ES2602486T3 - Análogos de glucagón que muestran actividad de receptor de GIP - Google Patents
Análogos de glucagón que muestran actividad de receptor de GIP Download PDFInfo
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- ES2602486T3 ES2602486T3 ES13731619.6T ES13731619T ES2602486T3 ES 2602486 T3 ES2602486 T3 ES 2602486T3 ES 13731619 T ES13731619 T ES 13731619T ES 2602486 T3 ES2602486 T3 ES 2602486T3
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- 239000003153 chemical reaction reagent Substances 0.000 description 1
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- 230000001904 diabetogenic effect Effects 0.000 description 1
- 125000001142 dicarboxylic acid group Chemical group 0.000 description 1
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- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US201261662868P | 2012-06-21 | 2012-06-21 | |
| US201261662868P | 2012-06-21 | ||
| US201261716878P | 2012-10-22 | 2012-10-22 | |
| US201261716878P | 2012-10-22 | ||
| PCT/US2013/046228 WO2013192129A1 (en) | 2012-06-21 | 2013-06-18 | Glucagon analogs exhibiting gip receptor activity |
Publications (1)
| Publication Number | Publication Date |
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| ES2602486T3 true ES2602486T3 (es) | 2017-02-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ES13731619.6T Active ES2602486T3 (es) | 2012-06-21 | 2013-06-18 | Análogos de glucagón que muestran actividad de receptor de GIP |
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| Country | Link |
|---|---|
| US (1) | US9340600B2 (enExample) |
| EP (1) | EP2864351B1 (enExample) |
| JP (1) | JP6311708B2 (enExample) |
| KR (1) | KR20150023013A (enExample) |
| CN (1) | CN104583232B (enExample) |
| AR (1) | AR091477A1 (enExample) |
| CA (1) | CA2877358A1 (enExample) |
| ES (1) | ES2602486T3 (enExample) |
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| MX (1) | MX2014015558A (enExample) |
| RU (1) | RU2015101697A (enExample) |
| TW (1) | TWI599575B (enExample) |
| WO (1) | WO2013192129A1 (enExample) |
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| CA2765026A1 (en) | 2009-06-16 | 2010-12-23 | Indiana University Research And Technology Corporation | Gip receptor-active glucagon compounds |
| MX391293B (es) | 2011-06-10 | 2025-03-21 | Hanmi Science Co Ltd | DERIVADOs DE OXINTOMODULINA NOVEDOSOS Y COMPOSICION FARMACEUTICA PARA TRATAR LA OBESIDAD QUE COMPRENDE LOS MISMOS. |
| TR201901402T4 (tr) | 2011-06-17 | 2019-02-21 | Hanmi Science Co Ltd | Oksintomodulin ve bir immünoglobulin fragmanı içeren bir konjugat ve onun kullanımı. |
| KR101972617B1 (ko) | 2011-06-22 | 2019-04-25 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 글루카곤/glp-1 수용체 공동-항진제들 |
| KR101968344B1 (ko) | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| UA126651C2 (uk) | 2012-11-06 | 2023-01-11 | Ханмі Фарм. Ко., Лтд. | Рідка композиція протеїнового кон'югата, що містить оксинтомодулін та фрагмент імуноглобуліну |
| KR101993393B1 (ko) | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
| LT2934567T (lt) | 2012-12-21 | 2018-09-10 | Sanofi | Eksendino-4 dariniai kaip dvigubi glp1/gip arba trigubi glp1/gip/gliukagono agonistai |
