NO336279B1 - IL-17 bindende antistoff, farmasøytisk sammensetning og kit omfattende slike antistoff, samt DNA konstruksjon som koder for slike IL-17 bindende antistoff og ekspresjonsvektor. - Google Patents
IL-17 bindende antistoff, farmasøytisk sammensetning og kit omfattende slike antistoff, samt DNA konstruksjon som koder for slike IL-17 bindende antistoff og ekspresjonsvektor.Info
- Publication number
- NO336279B1 NO336279B1 NO20070985A NO20070985A NO336279B1 NO 336279 B1 NO336279 B1 NO 336279B1 NO 20070985 A NO20070985 A NO 20070985A NO 20070985 A NO20070985 A NO 20070985A NO 336279 B1 NO336279 B1 NO 336279B1
- Authority
- NO
- Norway
- Prior art keywords
- amino acid
- seq
- acid sequence
- antibody
- fragment
- Prior art date
Links
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Description
Claims (16)
Applications Claiming Priority (2)
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GBGB0417487.6A GB0417487D0 (en) | 2004-08-05 | 2004-08-05 | Organic compound |
PCT/EP2005/008470 WO2006013107A1 (en) | 2004-08-05 | 2005-08-04 | Il-17 antagonistic antibodies |
Publications (2)
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NO20070985L NO20070985L (no) | 2007-03-30 |
NO336279B1 true NO336279B1 (no) | 2015-07-06 |
Family
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Application Number | Title | Priority Date | Filing Date |
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NO20070985A NO336279B1 (no) | 2004-08-05 | 2007-02-20 | IL-17 bindende antistoff, farmasøytisk sammensetning og kit omfattende slike antistoff, samt DNA konstruksjon som koder for slike IL-17 bindende antistoff og ekspresjonsvektor. |
NO20150065A NO337129B1 (no) | 2004-08-05 | 2015-01-13 | IL-17 bindende antistoff for anvendelse ved behandling av psoriasis artritt |
NO20150064A NO337286B1 (no) | 2004-08-05 | 2015-01-13 | IL-17 bindende antistoff for anvendelse ved behandling av ankyloserende spondylitt |
NO2015023C NO2015023I1 (no) | 2004-08-05 | 2015-10-26 | Sekukinumab |
NO20151787A NO341384B1 (no) | 2004-08-05 | 2015-12-23 | IL-17 bindende antistoff for anvendelse ved behandling av inflammatorisk artritt og anvendelse av det IL-17 bindende antistoff for fremstilling av medikament for behandling av ankyloserende spondylitt. |
NO2016017C NO2016017I1 (no) | 2004-08-05 | 2016-08-23 | Sekukinumab |
NO20171697A NO20171697A1 (no) | 2004-08-05 | 2017-10-24 | IL-17 Antagonistiske antistoffer |
NO2018007C NO2018007I1 (no) | 2004-08-05 | 2018-02-14 | sekukinumab |
NO2022026C NO2022026I1 (no) | 2004-08-05 | 2022-06-24 | Secukinumab - forlenget SPC |
Family Applications After (8)
Application Number | Title | Priority Date | Filing Date |
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NO20150065A NO337129B1 (no) | 2004-08-05 | 2015-01-13 | IL-17 bindende antistoff for anvendelse ved behandling av psoriasis artritt |
NO20150064A NO337286B1 (no) | 2004-08-05 | 2015-01-13 | IL-17 bindende antistoff for anvendelse ved behandling av ankyloserende spondylitt |
NO2015023C NO2015023I1 (no) | 2004-08-05 | 2015-10-26 | Sekukinumab |
NO20151787A NO341384B1 (no) | 2004-08-05 | 2015-12-23 | IL-17 bindende antistoff for anvendelse ved behandling av inflammatorisk artritt og anvendelse av det IL-17 bindende antistoff for fremstilling av medikament for behandling av ankyloserende spondylitt. |
NO2016017C NO2016017I1 (no) | 2004-08-05 | 2016-08-23 | Sekukinumab |
