | Bayer Animal Health Gmbh | Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4201861A (en) * | 1977-10-03 | 1980-05-06 | Merck & Co., Inc. | Acyl derivatives of C-076 compounds |
US4550160A (en) * | 1979-08-13 | 1985-10-29 | Merck & Co., Inc. | Processes for the interconversion of C-076 compounds |
JPS5632481A (en) * | 1979-08-23 | 1981-04-01 | Sankyo Co Ltd | Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent |
US4289760A (en) * | 1980-05-02 | 1981-09-15 | Merck & Co., Inc. | 23-Keto derivatives of C-076 compounds |
US4457920A (en) * | 1981-09-03 | 1984-07-03 | Merck & Co., Inc. | 4a-Substituted avermectin compounds |
US4423209A (en) * | 1982-02-26 | 1983-12-27 | Merck & Co., Inc. | Processes for the interconversion of avermectin compounds |
JPS59108785A (ja) * | 1982-11-25 | 1984-06-23 | Sankyo Co Ltd | ミルベマイシン類の5−オキシム誘導体 |
JPS60126289A (ja) * | 1983-11-14 | 1985-07-05 | Sankyo Co Ltd | ミルベマイシン類の5−カ−ボネ−ト誘導体 |
DE3519834C2 (de) * | 1984-06-05 | 1993-12-16 | American Cyanamid Co | Neue antibiotische Wirkstoffe, Verfahren zu ihrer Gewinnung und ihre Anwendung zur Bekämpfung von Infektionen bei Tieren und Pflanzen |
DE3532794A1 (de) * | 1984-09-14 | 1986-04-17 | Glaxo Group Ltd., London | Antibiotika, verfahren zu deren herstellung und diese verbindungen enthaltende mittel |
ES8800986A1 (es) * | 1985-07-27 | 1987-12-01 | Pfizer | Un procedimiento para la produccion de un nuevo derivado de avermectina |
-
1986
- 1986-04-28 ES ES554444A patent/ES8802229A1/es not_active Expired
- 1986-04-28 AU AU56767/86A patent/AU596586B2/en not_active Ceased
- 1986-04-28 IL IL78621A patent/IL78621A/xx not_active IP Right Cessation
- 1986-04-29 NL NL8601103A patent/NL193420C/nl not_active IP Right Cessation
- 1986-04-29 NZ NZ215997A patent/NZ215997A/xx unknown
- 1986-04-29 RU SU864027456A patent/RU2004545C1/ru active
- 1986-04-29 CA CA000507815A patent/CA1335368C/en not_active Expired - Fee Related
- 1986-04-29 LU LU86412A patent/LU86412A1/fr unknown
- 1986-04-29 AT AT0115486A patent/AT397095B/de not_active IP Right Cessation
- 1986-04-29 KR KR1019860003297A patent/KR930011282B1/ko not_active IP Right Cessation
- 1986-04-29 DE DE3614549A patent/DE3614549C2/de not_active Expired - Fee Related
- 1986-04-29 DK DK196586A patent/DK160992C/da not_active IP Right Cessation
- 1986-04-29 IE IE112786A patent/IE59070B1/en not_active IP Right Cessation
- 1986-04-29 SE SE8601998A patent/SE503571C2/sv not_active IP Right Cessation
- 1986-04-29 CH CH1749/86A patent/CH675124A5/de not_active IP Right Cessation
- 1986-04-30 PH PH33722A patent/PH23386A/en unknown
- 1986-04-30 HU HU861816A patent/HU200771B/hu not_active IP Right Cessation
- 1986-04-30 GB GB08610631A patent/GB2176182B/en not_active Expired
- 1986-04-30 BE BE0/216612A patent/BE904709A/fr not_active IP Right Cessation
- 1986-04-30 FR FR868606345A patent/FR2587344B1/fr not_active Expired - Fee Related
- 1986-04-30 PT PT82485A patent/PT82485B/pt not_active IP Right Cessation
- 1986-04-30 JP JP61098435A patent/JPH0819132B2/ja not_active Expired - Fee Related
-
1987
- 1987-04-30 ES ES557517A patent/ES8802522A1/es not_active Expired
- 1987-10-30 ES ES557774A patent/ES8900093A1/es not_active Expired
- 1987-11-10 US US07/119,347 patent/US4978675A/en not_active Expired - Lifetime
-
1988
- 1988-09-01 ES ES557851A patent/ES9000023A1/es not_active Expired
-
1993
- 1993-05-18 LV LVP-93-372A patent/LV10777B/lv unknown
- 1993-07-16 GE GEAP19931052A patent/GEP19971046B/en unknown
- 1993-12-31 LV LVP-93-1406A patent/LV10314B/lv unknown
-
1994
- 1994-12-29 GE GEAP19942319A patent/GEP19970833B/en unknown
-
1997
- 1997-02-07 GE GEAP19973574A patent/GEP20001917B/en unknown
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