ES2602474T3 - Angiogénesis que usa células madre placentarias - Google Patents
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- ES2602474T3 ES2602474T3 ES11766619.8T ES11766619T ES2602474T3 ES 2602474 T3 ES2602474 T3 ES 2602474T3 ES 11766619 T ES11766619 T ES 11766619T ES 2602474 T3 ES2602474 T3 ES 2602474T3
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Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002046373A1 (en) | 2000-12-06 | 2002-06-13 | Hariri Robert J | Method of collecting placental stem cells |
| NZ528035A (en) | 2001-02-14 | 2005-07-29 | Robert J Hariri | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US9119899B2 (en) * | 2006-01-18 | 2015-09-01 | Cormatrix Cardiovascular, Inc. | Method and system for treatment of cardiovascular disorders |
| NZ597304A (en) | 2005-10-13 | 2013-06-28 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
| DK2471904T3 (en) | 2005-12-29 | 2019-02-18 | Celularity Inc | Placenta stem cell populations |
| CN101688177A (zh) | 2007-02-12 | 2010-03-31 | 人类起源公司 | 来自贴壁胎盘干细胞的肝细胞和软骨细胞；以及cd34+、cd45-胎盘干细胞富集的细胞群 |
| US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
| AU2008307633C1 (en) | 2007-09-28 | 2015-04-30 | Celularity Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| MX339624B (es) | 2008-08-20 | 2016-06-02 | Anthrogenesis Corp | Composiciones mejoradas de celulas y metodos para preparar las mismas. |
| EP2331109B1 (en) | 2008-08-22 | 2013-05-29 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| MX353489B (es) | 2009-07-02 | 2018-01-16 | Anthrogenesis Corp | Metodo para producir eritrocitos sin celulas alimentadoras. |
| DK3284818T3 (da) | 2010-01-26 | 2022-06-20 | Celularity Inc | Behandling af knoglerelateret kræft ved hjælp af placenta stamceller |
| TW201703777A (zh) * | 2010-04-07 | 2017-02-01 | 安瑟吉納西斯公司 | 利用胎盤幹細胞之血管新生 |
| NZ602798A (en) | 2010-04-08 | 2014-10-31 | Anthrogenesis Corp | Treatment of sarcoidosis using placental stem cells |
| WO2012009422A1 (en) | 2010-07-13 | 2012-01-19 | Anthrogenesis Corporation | Methods of generating natural killer cells |
| AR093183A1 (es) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras |
| US20120264215A1 (en) * | 2011-04-18 | 2012-10-18 | Korea University Research And Business Foudation Of Korea University | Placenta-derived cell-conditioned culture media and animal-free, feeder-free method for culturing stem cells using the same |
| CN104220081A (zh) | 2011-06-01 | 2014-12-17 | 人类起源公司 | 利用胎盘干细胞治疗疼痛 |
| WO2013055476A1 (en) | 2011-09-09 | 2013-04-18 | Anthrogenesis Corporation | Treatment of amyotrophic lateral sclerosis using placental stem cells |
| WO2013082417A1 (en) * | 2011-11-30 | 2013-06-06 | Anthrogenesis Corporation | Treatment using placental stem cells |
| CN104822384A (zh) * | 2012-03-30 | 2015-08-05 | 南加州大学 | 用于间充质干细胞诱导的免疫调节的组合物和治疗方法 |
| CA2869163A1 (en) * | 2012-03-30 | 2013-10-03 | University Of Central Florida Research Foundation, Inc. | Methods and compositions using fgf-8 to enhance cardiac regeneration and attenuate adverse cardiac remodeling |
| US9943551B2 (en) | 2012-08-15 | 2018-04-17 | Mimedx Group, Inc. | Tissue grafts composed of micronized placental tissue and methods of making and using the same |
| US9180145B2 (en) | 2012-10-12 | 2015-11-10 | Mimedx Group, Inc. | Compositions and methods for recruiting and localizing stem cells |
| EP3556215A1 (en) | 2012-12-14 | 2019-10-23 | Celularity, Inc. | Anoikis resistant placental stem cells and uses thereof |
| US10206977B1 (en) | 2013-01-18 | 2019-02-19 | Mimedx Group, Inc. | Isolated placental stem cell recruiting factors |
| JP6545102B2 (ja) | 2013-01-18 | 2019-07-17 | ミメディクス グループ インコーポレイテッド | 心病態を治療する方法 |
| WO2014123879A1 (en) | 2013-02-05 | 2014-08-14 | Anthrogenesis Corporation | Natural killer cells from placenta |
| WO2014159806A1 (en) | 2013-03-14 | 2014-10-02 | Anthrogenesis Corporation | Enhanced placental stem cells and uses thereof |
| WO2014159826A1 (en) * | 2013-03-14 | 2014-10-02 | Antrhogenesis Corporation | Use of placental stem cells in treatment of acute kidney injury |
| US10029030B2 (en) | 2013-03-15 | 2018-07-24 | Mimedx Group, Inc. | Molded placental tissue compositions and methods of making and using the same |
| MX2016006270A (es) | 2013-11-15 | 2016-09-07 | Anthrogenesis Corp | Composiciones que comprenden células perfundidas de placenta humana, subpoblaciones de las mismas y sus usos. |
