ES2487533T7 - Anticuerpos antagonistas de IL-17 - Google Patents

Anticuerpos antagonistas de IL-17 Download PDF

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Publication number
ES2487533T7
ES2487533T7 ES10175150.1T ES10175150T ES2487533T7 ES 2487533 T7 ES2487533 T7 ES 2487533T7 ES 10175150 T ES10175150 T ES 10175150T ES 2487533 T7 ES2487533 T7 ES 2487533T7
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ES
Spain
Prior art keywords
seq
amino acid
antibody
acid sequence
binds
Prior art date
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Active
Application number
ES10175150.1T
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English (en)
Spanish (es)
Other versions
ES2487533T3 (es
Inventor
Franco E. Di Padova
Hermann Gram
Hans Hofstetter
Margit Jeschke
Jean-Michel Rondeau
Wim Van Den Berg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
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Novartis AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32982602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2487533(T7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of ES2487533T3 publication Critical patent/ES2487533T3/es
Application granted granted Critical
Publication of ES2487533T7 publication Critical patent/ES2487533T7/es
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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Plant Pathology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES10175150.1T 2004-08-05 2005-08-04 Anticuerpos antagonistas de IL-17 Active ES2487533T7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0417487.6A GB0417487D0 (en) 2004-08-05 2004-08-05 Organic compound
GB0417487 2004-08-05

Publications (2)

Publication Number Publication Date
ES2487533T3 ES2487533T3 (es) 2014-08-21
ES2487533T7 true ES2487533T7 (es) 2015-07-14

Family

ID=32982602

Family Applications (4)

Application Number Title Priority Date Filing Date
ES10175150.1T Active ES2487533T7 (es) 2004-08-05 2005-08-04 Anticuerpos antagonistas de IL-17
ES15156029.9T Expired - Lifetime ES2677245T3 (es) 2004-08-05 2005-08-04 Anticuerpos Antagonistas de IL-17
ES10174725.1T Expired - Lifetime ES2536228T3 (es) 2004-08-05 2005-08-04 Anticuerpos antagonistas de IL-17
ES05770286.2T Active ES2367440T7 (es) 2004-08-05 2005-08-04 Anticuerpos Antagonistas de IL-17

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES15156029.9T Expired - Lifetime ES2677245T3 (es) 2004-08-05 2005-08-04 Anticuerpos Antagonistas de IL-17
ES10174725.1T Expired - Lifetime ES2536228T3 (es) 2004-08-05 2005-08-04 Anticuerpos antagonistas de IL-17
ES05770286.2T Active ES2367440T7 (es) 2004-08-05 2005-08-04 Anticuerpos Antagonistas de IL-17

Country Status (40)

Country Link
US (9) US7807155B2 (enExample)
EP (5) EP2366405B1 (enExample)
JP (1) JP4682200B2 (enExample)
KR (2) KR20080029018A (enExample)
CN (1) CN101001645B (enExample)
AR (1) AR050200A1 (enExample)
AT (1) ATE517924T1 (enExample)
AU (2) AU2005268857C1 (enExample)
BE (1) BE2015C041I2 (enExample)
BR (3) BRPI0513078C1 (enExample)
CA (1) CA2573586C (enExample)
CY (6) CY1111963T1 (enExample)
DK (4) DK1776142T6 (enExample)
EC (1) ECSP077198A (enExample)
ES (4) ES2487533T7 (enExample)
FR (1) FR15C0048I2 (enExample)
GB (1) GB0417487D0 (enExample)
HK (1) HK1256639A1 (enExample)
HR (3) HRP20110758T4 (enExample)
HU (4) HUE038187T2 (enExample)
IL (1) IL180717A (enExample)
LT (3) LT2902039T (enExample)
LU (2) LU92768I2 (enExample)
MA (1) MA28982B1 (enExample)
MX (1) MX2007001338A (enExample)
MY (1) MY144925A (enExample)
NL (1) NL300749I2 (enExample)
NO (9) NO336279B1 (enExample)
NZ (1) NZ552658A (enExample)
PE (1) PE20060418A1 (enExample)
PL (4) PL2366405T3 (enExample)
PT (4) PT2902039T (enExample)
RU (2) RU2426741C3 (enExample)
SG (1) SG155186A1 (enExample)
SI (4) SI2366405T1 (enExample)
TN (1) TNSN07034A1 (enExample)
TR (1) TR201808057T4 (enExample)
TW (1) TWI359153B (enExample)
WO (1) WO2006013107A1 (enExample)
ZA (1) ZA200700242B (enExample)

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SG155186A1 (en) 2009-09-30
CY1115444T1 (el) 2017-01-04
HUE038187T2 (hu) 2018-10-29
EP3409288A1 (en) 2018-12-05
DK1776142T3 (da) 2011-10-31
PL1776142T6 (pl) 2016-06-30
EP1776142A1 (en) 2007-04-25
HRP20110758T4 (hr) 2015-07-31
SI2366405T1 (sl) 2015-07-31
HUS1500037I1 (hu) 2017-10-30
EP1776142B3 (en) 2015-06-24
US10344084B2 (en) 2019-07-09
JP4682200B2 (ja) 2011-05-11
BE2015C041I2 (enExample) 2024-10-08
EP2366405A2 (en) 2011-09-21
SI1776142T1 (sl) 2011-11-30
NO348010B1 (no) 2024-06-17
BR122017009404B1 (pt) 2022-02-22
PL2364729T3 (pl) 2014-10-31
CY1120723T1 (el) 2019-12-11
BRPI0513078A (pt) 2008-04-22
CY2018027I1 (el) 2020-05-29
ES2367440T7 (es) 2015-07-14
CA2573586A1 (en) 2006-02-09
EP2364729A2 (en) 2011-09-14
HK1101277A1 (en) 2007-10-12
US8119131B2 (en) 2012-02-21
RU2426741C2 (ru) 2011-08-20
EP2364729B1 (en) 2014-05-14
WO2006013107A1 (en) 2006-02-09
AU2005268857B2 (en) 2010-01-28
EP1776142B9 (en) 2016-09-07
US8617552B2 (en) 2013-12-31
BRPI0513078B8 (pt) 2019-08-27
HRP20110758T1 (en) 2011-11-30
IL180717A0 (en) 2007-06-03
CN101001645B (zh) 2012-09-05
US9765140B2 (en) 2017-09-19
NO336279B1 (no) 2015-07-06
SI2364729T1 (sl) 2014-08-29
EP2366405A3 (en) 2012-01-18
ES2367440T9 (es) 2021-04-28
CY1116256T1 (el) 2017-02-08
PT2364729E (pt) 2014-09-01
DK2364729T6 (en) 2015-07-06
NO20171697A1 (no) 2007-03-30
FR15C0048I2 (fr) 2015-11-20
RU2011113153A (ru) 2012-10-20
EP2902039B1 (en) 2018-04-11
BRPI0513078C1 (pt) 2021-05-25
MX2007001338A (es) 2008-03-11
LTPA2018515I1 (lt) 2018-10-25
PL2902039T3 (pl) 2018-09-28
EP2902039A1 (en) 2015-08-05
HUE025815T2 (en) 2016-04-28
EP1776142B1 (en) 2011-07-27
CY2018027I2 (el) 2020-05-29
US20140079719A1 (en) 2014-03-20
US20230235038A1 (en) 2023-07-27
PL1776142T3 (pl) 2011-12-30
KR20080029018A (ko) 2008-04-02
SI2902039T1 (en) 2018-07-31
EP2366405B1 (en) 2015-02-25
NO2015023I2 (no) 2015-10-26
PL1776142T4 (pl) 2018-04-30
NO2016017I1 (no) 2016-08-23
AU2005268857A1 (en) 2006-02-09
DK2364729T3 (da) 2014-07-21
NO337286B1 (no) 2016-02-29
KR100852523B9 (ko) 2025-03-28

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