CL2016002764A1 - Composiciones y métodos para modular la expresión del factor b del complemento - Google Patents

Composiciones y métodos para modular la expresión del factor b del complemento

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Publication number
CL2016002764A1
CL2016002764A1 CL2016002764A CL2016002764A CL2016002764A1 CL 2016002764 A1 CL2016002764 A1 CL 2016002764A1 CL 2016002764 A CL2016002764 A CL 2016002764A CL 2016002764 A CL2016002764 A CL 2016002764A CL 2016002764 A1 CL2016002764 A1 CL 2016002764A1
Authority
CL
Chile
Prior art keywords
modulate
expression
compositions
methods
complement factor
Prior art date
Application number
CL2016002764A
Other languages
English (en)
Spanish (es)
Inventor
Susan M Freier
Punit P Seth
Thazha P Prakash
Tamar R Grossman
Michael L Mccaleb
Andrew T Watt
Eric E Swayze
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of CL2016002764A1 publication Critical patent/CL2016002764A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21047—Alternative-complement-pathway C3/C5 convertase (3.4.21.47), i.e. properdin factor B
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
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    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy

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CL2016002764A 2014-05-01 2016-11-02 Composiciones y métodos para modular la expresión del factor b del complemento CL2016002764A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461987471P 2014-05-01 2014-05-01
US201462076273P 2014-11-06 2014-11-06

Publications (1)

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CL2016002764A1 true CL2016002764A1 (es) 2017-12-29

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CL2016002764A CL2016002764A1 (es) 2014-05-01 2016-11-02 Composiciones y métodos para modular la expresión del factor b del complemento
CL2018001996A CL2018001996A1 (es) 2014-05-01 2018-07-23 Composiciones y métodos para modular la expresión del factor b del complemento (divisional de solicitud 2764-16)

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CL2018001996A CL2018001996A1 (es) 2014-05-01 2018-07-23 Composiciones y métodos para modular la expresión del factor b del complemento (divisional de solicitud 2764-16)

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US (4) US10280423B2 (enExample)
EP (3) EP3608406B1 (enExample)
JP (2) JP6637442B2 (enExample)
KR (1) KR102369736B1 (enExample)
CN (2) CN106232804B (enExample)
AU (1) AU2015252858C1 (enExample)
BR (1) BR112016022593B1 (enExample)
CA (1) CA2943894A1 (enExample)
CL (2) CL2016002764A1 (enExample)
CR (2) CR20200228A (enExample)
DK (1) DK3137596T3 (enExample)
DO (1) DOP2016000291A (enExample)
EA (1) EA036496B1 (enExample)
ES (2) ES2745825T3 (enExample)
HR (1) HRP20191664T1 (enExample)
HU (1) HUE046272T2 (enExample)
IL (2) IL247883B (enExample)
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WO2021132462A1 (ja) 2019-12-26 2021-07-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 補体ｃ５の発現を抑制する二本鎖リボ核酸を含む医薬組成物
JP2023523790A (ja) * 2020-04-30 2023-06-07 アルナイラム ファーマシューティカルズ， インコーポレイテッド 補体因子Ｂ（ＣＦＢ）ｉＲＮＡ組成物およびその使用方法
JP2024525868A (ja) * 2021-07-17 2024-07-12 サーナオミクス インコーポレイテッド 産物及び組成物
EP4396346A1 (en) 2021-09-02 2024-07-10 Silence Therapeutics GmbH Nucleic acids for inhibiting expression of complement factor b (cfb) in a cell
AR127477A1 (es) * 2021-10-29 2024-01-31 Alnylam Pharmaceuticals Inc COMPOSICIONES DE ARNi CONTRA EL FACTOR B DEL COMPLEMENTO (CFB) Y MÉTODOS DE USO DE LAS MISMAS
AU2023372971A1 (en) * 2022-11-02 2025-05-15 Ionis Pharmaceuticals, Inc. Methods for modulating complement factor b expression
EP4638743A2 (en) * 2022-12-19 2025-10-29 Sanegene Bio USA Inc. Small interfering rna targeting cfb and uses thereof
WO2024197017A2 (en) * 2023-03-21 2024-09-26 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of complement factor b (cfb) pharmaceutical compositions thereof, and methods of use
TW202513799A (zh) * 2023-06-02 2025-04-01 大陸商維亞臻生物技術（蘇州）有限公司 用於免疫類疾病的雙鏈核苷酸化合物及其用途
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