AU2012347459A1 - Efficient lipid delivery to human tear film using a salt-sensitive emulsion system - Google Patents

Efficient lipid delivery to human tear film using a salt-sensitive emulsion system Download PDF

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Publication number
AU2012347459A1
AU2012347459A1 AU2012347459A AU2012347459A AU2012347459A1 AU 2012347459 A1 AU2012347459 A1 AU 2012347459A1 AU 2012347459 A AU2012347459 A AU 2012347459A AU 2012347459 A AU2012347459 A AU 2012347459A AU 2012347459 A1 AU2012347459 A1 AU 2012347459A1
Authority
AU
Australia
Prior art keywords
nge
dry eye
eye
treatment
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2012347459A
Other languages
English (en)
Inventor
Peter A. Simmons
Joseph G. Vehige
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47459152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2012347459(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AU2012347459A1 publication Critical patent/AU2012347459A1/en
Priority to AU2017265181A priority Critical patent/AU2017265181B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/717Celluloses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2012347459A 2011-12-07 2012-12-07 Efficient lipid delivery to human tear film using a salt-sensitive emulsion system Abandoned AU2012347459A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017265181A AU2017265181B2 (en) 2011-12-07 2017-11-27 Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161568089P 2011-12-07 2011-12-07
US61/568,089 2011-12-07
US201261625401P 2012-04-17 2012-04-17
US61/625,401 2012-04-17
PCT/US2012/068615 WO2013086449A1 (en) 2011-12-07 2012-12-07 Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017265181A Division AU2017265181B2 (en) 2011-12-07 2017-11-27 Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

Publications (1)

Publication Number Publication Date
AU2012347459A1 true AU2012347459A1 (en) 2014-07-03

Family

ID=47459152

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2012347459A Abandoned AU2012347459A1 (en) 2011-12-07 2012-12-07 Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
AU2017265181A Active AU2017265181B2 (en) 2011-12-07 2017-11-27 Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017265181A Active AU2017265181B2 (en) 2011-12-07 2017-11-27 Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

Country Status (27)

Country Link
US (2) US9314528B2 (enExample)
EP (5) EP3666257A1 (enExample)
JP (1) JP6142419B2 (enExample)
KR (1) KR102017922B1 (enExample)
CN (2) CN104114152A (enExample)
AR (1) AR089123A1 (enExample)
AU (2) AU2012347459A1 (enExample)
BR (1) BR112014013820A8 (enExample)
CA (1) CA2858574C (enExample)
CL (1) CL2014001518A1 (enExample)
CO (1) CO6990739A2 (enExample)
DK (2) DK2787968T3 (enExample)
ES (2) ES2797650T3 (enExample)
HU (2) HUE057140T2 (enExample)
IL (1) IL233008A (enExample)
IN (1) IN2014CN04809A (enExample)
MX (1) MX355216B (enExample)
MY (1) MY173378A (enExample)
PH (2) PH12014501296B1 (enExample)
PL (2) PL2787968T3 (enExample)
PT (2) PT2787969T (enExample)
RU (1) RU2014127074A (enExample)
SG (1) SG11201403013VA (enExample)
SI (2) SI2787969T1 (enExample)
TW (1) TWI652072B (enExample)
WO (2) WO2013086449A1 (enExample)
ZA (1) ZA201404228B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957048B2 (en) * 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
DK3266446T3 (en) 2016-07-07 2019-02-11 Salvat Lab Sa Eye preparation comprising castor oil and medium chain triglyceride
EP3500344A4 (en) 2016-08-19 2020-08-05 Akrivista, LLC METHODS OF DIAGNOSIS AND TREATMENT OF DRY EYE SYNDROME AND COMPOSITIONS FOR TREATMENT OF A HUMAN EYE
CA3072494A1 (en) 2017-08-18 2019-02-21 Akrivista, LLC Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye
TW202014194A (zh) 2018-04-27 2020-04-16 美商歐樂根公司 抗微生物功效增強且毒性降低之亞氯酸鈉組成物
WO2025175150A1 (en) * 2024-02-16 2025-08-21 Allergan, Inc. Enhanced artificial tear formulations

