JP2005510203A5 - - Google Patents
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- JP2005510203A5 JP2005510203A5 JP2002582209A JP2002582209A JP2005510203A5 JP 2005510203 A5 JP2005510203 A5 JP 2005510203A5 JP 2002582209 A JP2002582209 A JP 2002582209A JP 2002582209 A JP2002582209 A JP 2002582209A JP 2005510203 A5 JP2005510203 A5 JP 2005510203A5
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- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- activity
- acid sequence
- acp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000007523 nucleic acids Chemical class 0.000 claims 93
- 230000000694 effects Effects 0.000 claims 69
- 108020004707 nucleic acids Proteins 0.000 claims 60
- 102000039446 nucleic acids Human genes 0.000 claims 60
- 108010030975 Polyketide Synthases Proteins 0.000 claims 49
- 244000005700 microbiome Species 0.000 claims 47
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 45
- 150000001413 amino acids Chemical group 0.000 claims 43
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 33
- 238000000034 method Methods 0.000 claims 27
- 108700016155 Acyl transferases Proteins 0.000 claims 25
- 102000057234 Acyl transferases Human genes 0.000 claims 25
- 108010019608 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase Proteins 0.000 claims 22
- 102100037149 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial Human genes 0.000 claims 22
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 22
- 101710198510 Enoyl-[acyl-carrier-protein] reductase [NADH] Proteins 0.000 claims 22
- 101001110310 Lentilactobacillus kefiri NADP-dependent (R)-specific alcohol dehydrogenase Proteins 0.000 claims 18
- 230000000975 bioactive effect Effects 0.000 claims 17
- 101710146995 Acyl carrier protein Proteins 0.000 claims 12
- 230000004071 biological effect Effects 0.000 claims 12
- 230000001580 bacterial effect Effects 0.000 claims 9
- 108700037654 Acyl carrier protein (ACP) Proteins 0.000 claims 7
- 102000048456 Acyl carrier protein (ACP) Human genes 0.000 claims 7
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 claims 7
- 102000002508 Peptide Elongation Factors Human genes 0.000 claims 7
- 108010068204 Peptide Elongation Factors Proteins 0.000 claims 7
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000012467 final product Substances 0.000 claims 5
- 238000012239 gene modification Methods 0.000 claims 5
- 230000005017 genetic modification Effects 0.000 claims 5
- 235000013617 genetically modified food Nutrition 0.000 claims 5
- 241000233675 Thraustochytrium Species 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 239000000047 product Substances 0.000 claims 4
- 230000003252 repetitive effect Effects 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000000813 microbial effect Effects 0.000 claims 3
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 3
- 241000233671 Schizochytrium Species 0.000 claims 2
- 102000004357 Transferases Human genes 0.000 claims 2
- 108090000992 Transferases Proteins 0.000 claims 2
- 235000020244 animal milk Nutrition 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 238000006911 enzymatic reaction Methods 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 238000000855 fermentation Methods 0.000 claims 2
- 230000004151 fermentation Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229940126585 therapeutic drug Drugs 0.000 claims 2
- DJCQJZKZUCHHAL-UHFFFAOYSA-N (Z)-9-Pentadecensaeure Natural products CCCCCC=CCCCCCCCC(O)=O DJCQJZKZUCHHAL-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241000206602 Eukaryota Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010057249 Phagocytosis Diseases 0.000 claims 1
- 241000382353 Pupa Species 0.000 claims 1
- 241001467333 Thraustochytriaceae Species 0.000 claims 1
- UWHZIFQPPBDJPM-FPLPWBNLSA-M Vaccenic acid Natural products CCCCCC\C=C/CCCCCCCCCC([O-])=O UWHZIFQPPBDJPM-FPLPWBNLSA-M 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- UWHZIFQPPBDJPM-FPLPWBNLSA-N cis-vaccenic acid Chemical compound CCCCCC\C=C/CCCCCCCCCC(O)=O UWHZIFQPPBDJPM-FPLPWBNLSA-N 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 235000013350 formula milk Nutrition 0.000 claims 1
