ES8606296A1 - Procedimiento para la preparacion de una 5-pirimidincarboxamida o tiocarboxamida - Google Patents
Procedimiento para la preparacion de una 5-pirimidincarboxamida o tiocarboxamidaInfo
- Publication number
- ES8606296A1 ES8606296A1 ES538829A ES538829A ES8606296A1 ES 8606296 A1 ES8606296 A1 ES 8606296A1 ES 538829 A ES538829 A ES 538829A ES 538829 A ES538829 A ES 538829A ES 8606296 A1 ES8606296 A1 ES 8606296A1
- Authority
- ES
- Spain
- Prior art keywords
- sulfur
- thiocarboxamide
- procedure
- preparation
- selenium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CYEBJEDOHLIWNP-UHFFFAOYSA-N methanethioamide Chemical compound NC=S CYEBJEDOHLIWNP-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- 229910052717 sulfur Chemical group 0.000 abstract 3
- 239000011593 sulfur Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical group [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052711 selenium Chemical group 0.000 abstract 2
- 239000011669 selenium Chemical group 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 150000001720 carbohydrates Chemical group 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 150000002540 isothiocyanates Chemical class 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- QDXGKRWDQCEABB-UHFFFAOYSA-N pyrimidine-5-carboxamide Chemical compound NC(=O)C1=CN=CN=C1 QDXGKRWDQCEABB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/66—Thiobarbituric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56269383A | 1983-12-19 | 1983-12-19 | |
| US66520184A | 1984-10-26 | 1984-10-26 | |
| US66526784A | 1984-10-26 | 1984-10-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES538829A0 ES538829A0 (es) | 1986-04-16 |
| ES8606296A1 true ES8606296A1 (es) | 1986-04-16 |
Family
ID=27415896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES538829A Expired ES8606296A1 (es) | 1983-12-19 | 1984-12-19 | Procedimiento para la preparacion de una 5-pirimidincarboxamida o tiocarboxamida |
Country Status (19)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2145087B (en) * | 1983-08-19 | 1987-02-04 | Ciba Geigy Ag | Barbituric acid derivatives |
| EP0167491A3 (de) * | 1984-07-06 | 1986-12-30 | Ciba-Geigy Ag | Thiobarbitursäurederivate |
| PH24423A (en) * | 1985-02-15 | 1990-06-25 | Ciba Geigy Ag | 5-(azolyloxyphenylcarbamoyl)barbituric acid derivatives as anthelmintics |
| US4636508A (en) * | 1985-04-22 | 1987-01-13 | Uniroyal Chemical Company, Inc. | 5-pyrimidinecarboxyamides and treatment of leukemia therewith |
| US4845217A (en) * | 1985-05-17 | 1989-07-04 | Uniroyal Chemical Ltd./Ltee | Purification of 5-pyrimidinecarboxamides |
| EP0202823A3 (en) * | 1985-05-17 | 1987-11-19 | Uniroyal Limited | Purification of 5-pyrimidinecarboxamides |
| US4880811A (en) * | 1987-06-24 | 1989-11-14 | Memorial Hospital For Cancer And Allied Diseases | Use of C-5 mono-substituted barbiturates to treat disorders of uric acid metabolism |
| US4920126A (en) * | 1988-05-10 | 1990-04-24 | Uniroyal Chemical Ltd/Uniroyal Chemical Ltee | Barbituric acid derivative and treatment of leukemia and tumors therewith |
| WO1991013623A1 (en) * | 1990-03-09 | 1991-09-19 | Memorial Hospital For Cancer And Allied Diseases | C-5 mono-substituted barbiturates in combination with therapeutic agents and uses thereof |