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201706A (en) 1978-09-22 1980-05-06 Burton, Parsons & Company, Inc. Treatment of corneal edema
ATE6466T1 (de) * 1979-10-26 1984-03-15 Smith And Nephew Associated Companies P.L.C. Autoklavierbare emulsionen.
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
IT1224795B (it) 1988-12-01 1990-10-24 Sigma Tau Ind Farmaceuti Uso dell'acetil d-carnitina nel trattamento terapeutico del glaucoma e composizioni farmaceutiche utili in tale trattamento
WO1991001718A1 (en) 1989-08-03 1991-02-21 Eisai Co., Ltd. Method of photostabilizing eyewash and photostabilized eyewash
US5681555A (en) 1991-04-22 1997-10-28 Gleich; Gerald J. Method for the treatment of bronchial asthma by parenteral administration of anionic polymers
DE4229494A1 (de) 1992-09-04 1994-03-10 Basotherm Gmbh Arzneimittel zur topischen Anwendung am Auge zur Behandlung des erhöhten intraokularen Drucks
CA2199610A1 (en) 1994-09-14 1996-03-21 Taisho Pharmaceutical Co., Ltd. Eye drops for repairing repairing corneal damage
US5980865A (en) 1995-08-18 1999-11-09 Baker Norton Pharmaceuticals, Inc. Method for treating late phase allergic reactions and inflammatory diseases
FI106923B (fi) 1997-01-03 2001-05-15 Cultor Ltd Finnsugar Bioproduc Trimetyyliglysiinin käyttö kehon limakalvojen hygieniaan ja hoitoon tarkoitetuissa valmisteissa
AR002194A1 (es) 1997-03-17 1998-01-07 Sanchez Reynaldo Alemany Instrumento computarizado para el analisis del movimiento.
IT1302307B1 (it) 1998-09-01 2000-09-05 Sigma Tau Healthscience Spa Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil
DE69919379T2 (de) 1998-11-13 2005-09-08 Continental Projects Ltd. Komplexe von hyaluronic saure/carnitinen und pharmazeutische und kosmetische zusammensetzungen
JP2000159659A (ja) * 1998-11-30 2000-06-13 Kazuo Tsubota 眼科用人工涙液
US6228392B1 (en) 1999-04-29 2001-05-08 Gene Tools, Llc Osmotic delivery composition, solution, and method
JP2004503593A (ja) 2000-07-14 2004-02-05 アラーガン、インコーポレイテッド 増大した溶解度を持つ治療活性成分を含む組成物
CA2355814C (en) 2000-09-14 2010-06-29 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Pharmaceutical composition for ophthalmic use
CN1245166C (zh) 2000-11-08 2006-03-15 生物概念实验室 改进的含有单糖类作为防腐增强剂的眼科和隐形眼镜用溶液
US7045121B2 (en) 2001-12-14 2006-05-16 Allergan, Inc. Ophthalmic compositions for lubricating eyes and methods for making and using same
EP1551399A4 (en) 2002-09-30 2011-01-05 Mark A Babizhayev METHOD FOR THE TOPICAL TREATMENT OF EYE DISEASES AND COMPOSITION AND DEVICE FOR THIS TREATMENT
AU2003301263A1 (en) * 2002-10-18 2004-05-04 Joel S. Echols Three layer tear formulation
US20040137079A1 (en) 2003-01-08 2004-07-15 Cook James N. Contact lens and eye drop rewetter compositions and methods
US6635654B1 (en) * 2003-01-09 2003-10-21 Allergan, Inc. Ophthalmic compositions containing loratadine
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
JPWO2004084877A1 (ja) 2003-03-26 2006-06-29 株式会社メニコン 眼科用組成物
TWI336257B (en) * 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
KR101147046B1 (ko) * 2003-06-13 2012-05-22 알콘, 인코퍼레이티드 시너지성의 2개의 폴리머 배합물을 포함하는 안과용 조성물
US20050009836A1 (en) 2003-06-26 2005-01-13 Laskar Paul A. Ophthalmic composition containing quinolones and method of use
WO2005046728A1 (ja) * 2003-11-10 2005-05-26 Toray Industries, Inc. 多糖類含有組成物および涙液層安定化点眼剤
US8569367B2 (en) 2004-11-16 2013-10-29 Allergan, Inc. Ophthalmic compositions and methods for treating eyes
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US9561178B2 (en) * 2006-07-25 2017-02-07 Allergan, Inc. Cyclosporin compositions
WO2008035246A2 (en) * 2006-07-28 2008-03-27 Novagali Pharma Sa Compositions containing quaternary ammonium compounds
CN101896160A (zh) * 2006-10-17 2010-11-24 阿勒根公司 环胞菌素组合物
CA2679448A1 (en) * 2007-02-28 2008-09-04 Aciex, Inc. Methods and compositions for normalizing meibomian gland secretions
JP4929245B2 (ja) 2008-07-31 2012-05-09 株式会社ベッセル工業 工具類のグリップ
DK2437762T3 (da) * 2009-06-05 2017-11-20 Allergan Inc Kunstige tårer og terapeutiske anvendelser
WO2013049621A1 (en) * 2011-09-29 2013-04-04 The Board Of Regents Of The University Of Oklahoma Ophthalmic compositions comprising ppar-alpha agonists and methods of production and use thereof
US8957048B2 (en) * 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye

Also Published As

Publication number Publication date
CN108969482A (zh) 2018-12-11
HK1203057A1 (en) 2015-10-16
US20130197083A1 (en) 2013-08-01
PH12014501296A1 (en) 2014-10-08
US9314528B2 (en) 2016-04-19
MX355216B (es) 2018-04-10
EP4403220A2 (en) 2024-07-24
CL2014001518A1 (es) 2014-10-24
AU2017265181B2 (en) 2019-06-20
ES2896336T3 (es) 2022-02-24
AR089123A1 (es) 2014-07-30
MX2014006804A (es) 2014-09-22
HUE049489T2 (hu) 2020-09-28
PT2787968T (pt) 2020-06-16
JP2015504860A (ja) 2015-02-16
PH12014501296B1 (en) 2023-04-05
JP6142419B2 (ja) 2017-06-07
IN2014CN04809A (enExample) 2015-09-18
EP2787968B1 (en) 2020-03-04
EP2787969B1 (en) 2021-09-29
PT2787969T (pt) 2021-11-09
PL2787969T3 (pl) 2021-12-20
BR112014013820A2 (pt) 2017-06-13
SI2787969T1 (sl) 2021-12-31
CN104114152A (zh) 2014-10-22
PH12021553172A1 (en) 2024-05-27
BR112014013820A8 (pt) 2017-06-13
US20130150324A1 (en) 2013-06-13
EP3981387A1 (en) 2022-04-13
MY173378A (en) 2020-01-21
TW201325633A (zh) 2013-07-01
ZA201404228B (en) 2015-12-23
KR102017922B1 (ko) 2019-09-03
EP4403220A3 (en) 2024-10-23
EP2787968A1 (en) 2014-10-15
RU2018119362A (ru) 2018-11-08
CA2858574C (en) 2017-05-30
RU2014127074A (ru) 2016-02-10
SI2787968T1 (sl) 2020-08-31
IL233008A (en) 2017-07-31
CO6990739A2 (es) 2014-07-10
HUE057140T2 (hu) 2022-04-28
DK2787968T3 (da) 2020-06-02
KR20140107383A (ko) 2014-09-04
WO2013086438A1 (en) 2013-06-13
CA2858574A1 (en) 2013-06-13
HK1201458A1 (en) 2015-09-04
RU2018119362A3 (enExample) 2021-09-07
ES2797650T3 (es) 2020-12-03
DK2787969T3 (da) 2021-11-01
AU2017265181A1 (en) 2017-12-14
EP3666257A1 (en) 2020-06-17
SG11201403013VA (en) 2014-07-30
PL2787968T3 (pl) 2020-08-24
TWI652072B (zh) 2019-03-01
IL233008A0 (en) 2014-07-31
WO2013086449A1 (en) 2013-06-13
EP2787969A1 (en) 2014-10-15

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