ES8201164A1 - Un procedimiento para la preparacion de nuevos derivados de quinazolina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de quinazolina

Info

Publication number
ES8201164A1
ES8201164A1 ES499454A ES499454A ES8201164A1 ES 8201164 A1 ES8201164 A1 ES 8201164A1 ES 499454 A ES499454 A ES 499454A ES 499454 A ES499454 A ES 499454A ES 8201164 A1 ES8201164 A1 ES 8201164A1
Authority
ES
Spain
Prior art keywords
formula
see diagramm
compound
pharmaceutical preparations
quinazoline derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499454A
Other languages
English (en)
Other versions
ES499454A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/050,395 external-priority patent/US4256748A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES499454A0 publication Critical patent/ES499454A0/es
Publication of ES8201164A1 publication Critical patent/ES8201164A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE QUINAZOLINA DE FORMULA (I), EN QUE R1 ES BROMO Y R2 METILO O CLORO, O BIEN R1 ES METOXILO Y R2 CLORO. SE HACE REACCIONAR CON CALENTAMIENTO UN COMPUESTO DE FORMULA (II), EN QIE R3 ES ALQUILO INFERIOR, CON BROMURO DE CIANOGENO, EN UN MEDIO DISOLVENTE, COMO ALCANOL INFERIOR. SE AISLA EL PRODUCTO FINAL, Y OPCIONALMENTE, SE OBTIENE LA SAL DE ADICION DE ACIDO, POR REACCION CON UN ACIDO MINERAL. SE USAN EN PREPARDOS FARMACEUTICOS PARA LA PROFILAXIS DE LA TROMBOSIS, COMO AGENTES INHIBIDORES DE LA AGREGACION DE PLAQUETAS EN LA SANGRE.
ES499454A 1979-06-20 1981-02-16 Un procedimiento para la preparacion de nuevos derivados de quinazolina Expired ES8201164A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/050,395 US4256748A (en) 1977-07-25 1979-06-20 Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositions for treatment and prophylaxis of cardiac insufficiency and cardiac failure
CH360080 1980-05-08

Publications (2)

Publication Number Publication Date
ES499454A0 ES499454A0 (es) 1981-12-01
ES8201164A1 true ES8201164A1 (es) 1981-12-01

Family

ID=25693404

Family Applications (3)

Application Number Title Priority Date Filing Date
ES492573A Granted ES492573A0 (es) 1979-06-20 1980-06-19 Un procedimiento para la preparacion de nuevos derivados de quinazolina
ES499454A Expired ES8201164A1 (es) 1979-06-20 1981-02-16 Un procedimiento para la preparacion de nuevos derivados de quinazolina
ES499455A Granted ES499455A0 (es) 1979-06-20 1981-02-16 Un procedimiento para la preparacion de nuevos derivados de quinazolina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES492573A Granted ES492573A0 (es) 1979-06-20 1980-06-19 Un procedimiento para la preparacion de nuevos derivados de quinazolina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES499455A Granted ES499455A0 (es) 1979-06-20 1981-02-16 Un procedimiento para la preparacion de nuevos derivados de quinazolina

Country Status (14)

Country Link
EP (1) EP0021338B1 (es)
AU (1) AU538119B2 (es)
CA (1) CA1131631A (es)
DE (1) DE3065273D1 (es)
DK (1) DK259380A (es)
ES (3) ES492573A0 (es)
FI (1) FI66870C (es)
IL (1) IL60325A (es)
MC (1) MC1332A1 (es)
NO (1) NO801843L (es)
NZ (1) NZ194046A (es)
PH (1) PH16369A (es)
PT (1) PT71411B (es)
YU (1) YU161580A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054180A3 (de) * 1980-12-16 1982-12-01 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung eines Imidazochinazolinonderivates
US4783467A (en) * 1985-06-05 1988-11-08 Pfizer Inc. Tetrahydroimidazoquinazolinone inotropic agents
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
US7700608B2 (en) 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
US7910597B2 (en) 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
GB0623750D0 (en) 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
US3988340A (en) * 1975-01-23 1976-10-26 Bristol-Myers Company 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
US4146718A (en) * 1978-04-10 1979-03-27 Bristol-Myers Company Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides

Also Published As

Publication number Publication date
IL60325A (en) 1983-06-15
ES8206524A1 (es) 1982-08-16
NZ194046A (en) 1982-05-25
ES8105321A1 (es) 1981-06-01
CA1131631A (en) 1982-09-14
DE3065273D1 (de) 1983-11-17
MC1332A1 (fr) 1981-04-21
PT71411A (en) 1980-07-01
NO801843L (no) 1980-12-22
FI801910A (fi) 1980-12-21
PH16369A (en) 1983-09-14
FI66870C (fi) 1984-12-10
ES492573A0 (es) 1981-06-01
YU161580A (en) 1983-04-30
EP0021338B1 (de) 1983-10-12
AU538119B2 (en) 1984-08-02
DK259380A (da) 1980-12-21
IL60325A0 (en) 1980-09-16
PT71411B (en) 1981-12-11
ES499454A0 (es) 1981-12-01
AU5933980A (en) 1981-01-08
EP0021338A1 (de) 1981-01-07
ES499455A0 (es) 1982-08-16
FI66870B (fi) 1984-08-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009