- 235000003869 genetically modified organism Nutrition 0.000 claims 1
- 229940037467 helicobacter pylori Drugs 0.000 claims 1
- 238000006317 isomerization reaction Methods 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 150000004668 long chain fatty acids Chemical class 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000008782 phagocytosis Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28406601P | 2001-04-16 | 2001-04-16 | |
| US60/284,066 | 2001-04-16 | ||
| US29879601P | 2001-06-15 | 2001-06-15 | |
| US60/298,796 | 2001-06-15 | ||
| US32326901P | 2001-09-18 | 2001-09-18 | |
| US60/323,269 | 2001-09-18 | ||
| PCT/US2002/012254 WO2002083870A2 (en) | 2001-04-16 | 2002-04-16 | Pufa polyketide synthase systems and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008156666A Division JP4781399B2 (ja) | 2001-04-16 | 2008-06-16 | Ｐｕｆａポリケチドシンターゼ系およびそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005510203A JP2005510203A (ja) | 2005-04-21 |
| JP2005510203A6 JP2005510203A6 (ja) | 2005-08-04 |
| JP2005510203A5 true JP2005510203A5 (https=) | 2005-12-22 |
Family
ID=27403446
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002582209A Withdrawn JP2005510203A (ja) | 2001-04-16 | 2002-04-16 | Ｐｕｆａポリケチドシンターゼ系およびそれらの使用方法 |
| JP2008156666A Expired - Lifetime JP4781399B2 (ja) | 2001-04-16 | 2008-06-16 | Ｐｕｆａポリケチドシンターゼ系およびそれらの使用方法 |
| JP2009239439A Expired - Lifetime JP5460232B2 (ja) | 2001-04-16 | 2009-10-16 | Ｐｕｆａポリケチドシンターゼ系およびそれらの使用方法 |
| JP2013143216A Expired - Lifetime JP5806259B2 (ja) | 2001-04-16 | 2013-07-09 | Ｐｕｆａポリケチドシンターゼ系およびそれらの使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008156666A Expired - Lifetime JP4781399B2 (ja) | 2001-04-16 | 2008-06-16 | Ｐｕｆａポリケチドシンターゼ系およびそれらの使用方法 |
| JP2009239439A Expired - Lifetime JP5460232B2 (ja) | 2001-04-16 | 2009-10-16 | Ｐｕｆａポリケチドシンターゼ系およびそれらの使用方法 |
| JP2013143216A Expired - Lifetime JP5806259B2 (ja) | 2001-04-16 | 2013-07-09 | Ｐｕｆａポリケチドシンターゼ系およびそれらの使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (5) | EP2366773B1 (https=) |
| JP (4) | JP2005510203A (https=) |
| CN (2) | CN101892249A (https=) |
| AR (1) | AR040622A1 (https=) |
| AU (2) | AU2002303394B2 (https=) |
| CA (1) | CA2444164C (https=) |
| ES (3) | ES2567305T3 (https=) |
| TW (3) | TWI426126B (https=) |
| WO (1) | WO2002083870A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5340742A (en) | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
| US6566583B1 (en) | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| US8003772B2 (en) * | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7217856B2 (en) | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7247461B2 (en) | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| EP2960325B1 (en) | 2000-01-28 | 2017-09-27 | DSM IP Assets B.V. | Enhanced production of lipids containing polyenoic fatty acids by high density cultures of eukaryotic microbes in fermentors |
| CA2509227C (en) * | 2002-12-19 | 2013-05-21 | Monsanto Technology, Llc | Elevation of oil levels in brassica plants |
| KR101234199B1 (ko) * | 2003-03-26 | 2013-02-20 | 마텍 바이오싸이언스스 코포레이션 | Ｐｕｆａ 폴리케타이드 신타제 시스템 및 이의 용도 |
| AU2005214874B2 (en) * | 2004-02-13 | 2010-02-18 | Martek Biosciences Corporation | Schizochytrium fatty acid synthase (FAS) and products and methods related thereto |
| DE102004017369A1 (de) * | 2004-04-08 | 2005-11-03 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Screeningverfahren zur Identifizierung von PUFA-PKS in Proben |
| DE102004017370A1 (de) * | 2004-04-08 | 2005-10-27 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | PUFA-PKS Gene aus Ulkenia |
| CA3056110C (en) | 2004-04-22 | 2020-07-14 | Surinder Pal Singh | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| DK1756280T3 (en) | 2004-04-22 | 2015-02-02 | Commw Scient Ind Res Org | SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS |
| WO2006135866A2 (en) * | 2005-06-10 | 2006-12-21 | Martek Biosciences Corporation | Pufa polyketide synthase systems and uses thereof |
| AU2006265801B2 (en) | 2005-07-01 | 2011-07-14 | Martek Biosciences Corporation | Polyunsaturated fatty acid-containing oil product and uses and production thereof |
