ES8307818A1 - Procedimiento para preparar derivados de cefalosporina. - Google Patents

Procedimiento para preparar derivados de cefalosporina.

Info

Publication number
ES8307818A1
ES8307818A1 ES517824A ES517824A ES8307818A1 ES 8307818 A1 ES8307818 A1 ES 8307818A1 ES 517824 A ES517824 A ES 517824A ES 517824 A ES517824 A ES 517824A ES 8307818 A1 ES8307818 A1 ES 8307818A1
Authority
ES
Spain
Prior art keywords
radical
substituents
formula
hydrogen atom
antibacterially
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517824A
Other languages
English (en)
Other versions
ES517824A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES517824A0 publication Critical patent/ES517824A0/es
Publication of ES8307818A1 publication Critical patent/ES8307818A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CEFALOSPORINA, DE FORMULA GENERAL (I), EN LA QUE R>0 ES UN ATOMO DE HIDROGENO O UN RADICAL METILO; R>1 ES UNO CUALQUIERA DE LOS SUBSTITUYENTES C-3 DE CEFALOSPORINA ANTIBACTERIANAMENTE ACTIVO; R>2 ES UNO CUALQUIERA DE LOS SUSTITUYENTES C-4 DE CEFALOSPORINA ANTIBACTERIANAMENTE ACTIVO; X>1 ES HIDROGENO O UN RADICAL ALCOXI; X>2 ES NITROGENO; R>4 ES HIDROGENO O UN RADICAL ALQUILO; Y R>5 Y R>6 SON RADICALES HALOALQUILO, AZIDOALQUILO O CARBOXIALQUILO, Y LAS SALES DE ADICION DE ACIDO O BASE FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE R>4>8 ES UN RADICAL DESPLAZABLE, CON UN COMPUESTO DE FORMULA (III). DE APLICACION EN LA PREPARACION DE ANTIBIOTICOS TERAPEUTICOS.
ES517824A 1980-12-22 1982-11-30 Procedimiento para preparar derivados de cefalosporina. Expired ES8307818A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8027254A FR2496666A1 (fr) 1980-12-22 1980-12-22 Nouveaux derives de cephalosporine et composition pharmaceutique les contenant

Publications (2)

Publication Number Publication Date
ES517824A0 ES517824A0 (es) 1983-08-16
ES8307818A1 true ES8307818A1 (es) 1983-08-16

Family

ID=9249365

Family Applications (2)

Application Number Title Priority Date Filing Date
ES508280A Expired ES8304140A1 (es) 1980-12-22 1981-12-22 Procedimiento para preparar derivados de cefalosporina.
ES517824A Expired ES8307818A1 (es) 1980-12-22 1982-11-30 Procedimiento para preparar derivados de cefalosporina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES508280A Expired ES8304140A1 (es) 1980-12-22 1981-12-22 Procedimiento para preparar derivados de cefalosporina.

Country Status (15)

Country Link
US (1) US4492692A (es)
EP (1) EP0055562B1 (es)
JP (1) JPS57167991A (es)
AU (1) AU7878681A (es)
DE (1) DE3173789D1 (es)
DK (1) DK572581A (es)
ES (2) ES8304140A1 (es)
FI (1) FI814132L (es)
FR (1) FR2496666A1 (es)
GR (1) GR76914B (es)
IL (1) IL64512A0 (es)
NO (1) NO814372L (es)
PT (1) PT74173B (es)
YU (2) YU303981A (es)
ZA (1) ZA818594B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071370A3 (en) * 1981-07-23 1984-05-16 Ici Pharma Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them
US4504478A (en) * 1981-09-18 1985-03-12 Imperial Chemical Industries Plc Cephalosporin-1-oxide derivatives
EP0082648A3 (en) * 1981-12-21 1984-09-26 Imperial Chemical Industries Plc Cephalosporin derivatives
DK163000C (da) * 1982-09-30 1992-06-01 Shionogi & Co Analogifremgangsmaade til fremstilling af vinylthioacetamido-1-dethia-1-oxa-cephalosporinderivater
JPS59110695A (ja) * 1982-12-16 1984-06-26 Asahi Chem Ind Co Ltd 経口用セフアロスポリン
US4855420A (en) * 1983-06-03 1989-08-08 Ici Pharma Cephalosporin derivatives
US4547573A (en) * 1983-12-02 1985-10-15 Ici Pharma Process for preparing cephalosporin derivatives
US5817823A (en) * 1997-04-17 1998-10-06 Sepracor Inc. Method for synthesizing 2-substituted imidazoles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1032533A (en) * 1973-09-07 1978-06-06 William H. Koster Process for the production of cephalosporin compounds
JPS55133355A (en) * 1979-04-03 1980-10-17 Shionogi & Co Ltd Inversion of 3-amino group of beta-lactam ring
DE3071707D1 (en) * 1979-04-27 1986-09-25 Merck & Co Inc 7-n-heterocyclyl cephalosporins, a process for preparing and a pharmaceutical composition comprising the same
US4358447A (en) * 1979-04-27 1982-11-09 Merck & Co., Inc. 7-N-Heterocyclyl cephalosporins
FR2472574A1 (fr) * 1979-12-24 1981-07-03 Ici Pharma Derives de cephalosporine et composition pharmaceutique les contenant

