BR112014013820A2 - distribuição lipídica eficiente a um filme lacrimal humano usando um sistema de emulsão sensível ao sal - Google Patents
distribuição lipídica eficiente a um filme lacrimal humano usando um sistema de emulsão sensível ao salInfo
- Publication number
- BR112014013820A2 BR112014013820A2 BR112014013820A BR112014013820A BR112014013820A2 BR 112014013820 A2 BR112014013820 A2 BR 112014013820A2 BR 112014013820 A BR112014013820 A BR 112014013820A BR 112014013820 A BR112014013820 A BR 112014013820A BR 112014013820 A2 BR112014013820 A2 BR 112014013820A2
- Authority
- BR
- Brazil
- Prior art keywords
- salt
- tear film
- sensitive emulsion
- human tear
- emulsion system
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title abstract 4
- 150000002632 lipids Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 2
- 206010013774 Dry eye Diseases 0.000 abstract 2
- 239000004006 olive oil Substances 0.000 abstract 2
- 235000008390 olive oil Nutrition 0.000 abstract 2
- 241000499489 Castor canadensis Species 0.000 abstract 1
- 235000011779 Menyanthes trifoliata Nutrition 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 208000030533 eye disease Diseases 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
abstract a salt-free emulsion for the treatment of dry eye and other ocular conditions is disclosed which contains castor oil and does not contain olive oil which prolongs tbut and provides superior comfort. ______________________________________________________________ tradução resumo patente de invenção: "distribuição lipídica eficiente a um filme lacrimal humano usando um sistema de emulsão sensível ao sal". é descrita uma emulsão isenta de sal para o tratamento de olho seco e outras doenças oculares a qual contém óleo de rícino e não contém óleo de oliva, a qual prolonga o tbut e confere maior conforto.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161568089P | 2011-12-07 | 2011-12-07 | |
US201261625401P | 2012-04-17 | 2012-04-17 | |
PCT/US2012/068615 WO2013086449A1 (en) | 2011-12-07 | 2012-12-07 | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014013820A8 BR112014013820A8 (pt) | 2017-06-13 |
BR112014013820A2 true BR112014013820A2 (pt) | 2017-06-13 |
Family
ID=47459152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014013820A BR112014013820A2 (pt) | 2011-12-07 | 2012-12-07 | distribuição lipídica eficiente a um filme lacrimal humano usando um sistema de emulsão sensível ao sal |
Country Status (28)
Country | Link |
---|---|
US (2) | US20130150324A1 (pt) |
EP (5) | EP2787968B1 (pt) |
JP (1) | JP6142419B2 (pt) |
KR (1) | KR102017922B1 (pt) |
CN (2) | CN108969482A (pt) |
AR (1) | AR089123A1 (pt) |
AU (2) | AU2012347459A1 (pt) |
BR (1) | BR112014013820A2 (pt) |
CA (1) | CA2858574C (pt) |
CL (1) | CL2014001518A1 (pt) |
CO (1) | CO6990739A2 (pt) |
DK (2) | DK2787969T3 (pt) |
ES (2) | ES2896336T3 (pt) |
HK (2) | HK1201458A1 (pt) |
HU (2) | HUE057140T2 (pt) |
IL (1) | IL233008A (pt) |
IN (1) | IN2014CN04809A (pt) |
MX (1) | MX355216B (pt) |
MY (1) | MY173378A (pt) |
PH (1) | PH12014501296A1 (pt) |
PL (2) | PL2787969T3 (pt) |
PT (2) | PT2787969T (pt) |
RU (1) | RU2014127074A (pt) |
SG (1) | SG11201403013VA (pt) |
SI (2) | SI2787969T1 (pt) |
TW (1) | TWI652072B (pt) |
WO (2) | WO2013086449A1 (pt) |
ZA (1) | ZA201404228B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US8957048B2 (en) * | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
US9907826B2 (en) | 2011-12-07 | 2018-03-06 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
PL3266446T3 (pl) | 2016-07-07 | 2019-05-31 | Salvat Lab Sa | Kompozycja oftalmiczna zawierająca olej rycynowy i trójgliceryd o średniej długości łańcucha |
WO2018035469A1 (en) | 2016-08-19 | 2018-02-22 | Akrivista, LLC | Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye |
CN111295169A (zh) | 2017-08-18 | 2020-06-16 | 阿克里维斯塔有限责任公司 | 诊断和治疗干眼综合症的方法和用于治疗人类眼睛的组合物 |
CA3097998A1 (en) | 2018-04-27 | 2019-10-31 | Allergan, Inc. | Sodium chlorite compositions with enhanced anti-microbial efficacy and reduced toxicity |
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US4201706A (en) | 1978-09-22 | 1980-05-06 | Burton, Parsons & Company, Inc. | Treatment of corneal edema |
ATE6466T1 (de) * | 1979-10-26 | 1984-03-15 | Smith And Nephew Associated Companies P.L.C. | Autoklavierbare emulsionen. |
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IT1224795B (it) | 1988-12-01 | 1990-10-24 | Sigma Tau Ind Farmaceuti | Uso dell'acetil d-carnitina nel trattamento terapeutico del glaucoma e composizioni farmaceutiche utili in tale trattamento |
