TWI652072B - 使用鹽敏感性乳液系統對人類淚液膜進行高效脂質傳遞 - Google Patents
使用鹽敏感性乳液系統對人類淚液膜進行高效脂質傳遞 Download PDFInfo
- Publication number
- TWI652072B TWI652072B TW101146304A TW101146304A TWI652072B TW I652072 B TWI652072 B TW I652072B TW 101146304 A TW101146304 A TW 101146304A TW 101146304 A TW101146304 A TW 101146304A TW I652072 B TWI652072 B TW I652072B
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- Prior art keywords
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- salt
- pharmaceutical composition
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- ophthalmic pharmaceutical
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568089P | 2011-12-07 | 2011-12-07 | |
| US61/568,089 | 2011-12-07 | ||
| US201261625401P | 2012-04-17 | 2012-04-17 | |
| US61/625,401 | 2012-04-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201325633A TW201325633A (zh) | 2013-07-01 |
| TWI652072B true TWI652072B (zh) | 2019-03-01 |
Family
ID=47459152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101146304A TWI652072B (zh) | 2011-12-07 | 2012-12-07 | 使用鹽敏感性乳液系統對人類淚液膜進行高效脂質傳遞 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US20130150324A1 (enExample) |
| EP (5) | EP3981387A1 (enExample) |
| JP (1) | JP6142419B2 (enExample) |
| KR (1) | KR102017922B1 (enExample) |
| CN (2) | CN108969482A (enExample) |
| AR (1) | AR089123A1 (enExample) |
| AU (2) | AU2012347459A1 (enExample) |
| BR (1) | BR112014013820A2 (enExample) |
| CA (1) | CA2858574C (enExample) |
| CL (1) | CL2014001518A1 (enExample) |
| CO (1) | CO6990739A2 (enExample) |
| DK (2) | DK2787969T3 (enExample) |
| ES (2) | ES2797650T3 (enExample) |
| HU (2) | HUE057140T2 (enExample) |
| IL (1) | IL233008A (enExample) |
| IN (1) | IN2014CN04809A (enExample) |
| MX (1) | MX355216B (enExample) |
| MY (1) | MY173378A (enExample) |
| PH (2) | PH12014501296B1 (enExample) |
| PL (2) | PL2787968T3 (enExample) |
| PT (2) | PT2787968T (enExample) |
| RU (1) | RU2014127074A (enExample) |
| SG (1) | SG11201403013VA (enExample) |
| SI (2) | SI2787968T1 (enExample) |
| TW (1) | TWI652072B (enExample) |
| WO (2) | WO2013086449A1 (enExample) |
| ZA (1) | ZA201404228B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8957048B2 (en) * | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
| US9907826B2 (en) | 2011-12-07 | 2018-03-06 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
| DK3266446T3 (en) | 2016-07-07 | 2019-02-11 | Salvat Lab Sa | Eye preparation comprising castor oil and medium chain triglyceride |
| CA3032695C (en) | 2016-08-19 | 2021-11-23 | Akrivista, LLC | Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye |
| BR112020003276A2 (pt) | 2017-08-18 | 2020-09-01 | Akrivista, LLC | métodos de diagnóstico e tratamento da síndrome do olho seco e composições para tratamento de um olho humano |
| JP7490570B2 (ja) | 2018-04-27 | 2024-05-27 | アラーガン、インコーポレイテッド | 抗微生物有効性の増強及び毒性の減少を有する亜塩素酸ナトリウム組成物 |
| WO2025175150A1 (en) * | 2024-02-16 | 2025-08-21 | Allergan, Inc. | Enhanced artificial tear formulations |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201316984A (zh) | 2011-10-06 | 2013-05-01 | Allergan Inc | 治療乾眼病的組合物 |
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| US4201706A (en) | 1978-09-22 | 1980-05-06 | Burton, Parsons & Company, Inc. | Treatment of corneal edema |
| ATE6466T1 (de) * | 1979-10-26 | 1984-03-15 | Smith And Nephew Associated Companies P.L.C. | Autoklavierbare emulsionen. |
| US5192535A (en) | 1988-02-08 | 1993-03-09 | Insite Vision Incorporated | Ophthalmic suspensions |
| IT1224795B (it) | 1988-12-01 | 1990-10-24 | Sigma Tau Ind Farmaceuti | Uso dell'acetil d-carnitina nel trattamento terapeutico del glaucoma e composizioni farmaceutiche utili in tale trattamento |