| AU5723001A (en) | 2000-04-24 | 2001-11-07 | Aryx Therapeutics | Ultrashort acting hypnotic barbiturates |
| WO2015123003A1 (en) * | 2014-02-14 | 2015-08-20 | Warrell Raymond P | Bifunctional compounds and use for reducing uric acid levels |
| US10093658B2 (en) | 2015-01-22 | 2018-10-09 | Acquist Llc | Bifunctional compounds and use for reducing uric acid levels |
| TWI771303B (zh) | 2016-06-30 | 2022-07-21 | 美商艾克奎斯特有限責任公司 | 化合物及其於降低尿酸位準之用途(一) |
| CN109476642B (zh) | 2016-07-06 | 2022-01-25 | 阿奎斯特有限责任公司 | 化合物及其用于降低尿酸水平的用途 |
| IT201700028709A1 (it) * | 2017-03-15 | 2018-09-15 | Fondazione St Italiano Tecnologia | Acidi-5-carbossamide-2-tiobarbiturici e loro uso come medicamenti |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH602664A5 (en) * | 1973-06-14 | 1978-07-31 | Sandoz Ag | 2-Tert. amino-alkylamino-pyrimidine derivs. |
| DE2405733C2 (de) * | 1974-02-07 | 1984-12-13 | Bayer Ag, 5090 Leverkusen | Amidocarbonylthiobarbitursäurederivate und deren Salze, Verfahren zu ihrer Herstellung sowie ihre Verwendung zur Bekämpfung von Insekten, Milben und Pilzen |
| DE2405732A1 (de) * | 1974-02-07 | 1975-08-21 | Bayer Ag | Ekto- und endoparasitenmittel |
| CH614944A5 (en) * | 1974-04-16 | 1979-12-28 | Sandoz Ag | Process for the preparation of novel pyrimidine derivatives |
| PL103086B1 (pl) * | 1976-05-06 | 1979-05-31 | Ciba Geigy Ag | Srodek owadobojczy |
| CH616563A5 (en) * | 1976-05-06 | 1980-04-15 | Ciba Geigy Ag | Pesticide containing a 5-phenylcarbamoylbarbituric acid as active ingredient |
| DE2624856A1 (de) * | 1976-06-03 | 1977-12-22 | Hoechst Ag | 2-thiohexahydropyrimidin-4,6-dion-derivate und verfahren zu ihrer herstellung |
| US4283444A (en) * | 1978-09-12 | 1981-08-11 | Ciba-Geigy Corporation | Method of protecting keratinous material from attack by insects that feed on keratin by treatment with 5-phenylcarbamoylbarbituric acid compounds |
| EP0010941B1 (en) * | 1978-10-30 | 1982-05-12 | Fujisawa Pharmaceutical Co., Ltd. | 5-fluorouracil derivatives, preparation thereof and their pharmaceutical compositions |
| US4349552A (en) * | 1978-10-30 | 1982-09-14 | Fujisawa Pharmaceutical Company, Ltd. | 5-Fluorouracil derivatives, and their pharmaceutical compositions |
| CH654720A5 (de) * | 1981-09-03 | 1986-03-14 | Ciba Geigy Ag | Lagerstabile mottenschutzformulierungen. |
| US4410524A (en) * | 1982-06-01 | 1983-10-18 | American Cyanamid Company | Novel 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof |
| EP0102327A3 (de) * | 1982-08-26 | 1985-05-15 | Ciba-Geigy Ag | Barbitursäurederivate als Anthelmintika |
| CH658770A5 (de) * | 1982-08-26 | 1986-12-15 | Ciba Geigy Ag | Motten- und kaeferschutzmittel. |
| GB8431832D0 (en) * | 1983-12-19 | 1985-01-30 | Uniroyal Inc | 5-pyrimidinecarboxamides |
| EP0167491A3 (de) * | 1984-07-06 | 1986-12-30 | Ciba-Geigy Ag | Thiobarbitursäurederivate |
-
1984
- 1984-12-17 IL IL73840A patent/IL73840A/xx not_active IP Right Cessation
- 1984-12-18 NZ NZ220399A patent/NZ220399A/en unknown
- 1984-12-18 IT IT8424104A patent/IT1213257B/it active
- 1984-12-18 IE IE3237/84A patent/IE57675B1/en not_active IP Right Cessation
- 1984-12-18 SE SE8406450A patent/SE469171B/sv not_active IP Right Cessation