| US10052351B2 (en) | 2014-01-17 | 2018-08-21 | Mimedx Group, Inc. | Method for inducing angiogenesis |
| CN103756957B (zh) * | 2014-01-27 | 2015-11-18 | 山东省齐鲁干细胞工程有限公司 | 一种从胎盘中洗脱内皮祖细胞的方法 |
| CA2938431A1 (en) * | 2014-02-05 | 2015-08-13 | Muffin Incorporated | Compartmented cryopreservation container and uses thereof |
| JP6474549B2 (ja) * | 2014-03-03 | 2019-02-27 | 国立大学法人徳島大学 | 幹細胞の培養産物の評価指標及びその利用 |
| WO2016011283A1 (en) * | 2014-07-17 | 2016-01-21 | Cedars-Sinai Medical Center | Blood-vessel therapeutic patch composed of endothelial cells derived from ipscs pre-treated with leptin |
| WO2016049485A1 (en) * | 2014-09-26 | 2016-03-31 | Anthrogenesis Corporation | Treatment of diabetic foot ulcer using placental stem cells |
| CN107106615A (zh) * | 2014-10-09 | 2017-08-29 | 人类起源公司 | 胎盘来源的贴壁细胞外泌体及其用途 |
| KR101808762B1 (ko) * | 2014-10-29 | 2017-12-14 | 차의과학대학교 산학협력단 | C3 또는 C1r 보체를 분비하는 태반 유래 세포 및 이를 포함하는 조성물 |
| KR20170102319A (ko) * | 2014-12-31 | 2017-09-08 | 안트로제네시스 코포레이션 | 혈소판을 분리하는 방법 |
| EP3310173A4 (en) * | 2015-05-26 | 2019-02-20 | Celularity, Inc. | ANGIOGENESIS WITH STIMULATED PLAZENTAL STEM CELLS |
| US20180325960A1 (en) * | 2015-08-28 | 2018-11-15 | Cha Biotech Co., Ltd. | Enhanced postnatal adherent cell, and use for same |
| CN108367028A (zh) * | 2015-09-15 | 2018-08-03 | 细胞结构公司 | 使用胎盘细胞治疗糖尿病性周围神经病变 |
| CN108368479A (zh) * | 2015-09-29 | 2018-08-03 | 细胞结构公司 | 细胞效能分析 |
| CN106310227A (zh) * | 2016-09-30 | 2017-01-11 | 广州赛莱拉干细胞科技股份有限公司 | 一种干细胞制剂及其制备方法和应用 |
| WO2019177269A1 (ko) * | 2018-03-16 | 2019-09-19 | 주식회사 메디노 | 신경줄기세포를 이용한 혈관형성 유도 방법 |
| CN108904799A (zh) * | 2018-07-09 | 2018-11-30 | 夏荣木 | 一种抗肿瘤制剂及制备的方法 |
| KR102593791B1 (ko) * | 2021-02-26 | 2023-10-25 | 경희대학교 산학협력단 | Pdgf-bb를 이용한 혈관 형성능이 증진된 골수 유래 혈관내피전구세포의 제조방법 및 이를 이용한 혈관형성 부전-관련 질환 치료용 세포치료제의 제조방법 |
| CN116334210B (zh) * | 2023-03-06 | 2025-10-31 | 中国人民解放军总医院 | Aldh1a1和amigo2基因在制备房颤诊断和干预产品中的应用 |
Family Cites Families (272)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862002A (en) | 1962-05-08 | 1975-01-21 | Sanfar Lab Inc | Production of physiologically active placental substances |
| US4829000A (en) | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US5902741A (en) | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| NZ226750A (en) | 1987-10-29 | 1990-09-26 | Amrad Corp Ltd | Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US5192553A (en) | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| GB8803697D0 (en) | 1988-02-17 | 1988-03-16 | Deltanine Research Ltd | Clinical developments using amniotic membrane cells |
| US5284766A (en) | 1989-02-10 | 1994-02-08 | Kao Corporation | Bed material for cell culture |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5399493A (en) | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| US5635386A (en) | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
| US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5605822A (en) | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
| US5763266A (en) | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
| DE69033493D1 (de) | 1989-07-25 | 2004-08-12 | Cell Genesys Inc | Homologe rekombination für universelle donorzellen und chimerische säugetierzellen |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1991006667A1 (en) | 1989-11-06 | 1991-05-16 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| US6326198B1 (en) | 1990-06-14 | 2001-12-04 | Regents Of The University Of Michigan | Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US6010696A (en) | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
| US5733542A (en) | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
| US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5197985A (en) | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
| US5226914A (en) | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US5190556A (en) | 1991-03-19 | 1993-03-02 | O.B. Tech, Inc. | Cord cutter sampler |
| US5744361A (en) | 1991-04-09 | 1998-04-28 | Indiana University | Expansion of human hematopoietic progenitor cells in a liquid medium |
| EP0552380A4 (en) | 1991-08-08 | 1995-01-25 | Kao Corp | Cell culture support, production thereof, and production of cell cluster using same |
| EP0529751A1 (en) | 1991-08-09 | 1993-03-03 | W.R. Grace & Co.-Conn. | Cell culture substrate, test material for cell culture and preparations thereof |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| HUT69788A (en) | 1991-12-23 | 1995-09-28 | British Bio Technology | Stem cell inhibiting proteins |