| ES2038580T3 (es) | 1989-08-03 | 1994-10-16 | Eisai Co Ltd | Metodo de fotoestabilizacion de soluciones oftalmicas. |
| US5681555A (en) | 1991-04-22 | 1997-10-28 | Gleich; Gerald J. | Method for the treatment of bronchial asthma by parenteral administration of anionic polymers |
| DE4229494A1 (de) | 1992-09-04 | 1994-03-10 | Basotherm Gmbh | Arzneimittel zur topischen Anwendung am Auge zur Behandlung des erhöhten intraokularen Drucks |
| EP0778021A4 (en) | 1994-09-14 | 1998-06-03 | Taisho Pharmaceutical Co Ltd | DROPS TO CARE FOR THE CORNEA |
| US5980865A (en) | 1995-08-18 | 1999-11-09 | Baker Norton Pharmaceuticals, Inc. | Method for treating late phase allergic reactions and inflammatory diseases |
| FI106923B (fi) | 1997-01-03 | 2001-05-15 | Cultor Ltd Finnsugar Bioproduc | Trimetyyliglysiinin käyttö kehon limakalvojen hygieniaan ja hoitoon tarkoitetuissa valmisteissa |
| AR002194A1 (es) | 1997-03-17 | 1998-01-07 | Sanchez Reynaldo Alemany | Instrumento computarizado para el analisis del movimiento. |
| IT1302307B1 (it) | 1998-09-01 | 2000-09-05 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil |
| US6585987B1 (en) | 1998-11-13 | 2003-07-01 | Continental Projects Limited | Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions |
| JP2000159659A (ja) * | 1998-11-30 | 2000-06-13 | Kazuo Tsubota | 眼科用人工涙液 |
| US6228392B1 (en) | 1999-04-29 | 2001-05-08 | Gene Tools, Llc | Osmotic delivery composition, solution, and method |
| CA2416169C (en) | 2000-07-14 | 2008-09-23 | Allergan, Inc. | Compositions containing therapeutically active components having enhanced solubility |
| CA2355814C (en) | 2000-09-14 | 2010-06-29 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Pharmaceutical composition for ophthalmic use |
| DE60140007D1 (de) | 2000-11-08 | 2009-11-05 | Fxs Ventures Llc | Verbesserte ophthalmische und kontaktlinsenlösungen mit einfachen sacchariden als konservierungsverbesserer |
| US7045121B2 (en) | 2001-12-14 | 2006-05-16 | Allergan, Inc. | Ophthalmic compositions for lubricating eyes and methods for making and using same |
| US7795203B2 (en) | 2002-09-30 | 2010-09-14 | Babizhayev Mark A | Method for topical treatment of eye disease and composition and device for said treatment |
| PT1551417E (pt) * | 2002-10-18 | 2008-10-31 | Aqueous Pharma Ltd | Formulação de lágrimas com três camadas |
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| US6635654B1 (en) * | 2003-01-09 | 2003-10-21 | Allergan, Inc. | Ophthalmic compositions containing loratadine |
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| JPWO2004084877A1 (ja) | 2003-03-26 | 2006-06-29 | 株式会社メニコン | 眼科用組成物 |
| CA2839849C (en) * | 2003-06-13 | 2017-03-07 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| TWI336257B (en) * | 2003-06-13 | 2011-01-21 | Alcon Inc | Ophthalmic compositions containing a synergistic combination of three polymers |
| US20050009836A1 (en) | 2003-06-26 | 2005-01-13 | Laskar Paul A. | Ophthalmic composition containing quinolones and method of use |
| CA2549737A1 (en) * | 2003-11-10 | 2005-05-26 | Toray Industries, Inc. | Polysaccharide-containing composition and tear film stabilizing ophthalmic solution |
| US8569367B2 (en) * | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
| US7288520B2 (en) * | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
| US7501393B2 (en) * | 2005-07-27 | 2009-03-10 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
| US9561178B2 (en) * | 2006-07-25 | 2017-02-07 | Allergan, Inc. | Cyclosporin compositions |
