RU2014127074A - Состав для эффективной доставки липидов в слезную пленку человека с использованием чувствительной к соли эмульсионной системы - Google Patents
Состав для эффективной доставки липидов в слезную пленку человека с использованием чувствительной к соли эмульсионной системы Download PDFInfo
- Publication number
- RU2014127074A RU2014127074A RU2014127074A RU2014127074A RU2014127074A RU 2014127074 A RU2014127074 A RU 2014127074A RU 2014127074 A RU2014127074 A RU 2014127074A RU 2014127074 A RU2014127074 A RU 2014127074A RU 2014127074 A RU2014127074 A RU 2014127074A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- emulsion
- composition according
- dry eye
- castor oil
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 29
- 239000000839 emulsion Substances 0.000 title claims abstract 17
- 150000002632 lipids Chemical class 0.000 title 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims abstract 12
- 206010013774 Dry eye Diseases 0.000 claims abstract 12
- 235000019438 castor oil Nutrition 0.000 claims abstract 12
- 239000004359 castor oil Substances 0.000 claims abstract 12
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract 10
- 238000000034 method Methods 0.000 claims abstract 9
- 239000003755 preservative agent Substances 0.000 claims abstract 8
- 230000002335 preservative effect Effects 0.000 claims abstract 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract 4
- 239000003995 emulsifying agent Substances 0.000 claims abstract 4
- 235000011187 glycerol Nutrition 0.000 claims abstract 4
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract 2
- 239000004386 Erythritol Substances 0.000 claims abstract 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000013543 active substance Substances 0.000 claims abstract 2
- 239000008346 aqueous phase Substances 0.000 claims abstract 2
- 239000000607 artificial tear Substances 0.000 claims abstract 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract 2
- 235000019414 erythritol Nutrition 0.000 claims abstract 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract 2
- 229940009714 erythritol Drugs 0.000 claims abstract 2
- 229960001518 levocarnitine Drugs 0.000 claims abstract 2
- 239000003921 oil Substances 0.000 claims abstract 2
- 235000019198 oils Nutrition 0.000 claims abstract 2
- 239000004006 olive oil Substances 0.000 claims abstract 2
- 235000008390 olive oil Nutrition 0.000 claims abstract 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims abstract 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract 2
- 229920000136 polysorbate Polymers 0.000 claims abstract 2
- 229950008882 polysorbate Drugs 0.000 claims abstract 2
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract 2
- 229940068968 polysorbate 80 Drugs 0.000 claims abstract 2
- 208000024891 symptom Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568089P | 2011-12-07 | 2011-12-07 | |
| US61/568,089 | 2011-12-07 | ||
| US201261625401P | 2012-04-17 | 2012-04-17 | |
| US61/625,401 | 2012-04-17 | ||
| PCT/US2012/068615 WO2013086449A1 (en) | 2011-12-07 | 2012-12-07 | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018119362A Division RU2772357C2 (ru) | 2011-12-07 | 2012-12-07 | Состав для эффективной доставки липидов в слезную пленку человека с использованием чувствительной к соли эмульсионной системы |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014127074A true RU2014127074A (ru) | 2016-02-10 |
Family
ID=47459152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014127074A RU2014127074A (ru) | 2011-12-07 | 2012-12-07 | Состав для эффективной доставки липидов в слезную пленку человека с использованием чувствительной к соли эмульсионной системы |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US9314528B2 (enExample) |
| EP (5) | EP3666257A1 (enExample) |
| JP (1) | JP6142419B2 (enExample) |
| KR (1) | KR102017922B1 (enExample) |
| CN (2) | CN108969482A (enExample) |
| AR (1) | AR089123A1 (enExample) |
| AU (2) | AU2012347459A1 (enExample) |
| BR (1) | BR112014013820A8 (enExample) |
| CA (1) | CA2858574C (enExample) |
| CL (1) | CL2014001518A1 (enExample) |
| CO (1) | CO6990739A2 (enExample) |
| DK (2) | DK2787969T3 (enExample) |
| ES (2) | ES2896336T3 (enExample) |
| HU (2) | HUE057140T2 (enExample) |
| IL (1) | IL233008A (enExample) |
| IN (1) | IN2014CN04809A (enExample) |
| MX (1) | MX355216B (enExample) |
| MY (1) | MY173378A (enExample) |
| PH (2) | PH12014501296B1 (enExample) |
| PL (2) | PL2787969T3 (enExample) |
| PT (2) | PT2787969T (enExample) |
| RU (1) | RU2014127074A (enExample) |
| SG (1) | SG11201403013VA (enExample) |
| SI (2) | SI2787968T1 (enExample) |
| TW (1) | TWI652072B (enExample) |
| WO (2) | WO2013086438A1 (enExample) |
| ZA (1) | ZA201404228B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8957048B2 (en) * | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
| US9907826B2 (en) | 2011-12-07 | 2018-03-06 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
| RS58292B1 (sr) | 2016-07-07 | 2019-03-29 | Salvat Lab Sa | Oftalmološka kompozicija sa ricinusovim uljem i srednjim lancem triglicerida |