| EP0590156A4 (en) | 1992-03-31 | 1994-07-13 | Toray Industries | Novel, physiologically active protein and hemopoietic stem cell growth promoter |
| US5460964A (en) | 1992-04-03 | 1995-10-24 | Regents Of The University Of Minnesota | Method for culturing hematopoietic cells |
| US5552267A (en) | 1992-04-03 | 1996-09-03 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
| AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
| US5672346A (en) | 1992-07-27 | 1997-09-30 | Indiana University Foundation | Human stem cell compositions and methods |
| US5693482A (en) | 1992-07-27 | 1997-12-02 | California Institute Of Technology | Neural chest stem cell assay |
| US5849553A (en) | 1992-07-27 | 1998-12-15 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| SG86980A1 (en) | 1992-11-16 | 2002-03-19 | Applied Immunesciences | Pluripotential quiescent stem cell population |
| US5772992A (en) | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
| US5654186A (en) | 1993-02-26 | 1997-08-05 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
| AU694111B2 (en) | 1993-03-31 | 1998-07-16 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
| GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
| US5709854A (en) | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
| US5372581A (en) | 1993-07-21 | 1994-12-13 | Minneapolis Children's Services Corporation | Method and apparatus for placental blood collection |
| US5591625A (en) | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| US6288030B1 (en) | 1993-12-22 | 2001-09-11 | Amgen Inc. | Stem cell factor formulations and methods |
| US6001654A (en) | 1994-01-28 | 1999-12-14 | California Institute Of Technology | Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors |
| US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| JPH10505250A (ja) | 1994-06-06 | 1998-05-26 | ケース ウエスターン リザーブ ユニバーシティ | 組織再生のためのバイオマトリックス |
| US6174333B1 (en) | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
| DE4422667A1 (de) | 1994-06-30 | 1996-01-04 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Züchtung hämatopoetischer Vorläuferzellen |
| US6103522A (en) | 1994-07-20 | 2000-08-15 | Fred Hutchinson Cancer Research Center | Human marrow stromal cell lines which sustain hematopoiesis |
| US5516532A (en) | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
| US5827742A (en) | 1994-09-01 | 1998-10-27 | Beth Israel Deaconess Medical Center, Inc. | Method of selecting pluripotent hematopioetic progenitor cells |
| US5665557A (en) | 1994-11-14 | 1997-09-09 | Systemix, Inc. | Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof |
| US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5789147A (en) | 1994-12-05 | 1998-08-04 | New York Blood Center, Inc. | Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5695998A (en) | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
| US6011000A (en) | 1995-03-03 | 2000-01-04 | Perrine; Susan P. | Compositions for the treatment of blood disorders |
| US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| US5716616A (en) | 1995-03-28 | 1998-02-10 | Thomas Jefferson University | Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects |
| US5677139A (en) | 1995-04-21 | 1997-10-14 | President And Fellows Of Harvard College | In vitro differentiation of CD34+ progenitor cells into T lymphocytes |
| US5733541A (en) | 1995-04-21 | 1998-03-31 | The Regent Of The University Of Michigan | Hematopoietic cells: compositions and methods |
| WO1996034035A1 (en) | 1995-04-27 | 1996-10-31 | The Procter & Gamble Company | Carrier substrate treated with high internal water phase inverse emulsion made with an organopolysiloxane-polyoxyalkylene emulsifier |
| US5925567A (en) | 1995-05-19 | 1999-07-20 | T. Breeders, Inc. | Selective expansion of target cell populations |
| US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| US5830708A (en) | 1995-06-06 | 1998-11-03 | Advanced Tissue Sciences, Inc. | Methods for production of a naturally secreted extracellular matrix |
| WO1996040875A1 (en) | 1995-06-07 | 1996-12-19 | Novartis Ag | Methods for obtaining compositions enriched for hematopoietic stem cells and antibodies for use therein |
| US5654381A (en) | 1995-06-16 | 1997-08-05 | Massachusetts Institute Of Technology | Functionalized polyester graft copolymers |
