ES2941742T3 - Composiciones y procedimientos para modular la expresión del factor B del complemento - Google Patents

Composiciones y procedimientos para modular la expresión del factor B del complemento Download PDF

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Publication number
ES2941742T3
ES2941742T3 ES19184459T ES19184459T ES2941742T3 ES 2941742 T3 ES2941742 T3 ES 2941742T3 ES 19184459 T ES19184459 T ES 19184459T ES 19184459 T ES19184459 T ES 19184459T ES 2941742 T3 ES2941742 T3 ES 2941742T3
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compound
modified
certain embodiments
carbohydrate
antisense
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Thazha Prakash
Punit Seth
Eric Swayze
Tamar Grossman
Michael Mccaleb
Andrew Watt
Susan Freier
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21047—Alternative-complement-pathway C3/C5 convertase (3.4.21.47), i.e. properdin factor B
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
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    • C12N2310/3525—MOE, methoxyethoxy

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ES19184459T 2014-05-01 2015-05-01 Composiciones y procedimientos para modular la expresión del factor B del complemento Active ES2941742T3 (es)

Applications Claiming Priority (2)

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US201461987471P 2014-05-01 2014-05-01
US201462076273P 2014-11-06 2014-11-06

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ES2941742T3 true ES2941742T3 (es) 2023-05-25

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ES19184459T Active ES2941742T3 (es) 2014-05-01 2015-05-01 Composiciones y procedimientos para modular la expresión del factor B del complemento
ES15786214T Active ES2745825T3 (es) 2014-05-01 2015-05-01 Composiciones y métodos para modular la expresión del factor B del complemento

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US (4) US10280423B2 (enExample)
EP (3) EP3608406B1 (enExample)
JP (2) JP6637442B2 (enExample)
KR (1) KR102369736B1 (enExample)
CN (2) CN106232804B (enExample)
AU (1) AU2015252858C1 (enExample)
BR (1) BR112016022593B1 (enExample)
CA (1) CA2943894A1 (enExample)
CL (2) CL2016002764A1 (enExample)
CR (2) CR20160554A (enExample)
DK (1) DK3137596T3 (enExample)
DO (1) DOP2016000291A (enExample)
EA (1) EA036496B1 (enExample)
ES (2) ES2941742T3 (enExample)
HR (1) HRP20191664T1 (enExample)
HU (1) HUE046272T2 (enExample)
IL (2) IL247883B (enExample)
LT (1) LT3137596T (enExample)
MX (1) MX380866B (enExample)
PE (2) PE20170010A1 (enExample)
PH (1) PH12016502062B1 (enExample)
PL (2) PL3137596T3 (enExample)
PT (1) PT3137596T (enExample)
RS (1) RS59182B1 (enExample)
RU (1) RU2701645C2 (enExample)
SG (2) SG11201608502TA (enExample)
SI (1) SI3137596T1 (enExample)
UA (1) UA121656C2 (enExample)
WO (1) WO2015168635A2 (enExample)

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CN105744959B (zh) * 2013-09-13 2020-12-01 Ionis制药公司 补体因子b的调节剂
PT3137596T (pt) 2014-05-01 2019-09-27 Ionis Pharmaceuticals Inc Composições e métodos para modulação da expressão do factor b do complemento
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KR20250078597A (ko) * 2015-11-06 2025-06-02 아이오니스 파마수티컬즈, 인코포레이티드 아포리포프로테인 (a) 발현 조정
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EP3990465A1 (en) * 2019-06-25 2022-05-04 Amgen Inc. Purification methods for carbohydrate-linked oligonucleotides
US12290567B2 (en) 2019-09-03 2025-05-06 Arcturus Therapeutics, Inc. Asialoglycoprotein Receptor mediated delivery of therapeutically active conjugates
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US12447173B2 (en) 2019-12-26 2025-10-21 Eisai R&D Management Co., Ltd. Pharmaceutical composition containing double-stranded ribonucleic acid inhibiting expression of complement C5
KR20230017789A (ko) * 2020-04-30 2023-02-06 알닐람 파마슈티칼스 인코포레이티드 보체 인자 B (CFB) iRNA 조성물 및 이의 사용 방법
IL310180A (en) * 2021-07-17 2024-03-01 Sirnaomics Inc products and preparations
IL311146A (en) 2021-09-02 2024-04-01 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of complement factor b (cfb) in a cell
CA3234636A1 (en) * 2021-10-29 2023-05-04 Alnylam Pharmaceuticals, Inc. Complement factor b (cfb) irna compositions and methods of use thereof
EP4611768A1 (en) * 2022-11-02 2025-09-10 Ionis Pharmaceuticals, Inc. Methods for modulating complement factor b expression
EP4638743A2 (en) * 2022-12-19 2025-10-29 Sanegene Bio USA Inc. Small interfering rna targeting cfb and uses thereof
AU2024240837A1 (en) * 2023-03-21 2025-09-11 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of complement factor b (cfb) pharmaceutical compositions thereof, and methods of use
WO2024245424A1 (zh) * 2023-06-02 2024-12-05 维亚臻生物技术（苏州）有限公司 一种用于免疫类疾病的双链核苷酸化合物及其应用
CN118620964A (zh) * 2023-06-28 2024-09-10 百奥赛图(北京)医药科技股份有限公司 一种cfb基因修饰的非人动物
TW202519657A (zh) * 2023-07-28 2025-05-16 大陸商蘇州炫景生物科技有限公司 Cfb抑制劑組合物及其應用
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