ES2797650T3 - Administración de lípido eficiente a película lagrimal humana usando un sistema de emulsión sensible a sal - Google Patents

Administración de lípido eficiente a película lagrimal humana usando un sistema de emulsión sensible a sal Download PDF

Info

Publication number
ES2797650T3
ES2797650T3 ES12808606T ES12808606T ES2797650T3 ES 2797650 T3 ES2797650 T3 ES 2797650T3 ES 12808606 T ES12808606 T ES 12808606T ES 12808606 T ES12808606 T ES 12808606T ES 2797650 T3 ES2797650 T3 ES 2797650T3
Authority
ES
Spain
Prior art keywords
concentration
salt
pharmaceutical composition
ophthalmic pharmaceutical
low
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12808606T
Other languages
English (en)
Spanish (es)
Inventor
Peter A Simmons
Joseph G Vehige
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47459152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2797650(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ES2797650T3 publication Critical patent/ES2797650T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/717Celluloses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES12808606T 2011-12-07 2012-12-07 Administración de lípido eficiente a película lagrimal humana usando un sistema de emulsión sensible a sal Active ES2797650T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161568089P 2011-12-07 2011-12-07
US201261625401P 2012-04-17 2012-04-17
PCT/US2012/068603 WO2013086438A1 (en) 2011-12-07 2012-12-07 Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

Publications (1)

Publication Number Publication Date
ES2797650T3 true ES2797650T3 (es) 2020-12-03

Family

ID=47459152

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12808607T Active ES2896336T3 (es) 2011-12-07 2012-12-07 Suministro eficiente de lípidos a película lagrimal humana usando un sistema de emulsión sensible a sales
ES12808606T Active ES2797650T3 (es) 2011-12-07 2012-12-07 Administración de lípido eficiente a película lagrimal humana usando un sistema de emulsión sensible a sal

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES12808607T Active ES2896336T3 (es) 2011-12-07 2012-12-07 Suministro eficiente de lípidos a película lagrimal humana usando un sistema de emulsión sensible a sales

Country Status (27)

Country Link
US (2) US20130150324A1 (enExample)
EP (5) EP3666257A1 (enExample)
JP (1) JP6142419B2 (enExample)
KR (1) KR102017922B1 (enExample)
CN (2) CN104114152A (enExample)
AR (1) AR089123A1 (enExample)
AU (2) AU2012347459A1 (enExample)
BR (1) BR112014013820A8 (enExample)
CA (1) CA2858574C (enExample)
CL (1) CL2014001518A1 (enExample)
CO (1) CO6990739A2 (enExample)
DK (2) DK2787968T3 (enExample)
ES (2) ES2896336T3 (enExample)
HU (2) HUE057140T2 (enExample)
IL (1) IL233008A (enExample)
IN (1) IN2014CN04809A (enExample)
MX (1) MX355216B (enExample)
MY (1) MY173378A (enExample)
PH (2) PH12021553172A1 (enExample)
PL (2) PL2787968T3 (enExample)
PT (2) PT2787969T (enExample)
RU (1) RU2014127074A (enExample)
SG (1) SG11201403013VA (enExample)
SI (2) SI2787969T1 (enExample)
TW (1) TWI652072B (enExample)
WO (2) WO2013086449A1 (enExample)
ZA (1) ZA201404228B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957048B2 (en) * 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
PT3266446T (pt) 2016-07-07 2019-01-30 Salvat Lab Sa Composição oftálmica compreendendo óleo de rícino e triglicérido de cadeia média
WO2018035469A1 (en) 2016-08-19 2018-02-22 Akrivista, LLC Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye
WO2019036625A1 (en) 2017-08-18 2019-02-21 Akrivista, LLC METHODS FOR DIAGNOSING AND TREATING DRY-LIKE SYNDROME AND COMPOSITIONS FOR TREATING A HUMAN EYE
EP3784354A1 (en) 2018-04-27 2021-03-03 Allergan, Inc. Sodium chlorite compositions with enhanced anti-microbial efficacy and reduced toxicity
WO2025175150A1 (en) * 2024-02-16 2025-08-21 Allergan, Inc. Enhanced artificial tear formulations