| US6306575B1 (en) | 1995-06-16 | 2001-10-23 | Stemcell Technologies, Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| US5877299A (en) | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| US5858782A (en) | 1995-11-13 | 1999-01-12 | Regents Of The University Of Michigan | Functional human hematopoietic cells |
| US5922597A (en) | 1995-11-14 | 1999-07-13 | Regents Of The University Of Minnesota | Ex vivo culture of stem cells |
| DE69634303T2 (de) | 1995-11-16 | 2006-01-05 | Case Western Reserve University, Cleveland | Chondrogene in vitro induktion von menschlichen mensenchymalen stammzellen |
| DE69635899T2 (de) | 1995-11-17 | 2006-11-23 | Asahi Kasei Kabushiki Kaisha | Polypeptid, das die differenzierung unterdrueckt |
| US5716794A (en) | 1996-03-29 | 1998-02-10 | Xybernaut Corporation | Celiac antigen |
| ATE439849T1 (de) | 1996-04-19 | 2009-09-15 | Osiris Therapeutics Inc | Die wiederherstellung und verstärkung von knochen mittels mesenchymalen stammzellen |
| US6497875B1 (en) | 1996-04-26 | 2002-12-24 | Case Western Reserve University | Multilayer skin or dermal equivalent having a layer containing mesenchymal stem cells |
| US5919176A (en) | 1996-05-14 | 1999-07-06 | Children's Hospital Medical Center Of Northern California | Apparatus and method for collecting blood from an umbilical cord |
| US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| US5851984A (en) | 1996-08-16 | 1998-12-22 | Genentech, Inc. | Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides |
| US5916202A (en) | 1996-08-30 | 1999-06-29 | Haswell; John N. | Umbilical cord blood collection |
| US6227202B1 (en) | 1996-09-03 | 2001-05-08 | Maulana Azad Medical College | Method of organogenesis and tissue regeneration/repair using surgical techniques |
| US5945337A (en) | 1996-10-18 | 1999-08-31 | Quality Biological, Inc. | Method for culturing CD34+ cells in a serum-free medium |
| US5919702A (en) | 1996-10-23 | 1999-07-06 | Advanced Tissue Science, Inc. | Production of cartilage tissue using cells isolated from Wharton's jelly |
| US5969105A (en) | 1996-10-25 | 1999-10-19 | Feng; Yiqing | Stem cell factor receptor agonists |
| US6335195B1 (en) | 1997-01-28 | 2002-01-01 | Maret Corporation | Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation |
| US6152142A (en) | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| US6231880B1 (en) | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
| EP1028737B1 (en) | 1997-07-03 | 2007-04-04 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells from peripheral blood |
| DK1007631T4 (da) | 1997-07-14 | 2009-04-27 | Osiris Therapeutics Inc | Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller |
| US7514074B2 (en) | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US6077708A (en) | 1997-07-18 | 2000-06-20 | Collins; Paul C. | Method of determining progenitor cell content of a hematopoietic cell culture |
| US5879318A (en) | 1997-08-18 | 1999-03-09 | Npbi International B.V. | Method of and closed system for collecting and processing umbilical cord blood |
| WO1999011287A1 (en) | 1997-09-04 | 1999-03-11 | Osiris Therapeutics, Inc. | Ligands that modulate differentiation of mesenchymal stem cells |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| US6093531A (en) | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
| US6248587B1 (en) | 1997-11-26 | 2001-06-19 | University Of Southern Cailfornia | Method for promoting mesenchymal stem and lineage-specific cell proliferation |
| US6059968A (en) | 1998-01-20 | 2000-05-09 | Baxter International Inc. | Systems for processing and storing placenta/umbilical cord blood |
| US6291240B1 (en) | 1998-01-29 | 2001-09-18 | Advanced Tissue Sciences, Inc. | Cells or tissues with increased protein factors and methods of making and using same |
| EP1062321B1 (en) | 1998-03-13 | 2004-12-29 | Osiris Therapeutics, Inc. | Uses for humane non-autologous mesenchymal stem cells |
| US6368636B1 (en) | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| CA2320040C (en) | 1998-03-18 | 2007-05-22 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| US6797269B2 (en) | 1998-04-03 | 2004-09-28 | Osiris Therapeutics, Inc. | Mesenchymal stem cells as immunosuppressants |
| KR20010052302A (ko) | 1998-05-04 | 2001-06-25 | 바바라 피. 월너 | 조혈 자극 |
| US6835377B2 (en) | 1998-05-13 | 2004-12-28 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration |
| WO1999061588A1 (en) | 1998-05-22 | 1999-12-02 | Osiris Therapeutics, Inc. | Production of megakaryocytes by co-culturing human mesenchymal stem cells with cd34+ cells |