| WO2008035246A2 (en) * | 2006-07-28 | 2008-03-27 | Novagali Pharma Sa | Compositions containing quaternary ammonium compounds |
| CN101896160A (zh) * | 2006-10-17 | 2010-11-24 | 阿勒根公司 | 环胞菌素组合物 |
| US20080312194A1 (en) * | 2007-02-28 | 2008-12-18 | Ousler Iii George W | Methods and compositions for normalizing meibomian gland secretions |
| JP4929245B2 (ja) | 2008-07-31 | 2012-05-09 | 株式会社ベッセル工業 | 工具類のグリップ |
| NO2437762T3 (enExample) * | 2009-06-05 | 2018-01-06 | ||
| WO2013049621A1 (en) * | 2011-09-29 | 2013-04-04 | The Board Of Regents Of The University Of Oklahoma | Ophthalmic compositions comprising ppar-alpha agonists and methods of production and use thereof |
-
2012
- 2012-12-07 PL PL12808606T patent/PL2787968T3/pl unknown
- 2012-12-07 SI SI201231783T patent/SI2787968T1/sl unknown
- 2012-12-07 WO PCT/US2012/068615 patent/WO2013086449A1/en not_active Ceased
- 2012-12-07 JP JP2014546154A patent/JP6142419B2/ja active Active
- 2012-12-07 CN CN201810890387.0A patent/CN108969482A/zh active Pending
- 2012-12-07 PL PL12808607T patent/PL2787969T3/pl unknown
- 2012-12-07 IN IN4809CHN2014 patent/IN2014CN04809A/en unknown
- 2012-12-07 US US13/708,783 patent/US20130150324A1/en not_active Abandoned
- 2012-12-07 EP EP21198843.1A patent/EP3981387A1/en active Pending
- 2012-12-07 PT PT128086063T patent/PT2787968T/pt unknown
- 2012-12-07 EP EP12808606.3A patent/EP2787968B1/en active Active
- 2012-12-07 DK DK12808607.1T patent/DK2787969T3/da active
- 2012-12-07 AU AU2012347459A patent/AU2012347459A1/en not_active Abandoned
- 2012-12-07 MX MX2014006804A patent/MX355216B/es active IP Right Grant
- 2012-12-07 ES ES12808606T patent/ES2797650T3/es active Active
- 2012-12-07 ES ES12808607T patent/ES2896336T3/es active Active
- 2012-12-07 RU RU2014127074A patent/RU2014127074A/ru unknown
- 2012-12-07 SI SI201231957T patent/SI2787969T1/sl unknown
- 2012-12-07 TW TW101146304A patent/TWI652072B/zh not_active IP Right Cessation
- 2012-12-07 CA CA2858574A patent/CA2858574C/en active Active
- 2012-12-07 MY MYPI2014001672A patent/MY173378A/en unknown
- 2012-12-07 AR ARP120104614A patent/AR089123A1/es not_active Application Discontinuation
- 2012-12-07 EP EP12808607.1A patent/EP2787969B1/en active Active
- 2012-12-07 PH PH1/2014/501296A patent/PH12014501296B1/en unknown
- 2012-12-07 PT PT128086071T patent/PT2787969T/pt unknown
- 2012-12-07 KR KR1020147018598A patent/KR102017922B1/ko not_active Expired - Fee Related
- 2012-12-07 US US13/708,771 patent/US9314528B2/en active Active
- 2012-12-07 HU HUE12808607A patent/HUE057140T2/hu unknown
- 2012-12-07 HU HUE12808606A patent/HUE049489T2/hu unknown
- 2012-12-07 WO PCT/US2012/068603 patent/WO2013086438A1/en not_active Ceased
- 2012-12-07 PH PH1/2021/553172A patent/PH12021553172A1/en unknown
- 2012-12-07 BR BR112014013820A patent/BR112014013820A2/pt not_active Application Discontinuation
- 2012-12-07 CN CN201280067685.0A patent/CN104114152A/zh active Pending
- 2012-12-07 DK DK12808606.3T patent/DK2787968T3/da active
- 2012-12-07 SG SG11201403013VA patent/SG11201403013VA/en unknown
- 2012-12-07 EP EP24167560.2A patent/EP4403220A3/en active Pending
- 2012-12-07 EP EP20153344.5A patent/EP3666257A1/en not_active Withdrawn
-
2014
- 2014-06-08 IL IL233008A patent/IL233008A/en active IP Right Grant
- 2014-06-09 CL CL2014001518A patent/CL2014001518A1/es unknown
- 2014-06-09 ZA ZA2014/04228A patent/ZA201404228B/en unknown
- 2014-06-26 CO CO14138315A patent/CO6990739A2/es unknown
-
2017
- 2017-11-27 AU AU2017265181A patent/AU2017265181B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201316984A (zh) | 2011-10-06 | 2013-05-01 | Allergan Inc | 治療乾眼病的組合物 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |