AU2002303394B2 - PUFA polyketide synthase systems and uses thereof - Google Patents

PUFA polyketide synthase systems and uses thereof Download PDF

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Publication number
AU2002303394B2
AU2002303394B2 AU2002303394A AU2002303394A AU2002303394B2 AU 2002303394 B2 AU2002303394 B2 AU 2002303394B2 AU 2002303394 A AU2002303394 A AU 2002303394A AU 2002303394 A AU2002303394 A AU 2002303394A AU 2002303394 B2 AU2002303394 B2 AU 2002303394B2
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Australia
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domain
pks system
nucleic acid
seq
acid sequence
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AU2002303394A
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AU2002303394A1 (en
Inventor
William R. Barclay
James H. Flatt
Jerry M. Kuner
James G. Metz
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DSM IP Assets BV
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DSM IP Assets BV
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Priority to AU2008249168A priority Critical patent/AU2008249168B2/en
Assigned to DSM IP ASSETS B.V. reassignment DSM IP ASSETS B.V. Request for Assignment Assignors: MARTEK BIOSCIENCES CORPORATION
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    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
AU2002303394A 2001-04-16 2002-04-16 PUFA polyketide synthase systems and uses thereof Expired AU2002303394B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2008249168A AU2008249168B2 (en) 2001-04-16 2008-11-21 Pufa polyketide synthase systems and uses thereof

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US28406601P 2001-04-16 2001-04-16
US60/284,066 2001-04-16
US29879601P 2001-06-15 2001-06-15
US60/298,796 2001-06-15
US32326901P 2001-09-18 2001-09-18
US60/323,269 2001-09-18
PCT/US2002/012254 WO2002083870A2 (en) 2001-04-16 2002-04-16 Pufa polyketide synthase systems and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2008249168A Division AU2008249168B2 (en) 2001-04-16 2008-11-21 Pufa polyketide synthase systems and uses thereof

Publications (2)

Publication Number Publication Date
AU2002303394A1 AU2002303394A1 (en) 2003-04-17
AU2002303394B2 true AU2002303394B2 (en) 2008-08-21

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AU2002303394A Expired AU2002303394B2 (en) 2001-04-16 2002-04-16 PUFA polyketide synthase systems and uses thereof
AU2008249168A Expired AU2008249168B2 (en) 2001-04-16 2008-11-21 Pufa polyketide synthase systems and uses thereof

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AU2008249168A Expired AU2008249168B2 (en) 2001-04-16 2008-11-21 Pufa polyketide synthase systems and uses thereof

Country Status (9)

Country Link
EP (5) EP2366773B1 (https=)
JP (4) JP2005510203A (https=)
CN (2) CN101892249A (https=)
AR (1) AR040622A1 (https=)
AU (2) AU2002303394B2 (https=)
CA (1) CA2444164C (https=)
ES (3) ES2567305T3 (https=)
TW (3) TWI426126B (https=)
WO (1) WO2002083870A2 (https=)

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US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
US8003772B2 (en) * 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US7211418B2 (en) 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7217856B2 (en) 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7247461B2 (en) 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
EP2960325B1 (en) 2000-01-28 2017-09-27 DSM IP Assets B.V. Enhanced production of lipids containing polyenoic fatty acids by high density cultures of eukaryotic microbes in fermentors
CA2509227C (en) * 2002-12-19 2013-05-21 Monsanto Technology, Llc Elevation of oil levels in brassica plants
KR101234199B1 (ko) * 2003-03-26 2013-02-20 마텍 바이오싸이언스스 코포레이션 Ｐｕｆａ 폴리케타이드 신타제 시스템 및 이의 용도
AU2005214874B2 (en) * 2004-02-13 2010-02-18 Martek Biosciences Corporation Schizochytrium fatty acid synthase (FAS) and products and methods related thereto
DE102004017369A1 (de) * 2004-04-08 2005-11-03 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Screeningverfahren zur Identifizierung von PUFA-PKS in Proben
DE102004017370A1 (de) * 2004-04-08 2005-10-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh PUFA-PKS Gene aus Ulkenia
CA3056110C (en) 2004-04-22 2020-07-14 Surinder Pal Singh Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
DK1756280T3 (en) 2004-04-22 2015-02-02 Commw Scient Ind Res Org SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS
WO2006135866A2 (en) * 2005-06-10 2006-12-21 Martek Biosciences Corporation Pufa polyketide synthase systems and uses thereof
AU2006265801B2 (en) 2005-07-01 2011-07-14 Martek Biosciences Corporation Polyunsaturated fatty acid-containing oil product and uses and production thereof
KR101524398B1 (ko) 2006-03-15 2015-06-04 디에스엠 아이피 어셋츠 비.브이. Ｐｕｆａ 폴리케티드 신타제 시스템을 이용한 이종 생물체내 다불포화 지방산의 제조
WO2008027991A2 (en) * 2006-08-29 2008-03-06 Martek Biosciences Corporation USE OF DPA(n-6) OILS IN INFANT FORMULA
CN101578363A (zh) 2006-08-29 2009-11-11 联邦科学技术研究组织 脂肪酸的合成
NO2358882T3 (https=) 2008-11-18 2017-12-23
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