| EP1082410B1 (en) | 1998-05-29 | 2007-08-01 | Osiris Therapeutics, Inc. | Human cd45+ and/or fibroblast + mesenchymal stem cells |
| JP4526186B2 (ja) | 1998-06-08 | 2010-08-18 | オシリス セラピューティクス，インコーポレイテッド | 造血幹細胞を試験管内で維持する方法と組成物 |
| WO1999064565A2 (en) | 1998-06-08 | 1999-12-16 | Osiris Therapeutics, Inc. | Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells |
| US6713245B2 (en) | 1998-07-06 | 2004-03-30 | Diacrin, Inc. | Methods for storing neural cells such that they are suitable for transplantation |
| ES2198067T3 (es) | 1998-07-28 | 2004-01-16 | Synthes Ag Chur | Utilizacion de compuestos a base de creatina para tratar las celulas y los tejidos oseos y cartilaginosos. |
| US5958767A (en) | 1998-08-14 | 1999-09-28 | The Children's Medical Center Corp. | Engraftable human neural stem cells |
| JP3517359B2 (ja) | 1998-09-14 | 2004-04-12 | テルモ株式会社 | 細胞分離・回収装置および細胞の分離・回収方法 |
| CA2345397A1 (en) | 1998-09-23 | 2000-03-30 | Mount Sinai Hospital | Trophoblast cell preparations |
| EP1129176A4 (en) | 1998-11-09 | 2002-10-30 | Es Cell Int Pte Ltd | EMBRYONIC STEM CELLS |
| US6548299B1 (en) | 1999-11-12 | 2003-04-15 | Mark J. Pykett | Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices |
| AU1720400A (en) | 1998-11-12 | 2000-05-29 | Cell Science Therapeutics, Inc. | Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices |
| US6184035B1 (en) | 1998-11-18 | 2001-02-06 | California Institute Of Technology | Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells |
| US6328765B1 (en) | 1998-12-03 | 2001-12-11 | Gore Enterprise Holdings, Inc. | Methods and articles for regenerating living tissue |
| ATE271890T1 (de) | 1998-12-24 | 2004-08-15 | Biosafe Sa | Vorrichtung zur bluttrennung, insbesondere zur konzentrierung von hematopoietischen stammzellen |
| US20030007954A1 (en) | 1999-04-12 | 2003-01-09 | Gail K. Naughton | Methods for using a three-dimensional stromal tissue to promote angiogenesis |
| EP1210379B1 (en) | 1999-04-16 | 2007-03-21 | Wm. MARSH RICE UNIVERSITY | Biodegradable poly(propylene fumarate) networks cross linked with poly(propylene fumarate)-diacrylate macromers |
| IN191359B (enExample) | 1999-04-20 | 2003-11-29 | Nat Inst Immunology | |
| AU4860900A (en) | 1999-06-02 | 2000-12-18 | Lifebank Services, L.L.C. | Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells |
| US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
| US6355699B1 (en) | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US6239157B1 (en) | 1999-09-10 | 2001-05-29 | Osiris Therapeutics, Inc. | Inhibition of osteoclastogenesis |
| US6685936B2 (en) | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
| US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
| DK1264877T3 (da) | 2000-03-16 | 2013-10-28 | Cellseed Inc | Celledyrkningsbæremateriale, fremgangsmåde til samdyrkning af celler og samdyrket cellelag opnået derved |
| WO2001075094A1 (en) | 2000-04-04 | 2001-10-11 | Thomas Jefferson University | Application of myeloid-origin cells to the nervous system |
| DE60121440T2 (de) | 2000-06-06 | 2007-06-28 | Glaxo Group Ltd., Greenford | Zusammensetzung zur Krebsbehandlung, welche ein antineoplastisches Mittel und einen PDE4-Inhibitor enthält |
| JP4242651B2 (ja) | 2000-11-30 | 2009-03-25 | ザ チルドレンズ メディカル センター コーポレイション | ４−アミノ−サリドマイドエナンチオマーの合成法 |
| US20080152629A1 (en) | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| WO2002046373A1 (en) | 2000-12-06 | 2002-06-13 | Hariri Robert J | Method of collecting placental stem cells |
| US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
| US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| NZ527849A (en) | 2001-02-14 | 2006-09-29 | Anthrogenesis Corp | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| CA2438501C (en) | 2001-02-14 | 2014-09-16 | Leo T. Furcht | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| NZ528035A (en) | 2001-02-14 | 2005-07-29 | Robert J Hariri | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
| US20020132343A1 (en) | 2001-03-19 | 2002-09-19 | Clark Lum | System and method for delivering umbilical cord-derived tissue-matched stem cells for transplantation |
| US20030022358A1 (en) | 2001-05-29 | 2003-01-30 | Hall Jane H. | Growth of filterable organisms that require non-diffusable media components |
| CA2396536A1 (en) | 2001-08-10 | 2003-02-10 | Saiko Uchida | Human stem cells originated from human amniotic mesenchymal cell layer |
