ES8306741A1 - "un procedimiento para la preparacion de 4-(4-imidazolil)-piridinas 2-sustituidas". - Google Patents

"un procedimiento para la preparacion de 4-(4-imidazolil)-piridinas 2-sustituidas".

Info

Publication number
ES8306741A1
ES8306741A1 ES515243A ES515243A ES8306741A1 ES 8306741 A1 ES8306741 A1 ES 8306741A1 ES 515243 A ES515243 A ES 515243A ES 515243 A ES515243 A ES 515243A ES 8306741 A1 ES8306741 A1 ES 8306741A1
Authority
ES
Spain
Prior art keywords
imidazolylpyridine
therapeutic agents
reaction
formula
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515243A
Other languages
English (en)
Other versions
ES515243A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of ES8306741A1 publication Critical patent/ES8306741A1/es
Publication of ES515243A0 publication Critical patent/ES515243A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/51—Acetal radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 4-(4-IMIDAZOLIL)-PIRIDINAS 2-SUSTITUIDAS, DE FORMULA (I), EN LA QUE X ES -NR R O METILO; Y R Y R SON CADA UNO DE ELLOS HIDROGENO, ALQUILO DE 1 A 3 ATOMOS DE CARBONO O FENILALQUILO, Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE X TIENE LOS SIGNIFICADOS YA INDICADOS, CON UNA CIANAMIDA, EN PRESENCIA DE UN DISOLVENTE INERTE A LA REACCION, HASTA QUE LA REACCION ESTE PRACTICAMENTE COMPLETA. DE APLICACION EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS COMO AGENTES ANTIULCERANTES.
ES515243A 1980-10-16 1982-08-25 "un procedimiento para la preparacion de 4-(4-imidazolil)-piridinas 2-sustituidas". Granted ES515243A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/197,388 US4302464A (en) 1980-10-16 1980-10-16 Imidazolylpyridine therapeutic agents

Publications (2)

Publication Number Publication Date
ES8306741A1 true ES8306741A1 (es) 1983-06-01
ES515243A0 ES515243A0 (es) 1983-06-01

Family

ID=22729208

Family Applications (3)

Application Number Title Priority Date Filing Date
ES506281A Expired ES8301229A1 (es) 1980-10-16 1981-10-15 Un procedimiento para la preparacion de 4-(4-imidazolil)piridinas 2-sustituidas.
ES515243A Granted ES515243A0 (es) 1980-10-16 1982-08-25 "un procedimiento para la preparacion de 4-(4-imidazolil)-piridinas 2-sustituidas".
ES515244A Granted ES515244A0 (es) 1980-10-16 1982-08-25 "un procedimiento para la preparacion de 4-(4-imidazolil)-piridinas 2-sustituidas".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES506281A Expired ES8301229A1 (es) 1980-10-16 1981-10-15 Un procedimiento para la preparacion de 4-(4-imidazolil)piridinas 2-sustituidas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES515244A Granted ES515244A0 (es) 1980-10-16 1982-08-25 "un procedimiento para la preparacion de 4-(4-imidazolil)-piridinas 2-sustituidas".

Country Status (18)

Country Link
US (1) US4302464A (es)
EP (1) EP0051371B1 (es)
JP (1) JPS5795983A (es)
KR (1) KR850001226B1 (es)
AR (3) AR227941A1 (es)
AT (1) ATE9156T1 (es)
AU (1) AU524257B2 (es)
CA (1) CA1175435A (es)
DE (1) DE3165786D1 (es)
DK (1) DK457181A (es)
ES (3) ES8301229A1 (es)
FI (1) FI72974C (es)
GR (1) GR75096B (es)
IE (1) IE51683B1 (es)
IL (1) IL64054A (es)
PH (1) PH16715A (es)
PT (1) PT73835B (es)
YU (3) YU42734B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4463005A (en) * 1981-03-18 1984-07-31 Imperial Chemical Industries Plc Bicyclic guanidines
US4510151A (en) * 1984-02-10 1985-04-09 Usv Pharmaceutical Corporation Pyridinylimidazole pharmaceutical composition
SE8405588D0 (sv) * 1984-11-08 1984-11-08 Haessle Ab New compounds
DK337086A (da) * 1985-08-12 1987-02-13 Hoffmann La Roche Benzimidazolderivater
US4911753A (en) * 1987-01-21 1990-03-27 American Cyanamid Company Herbicidal 2-(2-imidazolin-2-yl)fluoroalkoxy-, alkenyloxy-, and alkynyloxypyridines and quinolines
FR2780973B1 (fr) * 1998-07-09 2001-10-05 Hoechst Marion Roussel Inc Procede de preparation du 4-(3-pyridinyl)-1h-imidazole, et les intermediaires mis en oeuvre
AR039241A1 (es) 2002-04-04 2005-02-16 Biogen Inc Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
UA80296C2 (en) * 2002-09-06 2007-09-10 Biogen Inc Imidazolopyridines and methods of making and using the same
UA80295C2 (en) 2002-09-06 2007-09-10 Biogen Inc Pyrazolopyridines and using the same
CL2004000234A1 (es) * 2003-02-12 2005-04-15 Biogen Idec Inc Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
KR100914375B1 (ko) * 2007-06-26 2009-08-28 한국원자력연구원 초음파를 이용한 균열 간극의 크기 산출방법
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5343958B2 (es) * 1972-07-29 1978-11-24

Also Published As

Publication number Publication date
YU42877B (en) 1988-12-31
FI72974C (fi) 1987-08-10
DK457181A (da) 1982-04-17
IE812411L (en) 1982-04-16
CA1175435A (en) 1984-10-02
EP0051371B1 (en) 1984-08-29
FI72974B (fi) 1987-04-30
ES8306742A1 (es) 1983-06-01
KR830007623A (ko) 1983-11-04
US4302464A (en) 1981-11-24
DE3165786D1 (en) 1984-10-04
FI813214L (fi) 1982-04-17
EP0051371A3 (en) 1982-06-09
YU247181A (en) 1984-02-29
AR228677A1 (es) 1983-03-30
ES506281A0 (es) 1982-12-01
AR228678A1 (es) 1983-03-30
PT73835B (en) 1983-11-07
JPS5795983A (en) 1982-06-15
KR850001226B1 (ko) 1985-08-23
ES8301229A1 (es) 1982-12-01
ES515244A0 (es) 1983-06-01
IL64054A0 (en) 1982-01-31
YU42734B (en) 1988-12-31
YU172483A (en) 1984-02-29
JPS6351155B2 (es) 1988-10-13
YU172583A (en) 1984-02-29
ATE9156T1 (de) 1984-09-15
AR227941A1 (es) 1982-12-30
IL64054A (en) 1984-11-30
ES515243A0 (es) 1983-06-01
EP0051371A2 (en) 1982-05-12
IE51683B1 (en) 1987-02-04
GR75096B (es) 1984-07-13
PT73835A (en) 1981-11-01
AU7639081A (en) 1982-04-22
PH16715A (en) 1984-01-25
YU42876B (en) 1988-12-31
AU524257B2 (en) 1982-09-09

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