DK196586A - Makrolidantibiotika - Google Patents

Makrolidantibiotika Download PDF

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Publication number
DK196586A
DK196586A DK196586A DK196586A DK196586A DK 196586 A DK196586 A DK 196586A DK 196586 A DK196586 A DK 196586A DK 196586 A DK196586 A DK 196586A DK 196586 A DK196586 A DK 196586A
Authority
DK
Denmark
Prior art keywords
macrolide antibiotics
macrolide
antibiotics
hydroxy
group
Prior art date
Application number
DK196586A
Other languages
English (en)
Other versions
DK160992B (da
DK196586D0 (da
DK160992C (da
Inventor
John Barrie Ward
Hazel Mary Noble
Neil Porter
Richard Alan Fletton
David Noble
Derek Ronald Sutherland
Michael Vincent John Ramsay
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858510943A external-priority patent/GB8510943D0/en
Priority claimed from GB858510944A external-priority patent/GB8510944D0/en
Priority claimed from GB858510942A external-priority patent/GB8510942D0/en
Priority claimed from GB868606103A external-priority patent/GB8606103D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK196586D0 publication Critical patent/DK196586D0/da
Publication of DK196586A publication Critical patent/DK196586A/da
Publication of DK160992B publication Critical patent/DK160992B/da
Application granted granted Critical
Publication of DK160992C publication Critical patent/DK160992C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Description

r! er nethyl, ethyl eller isopropyl; er hydrogen eller en gruppe OR^, hvor OR^ er hydroxy eller substitueret hydroxy med op til 25 carbonatomer, og R^ er hydrogen, eller og tilsammen med det carbonatom, til hvilket de er bundet, danner en gruppe >C-0; og OR^ er en gruppe OR^ som defineret ovenfor; med det forbehold, at hvis R^ er hydroxy, så er OR^ substitueret hydroxy forskellig fra methoxy.
Forbindelserne kan anvendes til bekæmpelse af insekt-, acarin, neraatid eller andre skadedyr.
DK196586A 1985-04-30 1986-04-29 Antibiotiske makrolidforbindelser, praeparater indeholdende disse, fremgangmaader til fremstilling af forbindelserne samt fremgangsmaade til anvendelse af forbindelserne eller praeparaterne DK160992C (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB858510943A GB8510943D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB8510943 1985-04-30
GB8510942 1985-04-30
GB858510944A GB8510944D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB858510942A GB8510942D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB8510944 1985-04-30
GB8606103 1986-03-12
GB868606103A GB8606103D0 (en) 1986-03-12 1986-03-12 Chemical compounds

Publications (4)

Publication Number Publication Date
DK196586D0 DK196586D0 (da) 1986-04-29
DK196586A true DK196586A (da) 1986-10-31
DK160992B DK160992B (da) 1991-05-13
DK160992C DK160992C (da) 1991-11-11

Family

ID=27449656

Family Applications (1)

Application Number Title Priority Date Filing Date
DK196586A DK160992C (da) 1985-04-30 1986-04-29 Antibiotiske makrolidforbindelser, praeparater indeholdende disse, fremgangmaader til fremstilling af forbindelserne samt fremgangsmaade til anvendelse af forbindelserne eller praeparaterne

Country Status (25)