| MX388826B (es) | 2013-05-28 | 2025-03-20 | Scohia Pharma Inc | Compuesto peptidico. |
| AR098614A1 (es) * | 2013-12-18 | 2016-06-01 | Lilly Co Eli | Compuesto para el tratamiento de hipoglicemia severa |
| CA2939763A1 (en) * | 2014-02-18 | 2015-08-27 | Novo Nordisk A/S | Stable glucagon analogues and use for treatment of hypoglycaemia |
| TWI772252B (zh) | 2014-09-16 | 2022-08-01 | 南韓商韓美藥品股份有限公司 | 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途 |
| CN104926934B (zh) * | 2014-09-23 | 2016-11-09 | 蒋先兴 | 胃泌酸调节素类似物 |
| US10232020B2 (en) * | 2014-09-24 | 2019-03-19 | Indiana University Research And Technology Corporation | Incretin-insulin conjugates |
| JP2018012644A (ja) * | 2014-11-26 | 2018-01-25 | 武田薬品工業株式会社 | ペプチド化合物 |
| KR102418477B1 (ko) | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
| PE20230304A1 (es) | 2014-12-30 | 2023-02-13 | Hanmi Pharm Ind Co Ltd | Derivados de glucagon como agentes hipoglucemicos y antiobesidad |
| JOP20200119A1 (ar) * | 2015-01-09 | 2017-06-16 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| WO2017003191A1 (en) | 2015-06-30 | 2017-01-05 | Hanmi Pharm. Co., Ltd. | Glucagon derivative and a composition comprising a long acting conjugate of the same |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| SG11201805586SA (en) * | 2015-12-31 | 2018-07-30 | Hanmi Pharmaceutical Co Ltd | Triple glucagon/glp-1/gip receptor agonist |
| JP6995042B2 (ja) | 2016-05-24 | 2022-02-04 | 武田薬品工業株式会社 | ペプチド化合物 |
| MX2019000019A (es) | 2016-06-29 | 2019-05-06 | Hanmi Pharm Ind Co Ltd | Derivado de glucagon, conjugado del mismo, composicion que comprende el mismo y uso terapeutico del mismo. |
| TW201833131A (zh) | 2016-12-02 | 2018-09-16 | 法商賽諾菲公司 | 作為胜肽類ｇｌｐ１／升糖素／ｇｉｐ受體促效劑之新化合物 |
| TW201833132A (zh) * | 2016-12-02 | 2018-09-16 | 法商賽諾菲公司 | 作為肽類ｇｌｐ１／升糖素／ｇｉｐ三重受體激動劑之新穎化合物 |
| GB201620611D0 (en) * | 2016-12-05 | 2017-01-18 | Univ Of Lancaster | Treatment of neurological diseases |
| JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
| EP3774837A1 (en) | 2018-04-10 | 2021-02-17 | Sanofi-Aventis Deutschland GmbH | Method for cleavage of solid phase-bound peptides from the solid phase |
| DK3774838T4 (da) | 2018-04-10 | 2025-12-15 | Sanofi Aventis Deutschland | Lixisenatidsyntese med capping |
| KR102379958B1 (ko) * | 2018-05-04 | 2022-04-01 | 노보 노르디스크 에이/에스 | Gip 유도체 및 이의 용도 |
| TW202015735A (zh) | 2018-05-30 | 2020-05-01 | 法商賽諾菲公司 | 包含ｇｌｐ－１／升糖素／ｇｉｐ三重受體促效劑、連接子及透明質酸之接合物 |
| US12122815B2 (en) * | 2018-09-24 | 2024-10-22 | Takeda Pharmaceutical Company Limited | GIP receptor agonist peptide compounds and uses thereof |
| CN111171134B (zh) * | 2018-11-12 | 2023-08-15 | 天津药物研究院有限公司 | 胰高血糖素衍生肽及其用途 |
| WO2020115049A1 (en) * | 2018-12-03 | 2020-06-11 | Antag Therapeutics Aps | Modified gip peptide analogues |
| CN110128526B (zh) * | 2019-05-30 | 2021-07-23 | 江苏诺泰澳赛诺生物制药股份有限公司 | 长效化艾塞那肽衍生物及其盐与制备方法和用途 |
| JP7111917B2 (ja) * | 2019-06-28 | 2022-08-02 | ハンミ ファーマシューティカル カンパニー リミテッド | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体の全てに対して活性を有する三重活性体又はその結合体の肝疾患に対する治療的使用 |
| EP4112637A4 (en) * | 2020-02-24 | 2024-04-03 | Shenzhen Turier Biotech Co., Ltd. | POLYPEPTIDE COMPOUND AND ITS APPLICATION IN THE PREVENTION OR TREATMENT OF DIABETES OR A COMPLICATION OF DIABETES |