NO20171697A NO20171697A1 (no) | 2004-08-05 | 2017-10-24 | IL-17 Antagonistiske antistoffer |
NO2018007C NO2018007I1 (no) | 2004-08-05 | 2018-02-14 | sekukinumab |
NO2022026C NO2022026I1 (no) | 2004-08-05 | 2022-06-24 | Secukinumab - forlenget SPC |
Country Status (39)
Country | Link |
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US (8) | US7807155B2 (no) |
EP (5) | EP3409288A1 (no) |
JP (1) | JP4682200B2 (no) |
KR (2) | KR100852523B1 (no) |
CN (1) | CN101001645B (no) |
AR (1) | AR050200A1 (no) |
AT (1) | ATE517924T1 (no) |
AU (2) | AU2005268857C1 (no) |
BR (3) | BR122018075556B1 (no) |
CA (1) | CA2573586C (no) |
CY (6) | CY1111963T1 (no) |
DK (4) | DK1776142T6 (no) |
EC (1) | ECSP077198A (no) |
ES (4) | ES2677245T3 (no) |
FR (1) | FR15C0048I2 (no) |
GB (1) | GB0417487D0 (no) |
HK (3) | HK1101277A1 (no) |
HR (3) | HRP20110758T4 (no) |
HU (4) | HUE038187T2 (no) |
IL (1) | IL180717A (no) |
LT (3) | LT2902039T (no) |
LU (2) | LU92768I2 (no) |
MA (1) | MA28982B1 (no) |
MX (1) | MX2007001338A (no) |
MY (1) | MY144925A (no) |
NL (1) | NL300749I2 (no) |
NO (9) | NO336279B1 (no) |
NZ (1) | NZ552658A (no) |
PE (1) | PE20060418A1 (no) |
PL (4) | PL2902039T3 (no) |
PT (4) | PT1776142E (no) |
RU (2) | RU2426741C3 (no) |
SG (1) | SG155186A1 (no) |
SI (4) | SI2364729T1 (no) |
TN (1) | TNSN07034A1 (no) |
TR (1) | TR201808057T4 (no) |
TW (1) | TWI359153B (no) |
WO (1) | WO2006013107A1 (no) |
ZA (1) | ZA200700242B (no) |
Families Citing this family (149)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
GB0417487D0 (en) * | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
GB0425569D0 (en) | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Biological products |
AU2006284841B2 (en) * | 2005-09-01 | 2012-11-08 | Merck Sharp & Dohme Corp. | Use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory disease |
KR101158959B1 (ko) * | 2005-12-13 | 2012-07-09 | 일라이 릴리 앤드 캄파니 | 항-il-17 항체 |
DK2913343T3 (en) | 2005-12-20 | 2018-11-26 | Sbi Biotech Co Ltd | Anti-ILT7 antibody |
AR060017A1 (es) | 2006-01-13 | 2008-05-21 | Novartis Ag | Composiciones y metodos de uso para anticuerpos de dickkopf -1 |
BRPI0706788A2 (pt) * | 2006-01-31 | 2011-04-05 | Novartis Ag | anticorpos antagonistas il-17 |
US7910703B2 (en) | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
WO2007147019A2 (en) | 2006-06-13 | 2007-12-21 | Zymogenetics, Inc. | Il-17 and il-23 antagonists and methods of using the same |
TW200815469A (en) * | 2006-06-23 | 2008-04-01 | Astrazeneca Ab | Compounds |
GB0612928D0 (en) * | 2006-06-29 | 2006-08-09 | Ucb Sa | Biological products |
WO2008021156A2 (en) * | 2006-08-11 | 2008-02-21 | Schering Corporation | Antibodies to il-17a |
GB0620729D0 (en) | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
TWI426918B (zh) | 2007-02-12 | 2014-02-21 | Merck Sharp & Dohme | Il-23拮抗劑於治療感染之用途 |
CA2679400A1 (en) | 2007-02-28 | 2008-09-04 | Schering Corporation | Combination therapy for treatment of immune disorders |
EP3406263A1 (en) | 2007-05-29 | 2018-11-28 | Novartis AG | New indications for anti-il-1beta therapy |
WO2008156865A2 (en) * | 2007-06-20 | 2008-12-24 | Schering Corporation | Joint destruction biomarkers for anti-il-17a therapy of inflammatory joint disease |
ES2614735T3 (es) * | 2007-07-23 | 2017-06-01 | Janssen Biotech, Inc. | Métodos y composiciones para tratar los trastornos relacionados con fibrosis usando antagonistas de la IL-17 |
US20110195509A1 (en) * | 2007-09-06 | 2011-08-11 | Drew Pardoll | Treatment of th17-mediated autoimmune disease via inhibition of stat 3 |
KR101616995B1 (ko) * | 2007-12-03 | 2016-06-07 | (주)아모레퍼시픽 | 슬리밍용 조성물 |
WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
US9309313B2 (en) | 2008-01-09 | 2016-04-12 | The Schepens Eye Research Institute, Inc. | Therapeutic compositions for treatment of ocular inflammatory disorders |
GB0807413D0 (en) | 2008-04-23 | 2008-05-28 | Ucb Pharma Sa | Biological products |
CN104338136A (zh) | 2008-04-29 | 2015-02-11 | 安进研发(慕尼黑)股份有限公司 | 用于治疗的gm-csf和il-17抑制剂 |
SG190572A1 (en) | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
KR20110025649A (ko) | 2008-05-05 | 2011-03-10 | 노비뮨 에스 에이 | 항-il-17a/il-17f 교차-반응성 항체 및 그의 사용 방법 |
RU2010153578A (ru) | 2008-06-03 | 2012-07-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двойными вариабельными доменами и их применение |
CA2726087A1 (en) | 2008-06-03 | 2009-12-10 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
RU2011104348A (ru) | 2008-07-08 | 2012-08-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двойным вариабельным доменом против простагландина е2 и их применение |
MX2011003184A (es) * | 2008-09-29 | 2011-04-21 | Roche Glycart Ag | Anticuerpos contra il17 humana y usos de los mismos. |
EP2810652A3 (en) | 2009-03-05 | 2015-03-11 | AbbVie Inc. | IL-17 binding proteins |
JP5766179B2 (ja) * | 2009-04-27 | 2015-08-19 | ノバルティス アーゲー | 筋肉増殖を増加させるための組成物および方法 |
PE20160652A1 (es) | 2009-05-05 | 2016-07-09 | Novimmune Sa | Anticuerpos que se unen a il-17f |
KR20120060877A (ko) | 2009-09-01 | 2012-06-12 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
US20130064788A1 (en) * | 2009-10-10 | 2013-03-14 | Eleven Biotherapeutics, Inc. | Il-17 family cytokine compositions and uses |
AU2010306677B2 (en) | 2009-10-15 | 2013-05-23 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
KR101836217B1 (ko) | 2009-10-30 | 2018-03-08 | 얀센 바이오테크 인코포레이티드 | Il-17a 길항제 |
RU2012149227A (ru) | 2010-05-20 | 2014-06-27 | Аблинкс Нв | Биологические материалы, относящиеся к her3 |
KR20130100118A (ko) | 2010-08-03 | 2013-09-09 | 아비에 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
WO2012018767A2 (en) | 2010-08-05 | 2012-02-09 | Anaptysbio, Inc. | Antibodies directed against il-17 |
EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
CA2809433A1 (en) | 2010-08-26 | 2012-03-01 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
US20120237975A1 (en) | 2010-10-01 | 2012-09-20 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
CN103154031A (zh) | 2010-10-08 | 2013-06-12 | 诺华有限公司 | 利用il-17拮抗剂治疗牛皮癣的方法 |
EP3757126A1 (en) | 2010-11-05 | 2020-12-30 | Novartis AG | Methods of treating psoriatic arthritis using il-17 antagonists |
AU2014259526B2 (en) * | 2010-11-05 | 2016-02-04 | Novartis Ag | Methods of treating ankylosing spondylitis using IL-17 antagonists |
TW201307845A (zh) | 2010-12-13 | 2013-02-16 | Novartis Ag | 預測方法及利用il-17拮抗劑治療關節炎的方法 |
JP5947041B2 (ja) * | 2011-01-07 | 2016-07-06 | 第一三共ヘルスケア株式会社 | 安全なil−17産生抑制剤 |
US10208349B2 (en) | 2011-01-07 | 2019-02-19 | Ucb Biopharma Sprl | Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy |
GB201100282D0 (en) | 2011-01-07 | 2011-02-23 | Ucb Pharma Sa | Biological methods |
WO2012095507A1 (en) * | 2011-01-13 | 2012-07-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for predicting the risk of having a cardiovascular event in a subject |
BR112013017951B1 (pt) | 2011-01-14 | 2022-09-27 | UCB Biopharma SRL | Anticorpo de neutralização, sequência de dna isolada, vetor de clonagem ou expressão, processo para a produção do anticorpo, composição farmacêutica, uso de anticorpo e uso da composição farmacêutica |
WO2012125680A1 (en) | 2011-03-16 | 2012-09-20 | Novartis Ag | Methods of treating vasculitis using an il-17 binding molecule |
EP2691411B1 (en) * | 2011-03-29 | 2020-02-26 | GlaxoSmithKline LLC | Buffer system for protein purification |
EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
CA2850624A1 (en) | 2011-10-03 | 2013-04-11 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
BR112014012101A2 (pt) * | 2011-11-21 | 2019-09-24 | Novartis Ag | métodos de tratamento de artrite psoriática (psa) usando os antagonistas de il- 17 e alelos de resposta ou não resposta à psa |
US20140348848A1 (en) | 2011-12-02 | 2014-11-27 | Dhananjay Kaul | Anti-il-1beta (interleukin-1beta) antibody-based prophylactic therapy to prevent complications leading to vaso-occlusion in sickle cell disease |
WO2013087913A1 (en) | 2011-12-16 | 2013-06-20 | Synthon Biopharmaceuticals B.V. | Compounds and methods for treating inflammatory diseases |
KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
TW201333035A (zh) | 2011-12-30 | 2013-08-16 | Abbvie Inc | 針對il-13及/或il-17之雙特異性結合蛋白 |
US9284283B2 (en) | 2012-02-02 | 2016-03-15 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating IL-17 |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
CA2868398A1 (en) | 2012-04-02 | 2013-10-10 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
SG11201406238UA (en) | 2012-04-05 | 2014-10-30 | Hoffmann La Roche | Bispecific antibodies against human tweak and human il17 and uses thereof |
CA2870025A1 (en) | 2012-04-20 | 2013-10-24 | Novartis Ag | Methods of treating ankylosing spondylitis using il-17 antagonists |
WO2013177101A2 (en) | 2012-05-22 | 2013-11-28 | Bristol-Myers Squibb Company | Bispecific antibodies and methods of using the same |
AR093297A1 (es) | 2012-10-31 | 2015-05-27 | Amgen Res (Munich) Gmbh | Formulacion liquida que comprende un compuesto neutralizante de gm-csf |
EP2914289B1 (en) | 2012-10-31 | 2019-05-22 | Takeda GmbH | Lyophilized formulation comprising gm-csf neutralizing compound |
CA2890263C (en) | 2012-11-01 | 2020-03-10 | Abbvie Inc. | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
JP6144355B2 (ja) | 2012-11-26 | 2017-06-07 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | 化学修飾mRNA |
WO2014107737A2 (en) | 2013-01-07 | 2014-07-10 | Eleven Biotherapeutics, Inc. | Local delivery of il-17 inhibitors for treating ocular disease |
SI2953969T1 (sl) | 2013-02-08 | 2020-01-31 | Novartis Ag | Protitelesa proti-IL-17A in njihova uporaba v zdravljenju avtoimunskih in vnetnih motenj |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
WO2014144280A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Inc. | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1β AND / OR IL-17 |
WO2014155278A2 (en) * | 2013-03-26 | 2014-10-02 | Novartis Ag | Methods of treating autoimmune diseases using il-17 antagonists |
WO2014161570A1 (en) | 2013-04-03 | 2014-10-09 | Roche Glycart Ag | Antibodies against human il17 and uses thereof |
US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
US9603882B2 (en) | 2013-08-13 | 2017-03-28 | Industrial Technology Research Institute | Method for modulating Th17 cells and method for treating a disease related to modulation of Th17 cells |
WO2015022656A1 (en) | 2013-08-15 | 2015-02-19 | Novartis Ag | Methods of treating generalized pustular psoriasis (gpp) using il-17 antagonists |
US10745475B2 (en) | 2013-08-30 | 2020-08-18 | Takeda Gmbh | Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics |
EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
KR102278487B1 (ko) | 2013-11-18 | 2021-07-19 | 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 | Il-17a 접합체 및 이의 용도 |
KR20160113268A (ko) * | 2014-01-28 | 2016-09-28 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | 이기능 융합단백질,이의 제조방법 및 용도 |
TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
BR112017003332A2 (pt) * | 2014-09-10 | 2017-11-28 | Novartis Ag | uso de antagonistas de il-17 para inibir a progressão de dano estrutural em pacientes com artrite psoriásica |
RU2609627C2 (ru) * | 2014-09-26 | 2017-02-02 | Закрытое Акционерное Общество "Биокад" | Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
CU20170052A7 (es) | 2014-10-14 | 2017-11-07 | Dana Farber Cancer Inst Inc | Moléculas de anticuerpo que se unen a pd-l1 |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
AR103172A1 (es) * | 2014-12-22 | 2017-04-19 | Novartis Ag | Reducción selectiva de residuos de cisteina en anticuerpos il-17 |
AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
RU2749712C2 (ru) | 2015-01-12 | 2021-06-16 | Аффибоди Аб | IL-17A-связывающие полипептиды |
CN107407677B (zh) | 2015-01-28 | 2020-07-17 | 豪夫迈·罗氏有限公司 | 多发性硬化的基因表达标志和治疗 |
CN105315371B (zh) * | 2015-03-05 | 2018-05-29 | 北京百特美博生物科技有限公司 | 抗人il-17单克隆抗体 |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
MA42444A (fr) | 2015-07-16 | 2018-05-23 | Lilly Co Eli | Traitement du prurit |
EP3316902A1 (en) | 2015-07-29 | 2018-05-09 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
SI3317301T1 (sl) | 2015-07-29 | 2021-10-29 | Novartis Ag | Kombinirane terapije, ki obsegajo molekule protitelesa na LAG-3 |
US20190330328A1 (en) | 2015-10-19 | 2019-10-31 | Christian Mann | Methods of treating non-radiographic axial spondyloarthritis using interleukin-17 (il-17) antagonists |
CA3007671A1 (en) | 2015-12-17 | 2017-06-22 | Novartis Ag | Antibody molecules to pd-1 and uses thereof |
WO2017156488A2 (en) | 2016-03-10 | 2017-09-14 | Acceleron Pharma, Inc. | Activin type 2 receptor binding proteins and uses thereof |
SG11201807523PA (en) | 2016-03-10 | 2018-09-27 | Viela Bio Inc | Ilt7 binding molecules and methods of using the same |
RU2680011C2 (ru) | 2016-04-29 | 2019-02-14 | Закрытое Акционерное Общество "Биокад" | Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы |
FR3051673B1 (fr) * | 2016-05-24 | 2018-06-22 | Assistance Publique - Hopitaux De Paris | Inhibiteurs de la voie de l'interleukine 17 pour le traitement des infections chroniques dues a hpv |
CN107488227A (zh) * | 2016-06-12 | 2017-12-19 | 三生国健药业(上海)股份有限公司 | 抗人白细胞介素‑17a单克隆抗体、其制备方法和应用 |
WO2017221174A1 (en) | 2016-06-22 | 2017-12-28 | Novartis Ag | Methods of treating vitiligo using interleukin-17 (il-17) antibodies |
EP3487881A1 (en) | 2016-07-19 | 2019-05-29 | Novartis AG | Methods of treating new-onset plaque type psoriasis using il-17 antagonists |
ES2905917T3 (es) | 2016-09-14 | 2022-04-12 | Beijing Hanmi Pharmaceutical Co Ltd | Anticuerpo que se une específicamente a IL-17A y fragmento funcional del mismo |
WO2018096467A1 (en) | 2016-11-28 | 2018-05-31 | Novartis Ag | Methods of treating acne using interleukin-17 (il-17) antagonists |
AR110873A1 (es) | 2017-02-10 | 2019-05-08 | Genentech Inc | Anticuerpos contra triptasa, composiciones de estos y usos de estos |
WO2018158741A1 (en) | 2017-03-03 | 2018-09-07 | Novartis Ag | Psoriasis disease modification following long-term treatment with an il-17 antagonist |
US10676522B2 (en) | 2017-05-05 | 2020-06-09 | Novartis Ag | Methods of selectively treating asthma using IL-17 antagonists |
CN108359011B (zh) | 2017-07-21 | 2019-06-25 | 华博生物医药技术(上海)有限公司 | 靶向于白介素17a的抗体、其制备方法和应用 |
US20210179702A1 (en) | 2017-11-02 | 2021-06-17 | Novartis Ag | Method of treating tendinopathy using interleukin-17 (il-17) |
US20200277369A1 (en) * | 2017-11-20 | 2020-09-03 | Novartis Ag | Method of treating hidradentitis suppurativa with il-17 antagonists |
KR20200096253A (ko) | 2017-11-30 | 2020-08-11 | 노파르티스 아게 | Bcma-표적화 키메라 항원 수용체, 및 이의 용도 |
CN112203685A (zh) * | 2018-03-29 | 2021-01-08 | 瑞美德生物医药科技有限公司 | 使用结合白细胞介素-17a(il-17a)的抗体的自身免疫紊乱和炎性紊乱的治疗 |
AU2019277029C1 (en) | 2018-06-01 | 2024-01-04 | Novartis Ag | Binding molecules against BCMA and uses thereof |
CN112513078B (zh) * | 2018-07-31 | 2022-11-18 | 沈为群 | 抗il-17a抗体及其用途 |
WO2020064702A1 (en) | 2018-09-25 | 2020-04-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of antagonists of th17 cytokines for the treatment of bronchial remodeling in patients suffering from allergic asthma |
WO2020157305A1 (en) | 2019-01-31 | 2020-08-06 | Numab Therapeutics AG | Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof |
EP3689907A1 (en) | 2019-01-31 | 2020-08-05 | Numab Therapeutics AG | Antibodies targeting il-17a and methods of use thereof |
MA55033A (fr) | 2019-02-18 | 2021-12-29 | Lilly Co Eli | Formulation d'anticorps thérapeutique |
CN110179746A (zh) * | 2019-05-17 | 2019-08-30 | 通化东宝生物科技有限公司 | 一种稳定的苏金单抗注射剂及其制备方法 |
WO2020243504A1 (en) * | 2019-05-31 | 2020-12-03 | Figene, Llc | Concurrent activation of regenerative and tolerogenic processes by fibroblast-based compositions for the treatment of multiple sclerosis |
CN110343666B (zh) * | 2019-07-10 | 2023-05-30 | 通化东宝药业股份有限公司 | 一种cho细胞培养的补料培养基及其制备方法和应用 |
MX2022001068A (es) | 2019-07-26 | 2022-02-14 | Sinocelltech Ltd | Anticuerpo anti-il17a humanizado y uso del mismo. |
CN114127108A (zh) | 2019-07-30 | 2022-03-01 | 江苏恒瑞医药股份有限公司 | Il-17拮抗剂治疗自身免疫疾病的方法 |
KR20220066318A (ko) | 2019-09-20 | 2022-05-24 | 노파르티스 아게 | 인터류킨-17(il-17) 길항제를 사용한 자가면역 질환의 치료 방법 |
WO2021067195A1 (en) | 2019-09-30 | 2021-04-08 | Janssen Biotech, Inc. | Compositions and methods for an il-17 target engagement assay with large molecule modulators |
KR20220103141A (ko) | 2019-11-19 | 2022-07-21 | 노파르티스 아게 | 인터류킨-17(il-17) 길항제를 사용하여 루푸스 신장염을 치료하는 방법 |
KR20220110512A (ko) | 2019-12-06 | 2022-08-08 | 노파르티스 아게 | 인터류킨-17(il-17) 길항제를 사용하여 편평 태선을 치료하는 방법 |
CN114805577B (zh) * | 2019-12-31 | 2023-11-21 | 南京融捷康生物科技有限公司 | 针对il-17ra蛋白的抗体及其制备方法和应用 |
CA3187136A1 (en) | 2020-06-23 | 2021-12-30 | Novartis Ag | Methods of treating thyroid eye disease and graves' orbitopahy using interleukin-17 (il-17) antagonists |
UY39484A (es) | 2020-11-02 | 2022-06-30 | Novartis Ag | Inhibidores de interleucina-17 |
WO2022097060A1 (en) | 2020-11-06 | 2022-05-12 | Novartis Ag | Cd19 binding molecules and uses thereof |
CA3202877A1 (en) | 2020-12-02 | 2022-06-09 | Fresenius Kabi Deutschland Gmbh | Methods of selectively reducing antibodies |
US20220251502A1 (en) | 2020-12-22 | 2022-08-11 | Novartis Ag | Methods for reducing the oxidation level of cysteine residues in a secreted recombinantly-expressed protein during cell culture |
WO2023209519A1 (en) | 2022-04-25 | 2023-11-02 | Novartis Ag | Crystalline forms of an il-17 inhibitor |
WO2023223211A1 (en) | 2022-05-16 | 2023-11-23 | Novartis Ag | Methods of treating giant cell arteritis using interleukin-17 (il-17) antagonists |
WO2023223263A1 (en) | 2022-05-18 | 2023-11-23 | Novartis Ag | Methods of selectively treating tendinopathy using interleukin-17 (il-17) antagonists |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
EP0281604B1 (en) | 1986-09-02 | 1993-03-31 | Enzon Labs Inc. | Single polypeptide chain binding molecules |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US6274711B1 (en) | 1993-06-14 | 2001-08-14 | Inserm, Institut National De La Sante Et De La Recherche Medicale | Purified mammalian CTLA-8 antigens and related reagents |
US6562333B1 (en) | 1993-06-14 | 2003-05-13 | Schering Corporation | Purified mammalian CTLA-8 antigens and related reagents |
WO1996029408A1 (en) | 1995-03-23 | 1996-09-26 | Immunex Corporation | Il-17 receptor |
US6074849A (en) | 1995-07-19 | 2000-06-13 | Genetics Institute, Inc. | Polynucleotides encoding human CTLA-8 related proteins |
CA2227220A1 (en) * | 1995-07-19 | 1997-02-06 | Genetics Institute, Inc. | Human ctla-8 and uses of ctla-8-related proteins |
DK0862454T3 (da) | 1995-10-27 | 2002-12-30 | Schering Corp | CTLA-8 i kombination med G-CSF eller med G-CSF og IL-6 og anvendelse af CTLA-8 til behandling af infektioner |
EP0959897B1 (en) | 1996-11-27 | 2009-04-22 | Immunex Corporation | Method of regulating nitric oxide production |
ATE442385T1 (de) | 1997-09-17 | 2009-09-15 | Human Genome Sciences Inc | Interleukin-17 rezeptor-ähnliches protein |
US6482923B1 (en) | 1997-09-17 | 2002-11-19 | Human Genome Sciences, Inc. | Interleukin 17-like receptor protein |
US6849719B2 (en) | 1997-09-17 | 2005-02-01 | Human Genome Sciences, Inc. | Antibody to an IL-17 receptor like protein |
AU760035B2 (en) | 1997-11-10 | 2003-05-08 | Cytimmune Sciences, Inc. | Compositions and methods for targeted delivery of factors |
US6562578B1 (en) | 1999-01-11 | 2003-05-13 | Schering Corporation | IL-17-like cytokine binding compounds and antibodies |
WO1999032632A1 (en) | 1997-12-19 | 1999-07-01 | Millennium Pharmaceuticals, Inc. | Novel embryo-derived interleukin related factor molecules and uses therefor |
EP1045905A2 (en) | 1998-01-09 | 2000-10-25 | Immunex Corporation | Il-17rh dna and polypeptides |
AU2031399A (en) | 1998-01-09 | 1999-07-26 | Immunex Corporation | Human and murine il-17d, cytokine related to interleukin-17: dna and polypeptides |
JP2002507392A (ja) | 1998-02-11 | 2002-03-12 | マキシジェン, インコーポレイテッド | 遺伝子ワクチンの免疫調節特性の最適化 |
EP2333069A3 (en) | 1998-05-15 | 2011-09-14 | Genentech, Inc. | Therapeutic uses of IL-17 homologous polypeptides |
JP2002525056A (ja) | 1998-09-17 | 2002-08-13 | ザイモジェネティクス,インコーポレイティド | 哺乳類のトランスフォーミング増殖因子β−9 |
WO2000020593A1 (en) | 1998-10-02 | 2000-04-13 | Eli Lilly And Company | Il-17 homolog nucleic acids, polypeptides, vectors, host cells, methods and uses thereof |
JP2000186046A (ja) * | 1998-10-14 | 2000-07-04 | Snow Brand Milk Prod Co Ltd | 慢性関節リウマチ治療剤及び診断方法 |
WO2000022909A2 (en) | 1998-10-19 | 2000-04-27 | Biotech Australia Pty. Limited | Systems for oral delivery |
DE29820466U1 (de) | 1998-11-16 | 1999-04-08 | Reutter Werner Prof Dr Med | Rekombinante Glycoproteine und sie enthaltende Arzneimittel |
US6734172B2 (en) | 1998-11-18 | 2004-05-11 | Pacific Northwest Research Institute | Surface receptor antigen vaccines |
ATE444365T1 (de) | 1999-01-11 | 2009-10-15 | Schering Corp | Interleukin-17 verwandte zytokine aus säugetieren. dafür kodierende polynukleotide. verwendungen |
WO2000042187A1 (en) | 1999-01-11 | 2000-07-20 | Schering Corporation | Interleukin-17 related mammalian cytokine (il-171). polynucleotides encoding them. uses |
ATE216875T1 (de) | 1999-01-27 | 2002-05-15 | Idea Ag | Nichtinvasive impfung durch die haut |
SK287357B6 (sk) | 1999-02-12 | 2010-08-09 | The Scripps Research Institute | Použitie antagonistu alfa v beta 3 na prípravu farmaceutickej kompozície na liečbu tumorových buniek a terapeutická kompozícia a súprava na liečenie tumoru alebo tumorových metastáz |
EP1053751A1 (en) * | 1999-05-17 | 2000-11-22 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Compositions and methods for treating cell proliferation disorders |
US6036128A (en) | 1999-05-17 | 2000-03-14 | Common Ground Recycling, Inc. | Tire shredding machine and method of using the same |
WO2001015728A1 (en) | 1999-08-27 | 2001-03-08 | University Health Network | Method for activating cytotoxic t-lymphocytes (ctls) in vivo : composition comprising antibody anti cd40 (or cd40l or cd40 binding protein) and an antigen |
JP2001086046A (ja) * | 1999-09-09 | 2001-03-30 | Nec Corp | カメラ付き携帯電話装置 |
US7220840B2 (en) | 2000-06-16 | 2007-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator protein |
PT2275449T (pt) | 2000-06-16 | 2016-12-27 | Human Genome Sciences Inc | Anticorpos que se ligam imunoespecificamente a blys |
WO2002033083A2 (en) | 2000-10-13 | 2002-04-25 | Eli Lilly And Company | Methods of using a human il-17-related polypeptide to treat disease |
MXPA03003407A (es) * | 2000-10-18 | 2004-05-04 | Immunex Corp | Metodos para el tratamiento de artritis reumatoide usando antagonistas il-17. |
CA2435151A1 (en) | 2001-01-25 | 2002-12-27 | Zymogenetics, Inc. | Method for treating psoriasis |
EP2009027B1 (en) * | 2001-04-27 | 2014-05-21 | Kyowa Hakko Kirin Co., Ltd. | Anti-CD40 monoclonal antibody |
EP1456347A4 (en) | 2001-11-16 | 2006-08-02 | Human Genome Sciences Inc | ANTIBODIES BINDING TO BLYS ACCORDING TO AN IMMUNOSPECIFIC MODE |
EP1545578A4 (en) | 2002-08-28 | 2010-07-07 | Immunex Corp | COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASES |
AU2004270103B2 (en) * | 2003-05-21 | 2012-02-23 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies against Bacillusanthracis protective antigen |
JP4833850B2 (ja) | 2003-11-21 | 2011-12-07 | ユセベ ファルマ ソシエテ アノニム | Il−17活性阻害による多発性硬化症を治療するための方法 |
US7501247B2 (en) | 2004-05-03 | 2009-03-10 | Schering Corporation | Method of treating skin inflammation |
GB0417487D0 (en) * | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
AU2006284841B2 (en) | 2005-09-01 | 2012-11-08 | Merck Sharp & Dohme Corp. | Use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory disease |
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