Country Link
US (1) US4978675A (da)
JP (1) JPH0819132B2 (da)
KR (1) KR930011282B1 (da)
AT (1) AT397095B (da)
AU (1) AU596586B2 (da)
BE (1) BE904709A (da)
CA (1) CA1335368C (da)
CH (1) CH675124A5 (da)
DE (1) DE3614549C2 (da)
DK (1) DK160992C (da)
ES (4) ES8802229A1 (da)
FR (1) FR2587344B1 (da)
GB (1) GB2176182B (da)
GE (3) GEP19971046B (da)
HU (1) HU200771B (da)
IE (1) IE59070B1 (da)
IL (1) IL78621A (da)
LU (1) LU86412A1 (da)
LV (2) LV10777B (da)
NL (1) NL193420C (da)
NZ (1) NZ215997A (da)
PH (1) PH23386A (da)
PT (1) PT82485B (da)
RU (1) RU2004545C1 (da)
SE (1) SE503571C2 (da)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
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AT396250B (de) * 1984-09-14 1993-07-26 American Cyanamid Co Verfahren zur herstellung von neuen antibiotisch wirkenden verbindungen
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
IE67373B1 (en) * 1985-09-13 1996-03-20 American Cyanamid Co Macrolide antibiotics and their preparation
US5185456A (en) * 1986-03-12 1993-02-09 American Cyanamid Company Macrolide compounds
GB8606108D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
US5336789A (en) * 1986-03-12 1994-08-09 American Cyanamid Company Macrolide compounds
ES2059366T3 (es) * 1986-03-12 1994-11-16 American Cyanamid Co Compuestos macrolidos.
GB8606123D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
AU609032B2 (en) * 1986-03-12 1991-04-26 American Cyanamid Company Macrolide compounds
BR8701118A (pt) * 1986-03-12 1988-01-05 Glaxo Group Ltd Processo para a preparacao de um composto quimico,processo para combater pestes em agricultura,horicultura ou silvicultura,ou em lojas,predios e outros locais publicos e composicao de controle de pestes
GB8613790D0 (en) * 1986-06-06 1986-07-09 Glaxo Group Ltd Chemical compounds
CA1296329C (en) * 1986-06-06 1992-02-25 Derek R. Sutherland Macrolide compounds
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
DE3750495T2 (de) * 1986-07-24 1995-02-23 Beecham Group Plc Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen.
EP0260537A1 (en) * 1986-09-12 1988-03-23 American Cyanamid Company 13-Deoxy-23-oxo(keto) and 23-imino derivatives of 13-deoxy C-076-aglycone compounds
ES2055695T3 (es) * 1986-09-12 1994-09-01 American Cyanamid Co Derivados 23-desoxi de compuestos ll-f28249.
EP0259779B1 (en) * 1986-09-12 1994-08-10 American Cyanamid Company 23-Oxo (Keto) and 23-imino Derivatives of LL-F28249 Compounds
US5149832A (en) * 1986-09-12 1992-09-22 American Cyanamid Company Mono and diacyl derivatives of ll-f28249 compounds
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
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US4886830A (en) * 1987-03-06 1989-12-12 American Cyanamid Company Mono- and diepoxide derivatives of 23-deoxyl-LL-F28249 compounds
US4956479A (en) * 1987-03-06 1990-09-11 American Cyanamid Company 23-deoxy-27-chloro derivatives of LL-F28249 compounds
US4886829A (en) * 1987-03-06 1989-12-12 American Cyanamid Company 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
US4871719A (en) * 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
EP0285561A3 (de) * 1987-03-27 1989-10-25 Ciba-Geigy Ag Parasitizide und insektizide Milbemycin-Derivate
JPS6431776A (en) * 1987-07-28 1989-02-02 Sankyo Co Novel macrolide compound and production thereof
PT88465B (pt) * 1987-09-11 1992-11-30 American Cyanamid Co Processo para a preparacao de um composto macrolido
GB8721377D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721378D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721373D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721375D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721376D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721647D0 (en) * 1987-09-15 1987-10-21 Pfizer Ltd Antiparasitic agents
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
ES2045146T3 (es) * 1987-11-09 1994-01-16 Pfizer Avermectinas etiladas.
GB8726384D0 (en) * 1987-11-11 1987-12-16 Coopers Animal Health Veterinary treatment
GB8726730D0 (en) * 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
GB8801908D0 (en) * 1988-01-28 1988-02-24 Glaxo Group Ltd Chemical compounds
GB8804440D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Antiparasitic agents
GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
JP2629047B2 (ja) * 1988-05-10 1997-07-09 アメリカン・サイアナミツド・カンパニー マクロライド化合物
GB8811037D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8813150D0 (en) * 1988-06-03 1988-07-06 American Cyanamid Co Chemical compounds
GB8813760D0 (en) * 1988-06-10 1988-07-13 American Cyanamid Co Chemical process
US5428034A (en) * 1988-09-02 1995-06-27 Sankyo Co., Ltd. Milbemycin derivatives, their preparation and their use
US6001822A (en) * 1989-04-11 1999-12-14 Pfizer Inc. Antiparasitic formulations
DK0393890T3 (da) * 1989-04-11 1992-09-28 Pfizer Injicerbart præparat indeholdende 25-cyclohexyl-avermectin B1
NZ234802A (en) * 1989-08-14 1992-11-25 Merck & Co Inc Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals
US5055486A (en) * 1989-12-22 1991-10-08 American Cyanamid Company 13-alkyl-23-imino derivative of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents
US4988824A (en) * 1989-09-11 1991-01-29 Maulding Donald R Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds
JP2622197B2 (ja) * 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
US5290804A (en) * 1991-05-01 1994-03-01 Merck & Co., Inc. Anthelmintic milbemycin analogs of novel microorganisms
DK0535734T3 (da) * 1991-09-30 1999-08-09 Merck & Co Inc Langtidsvirkende injicerbare formuleringer indeholdende hydrogeneret castorolie
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
DE19534366C2 (de) * 1995-09-15 2000-08-17 Asta Medica Ag Verfahren zur Herstellung von 2,3,4,6-Tetra-O-benzyl-D-glucopyranose und 2,3,4,6-Tetra-O-allyl-D-glucopyranose
CA2211949A1 (en) * 1997-07-21 1999-01-29 David Farley Johnson Nonaqueous compositions for parenteral administration
PT1197215E (pt) 2000-10-10 2006-07-31 Wyeth Corp Composicoes antelminticas
NZ552040A (en) * 2006-12-13 2009-04-30 Bomac Research Ltd Veterinary formulation comprising an anthelmintic compound and glyceryl acetate
DE102010064245A1 (de) 2010-12-28 2012-06-28 Bayer Animal Health Gmbh Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen
WO2012028556A1 (en) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Macrocyclic lactones and their use and their combinations with other active substances