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201706A (en) 1978-09-22 1980-05-06 Burton, Parsons & Company, Inc. Treatment of corneal edema
DE3066859D1 (en) * 1979-10-26 1984-04-12 Smith & Nephew Ass Autoclavable emulsions
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
IT1224795B (it) 1988-12-01 1990-10-24 Sigma Tau Ind Farmaceuti Uso dell'acetil d-carnitina nel trattamento terapeutico del glaucoma e composizioni farmaceutiche utili in tale trattamento
DK0436726T3 (da) 1989-08-03 1993-12-27 Eisai Co Ltd Fotostabil oftalmisk opløsning og fremgangsmåde til fremstilling deraf
US5681555A (en) 1991-04-22 1997-10-28 Gleich; Gerald J. Method for the treatment of bronchial asthma by parenteral administration of anionic polymers
DE4229494A1 (de) 1992-09-04 1994-03-10 Basotherm Gmbh Arzneimittel zur topischen Anwendung am Auge zur Behandlung des erhöhten intraokularen Drucks
AU3484895A (en) 1994-09-14 1996-03-29 Taisho Pharmaceutical Co., Ltd. Eye drops for repairing corneal disturbance
US5980865A (en) 1995-08-18 1999-11-09 Baker Norton Pharmaceuticals, Inc. Method for treating late phase allergic reactions and inflammatory diseases
FI106923B (fi) 1997-01-03 2001-05-15 Cultor Ltd Finnsugar Bioproduc Trimetyyliglysiinin käyttö kehon limakalvojen hygieniaan ja hoitoon tarkoitetuissa valmisteissa
AR002194A1 (es) 1997-03-17 1998-01-07 Sanchez Reynaldo Alemany Instrumento computarizado para el analisis del movimiento.
IT1302307B1 (it) 1998-09-01 2000-09-05 Sigma Tau Healthscience Spa Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil
AU1295200A (en) 1998-11-13 2000-06-05 Continental Projects Limited Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions
JP2000159659A (ja) * 1998-11-30 2000-06-13 Kazuo Tsubota 眼科用人工涙液
US6228392B1 (en) 1999-04-29 2001-05-08 Gene Tools, Llc Osmotic delivery composition, solution, and method
CN1441679A (zh) 2000-07-14 2003-09-10 阿勒根公司 包含具有提高的溶解度的治疗活性组分的组合物
CA2355814C (en) 2000-09-14 2010-06-29 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Pharmaceutical composition for ophthalmic use
DK1339418T3 (da) 2000-11-08 2009-12-14 Fxs Ventures Llc Forbedret ophthalmiske og kontaktlinseoplösninger indeholdende simple saccharider som konserverende forstærkere
US7045121B2 (en) 2001-12-14 2006-05-16 Allergan, Inc. Ophthalmic compositions for lubricating eyes and methods for making and using same
JP2006504701A (ja) 2002-09-30 2006-02-09 マーク・エー・バビザイェフ 眼疾患の局所的治療方法、並びに、その治療用組成物及び治療用手段
ES2314284T3 (es) * 2002-10-18 2009-03-16 Aqueous Pharma Limited Formulacion lagrimal de tres capas.
US20040137079A1 (en) 2003-01-08 2004-07-15 Cook James N. Contact lens and eye drop rewetter compositions and methods
US6635654B1 (en) * 2003-01-09 2003-10-21 Allergan, Inc. Ophthalmic compositions containing loratadine
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
WO2004084877A1 (ja) 2003-03-26 2004-10-07 Menicon Co., Ltd. 眼科用組成物
CA2839930C (en) * 2003-06-13 2016-07-05 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
TWI336257B (en) * 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
US20050009836A1 (en) 2003-06-26 2005-01-13 Laskar Paul A. Ophthalmic composition containing quinolones and method of use
KR20060121151A (ko) * 2003-11-10 2006-11-28 도레이 가부시끼가이샤 다당류 함유 조성물 및 누액층 안정화 점안제
US8569367B2 (en) * 2004-11-16 2013-10-29 Allergan, Inc. Ophthalmic compositions and methods for treating eyes
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US9561178B2 (en) * 2006-07-25 2017-02-07 Allergan, Inc. Cyclosporin compositions
WO2008035246A2 (en) * 2006-07-28 2008-03-27 Novagali Pharma Sa Compositions containing quaternary ammonium compounds
CN101896160A (zh) * 2006-10-17 2010-11-24 阿勒根公司 环胞菌素组合物
US20080312194A1 (en) * 2007-02-28 2008-12-18 Ousler Iii George W Methods and compositions for normalizing meibomian gland secretions
JP4929245B2 (ja) 2008-07-31 2012-05-09 株式会社ベッセル工業 工具類のグリップ
HRP20171691T1 (hr) * 2009-06-05 2017-12-15 Allergan, Inc. Umjetne suze i njihova upotreba u terapiji
WO2013049621A1 (en) * 2011-09-29 2013-04-04 The Board Of Regents Of The University Of Oklahoma Ophthalmic compositions comprising ppar-alpha agonists and methods of production and use thereof
US8957048B2 (en) * 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye

Also Published As

Publication number Publication date
RU2018119362A3 (enExample) 2021-09-07
CA2858574C (en) 2017-05-30
CO6990739A2 (es) 2014-07-10
CN104114152A (zh) 2014-10-22
JP6142419B2 (ja) 2017-06-07
HK1201458A1 (en) 2015-09-04
PT2787968T (pt) 2020-06-16
PL2787968T3 (pl) 2020-08-24
WO2013086449A1 (en) 2013-06-13
IN2014CN04809A (enExample) 2015-09-18
KR20140107383A (ko) 2014-09-04
EP3666257A1 (en) 2020-06-17
IL233008A0 (en) 2014-07-31
SI2787969T1 (sl) 2021-12-31
AR089123A1 (es) 2014-07-30
PH12014501296A1 (en) 2014-10-08
US20130150324A1 (en) 2013-06-13
KR102017922B1 (ko) 2019-09-03
EP4403220A2 (en) 2024-07-24
MX355216B (es) 2018-04-10
WO2013086438A1 (en) 2013-06-13
HUE057140T2 (hu) 2022-04-28
RU2014127074A (ru) 2016-02-10
EP2787969A1 (en) 2014-10-15
TWI652072B (zh) 2019-03-01
AU2012347459A1 (en) 2014-07-03
HUE049489T2 (hu) 2020-09-28
HK1203057A1 (en) 2015-10-16
JP2015504860A (ja) 2015-02-16
DK2787969T3 (da) 2021-11-01
ES2896336T3 (es) 2022-02-24
PL2787969T3 (pl) 2021-12-20
SG11201403013VA (en) 2014-07-30
US20130197083A1 (en) 2013-08-01
US9314528B2 (en) 2016-04-19
PT2787969T (pt) 2021-11-09
EP2787968A1 (en) 2014-10-15
EP2787968B1 (en) 2020-03-04
PH12021553172A1 (en) 2024-05-27
EP2787969B1 (en) 2021-09-29
SI2787968T1 (sl) 2020-08-31
CA2858574A1 (en) 2013-06-13
PH12014501296B1 (en) 2023-04-05
AU2017265181A1 (en) 2017-12-14
TW201325633A (zh) 2013-07-01
BR112014013820A2 (pt) 2017-06-13
BR112014013820A8 (pt) 2017-06-13
IL233008A (en) 2017-07-31
EP3981387A1 (en) 2022-04-13
AU2017265181B2 (en) 2019-06-20
MY173378A (en) 2020-01-21
ZA201404228B (en) 2015-12-23
MX2014006804A (es) 2014-09-22
RU2018119362A (ru) 2018-11-08
CL2014001518A1 (es) 2014-10-24
DK2787968T3 (da) 2020-06-02
EP4403220A3 (en) 2024-10-23
CN108969482A (zh) 2018-12-11

Similar Documents

Publication Publication Date Title
ES2797650T3 (es) Administración de lípido eficiente a película lagrimal humana usando un sistema de emulsión sensible a sal
CN102355889B (zh) 基于多不饱和ω-3和ω-6脂肪酸的眼用组合物
ES2965828T3 (es) Composiciones de alcano semifluorado
Ammar et al. Nanoemulsion as a potential ophthalmic delivery system for dorzolamide hydrochloride
ES2974663T3 (es) Alcanos semifluorados para uso en la solubilización de meibomio
US8530449B2 (en) Composition for a topical ophthalmic clear colloidal liquid which undergoes a liquid-gel phase transition in the eye
US20240293491A1 (en) Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
ES2638868T3 (es) Emulsión lacrimomimética
Robciuc et al. Pure glaucoma drugs are toxic to immortalized human corneal epithelial cells, but they do not destabilize lipid membranes
ES2704918T3 (es) Composición oftálmica estable en almacenamiento
WO2011006079A2 (en) Ophthalmic formulations of reversed liquid crystalline phase materials and methods of using
BR112021011210A2 (pt) Formulações oftálmicas que proporcionam lubrificação ocular durável
EP3893887A1 (en) Lxr agonist in topical ophthalmic formulation for treatment of dry-eye disorder
BR112020014710A2 (pt) Emulsão oftálmica à base de lipídio
ES2731151T3 (es) Composiciones oftálmicas basadas en ácidos poliinsaturados y triacilgliceroles
HK40032380A (en) Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US20110177169A1 (en) Ophthalmic formulations of reversed liquid crystalline phase materials and methods of using
HK1201458B (en) Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US20260000725A1 (en) Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
WO2021045606A1 (es) Composición farmacéutica oftálmica, procesos de preparación y usos de las mismas
Fawzia et al. Ocular drug deliver and the importance of microemulsion as a potential delivery system
HK1166714B (en) Ophthalmic compositions based on polyunsaturated omega-3 and omega-6 fatty acids
TR201603173A1 (tr) Oftalmi̇k farmasöti̇k bi̇leşi̇mler