ES2613553T3 - Enzimas CAR y producción mejorada de alcoholes grasos - Google Patents
Enzimas CAR y producción mejorada de alcoholes grasos Download PDFInfo
- Publication number
- ES2613553T3 ES2613553T3 ES13766728.3T ES13766728T ES2613553T3 ES 2613553 T3 ES2613553 T3 ES 2613553T3 ES 13766728 T ES13766728 T ES 13766728T ES 2613553 T3 ES2613553 T3 ES 2613553T3
- Authority
- ES
- Spain
- Prior art keywords
- seq
- fatty
- car
- carb
- carb4
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000002191 fatty alcohols Chemical class 0.000 title abstract description 13
- 238000004519 manufacturing process Methods 0.000 title description 7
- 102000004190 Enzymes Human genes 0.000 title description 5
- 108090000790 Enzymes Proteins 0.000 title description 5
- 102220534644 Protein quaking_E20R_mutation Human genes 0.000 abstract description 20
- 102220289826 rs1555407420 Human genes 0.000 abstract description 12
- 230000035772 mutation Effects 0.000 abstract description 9
- 229920001184 polypeptide Polymers 0.000 abstract description 8
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 8
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 8
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 6
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 102220242995 rs1555187010 Human genes 0.000 abstract 1
- 102220075807 rs202025584 Human genes 0.000 abstract 1
- 102220095963 rs758112386 Human genes 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 16
- 229930195729 fatty acid Natural products 0.000 description 16
- 239000000194 fatty acid Substances 0.000 description 16
- 150000004665 fatty acids Chemical class 0.000 description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 10
- 229910052799 carbon Inorganic materials 0.000 description 10
- 239000002028 Biomass Substances 0.000 description 9
- 239000013612 plasmid Substances 0.000 description 9
- 101100218898 Pseudomonas aeruginosa carB4 gene Proteins 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 7
- 150000002192 fatty aldehydes Chemical class 0.000 description 7
- 230000014509 gene expression Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 5
- 230000002759 chromosomal effect Effects 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
- 101150071111 FADD gene Proteins 0.000 description 3
- 108020005350 Initiator Codon Proteins 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 description 2
- 101100218932 Pseudomonas aeruginosa pse1 gene Proteins 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 101150112203 carB2 gene Proteins 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 description 2
- 238000002703 mutagenesis Methods 0.000 description 2
- 231100000350 mutagenesis Toxicity 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 1
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 1
- 102000016614 Autophagy-Related Protein 5 Human genes 0.000 description 1
- 108010092776 Autophagy-Related Protein 5 Proteins 0.000 description 1
- 108010018763 Biotin carboxylase Proteins 0.000 description 1
- 240000005430 Bromus catharticus Species 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 241000186226 Corynebacterium glutamicum Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 102000000476 Fatty Acid Transport Proteins Human genes 0.000 description 1
- 108010055870 Fatty Acid Transport Proteins Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 101100111666 Pseudomonas aeruginosa carB3 gene Proteins 0.000 description 1
- 101100218933 Pseudomonas aeruginosa pse4 gene Proteins 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 235000016536 Sporobolus cryptandrus Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- -1 acyl-ACP Chemical class 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 230000001147 anti-toxic effect Effects 0.000 description 1
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000002551 biofuel Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
- 101150031021 birA gene Proteins 0.000 description 1
- 101150058190 carB1 gene Proteins 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000012707 chemical precursor Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000010791 domestic waste Substances 0.000 description 1