- 1984-12-18 DK DK609184A patent/DK164055C/da not_active IP Right Cessation
- 1984-12-18 BE BE0/214179A patent/BE901301A/fr not_active IP Right Cessation
- 1984-12-18 GR GR82494A patent/GR82494B/el unknown
- 1984-12-18 NZ NZ210599A patent/NZ210599A/en unknown
- 1984-12-19 NL NL8403856A patent/NL8403856A/nl not_active Application Discontinuation
- 1984-12-19 AT AT0402684A patent/AT394194B/de not_active IP Right Cessation
- 1984-12-19 LU LU85696A patent/LU85696A1/fr unknown
- 1984-12-19 AU AU36908/84A patent/AU580746B2/en not_active Ceased
- 1984-12-19 CH CH6089/84A patent/CH671225A5/de not_active IP Right Cessation
- 1984-12-19 ES ES538829A patent/ES8606296A1/es not_active Expired
- 1984-12-19 FR FR8419455A patent/FR2557108B1/fr not_active Expired
- 1984-12-19 DE DE19843446371 patent/DE3446371A1/de active Granted
- 1984-12-19 GB GB08432112A patent/GB2152047B/en not_active Expired
-
1985
- 1985-02-08 US US06/699,776 patent/US4634707A/en not_active Expired - Lifetime
-
1986
- 1986-12-03 JP JP61288650A patent/JPH0660164B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8606296A1 (es) | Procedimiento para la preparacion de una 5-pirimidincarboxamida o tiocarboxamida | |
| BG41820A3 (en) | Method for preparing n- (3- hydroxy- 4- piperidinyl) benzamide derivatives | |
| ES8705444A1 (es) | Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas | |
| ES8506612A1 (es) | Un metodo para producir un derivado de amina | |
| SE8204879D0 (sv) | Novel chemical intermediates | |
| ES8307231A1 (es) | Procedimiento para preparar derivados de piridona. | |
| ES8301980A1 (es) | Procedimiento para la preparacion de 8-arilalcohil-3-fenil-3-nortropanoles . | |
| ES2062215T3 (es) | Derivados aminoalcoxibencenicos sustituidos. | |
| BG41821A3 (en) | Method for preparing pyridyl derivatives | |
| ES8600284A1 (es) | Un procedimiento para la preparacion de nuevas benzamidas | |
| ES8604922A1 (es) | Procedimiento para la preparacion de n-piridilindoles | |
| ES484784A1 (es) | Procedimiento para la obtencion de n-benzoil-n'-terc.-alco- xicarbonilfenil-(tio)ureas sustituidas, de efecto insectici-da | |
| BG28068A3 (bg) | Метод за получаване на -3- хлорцефалоспорини | |
| ES2031509T3 (es) | Un procedimiento para la preparacion de agentes antiarritmicos. | |
| ES8104245A1 (es) | Procedimiento para la preparacion de derivados de bencimida-zol | |
| ES8507529A1 (es) | Una piperazinilalcanoilanilida | |
| SE8102337L (sv) | Radiomottagare | |
| ES8306741A1 (es) | "un procedimiento para la preparacion de 4-(4-imidazolil)-piridinas 2-sustituidas". | |
| ES8703464A1 (es) | Procedimiento para preparar pirazol (3,4-b) piridinamidas. | |
| ES8604164A1 (es) | Procedimiento para preparar nuevos bencimidazoles | |
| ES8200884A1 (es) | Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos | |
| ES475565A1 (es) | Un procedimiento para la preparacion de nuevos derivados de indol | |
| ES8202000A1 (es) | Procedimiento para preparar pirimidil-quinazolinas | |
| ES8401449A1 (es) | "procedimiento para la preparacion de un diisocianato". | |
| ES8504179A1 (es) | "procedimiento para preparar derivados de 1,4-dihidropiridina". |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990503 |