| DE10139783C1 (de) | 2001-08-14 | 2003-04-17 | Transtissue Technologies Gmbh | Zellzusammensetzungen zur Behandlung von Osteoarthrose, sowie Verfahren zu deren Herstellung |
| EP1288293A1 (en) | 2001-08-30 | 2003-03-05 | Norio Sakuragawa | Human neural stem cells originated from human amniotic mesenchymal cell layer |
| CN1195055C (zh) | 2001-09-06 | 2005-03-30 | 周胜利 | 从胎盘组织中提取造血干细胞用于建立造血干细胞库的新方法 |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| ATE438708T1 (de) | 2001-11-15 | 2009-08-15 | Childrens Medical Center | Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon |
| JP3728750B2 (ja) | 2001-11-22 | 2005-12-21 | ニプロ株式会社 | 培養皮膚及びその製造方法 |
| US7799324B2 (en) | 2001-12-07 | 2010-09-21 | Geron Corporation | Using undifferentiated embryonic stem cells to control the immune system |
| JP3934539B2 (ja) | 2001-12-12 | 2007-06-20 | 独立行政法人科学技術振興機構 | 胎盤等由来の成体又は生後組織の前駆細胞 |
| AU2003205266A1 (en) | 2002-01-22 | 2003-09-02 | Advanced Cell Technology, Inc. | Stem cell-derived endothelial cells modified to disrupt tumor angiogenesis |
| JP2005517402A (ja) | 2002-02-13 | 2005-06-16 | アンスロジェネシス コーポレーション | 分娩後の哺乳動物胎盤由来の胚様幹細胞、ならびに該細胞の用途および該細胞を用いる治療法 |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| US20030161818A1 (en) | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
| US7282222B2 (en) | 2002-03-15 | 2007-10-16 | The United States Of America As Represented By The Department Of Veterans Affairs | Methods and compositions for directing cells to target organs |
| US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| WO2003087333A2 (en) | 2002-04-12 | 2003-10-23 | Celgene Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| JP2005536189A (ja) | 2002-04-12 | 2005-12-02 | セルジーン・コーポレーション | 血管新生のモジュレーターの同定方法、それにより見出された化合物および該化合物を使用する治療方法 |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US20040161419A1 (en) | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
| WO2003089619A2 (en) | 2002-04-19 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Placental derived stem cells and uses thereof |
| AU2003231950A1 (en) | 2002-05-30 | 2003-12-19 | Celgene Corporation | Modulating cell differentiation and treating myeloproliferative disorders with JNK/MKK inhibitors |
| US7422736B2 (en) | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
| CA2493532C (fr) | 2002-07-31 | 2014-05-27 | Yves Saint-Laurent Parfums | Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules |
| WO2004018658A1 (ja) | 2002-08-23 | 2004-03-04 | Srl, Inc. | ヒト骨幹細胞 |
| US20040062753A1 (en) | 2002-09-27 | 2004-04-01 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
| US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| WO2004047770A2 (en) | 2002-11-26 | 2004-06-10 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
| JP4790592B2 (ja) | 2003-02-11 | 2011-10-12 | ダビース，ジヨン・イー | ヒト臍帯のウォートンジェリーからの前駆細胞 |
| AU2004212009B2 (en) | 2003-02-13 | 2010-07-29 | Celularity Inc. | Use of umbilical cord blood to treat individuals having a disease, disorder or condition |
| WO2004087896A2 (en) | 2003-03-31 | 2004-10-14 | Pfizer Products Inc. | Hepatocyte differentiation of stem cells |
| CN1548529A (zh) | 2003-05-09 | 2004-11-24 | 中国人民解放军军事医学科学院基础医 | 一种人胎盘间充质干细胞的分离方法 |
| US7255729B2 (en) | 2003-05-30 | 2007-08-14 | Noritake Co., Limited | Porous cylindrical-body module, structure for supporting porous cylindrical bodies, and method for fastening a supporting member |
| US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| CA2530421C (en) | 2003-06-27 | 2015-04-21 | Ethicon, Incorporated | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US20050042595A1 (en) | 2003-08-14 | 2005-02-24 | Martin Haas | Banking of multipotent amniotic fetal stem cells |
| US20050089513A1 (en) | 2003-10-28 | 2005-04-28 | Norio Sakuragawa | Side population cells originated from human amnion and their uses |
| US20050186182A1 (en) | 2003-11-10 | 2005-08-25 | Theresa Deisher | Methods of using G-CSF mobilized C-Kit+ cells in the production of embryoid body-like cell clusters for tissue repair and in the treatment of cardiac myopathy |
| KR100560340B1 (ko) | 2003-11-11 | 2006-03-14 | 한훈 | 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법 |
| JP2005151907A (ja) | 2003-11-27 | 2005-06-16 | Shigeo Saito | 胎盤又は羊膜由来ヒト幹細胞及びその樹立方法並びに臓器への分化誘導方法 |
| KR20060109979A (ko) | 2003-12-02 | 2006-10-23 | 셀진 코포레이션 | 혈색소병증 및 빈혈의 치료 및 관리를 위한 방법및 조성물 |