- 230000004133 fatty acid degradation Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 239000010813 municipal solid waste Substances 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 239000004460 silage Substances 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0105—Long-chain-fatty-acyl-CoA reductase (1.2.1.50)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/99—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with other acceptors (1.2.99)
- C12Y102/99006—Carboxylate reductase (1.2.99.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01041—Beta-ketoacyl-acyl-carrier-protein synthase I (2.3.1.41)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/02—Thioester hydrolases (3.1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P2203/00—Fermentation products obtained from optionally pretreated or hydrolyzed cellulosic or lignocellulosic material as the carbon source
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261619309P | 2012-04-02 | 2012-04-02 | |
| US201261619309P | 2012-04-02 | ||
| PCT/US2013/035040 WO2013152052A2 (en) | 2012-04-02 | 2013-04-02 | Novel car enzymes and improved production of fatty alcohols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2613553T3 true ES2613553T3 (es) | 2017-05-24 |
Family
ID=49237582
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13766728.3T Active ES2613553T3 (es) | 2012-04-02 | 2013-04-02 | Enzimas CAR y producción mejorada de alcoholes grasos |
| ES18160746T Active ES2786633T3 (es) | 2012-04-02 | 2013-04-02 | Enzimas CAR y producción mejorada de alcoholes grasos |
| ES16198810.0T Active ES2666157T3 (es) | 2012-04-02 | 2013-04-02 | Enzimas CAR y producción mejorada de alcoholes grasos |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18160746T Active ES2786633T3 (es) | 2012-04-02 | 2013-04-02 | Enzimas CAR y producción mejorada de alcoholes grasos |
| ES16198810.0T Active ES2666157T3 (es) | 2012-04-02 | 2013-04-02 | Enzimas CAR y producción mejorada de alcoholes grasos |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9340801B2 (https=) |
| EP (6) | EP3153579B1 (https=) |
| JP (1) | JP6230594B2 (https=) |
| KR (6) | KR20210095226A (https=) |
| CN (1) | CN104704113B (https=) |
| AU (2) | AU2013243602B2 (https=) |
| BR (2) | BR122019026987B1 (https=) |
| CA (1) | CA2883064A1 (https=) |
| CO (1) | CO7170148A2 (https=) |
| ES (3) | ES2613553T3 (https=) |
| MX (2) | MX358177B (https=) |
| MY (1) | MY170889A (https=) |
| SI (1) | SI3385374T1 (https=) |
| WO (1) | WO2013152052A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101636403B1 (ko) * | 2008-10-28 | 2016-07-05 | 알이지 라이프 사이언시스, 엘엘씨 | 지방족 알코올들을 생산하기 위한 방법들과 조성물들 |
| EP2834352B1 (en) * | 2012-04-02 | 2020-01-08 | Genomatica, Inc. | Improved production of fatty acid derivatives |
| BR122019026987B1 (pt) * | 2012-04-02 | 2022-01-18 | Genomatica, Inc | Polipeptídeo variante da ácido carboxílico redutase (car), célula hospedeira recombinante, cultura de células e método de produzir uma composição de álcool graxo com alto título, rendimento ou produtividade |
| MX2015001780A (es) | 2012-08-10 | 2015-09-28 | Opx Biotechnologies Inc | Microorganismos y métodos para la producción de ácidos grasos y productos derivados de ácidos grasos. |
| US20150119601A1 (en) | 2013-03-15 | 2015-04-30 | Opx Biotechnologies, Inc. | Monofunctional mcr + 3-hp dehydrogenase |
| WO2014145344A2 (en) * | 2013-03-15 | 2014-09-18 | Opx Biotechnologies, Inc. | Control of growth-induction-production phases |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| EP3022310B1 (en) | 2013-07-19 | 2019-10-16 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| EP4089176A1 (en) * | 2014-07-18 | 2022-11-16 | Genomatica, Inc. | Microbial production of 1,3 diols |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| CN105985987B (zh) * | 2015-03-02 | 2020-01-31 | 苏州安捷生物科技有限公司 | 一种生物法制备脂肪醇的方法 |
| US10538746B2 (en) | 2016-03-17 | 2020-01-21 | INVISTA North America S.à r.l. | Polypeptides and variants having improved activity, materials and processes relating thereto |
| US11345938B2 (en) | 2017-02-02 | 2022-05-31 | Cargill, Incorporated | Genetically modified cells that produce C6-C10 fatty acid derivatives |