| KR101524398B1 (ko) | 2006-03-15 | 2015-06-04 | 디에스엠 아이피 어셋츠 비.브이. | Ｐｕｆａ 폴리케티드 신타제 시스템을 이용한 이종 생물체내 다불포화 지방산의 제조 |
| WO2008027991A2 (en) * | 2006-08-29 | 2008-03-06 | Martek Biosciences Corporation | USE OF DPA(n-6) OILS IN INFANT FORMULA |
| CN101578363A (zh) | 2006-08-29 | 2009-11-11 | 联邦科学技术研究组织 | 脂肪酸的合成 |
| NO2358882T3 (https=) | 2008-11-18 | 2017-12-23 | ||
| ES2717102T3 (es) | 2009-03-19 | 2019-06-19 | Dsm Ip Assets Bv | Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos |
| PL2861059T3 (pl) | 2012-06-15 | 2017-10-31 | Commw Scient Ind Res Org | Wytwarzanie długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach roślinnych |
| NZ721036A (en) | 2013-12-18 | 2023-07-28 | Grains Res & Dev Corp | Lipid comprising long chain polyunsaturated fatty acids |
| PH12016502586B1 (en) | 2014-06-27 | 2023-07-19 | Commw Scient Ind Res Org | Lipid comprising docosapentaenoic acid |
| US12241101B2 (en) | 2018-08-10 | 2025-03-04 | Kyowa Hakko Bio Co., Ltd. | Microorganism producing polyunsaturated fatty acid and method for producing polyunsaturated fatty acid |
| US11613728B2 (en) | 2018-08-10 | 2023-03-28 | Kyowa Hakko Bio Co., Ltd. | Microorganism producing eicosapentaenoic acid and method for producing eicosapentaenoic acid |
| US12522142B2 (en) * | 2019-10-23 | 2026-01-13 | Sony Group Corporation | Display system, display device, display method, and mobile apparatus |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4743546A (en) | 1985-02-13 | 1988-05-10 | Biotechnica International, Inc. | Controlled gene excision |
| US5130742A (en) | 1986-05-20 | 1992-07-14 | Canon Kabushiki Kaisha | Camera having selectable white balance modes |
| US5130242A (en) * | 1988-09-07 | 1992-07-14 | Phycotech, Inc. | Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids |
| AU5346296A (en) * | 1995-04-17 | 1996-11-07 | Japan As Represented By Director-General Of Agency Of Industrial Science And Technology | Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fa tty acids by using the microorganisms |
| BR9809946A (pt) | 1997-06-04 | 2000-08-01 | Calgene Llc | Produção de ácidos graxos poliinsaturados por expressão de genes de sìntese semelhantes a policetìdeo em plantas |
| US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| JP6257306B2 (ja) | 2013-12-18 | 2018-01-10 | キヤノン株式会社 | 着弾位置測定装置および着弾位置測定方法 |
-
2002
- 2002-04-15 TW TW099125328A patent/TWI426126B/zh not_active IP Right Cessation
- 2002-04-15 TW TW091107633A patent/TWI337619B/zh not_active IP Right Cessation
- 2002-04-15 TW TW100122042A patent/TWI426127B/zh not_active IP Right Cessation
- 2002-04-16 CN CN2010102222164A patent/CN101892249A/zh active Pending
- 2002-04-16 EP EP10178962.6A patent/EP2366773B1/en not_active Expired - Lifetime
- 2002-04-16 EP EP10178976A patent/EP2366774A3/en not_active Withdrawn
- 2002-04-16 CA CA2444164A patent/CA2444164C/en not_active Expired - Lifetime
- 2002-04-16 EP EP10178950.1A patent/EP2366772B1/en not_active Expired - Lifetime
- 2002-04-16 EP EP10178938A patent/EP2366771A3/en not_active Withdrawn
- 2002-04-16 ES ES10178950.1T patent/ES2567305T3/es not_active Expired - Lifetime
- 2002-04-16 AU AU2002303394A patent/AU2002303394B2/en not_active Expired
- 2002-04-16 ES ES10178962.6T patent/ES2628553T3/es not_active Expired - Lifetime
- 2002-04-16 WO PCT/US2002/012254 patent/WO2002083870A2/en not_active Ceased
- 2002-04-16 CN CNA028117492A patent/CN1535312A/zh active Pending
- 2002-04-16 AR AR20020101372A patent/AR040622A1/es not_active Application Discontinuation
- 2002-04-16 ES ES02731415.2T patent/ES2562766T3/es not_active Expired - Lifetime
- 2002-04-16 EP EP02731415.2A patent/EP1385934B1/en not_active Expired - Lifetime
- 2002-04-16 JP JP2002582209A patent/JP2005510203A/ja not_active Withdrawn
-
2008
- 2008-06-16 JP JP2008156666A patent/JP4781399B2/ja not_active Expired - Lifetime
- 2008-11-21 AU AU2008249168A patent/AU2008249168B2/en not_active Expired
-
2009
- 2009-10-16 JP JP2009239439A patent/JP5460232B2/ja not_active Expired - Lifetime
-
2013
- 2013-07-09 JP JP2013143216A patent/JP5806259B2/ja not_active Expired - Lifetime
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