| CA3032695C (en) | 2016-08-19 | 2021-11-23 | Akrivista, LLC | Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye |
| JP7311160B2 (ja) | 2017-08-18 | 2023-07-19 | アクリビスタ エルエルシー | ドライアイ症候群を診断及び処置する方法及びヒトの眼を処置するための組成物 |
| JP7490570B2 (ja) | 2018-04-27 | 2024-05-27 | アラーガン、インコーポレイテッド | 抗微生物有効性の増強及び毒性の減少を有する亜塩素酸ナトリウム組成物 |
| WO2025175150A1 (en) * | 2024-02-16 | 2025-08-21 | Allergan, Inc. | Enhanced artificial tear formulations |
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| US4201706A (en) | 1978-09-22 | 1980-05-06 | Burton, Parsons & Company, Inc. | Treatment of corneal edema |
| EP0028110B1 (en) | 1979-10-26 | 1984-03-07 | Smith and Nephew Associated Companies p.l.c. | Autoclavable emulsions |
| US5192535A (en) | 1988-02-08 | 1993-03-09 | Insite Vision Incorporated | Ophthalmic suspensions |
| IT1224795B (it) | 1988-12-01 | 1990-10-24 | Sigma Tau Ind Farmaceuti | Uso dell'acetil d-carnitina nel trattamento terapeutico del glaucoma e composizioni farmaceutiche utili in tale trattamento |
| DE69004066T2 (de) | 1989-08-03 | 1994-02-17 | Eisai Co Ltd | Verfahren zur photostabilisierung von augenspüllösungen. |
| US5681555A (en) | 1991-04-22 | 1997-10-28 | Gleich; Gerald J. | Method for the treatment of bronchial asthma by parenteral administration of anionic polymers |
| DE4229494A1 (de) | 1992-09-04 | 1994-03-10 | Basotherm Gmbh | Arzneimittel zur topischen Anwendung am Auge zur Behandlung des erhöhten intraokularen Drucks |
| AU3484895A (en) | 1994-09-14 | 1996-03-29 | Taisho Pharmaceutical Co., Ltd. | Eye drops for repairing corneal disturbance |
| US5980865A (en) | 1995-08-18 | 1999-11-09 | Baker Norton Pharmaceuticals, Inc. | Method for treating late phase allergic reactions and inflammatory diseases |
| FI106923B (fi) | 1997-01-03 | 2001-05-15 | Cultor Ltd Finnsugar Bioproduc | Trimetyyliglysiinin käyttö kehon limakalvojen hygieniaan ja hoitoon tarkoitetuissa valmisteissa |
| AR002194A1 (es) | 1997-03-17 | 1998-01-07 | Sanchez Reynaldo Alemany | Instrumento computarizado para el analisis del movimiento. |
| IT1302307B1 (it) | 1998-09-01 | 2000-09-05 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil |
| US6585987B1 (en) | 1998-11-13 | 2003-07-01 | Continental Projects Limited | Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions |
| JP2000159659A (ja) * | 1998-11-30 | 2000-06-13 | Kazuo Tsubota | 眼科用人工涙液 |
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| HU230383B1 (hu) | 2000-07-14 | 2016-03-29 | Allergan, Inc | Oldékonyságfokozó komponens használata brimodinin-tartarátot tartalmazó vizes készítményekben |
| CA2355814C (en) | 2000-09-14 | 2010-06-29 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Pharmaceutical composition for ophthalmic use |
| US9492581B2 (en) | 2000-11-08 | 2016-11-15 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers |
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| WO2013049621A1 (en) * | 2011-09-29 | 2013-04-04 | The Board Of Regents Of The University Of Oklahoma | Ophthalmic compositions comprising ppar-alpha agonists and methods of production and use thereof |
| US8957048B2 (en) * | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
-
2012
- 2012-12-07 PT PT128086071T patent/PT2787969T/pt unknown
- 2012-12-07 PL PL12808607T patent/PL2787969T3/pl unknown
- 2012-12-07 ES ES12808607T patent/ES2896336T3/es active Active
- 2012-12-07 MY MYPI2014001672A patent/MY173378A/en unknown
- 2012-12-07 EP EP20153344.5A patent/EP3666257A1/en not_active Withdrawn
- 2012-12-07 CN CN201810890387.0A patent/CN108969482A/zh active Pending
- 2012-12-07 PL PL12808606T patent/PL2787968T3/pl unknown
- 2012-12-07 SI SI201231783T patent/SI2787968T1/sl unknown
- 2012-12-07 AU AU2012347459A patent/AU2012347459A1/en not_active Abandoned
- 2012-12-07 IN IN4809CHN2014 patent/IN2014CN04809A/en unknown
- 2012-12-07 US US13/708,771 patent/US9314528B2/en active Active
- 2012-12-07 EP EP12808606.3A patent/EP2787968B1/en active Active
- 2012-12-07 TW TW101146304A patent/TWI652072B/zh not_active IP Right Cessation
- 2012-12-07 DK DK12808607.1T patent/DK2787969T3/da active
- 2012-12-07 US US13/708,783 patent/US20130150324A1/en not_active Abandoned
- 2012-12-07 PH PH1/2014/501296A patent/PH12014501296B1/en unknown
- 2012-12-07 JP JP2014546154A patent/JP6142419B2/ja active Active
- 2012-12-07 WO PCT/US2012/068603 patent/WO2013086438A1/en not_active Ceased
- 2012-12-07 EP EP21198843.1A patent/EP3981387A1/en active Pending
- 2012-12-07 SI SI201231957T patent/SI2787969T1/sl unknown
- 2012-12-07 KR KR1020147018598A patent/KR102017922B1/ko not_active Expired - Fee Related
- 2012-12-07 WO PCT/US2012/068615 patent/WO2013086449A1/en not_active Ceased
- 2012-12-07 CA CA2858574A patent/CA2858574C/en active Active
- 2012-12-07 HU HUE12808607A patent/HUE057140T2/hu unknown
- 2012-12-07 EP EP12808607.1A patent/EP2787969B1/en active Active
- 2012-12-07 EP EP24167560.2A patent/EP4403220A3/en active Pending
- 2012-12-07 AR ARP120104614A patent/AR089123A1/es not_active Application Discontinuation
- 2012-12-07 PT PT128086063T patent/PT2787968T/pt unknown
- 2012-12-07 CN CN201280067685.0A patent/CN104114152A/zh active Pending
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