| TWI338714B (en) | 2003-12-02 | 2011-03-11 | Cathay General Hospital | Method of isolation and enrichment of mesenchymal stem cells from amniotic fluid |
| US20050176139A1 (en) | 2004-01-12 | 2005-08-11 | Yao-Chang Chen | Placental stem cell and methods thereof |
| US20050266391A1 (en) | 2004-01-15 | 2005-12-01 | Bennett Brydon L | Methods for preserving tissue |
| EP2298861B1 (en) | 2004-03-22 | 2017-09-13 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| CN1961283A (zh) | 2004-03-26 | 2007-05-09 | 细胞基因公司 | 建立干细胞库的系统和方法 |
| WO2005105992A1 (en) | 2004-04-21 | 2005-11-10 | New York Eye & Ear Infirmary | Chondrocyte culture formulations |
| JP2006006249A (ja) | 2004-06-28 | 2006-01-12 | Hiroshima Univ | 羊膜由来細胞の培養方法及びその利用 |
| US7244759B2 (en) | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| WO2006015214A2 (en) | 2004-07-29 | 2006-02-09 | Steenblock Research Institute, Inc. | Umbilical cord stem cell composition & method of treating neurological diseases |
| NZ553695A (en) | 2004-08-16 | 2009-10-30 | Cellres Corp Pte Ltd | Isolation of stem/progenitor cells from amniotic membrane of umbilical cord |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| US7909806B2 (en) | 2004-09-23 | 2011-03-22 | Anthrogenesis Corporation | Cord blood and placenta collection kit |
| US8039258B2 (en) | 2004-09-28 | 2011-10-18 | Ethicon, Inc. | Tissue-engineering scaffolds containing self-assembled-peptide hydrogels |
| WO2006101548A2 (en) | 2004-12-21 | 2006-09-28 | Ethicon, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
| US20060166361A1 (en) | 2004-12-21 | 2006-07-27 | Agnieszka Seyda | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
| EP1835924B1 (en) | 2004-12-23 | 2013-08-21 | Ethicon, Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| JP5340599B2 (ja) | 2004-12-23 | 2013-11-13 | エシコン・インコーポレイテッド | 臍帯組織由来産褥細胞ならびにその製造方法および使用方法 |
| US20070041943A1 (en) | 2004-12-29 | 2007-02-22 | Children's Hospital Research | Expression of virus entry inhibitors and recombinant AAV thereof |
| EP1833494B1 (en) | 2005-01-07 | 2016-05-18 | Wake Forest University Health Sciences | Regeneration of pancreatic islets by amniotic fluid stem cell therapy |
| US7642091B2 (en) | 2005-02-24 | 2010-01-05 | Jau-Nan Lee | Human trophoblast stem cells and use thereof |
| US20060222634A1 (en) | 2005-03-31 | 2006-10-05 | Clarke Diana L | Amnion-derived cell compositions, methods of making and uses thereof |
| CA2648506A1 (en) | 2005-04-16 | 2006-10-26 | Axordia Limited | Cytotrophoblast stem cell |
| AU2006202209B2 (en) | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
| AU2006257878A1 (en) | 2005-06-10 | 2006-12-21 | Celgene Corporation | Human placental collagen compositions, processes for their preparation, methods of their use and kits comprising the compositions |
| WO2007005807A2 (en) | 2005-06-30 | 2007-01-11 | Anthrogenesis Corporation | Repair of tympanic membrane using placenta derived collagen biofabric |
| WO2007009061A2 (en) | 2005-07-13 | 2007-01-18 | Anthrogenesis Corporation | Ocular plug formed from placenta derived collagen biofabric |
| US7928280B2 (en) | 2005-07-13 | 2011-04-19 | Anthrogenesis Corporation | Treatment of leg ulcers using placenta derived collagen biofabric |
| WO2007011693A2 (en) | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions of placentally-derived stem cells for the treatment of cancer |
| EP1915440A4 (en) | 2005-08-19 | 2009-11-04 | Bio Regenerate Inc | COMPOSITIONS OF CELLS ENRICHED WITH COMBINATIONS OF VARIOUS STRAIN AND PRECURSOR CELL POPULATIONS, METHOD OF USE THEREOF, AND METHOD FOR THE PREPARATION OF PRIVATE BANKS THEREOF |
| NZ597304A (en) | 2005-10-13 | 2013-06-28 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
| EP2368973A1 (en) | 2005-10-13 | 2011-09-28 | Anthrogenesis Corporation | Production Of Oligodendrocytes From Placenta-Derived Stem Cells |
| CN100344757C (zh) | 2005-10-18 | 2007-10-24 | 天津昂赛细胞基因工程有限公司 | 人胎盘、脐带间充质干细胞库及其构建方法 |
| PL1971681T3 (pl) | 2005-12-16 | 2018-01-31 | Depuy Synthes Products Inc | Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej |
| JP5179376B2 (ja) | 2005-12-19 | 2013-04-10 | エシコン・インコーポレイテッド | ローラーボトルでの分娩後取り出し細胞の体外増殖 |
| WO2007071048A1 (en) | 2005-12-22 | 2007-06-28 | Jane Ennis | Viable cells from frozen umbilical cord tissue |
| WO2007076522A2 (en) | 2005-12-28 | 2007-07-05 | Ethicon, Incorporated | Treatment of peripheral vascular disease using postpartum-derived cells |
| DK2471904T3 (en) | 2005-12-29 | 2019-02-18 | Celularity Inc | Placenta stem cell populations |