Also Published As

Publication number Publication date
DE3173789D1 (en) 1986-03-27
AU7878681A (en) 1982-07-01
PT74173A (en) 1982-01-01
ES508280A0 (es) 1983-02-16
FI814132L (fi) 1982-06-23
YU45886B (sh) 1992-09-07
ES517824A0 (es) 1983-08-16
DK572581A (da) 1982-06-23
US4492692A (en) 1985-01-08
ZA818594B (en) 1982-12-29
FR2496666A1 (fr) 1982-06-25
EP0055562A3 (en) 1982-08-11
GR76914B (es) 1984-09-04
YU110983A (en) 1983-12-31
YU303981A (en) 1983-12-31
IL64512A0 (en) 1982-03-31
NO814372L (no) 1982-06-23
JPS57167991A (en) 1982-10-16
EP0055562B1 (en) 1986-02-12
ES8304140A1 (es) 1983-02-16
EP0055562A2 (en) 1982-07-07
PT74173B (en) 1983-05-17

Similar Documents

Publication Publication Date Title
AU557691B2 (en) 2-penem antibiotics and their oxa-aza-, and carba analogues
MY106366A (en) Bicyclic heterocyclic pryan derivatives and their use as inhibitors of 5-lipoxygenase
ES8307818A1 (es) Procedimiento para preparar derivados de cefalosporina.
NZ218243A (en) B-carboline derivatives and pharmaceutical compositions
ES8507090A1 (es) Procedimiento para la obtencion de nuevas 1, 5-benzotiacepinas
JPS57116088A (en) Novel cephalosporin derivatives and manufacture
FI832639A (fi) Nya muramylpeptider och foerfarande foer deras framstaellning
ES8502093A1 (es) Derivados de quinolina.
ES8502091A1 (es) Procedimiento para preparar derivados de bencilcarbamoilpiridina.
ES428267A1 (es) Procedimiento para la produccion de derivados de guanidina.
ES466363A1 (es) Procedimiento para la obtencion de acido n-9,10-dihidro - lisergil-m-amino-benzoico
ES479444A1 (es) Un procedimiento para preparar derivados de pirrolidincarbo-xaldehido y piperidicarboxaldehido.
DK481883A (da) Fremgangsmaade til fremstilling af cephalosporinderivater
ES8307821A1 (es) "procedimiento para la preparacion de nuevas cefalosporinas".
ES8403888A1 (es) Un procedimiento para la preparacion de un 1h- o 2h-tetrazol-5-tiol.
ES8504707A1 (es) Derivados del indol
ES475780A1 (es) Un proceso para la produccion de nueva penicilina y deriva- dos cefalosporinicos
GB2023142A (en) Ureido Cephelosporins
AU551901B2 (en) Substituted thienobenzodiazepinones
ES8307255A1 (es) Procedimiento para preparar derivados de cefalosporina.
ES482550A1 (es) Un procedimiento para la produccion de derivados de cefalos-porina.
ES479378A1 (es) Un procedimiento para la preparacion de compuestos de cefa- losporina.
ATE148462T1 (de) Isoxazole derivate als lichtschutzmittel
ES8506725A1 (es) Procedimiento para la preparacion de un derivado de cefalosporina
ES448065A1 (es) Procedimiento para la preparacion de derivados de 3-nitropi-razol.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201