| KR20230018395A (ko) * | 2020-05-29 | 2023-02-07 | 베이징 투오 지에 바이오파마수티컬 컴퍼니 리미티드 | Glp-1 및 gip 수용체 둘 모두에 대한 이중 작용제 화합물 및 이의 적용 |
| AU2021308828A1 (en) * | 2020-07-15 | 2023-02-23 | Hanmi Pharm. Co., Ltd. | Therapeutic use of glucagon derivative or conjugate thereof for liver disease |
| WO2022015115A1 (ko) * | 2020-07-17 | 2022-01-20 | 한미약품 주식회사 | 3중 작용성 지속형 결합체 또는 3중 작용제를 포함하는 조합물의 치료학적 용도 |
| WO2022035271A1 (ko) * | 2020-08-14 | 2022-02-17 | 한미약품 주식회사 | 삼중 활성체 지속형 결합체를 유효성분으로 포함하는 약학 조성물 |
| JP2023543036A (ja) * | 2020-09-25 | 2023-10-12 | ハンミ ファーマシューティカル カンパニー リミテッド | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体の全てに対して活性を有する三重活性体またはその結合体の神経退行性疾患の治療用途 |
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| WO2022090447A1 (en) * | 2020-10-30 | 2022-05-05 | Novo Nordisk A/S | Glp-1, gip and glucagon receptor triple agonists |
| EP4249505A4 (en) * | 2020-12-23 | 2024-08-21 | Zhejiang Doer Biologics Co., Ltd. | GLUCAGONE DERIVATIVE WITH LONG-TERM EFFECTS |
| EP4289860A4 (en) * | 2021-01-22 | 2025-01-01 | Shenzhen Turier Biotech Co., Ltd. | Use of polypeptide compound in prevention or treatment of inflammatory bowel disease and intestinal fibrosis related thereto |
| WO2022216129A1 (ko) * | 2021-04-09 | 2022-10-13 | 한미약품 주식회사 | 글루카곤 유도체를 포함하는 만성 신장 질환 예방 또는 치료용 약학 조성물 |
| EP4357358A4 (en) * | 2021-06-18 | 2024-11-06 | Beijing Tuo Jie Biopharmaceutical Co. Ltd. | GLUCAGONE ANALOGUE AND MEDICAL USE THEREOF |
| KR20230095666A (ko) * | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 간 표적 물질 및 이의 용도 |
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-
2013
- 2013-06-18 ES ES13731619.6T patent/ES2602486T3/es active Active
- 2013-06-18 RU RU2015101697A patent/RU2015101697A/ru unknown
- 2013-06-18 KR KR20157000956A patent/KR20150023013A/ko not_active Withdrawn
- 2013-06-18 CN CN201380040322.2A patent/CN104583232B/zh not_active Expired - Fee Related
- 2013-06-18 WO PCT/US2013/046228 patent/WO2013192129A1/en not_active Ceased
- 2013-06-18 MX MX2014015558A patent/MX2014015558A/es unknown
- 2013-06-18 CA CA2877358A patent/CA2877358A1/en not_active Abandoned
- 2013-06-18 AR ARP130102142 patent/AR091477A1/es unknown
- 2013-06-18 EP EP13731619.6A patent/EP2864351B1/en not_active Not-in-force
- 2013-06-18 TW TW102121606A patent/TWI599575B/zh not_active IP Right Cessation
- 2013-06-18 JP JP2015518505A patent/JP6311708B2/ja active Active
- 2013-06-18 HK HK15110472.9A patent/HK1209764A1/xx unknown
- 2013-06-18 US US13/920,188 patent/US9340600B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013192129A1 (en) | 2013-12-27 |
| HK1209764A1 (en) | 2016-04-08 |
| CA2877358A1 (en) | 2013-12-27 |
| MX2014015558A (es) | 2015-03-05 |
| CN104583232A (zh) | 2015-04-29 |
| TW201402598A (zh) | 2014-01-16 |
| RU2015101697A (ru) | 2016-08-10 |
| EP2864351A1 (en) | 2015-04-29 |
| KR20150023013A (ko) | 2015-03-04 |
| JP2015521622A (ja) | 2015-07-30 |
| TWI599575B (zh) | 2017-09-21 |
| CN104583232B (zh) | 2018-04-13 |
| US9340600B2 (en) | 2016-05-17 |
| EP2864351B1 (en) | 2016-08-10 |
| AR091477A1 (es) | 2015-02-04 |
| JP6311708B2 (ja) | 2018-04-18 |
| US20140011738A1 (en) | 2014-01-09 |
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