ES8507529A1 - Una piperazinilalcanoilanilida - Google Patents

Una piperazinilalcanoilanilida

Info

Publication number
ES8507529A1
ES8507529A1 ES529642A ES529642A ES8507529A1 ES 8507529 A1 ES8507529 A1 ES 8507529A1 ES 529642 A ES529642 A ES 529642A ES 529642 A ES529642 A ES 529642A ES 8507529 A1 ES8507529 A1 ES 8507529A1
Authority
ES
Spain
Prior art keywords
alkyl
piperazinylalkanoylanilides
acyl
antihypertensive
guanidinosulphonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529642A
Other languages
English (en)
Other versions
ES529642A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recordati SA
Original Assignee
Recordati SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati SA filed Critical Recordati SA
Publication of ES529642A0 publication Critical patent/ES529642A0/es
Publication of ES8507529A1 publication Critical patent/ES8507529A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA N-PIPERAZINILALCANOILANILIDA, DE FORMULA GENERAL (I), EN LA QUE N ES CERO, 1 O 2; R Y R1 SON CADA UNO DE ELLOS INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO; Y R2, R3 Y R4 SON CADA UNO DE ELLOS INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O DE HALOGENO, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R, R1, R2, R3, R4 Y N TIENEN LOS SIGNIFICADOS YA MENCIONADOS, CON 1-(2-METOXILENILPIPERAZINA, EN PRESENCIA DE UN DISOLVENTE.DE APLICACION EN MEDICINA COMO AGENTES ANTIHIPERTENSIVOS.
ES529642A 1983-02-12 1984-02-10 Una piperazinilalcanoilanilida Expired ES8507529A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838303946A GB8303946D0 (en) 1983-02-12 1983-02-12 Antihypertensive n-piperazinylalkanoylanilides

Publications (2)

Publication Number Publication Date
ES529642A0 ES529642A0 (es) 1985-09-01
ES8507529A1 true ES8507529A1 (es) 1985-09-01

Family

ID=10537908

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529642A Expired ES8507529A1 (es) 1983-02-12 1984-02-10 Una piperazinilalcanoilanilida

Country Status (23)

Country Link
US (1) US4940711A (es)
EP (1) EP0120558B1 (es)
JP (1) JPS59152379A (es)
KR (1) KR910000451B1 (es)
AR (1) AR241182A1 (es)
AT (1) ATE41150T1 (es)
AU (1) AU565208B2 (es)
CA (1) CA1254894A (es)
DE (1) DE3476998D1 (es)
DK (1) DK162640C (es)
ES (1) ES8507529A1 (es)
FI (1) FI80025C (es)
GB (1) GB8303946D0 (es)
GR (1) GR81460B (es)
HU (1) HU191270B (es)
IE (1) IE56652B1 (es)
IL (1) IL70733A (es)
MX (1) MX156049A (es)
NZ (1) NZ206823A (es)
PH (1) PH20244A (es)
PT (1) PT78081B (es)
SG (1) SG34889G (es)
ZA (1) ZA84316B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides
JPS61134382A (ja) * 1984-12-04 1986-06-21 Kyorin Pharmaceut Co Ltd 新規なスルファモイル安息香酸誘導体およびその製造法
IT1190375B (it) * 1985-06-20 1988-02-16 Recordati Chem Pharm N-benzidrildiazacicloalchil-alcanilidi ad attivita' antianafilattica ed antibroncospastica
DE3642497A1 (de) * 1986-12-12 1988-06-23 Hoechst Ag Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
JP2712222B2 (ja) * 1988-01-29 1998-02-10 三菱化学株式会社 抗不安薬
DK203990D0 (da) * 1990-08-24 1990-08-24 Novo Nordisk As Piperazinylderivater
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone
WO2015046595A1 (ja) * 2013-09-30 2015-04-02 国立大学法人東京大学 アディポネクチン受容体活性化化合物
WO2016020373A1 (en) * 2014-08-06 2016-02-11 Ascendis Pharma A/S Prodrugs comprising an aminoalkyl glycine linker
CA3001857A1 (en) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB912788A (en) * 1959-11-16 1962-12-12 Miles Lab Phenylpiperazinylacyl anilines
DE1670200A1 (de) * 1967-03-22 1972-03-02 Byk Gulden Lomberg Chem Fab Neue arylsubstituierte Piperazinylcarbonsaeureanilide und Verfahren zu deren Herstellung
JPS5064282A (es) * 1973-10-17 1975-05-31
JPS5849550B2 (ja) * 1974-02-07 1983-11-05 住友化学工業株式会社 シンキナアニリンユウドウタイ ノ セイホウ
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
US4202978A (en) * 1978-02-08 1980-05-13 Hoffmann-La Roche Inc. (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines
JPS58154573A (ja) * 1982-03-09 1983-09-14 Mitsubishi Chem Ind Ltd アルキレンジオキシベンゼン誘導体及びその酸付加塩
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides

Also Published As

Publication number Publication date
DK162640C (da) 1992-04-13
GB8303946D0 (en) 1983-03-16
CA1254894A (en) 1989-05-30
IL70733A (en) 1987-10-30
HU191270B (en) 1987-01-28
MX156049A (es) 1988-06-21
GR81460B (es) 1984-12-11
KR840007593A (ko) 1984-12-08
AR241182A1 (es) 1992-01-31
IE840207L (en) 1984-08-14
EP0120558A1 (en) 1984-10-03
EP0120558B1 (en) 1989-03-08
JPS59152379A (ja) 1984-08-31
FI840478A0 (fi) 1984-02-06
IE56652B1 (en) 1991-10-23
ES529642A0 (es) 1985-09-01
IL70733A0 (en) 1984-04-30
ZA84316B (en) 1985-02-27
DK48584A (da) 1984-08-13
DK48584D0 (da) 1984-02-03
FI80025C (fi) 1990-04-10
JPH0434549B2 (es) 1992-06-08
PH20244A (en) 1986-11-10
PT78081B (en) 1986-04-17
KR910000451B1 (en) 1991-01-25
AU565208B2 (en) 1987-09-10
FI840478A (fi) 1984-08-13
DK162640B (da) 1991-11-25
DE3476998D1 (de) 1989-04-13
SG34889G (en) 1989-10-13
FI80025B (fi) 1989-12-29
NZ206823A (en) 1987-07-31
AU2449484A (en) 1984-08-16
ATE41150T1 (de) 1989-03-15
PT78081A (en) 1984-03-01
US4940711A (en) 1990-07-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601