ES2523734T3 - Derivados aminopropiónicos sustituidos como inhibidores de neprilisina - Google Patents

Derivados aminopropiónicos sustituidos como inhibidores de neprilisina Download PDF

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Publication number
ES2523734T3
ES2523734T3 ES10720165.9T ES10720165T ES2523734T3 ES 2523734 T3 ES2523734 T3 ES 2523734T3 ES 10720165 T ES10720165 T ES 10720165T ES 2523734 T3 ES2523734 T3 ES 2523734T3
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Prior art keywords
7alkyl
halo
acid
pharmaceutically acceptable
hydroxy
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Spanish (es)
Inventor
Gary Mark Coppola
Yuki Iwaki
Rajeshri Ganesh Karki
Toshio Kawanami
Gary Michael Ksander
Muneto Mogi
Robert Sun
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Novartis AG
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Novartis AG
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    • C07—ORGANIC CHEMISTRY
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    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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