| MY205555A (en) | 2017-04-03 | 2024-10-25 | Genomatica Inc | Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives |
| EP3844179A4 (en) | 2018-08-31 | 2022-08-31 | Genomatica, Inc. | XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE |
| US12221644B2 (en) | 2018-08-31 | 2025-02-11 | Genomatica, Inc. | Production of non-native monounsaturated fatty acids in bacteria |
| JPWO2022209763A1 (https=) | 2021-03-30 | 2022-10-06 | ||
| EP4493683A1 (en) | 2022-03-16 | 2025-01-22 | Genomatica, Inc. | Acyl-acp thioesterase variants and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
| US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
| US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
| WO1991016427A1 (en) | 1990-04-24 | 1991-10-31 | Stratagene | Methods for phenotype creation from multiple gene populations |
| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| US7056714B2 (en) * | 2003-03-11 | 2006-06-06 | University Of Iowa Research Foundation, Inc. | Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use |
| DE102004052115A1 (de) | 2004-10-26 | 2006-04-27 | Westfälische Wilhelms-Universität Münster | Mikroorganismen zur Herstellung von Fettsäureestern, Verfahren zu deren Herstellung und deren Verwendung |
| CA2650773C (en) | 2006-05-19 | 2014-12-02 | Jay D. Keasling | Microorganisms transformed with acetyl-coa carboxylase and wax synthase for production of fatty acid derivatives |
| CN101680009B (zh) | 2007-03-28 | 2017-02-22 | Reg生命科学有限责任公司 | 提高脂肪酸衍生物的产量 |
| BRPI0813359A2 (pt) | 2007-05-22 | 2014-10-14 | Ls9 Inc | Ácidos nucleicos isolados, vetor, células, métodos para produzir um hidrocarboneto, para produzir uma cetona alifática, para produzir um polipeptídeo purificado, para produzir um hidrocarboneto, para produzir biocombustíveis, hidrocarboneto, biocombustível, polipeptídeo isolado, ácido nucleico isolado, organismos geneticamente engenheirados, método para identificar uma enzima útil para a produção de hidrocarbonetos |
| TWI351779B (en) | 2007-12-03 | 2011-11-01 | Advance Smart Ind Ltd | Apparatus and method for correcting residual capac |
| WO2009085278A1 (en) | 2007-12-21 | 2009-07-09 | Ls9, Inc. | Methods and compositions for producing olefins |
| KR101717569B1 (ko) | 2008-10-07 | 2017-03-17 | 알이지 라이프 사이언시스, 엘엘씨 | 지방족 알데히드를 생산하기 위한 방법과 조성물들 |
| KR101636403B1 (ko) * | 2008-10-28 | 2016-07-05 | 알이지 라이프 사이언시스, 엘엘씨 | 지방족 알코올들을 생산하기 위한 방법들과 조성물들 |
| CA3055144C (en) | 2008-12-23 | 2022-07-19 | REG Life Sciences, LLC | Methods and compositions related to thioesterase enzymes |
| US20120115195A1 (en) | 2009-05-01 | 2012-05-10 | The Regents Of The University Of California | Product of fatty acid esters from biomass polymers |
| BRPI1010920B1 (pt) * | 2009-05-22 | 2020-04-28 | Codexis Inc | processo para a produção biológica de álcoois graxos |
| KR20120083908A (ko) * | 2009-10-13 | 2012-07-26 | 게노마티카 인코포레이티드 | 1,4-부탄다이올, 4-하이드록시부탄알, 4-하이드록시부티릴-ｃｏａ, 푸트레신 및 관련 화합물의 제조를 위한 미생물 및 관련 방법 |
| WO2011100667A1 (en) | 2010-02-14 | 2011-08-18 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
| US20110250663A1 (en) | 2010-04-08 | 2011-10-13 | Ls9, Inc. | Methods and compositions related to fatty alcohol biosynthetic enzymes |
| BR112013025226A2 (pt) * | 2011-04-01 | 2018-09-11 | Genomatica Inc | micro-organismos para produzir ácido metacrílico e ésteres de metacrilato e métodos relacionados a eles |
| WO2012154329A1 (en) * | 2011-04-01 | 2012-11-15 | Ls9, Inc. | Methods and compositions for improved production of fatty acids and derivatives thereof |
| US8617862B2 (en) * | 2011-06-22 | 2013-12-31 | Genomatica, Inc. | Microorganisms for producing propylene and methods related thereto |
| BR122019026987B1 (pt) * | 2012-04-02 | 2022-01-18 | Genomatica, Inc | Polipeptídeo variante da ácido carboxílico redutase (car), célula hospedeira recombinante, cultura de células e método de produzir uma composição de álcool graxo com alto título, rendimento ou produtividade |
-
2013
- 2013-04-02 BR BR122019026987-4A patent/BR122019026987B1/pt active IP Right Grant
- 2013-04-02 KR KR1020217023277A patent/KR20210095226A/ko not_active Ceased
