KR840007593A - N-피페라지닐알카노일아닐리드의 제조방법 - Google Patents

N-피페라지닐알카노일아닐리드의 제조방법 Download PDF

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KR840007593A
KR840007593A KR1019840000641A KR840000641A KR840007593A KR 840007593 A KR840007593 A KR 840007593A KR 1019840000641 A KR1019840000641 A KR 1019840000641A KR 840000641 A KR840000641 A KR 840000641A KR 840007593 A KR840007593 A KR 840007593A
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alkyl
group
hydrogen atom
alkoxy
solvent
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KR1019840000641A
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KR910000451B1 (en
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3) 단테나르디(외
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원본미기재
레코르다티 에스. 에이, 케미컬 엔드 파마세미컬 컴패니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

N-피페라지닐알카노일아닐리드의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 용매의 존재하에 다음 일반식 II의 화합물과 1-(2-메톡시페닐)-피페라진과의 반응을 특징으로 하는 다음 일반식 I로 표시되는 N-피페라지닐알카노일아닐리드 또는 제약에 수용할 수 있는 그 염의 제조방법.
    상기식에서, n은 0, 1 또는 2이고, R 및 R1은 각각 수소원자 또는 알킬기이고, R2,R3및 R4의 각각은 수소원자, 할로겐원자, 알킬, 히드록시알킬, 알콕시, 아랄콕시, 알킬티오, 아랄킬티오, 알킬술포닐, 알킬술페닐, 니트로, 아미노, 알킬아미노, 아실아미노, 우레이도, 알킬우레이도, 아릴우레이도, 알킬술포닐아미노, 트리플루오로메틸, 아실, 시아노, 카르복시, 알콕시카르보닐, 카르바모일, 술포, 구아니디, 노술포닐, 카르바모일옥시, 히드록시, 아실옥시, 알킬술포닐옥시 또는 알킬렌디옥시기 또는 R5및 R6의 각각이 수소원자 또는 알킬, 아릴 또는 아실기인 식 SO2NR5R6의 기를 나타낸다(알킬, 알콕시 또는 알킬렌기의 각각은 C1∼C4를 갖는다.).
    상기식에서 R, R1, R2, R3, R4및 n은 상기에 정의한 것과 같고, X는 할로겐 원자이다.
  2. 용매의 존재하에 다음 일반식 III의 화합물과 1-(2-메톡시페닐)-피페라진과의 반응을 특징으로 하는 다음 일반식 I로 표시되는 N-피페라지닐알카노일아닐리드의 제조방법.
    상기식에서, n은 1이고, R 및 R1은 각각 수소원자 또는 알킬기이고, R2, R3및 R4의 각각은 수소원자, 할로겐원자, 알킬, 히드록시알킬, 알콕시, 아랄콕시, 알킬티오, 알킬티오, 아랄킬티오, 알킬술포닐, 알킬술페닐, 니트로아미노, 알킬아미노, 아실아미노, 우레이도, 알킬우레이도, 아릴우레이도, 알킬술포닐아미노, 트리플루오로메틸, 아실, 시아노, 카르복시, 알콕시카르보닐, 카르바모일, 술포, 구아니디노술포닐, 카르바모일옥시, 히드록시, 아실옥시, 알킬술포닐옥시 또는 알킬렌디옥시기, 또는 R5및 R6의 각각이 수소원자 또는 알킬, 아릴 또는 아실기인 식 SO2NR5R6의 기를 나타낸다(알킬, 알콕시 또는 알킬렌기의 각각은 C1∼C4를 갖는다).
  3. 제1항 또는 2항에 있어서, 용매가 디메틸 술폭사이드이고, 반응이 40℃∼60℃에서 수행됨을 특징으로 하는 방법.
  4. 제1항 또는 2항에 있어서, 용매가 케톤 또는 탄화수소이고, 반응이 환류하에수행됨을 특징으로 하는 방법.
  5. 제약에 수용할 수 있는 희석제 또는 담체와 제1항에 따른 N-피페라지닐알카노일아닐리드 또는 제약에 수용할 수 있는 그 염으로 구성되는 제약조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8400641A 1983-02-12 1984-02-10 A process for producing n-pipe-razinyl alkanoylanilides KR910000451B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838303946A GB8303946D0 (en) 1983-02-12 1983-02-12 Antihypertensive n-piperazinylalkanoylanilides
GB8303946 1983-02-12

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KR840007593A true KR840007593A (ko) 1984-12-08
KR910000451B1 KR910000451B1 (en) 1991-01-25

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US (1) US4940711A (ko)
EP (1) EP0120558B1 (ko)
JP (1) JPS59152379A (ko)
KR (1) KR910000451B1 (ko)
AR (1) AR241182A1 (ko)
AT (1) ATE41150T1 (ko)
AU (1) AU565208B2 (ko)
CA (1) CA1254894A (ko)
DE (1) DE3476998D1 (ko)
DK (1) DK162640C (ko)
ES (1) ES529642A0 (ko)
FI (1) FI80025C (ko)
GB (1) GB8303946D0 (ko)
GR (1) GR81460B (ko)
HU (1) HU191270B (ko)
IE (1) IE56652B1 (ko)
IL (1) IL70733A (ko)
MX (1) MX156049A (ko)
NZ (1) NZ206823A (ko)
PH (1) PH20244A (ko)
PT (1) PT78081B (ko)
SG (1) SG34889G (ko)
ZA (1) ZA84316B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides
JPS61134382A (ja) * 1984-12-04 1986-06-21 Kyorin Pharmaceut Co Ltd 新規なスルファモイル安息香酸誘導体およびその製造法
IT1190375B (it) * 1985-06-20 1988-02-16 Recordati Chem Pharm N-benzidrildiazacicloalchil-alcanilidi ad attivita' antianafilattica ed antibroncospastica
DE3642497A1 (de) * 1986-12-12 1988-06-23 Hoechst Ag Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
JP2712222B2 (ja) * 1988-01-29 1998-02-10 三菱化学株式会社 抗不安薬
DK203990D0 (da) * 1990-08-24 1990-08-24 Novo Nordisk As Piperazinylderivater
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone
US20160214967A1 (en) * 2013-09-30 2016-07-28 The University Of Tokyo Activator of adiponectin receptor
AU2015299055C1 (en) * 2014-08-06 2021-05-06 Ascendis Pharma A/S Prodrugs comprising an aminoalkyl glycine linker
US20180305334A1 (en) * 2015-10-14 2018-10-25 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules

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Publication number Priority date Publication date Assignee Title
GB912788A (en) * 1959-11-16 1962-12-12 Miles Lab Phenylpiperazinylacyl anilines
DE1670200A1 (de) * 1967-03-22 1972-03-02 Byk Gulden Lomberg Chem Fab Neue arylsubstituierte Piperazinylcarbonsaeureanilide und Verfahren zu deren Herstellung
JPS5064282A (ko) * 1973-10-17 1975-05-31
JPS5849550B2 (ja) * 1974-02-07 1983-11-05 住友化学工業株式会社 シンキナアニリンユウドウタイ ノ セイホウ
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
US4202978A (en) * 1978-02-08 1980-05-13 Hoffmann-La Roche Inc. (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines
JPS58154573A (ja) * 1982-03-09 1983-09-14 Mitsubishi Chem Ind Ltd アルキレンジオキシベンゼン誘導体及びその酸付加塩
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides

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JPS59152379A (ja) 1984-08-31
ES8507529A1 (es) 1985-09-01
DK162640C (da) 1992-04-13
GB8303946D0 (en) 1983-03-16
SG34889G (en) 1989-10-13
IE56652B1 (en) 1991-10-23
AU2449484A (en) 1984-08-16
IL70733A0 (en) 1984-04-30
DK162640B (da) 1991-11-25
FI80025C (fi) 1990-04-10
DK48584A (da) 1984-08-13
DK48584D0 (da) 1984-02-03
AU565208B2 (en) 1987-09-10
JPH0434549B2 (ko) 1992-06-08
US4940711A (en) 1990-07-10
EP0120558A1 (en) 1984-10-03
PH20244A (en) 1986-11-10
AR241182A1 (es) 1992-01-31
PT78081B (en) 1986-04-17
GR81460B (ko) 1984-12-11
PT78081A (en) 1984-03-01
FI840478A0 (fi) 1984-02-06
ZA84316B (en) 1985-02-27
DE3476998D1 (de) 1989-04-13
KR910000451B1 (en) 1991-01-25
IL70733A (en) 1987-10-30
NZ206823A (en) 1987-07-31
FI80025B (fi) 1989-12-29
ES529642A0 (es) 1985-09-01
EP0120558B1 (en) 1989-03-08
ATE41150T1 (de) 1989-03-15
FI840478A (fi) 1984-08-13
MX156049A (es) 1988-06-21
IE840207L (en) 1984-08-14
HU191270B (en) 1987-01-28
CA1254894A (en) 1989-05-30

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