WO1991001718A1 (fr) | 1989-08-03 | 1991-02-21 | Eisai Co., Ltd. | Procede de photostabilisation pour collyre liquide et collyre liquide photostabilise |
US5681555A (en) | 1991-04-22 | 1997-10-28 | Gleich; Gerald J. | Method for the treatment of bronchial asthma by parenteral administration of anionic polymers |
DE4229494A1 (de) | 1992-09-04 | 1994-03-10 | Basotherm Gmbh | Arzneimittel zur topischen Anwendung am Auge zur Behandlung des erhöhten intraokularen Drucks |
AU3484895A (en) | 1994-09-14 | 1996-03-29 | Taisho Pharmaceutical Co., Ltd. | Eye drops for repairing corneal disturbance |
US5980865A (en) | 1995-08-18 | 1999-11-09 | Baker Norton Pharmaceuticals, Inc. | Method for treating late phase allergic reactions and inflammatory diseases |
FI106923B (fi) | 1997-01-03 | 2001-05-15 | Cultor Ltd Finnsugar Bioproduc | Trimetyyliglysiinin käyttö kehon limakalvojen hygieniaan ja hoitoon tarkoitetuissa valmisteissa |
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IT1302307B1 (it) | 1998-09-01 | 2000-09-05 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil |
WO2000029030A1 (en) | 1998-11-13 | 2000-05-25 | Continental Projects Limited | Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions |
JP2000159659A (ja) * | 1998-11-30 | 2000-06-13 | Kazuo Tsubota | 眼科用人工涙液 |
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KR20060121151A (ko) * | 2003-11-10 | 2006-11-28 | 도레이 가부시끼가이샤 | 다당류 함유 조성물 및 누액층 안정화 점안제 |
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US8957048B2 (en) * | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
-
2012
- 2012-12-07 SI SI201231957T patent/SI2787969T1/sl unknown
- 2012-12-07 MY MYPI2014001672A patent/MY173378A/en unknown
- 2012-12-07 US US13/708,783 patent/US20130150324A1/en not_active Abandoned
- 2012-12-07 MX MX2014006804A patent/MX355216B/es active IP Right Grant
- 2012-12-07 DK DK12808607.1T patent/DK2787969T3/da active
- 2012-12-07 CA CA2858574A patent/CA2858574C/en active Active
- 2012-12-07 PL PL12808607T patent/PL2787969T3/pl unknown
- 2012-12-07 BR BR112014013820A patent/BR112014013820A2/pt not_active Application Discontinuation
- 2012-12-07 HU HUE12808607A patent/HUE057140T2/hu unknown
- 2012-12-07 RU RU2014127074A patent/RU2014127074A/ru unknown
- 2012-12-07 PT PT128086071T patent/PT2787969T/pt unknown
- 2012-12-07 EP EP12808606.3A patent/EP2787968B1/en active Active
- 2012-12-07 CN CN201810890387.0A patent/CN108969482A/zh active Pending
- 2012-12-07 IN IN4809CHN2014 patent/IN2014CN04809A/en unknown
- 2012-12-07 EP EP21198843.1A patent/EP3981387A1/en active Pending
- 2012-12-07 JP JP2014546154A patent/JP6142419B2/ja active Active
- 2012-12-07 US US13/708,771 patent/US9314528B2/en active Active
- 2012-12-07 KR KR1020147018598A patent/KR102017922B1/ko active IP Right Grant
- 2012-12-07 SI SI201231783T patent/SI2787968T1/sl unknown
- 2012-12-07 EP EP24167560.2A patent/EP4403220A2/en active Pending
- 2012-12-07 HU HUE12808606A patent/HUE049489T2/hu unknown
- 2012-12-07 DK DK12808606.3T patent/DK2787968T3/da active
- 2012-12-07 ES ES12808607T patent/ES2896336T3/es active Active
- 2012-12-07 PT PT128086063T patent/PT2787968T/pt unknown
- 2012-12-07 WO PCT/US2012/068615 patent/WO2013086449A1/en active Application Filing
- 2012-12-07 AU AU2012347459A patent/AU2012347459A1/en not_active Abandoned
- 2012-12-07 EP EP12808607.1A patent/EP2787969B1/en active Active
- 2012-12-07 ES ES12808606T patent/ES2797650T3/es active Active
- 2012-12-07 WO PCT/US2012/068603 patent/WO2013086438A1/en active Application Filing
- 2012-12-07 CN CN201280067685.0A patent/CN104114152A/zh active Pending
- 2012-12-07 TW TW101146304A patent/TWI652072B/zh active
- 2012-12-07 EP EP20153344.5A patent/EP3666257A1/en active Pending
- 2012-12-07 PL PL12808606T patent/PL2787968T3/pl unknown
- 2012-12-07 AR ARP120104614A patent/AR089123A1/es not_active Application Discontinuation
- 2012-12-07 SG SG11201403013VA patent/SG11201403013VA/en unknown
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2014
- 2014-06-06 PH PH12014501296A patent/PH12014501296A1/en unknown
- 2014-06-08 IL IL233008A patent/IL233008A/en active IP Right Grant
- 2014-06-09 ZA ZA2014/04228A patent/ZA201404228B/en unknown
- 2014-06-09 CL CL2014001518A patent/CL2014001518A1/es unknown
- 2014-06-26 CO CO14138315A patent/CO6990739A2/es unknown
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2015
- 2015-02-27 HK HK15102023.0A patent/HK1201458A1/xx unknown
- 2015-04-14 HK HK15103604.5A patent/HK1203057A1/xx unknown
-
2017
- 2017-11-27 AU AU2017265181A patent/AU2017265181B2/en active Active
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