| CA2633980A1 (en) | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
| JP2009521930A (ja) | 2005-12-29 | 2009-06-11 | アントフロゲネシス コーポレーション | 胎盤幹細胞及び第２供給源由来幹細胞の共存培養 |
| US20070253931A1 (en) | 2006-01-12 | 2007-11-01 | Osiris Therapeutics, Inc. | Use of mesenchymal stem cells for treating genetic diseases and disorders |
| US9944900B2 (en) | 2006-01-18 | 2018-04-17 | Hemacell Perfusion | Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells |
| US11992507B2 (en) | 2006-01-23 | 2024-05-28 | Abt Holding Company | MAPC therapeutics without adjunctive immunosuppressive treatment |
| MX2008015645A (es) | 2006-06-09 | 2009-02-06 | Anthrogenesis Corp | Nicho placentario y uso de este para cultivar celulas primordiales. |
| US20070287176A1 (en) | 2006-06-13 | 2007-12-13 | Alireza Rezania | Chorionic villus derived cells |
| US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| US8105634B2 (en) | 2006-08-15 | 2012-01-31 | Anthrogenesis Corporation | Umbilical cord biomaterial for medical use |
| US20080131522A1 (en) | 2006-10-03 | 2008-06-05 | Qing Liu | Use of placental biomaterial for ocular surgery |
| WO2008060377A2 (en) | 2006-10-04 | 2008-05-22 | Anthrogenesis Corporation | Placental or umbilical cord tissue compositions |
| EP2076279B1 (en) | 2006-10-06 | 2014-08-27 | Anthrogenesis Corporation | Native (telopeptide) placental collagen compositions |
| CA2850793A1 (en) | 2006-10-23 | 2008-05-02 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| ES2524443T3 (es) | 2006-11-13 | 2014-12-09 | DePuy Synthes Products, LLC | Expansión in vitro de células postparto usando microportadores |
| CN101688177A (zh) | 2007-02-12 | 2010-03-31 | 人类起源公司 | 来自贴壁胎盘干细胞的肝细胞和软骨细胞；以及cd34+、cd45-胎盘干细胞富集的细胞群 |
| HRP20130765T1 (hr) | 2007-02-12 | 2013-10-25 | Anthrogenesis Corporation | Lijeäśenje protuupalnih bolesti putem matiäśnih stanica posteljice |
| US20100172830A1 (en) | 2007-03-29 | 2010-07-08 | Cellx Inc. | Extraembryonic Tissue cells and method of use thereof |
| CN107028981B (zh) * | 2007-09-19 | 2021-04-20 | 普拉里斯坦有限公司 | 来自脂肪或胎盘组织的粘附细胞及其在治疗中的用途 |
| RU2010116271A (ru) | 2007-09-26 | 2011-11-10 | Селджин Селльюлар Терапьютикс (Us) | Ангиогенные клетки из плацентарного перфузата человека |
| AU2008307633C1 (en) | 2007-09-28 | 2015-04-30 | Celularity Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| KR20210056449A (ko) | 2007-11-07 | 2021-05-18 | 안트로제네시스 코포레이션 | 조산 합병증의 치료에 있어서의 제대혈의 용도 |
| MX339624B (es) | 2008-08-20 | 2016-06-02 | Anthrogenesis Corp | Composiciones mejoradas de celulas y metodos para preparar las mismas. |
| JP5950577B2 (ja) * | 2008-08-20 | 2016-07-13 | アンスロジェネシス コーポレーション | 単離胎盤細胞を使用した脳卒中の治療 |
| EP2331109B1 (en) | 2008-08-22 | 2013-05-29 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| CN102282249A (zh) * | 2008-09-02 | 2011-12-14 | 普拉里斯坦有限公司 | 来自胎盘组织的粘附细胞及其在治疗中的用途 |
| CA2743566C (en) | 2008-11-19 | 2021-11-09 | Anthrogenesis Corporation | Amnion derived adherent cells |
| WO2010060031A1 (en) | 2008-11-21 | 2010-05-27 | Anthrogenesis Corporation | Treatment of diseases, disorders or conditions of the lung using placental cells |
| WO2010141654A1 (en) | 2009-06-05 | 2010-12-09 | Anthrogenesis Corporation | Improved method of collecting placental cells |
| MX353489B (es) | 2009-07-02 | 2018-01-16 | Anthrogenesis Corp | Metodo para producir eritrocitos sin celulas alimentadoras. |
| DK3284818T3 (da) | 2010-01-26 | 2022-06-20 | Celularity Inc | Behandling af knoglerelateret kræft ved hjælp af placenta stamceller |
| US20110280849A1 (en) | 2010-03-26 | 2011-11-17 | Anthrogenesis Corporation | Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds |
| TW201703777A (zh) | 2010-04-07 | 2017-02-01 | 安瑟吉納西斯公司 | 利用胎盤幹細胞之血管新生 |
| NZ602798A (en) | 2010-04-08 | 2014-10-31 | Anthrogenesis Corp | Treatment of sarcoidosis using placental stem cells |
| WO2012009422A1 (en) | 2010-07-13 | 2012-01-19 | Anthrogenesis Corporation | Methods of generating natural killer cells |
| WO2012092458A2 (en) | 2010-12-30 | 2012-07-05 | Anthrogenesis Corporation | Compositions comprising placental stem cells and platelet rich plasma, and methods of use thereof |
| CN103648507A (zh) | 2010-12-30 | 2014-03-19 | 人类起源公司 | 用于冷冻保存和包封细胞的方法 |
| AR093183A1 (es) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras |
| CN104220081A (zh) | 2011-06-01 | 2014-12-17 | 人类起源公司 | 利用胎盘干细胞治疗疼痛 |
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