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JPS59108785A (ja) * 1982-11-25 1984-06-23 Sankyo Co Ltd ミルベマイシン類の５−オキシム誘導体
JPS60126289A (ja) * 1983-11-14 1985-07-05 Sankyo Co Ltd ミルベマイシン類の５−カ−ボネ−ト誘導体
PT80577B (pt) * 1984-06-05 1987-09-18 American Cyanamid Co Processo para a producao de novos agentes macrolidos ll-f28249 uteis no tratamento de infeccoes helminticas por ectoparasitas artropodes e por acarideos
AT396250B (de) * 1984-09-14 1993-07-26 American Cyanamid Co Verfahren zur herstellung von neuen antibiotisch wirkenden verbindungen
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina

Also Published As

Publication number Publication date
IL78621A0 (en) 1986-08-31
NL193420C (nl) 1999-10-04
ES8802522A1 (es) 1988-07-16
GEP20001917B (en) 2000-01-05
DE3614549A1 (de) 1987-01-02
DK160992B (da) 1991-05-13
LV10777B (en) 1996-04-20
ATA115486A (de) 1993-06-15
RU2004545C1 (ru) 1993-12-15
JPS61280496A (ja) 1986-12-11
IE861127L (en) 1986-10-30
ES557851A0 (es) 1990-05-01
ES9000023A1 (es) 1990-05-01
DK196586D0 (da) 1986-04-29
KR930011282B1 (ko) 1993-11-29
SE503571C2 (sv) 1996-07-08
ES8900093A1 (es) 1988-12-01
HU200771B (en) 1990-08-28
GB2176182B (en) 1989-02-01
GEP19971046B (en) 1997-11-26
AU5676786A (en) 1986-11-06
LV10777A (lv) 1995-08-20
ES557517A0 (es) 1988-07-16
JPH0819132B2 (ja) 1996-02-28
LU86412A1 (fr) 1986-11-05
GB8610631D0 (en) 1986-06-04
US4978675A (en) 1990-12-18
IE59070B1 (en) 1993-12-15
PH23386A (en) 1989-07-26
NL193420B (nl) 1999-06-01
PT82485B (pt) 1988-03-03
LV10314A (lv) 1994-10-20
GB2176182A (en) 1986-12-17
KR860008205A (ko) 1986-11-14
HUT46012A (en) 1988-09-28
DE3614549C2 (de) 1998-03-12
SE8601998L (sv) 1986-10-31
SE8601998D0 (sv) 1986-04-29
ES8802229A1 (es) 1988-04-16
AT397095B (de) 1994-01-25
PT82485A (en) 1986-05-01
BE904709A (fr) 1986-10-30
DK160992C (da) 1991-11-11
NZ215997A (en) 1989-06-28
AU596586B2 (en) 1990-05-10
FR2587344B1 (fr) 1991-04-05
LV10314B (en) 1995-08-20
FR2587344A1 (fr) 1987-03-20
CA1335368C (en) 1995-04-25
GEP19970833B (en) 1997-02-10
ES554444A0 (es) 1988-04-16
ES557774A0 (es) 1988-12-01
IL78621A (en) 1991-06-30
NL8601103A (nl) 1986-11-17
CH675124A5 (da) 1990-08-31

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