- 2013-04-02 WO PCT/US2013/035040 patent/WO2013152052A2/en not_active Ceased
- 2013-04-02 ES ES13766728.3T patent/ES2613553T3/es active Active
- 2013-04-02 CN CN201380026546.8A patent/CN104704113B/zh not_active Expired - Fee Related
- 2013-04-02 KR KR1020147030704A patent/KR101831331B1/ko active Active
- 2013-04-02 EP EP16198810.0A patent/EP3153579B1/en not_active Not-in-force
- 2013-04-02 BR BR112014024674-2A patent/BR112014024674B1/pt not_active IP Right Cessation
- 2013-04-02 EP EP18160746.6A patent/EP3385374B1/en active Active
- 2013-04-02 EP EP22202380.6A patent/EP4186974A1/en active Pending
- 2013-04-02 SI SI201331706T patent/SI3385374T1/sl unknown
- 2013-04-02 KR KR1020177026945A patent/KR20170113710A/ko not_active Ceased
- 2013-04-02 KR KR1020207009760A patent/KR102282677B1/ko not_active Expired - Fee Related
- 2013-04-02 KR KR1020197017717A patent/KR102185762B1/ko not_active Expired - Fee Related
- 2013-04-02 JP JP2015504688A patent/JP6230594B2/ja active Active
- 2013-04-02 CA CA2883064A patent/CA2883064A1/en active Pending
- 2013-04-02 KR KR1020197005741A patent/KR102114841B1/ko not_active Expired - Fee Related
- 2013-04-02 MY MYPI2014002838A patent/MY170889A/en unknown
- 2013-04-02 EP EP21191034.4A patent/EP3985108A1/en not_active Withdrawn
- 2013-04-02 ES ES18160746T patent/ES2786633T3/es active Active
- 2013-04-02 US US14/390,350 patent/US9340801B2/en active Active
- 2013-04-02 EP EP13766728.3A patent/EP2834350B1/en active Active
- 2013-04-02 AU AU2013243602A patent/AU2013243602B2/en not_active Ceased
- 2013-04-02 MX MX2016013852A patent/MX358177B/es unknown
- 2013-04-02 ES ES16198810.0T patent/ES2666157T3/es active Active
- 2013-04-02 EP EP19212944.3A patent/EP3674399B1/en active Active
- 2013-04-02 MX MX2014011903A patent/MX343296B/es active IP Right Grant
-
2014
- 2014-10-29 CO CO14240039A patent/CO7170148A2/es unknown
-
2016
- 2016-05-13 US US15/154,636 patent/US9758769B2/en active Active
- 2016-09-20 AU AU2016231497A patent/AU2016231497B2/en not_active Ceased
-
2017
- 2017-09-05 US US15/695,205 patent/US10301603B2/en active Active
-
2019
- 2019-05-16 US US16/414,550 patent/US11034937B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2613553T3 (es) | Enzimas CAR y producción mejorada de alcoholes grasos | |
| ES2592887T3 (es) | Procedimiento la producción de cadaverina | |
| ES2678647T3 (es) | Acil-ACP sintasas de éster de cera | |
| EP2231864B1 (en) | Secretion of fatty acids by photosynthetic microorganisms | |
| CN106795483A (zh) | 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 | |
| JP2005510203A5 (https=) | ||
| US20240360404A1 (en) | Expression of functional bacterial type i fatty acid synthase in photosynthetic hosts | |
| Xu et al. | Growth and fatty acid composition of Nannochloropsis sp. grown mixotrophically in fed-batch culture | |
| ES2772259T3 (es) | Método de fabricación de 7-deshidrocolesterol y vitamina D3 | |
| ES2908400T3 (es) | Variantes de polipéptidos de fusión relacionados con omega-hidroxilasa con propiedades mejoradas | |
| US9783581B2 (en) | Method for producing plastic raw material from blue-green algae | |
| KR102211740B1 (ko) | 파에오닥틸룸 트리코르누툼(Phaeodactylum tricornutum)의 신규 프로모터 HASP1와 이의 신호 펩타이드 및 이의 용도 | |
| US10006066B2 (en) | Modified cyanobacteria | |
| US11981937B2 (en) | Light-powered, biological methyl laurate production from CO2 and water | |
| JP6778870B2 (ja) | 藍藻変異株及びそれを用いたコハク酸及びｄ−乳酸産生方法 | |
| CN111334445B (zh) | 长链二元酸生产菌株及其制备方法和应用 | |
| US20250388850A1 (en) | Enhanced triacylglycerol productivity and extractability in an engineered microalga | |
| Hambalko et al. | Comparative Expression of Diacylglycerol Acyltransferases for Enhanced Accumulation of Punicic Acid-Enriched Triacylglycerols in Yarrowia lipolytica | |
| JP7039625B2 (ja) | Ｄｈａおよびｅｐａを生産する細菌、細菌のゲノムの６つの遺伝子断片およびそれらの使用 | |
| Sağlam et al. | Streamlining ε‐PL Production: Recent Trends in Fermentation and Downstream Processing | |
| US20220090002A1 (en) | Recombinant algae having high lipid productivity | |
| JPWO2016163382A1 (ja) | 有機酸の製造方法 | |
| CN105018358B (zh) | 长链二元酸生产菌株及其制备方法和应用 | |
| CN118389558A (zh) | 合成高不饱和脂肪酸蜡酯的微藻及其构建方法 | |
| Kothari | Biocatalytic Preparation of Amino Acids |