CY2015030I1 - Ανταγωνιστικα αντισωματα il-17 - Google Patents
Ανταγωνιστικα αντισωματα il-17Info
- Publication number
- CY2015030I1 CY2015030I1 CY2015030C CY2015030C CY2015030I1 CY 2015030 I1 CY2015030 I1 CY 2015030I1 CY 2015030 C CY2015030 C CY 2015030C CY 2015030 C CY2015030 C CY 2015030C CY 2015030 I1 CY2015030 I1 CY 2015030I1
- Authority
- CY
- Cyprus
- Prior art keywords
- competitive
- antibodies
- Prior art date
Links
- 230000002860 competitive effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0417487.6A GB0417487D0 (en) | 2004-08-05 | 2004-08-05 | Organic compound |
PCT/EP2005/008470 WO2006013107A1 (en) | 2004-08-05 | 2005-08-04 | Il-17 antagonistic antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
CY2015030I1 true CY2015030I1 (el) | 2015-11-04 |
CY2015030I2 CY2015030I2 (el) | 2017-11-14 |
Family
ID=32982602
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100936T CY1111963T1 (el) | 2004-08-05 | 2011-09-27 | Ανταγωνιστικα αντισωματα il-17 |
CY20141100628T CY1115444T1 (el) | 2004-08-05 | 2014-08-08 | Ανταγωνιστικα αντισωματα il-17 |
CY20151100401T CY1116256T1 (el) | 2004-08-05 | 2015-05-07 | Il-17 ανταγωνιστικα αντισωματα |
CY2015030C CY2015030I2 (el) | 2004-08-05 | 2015-07-10 | Ανταγωνιστικα αντισωματα il-17 |
CY181100727T CY1120723T1 (el) | 2004-08-05 | 2018-07-11 | Ανταγωνιστικα αντισωματα il-17 |
CY2018027C CY2018027I1 (el) | 2004-08-05 | 2018-10-10 | Ανταγωνιστικα αντισωματα il-17 |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100936T CY1111963T1 (el) | 2004-08-05 | 2011-09-27 | Ανταγωνιστικα αντισωματα il-17 |
CY20141100628T CY1115444T1 (el) | 2004-08-05 | 2014-08-08 | Ανταγωνιστικα αντισωματα il-17 |
CY20151100401T CY1116256T1 (el) | 2004-08-05 | 2015-05-07 | Il-17 ανταγωνιστικα αντισωματα |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY181100727T CY1120723T1 (el) | 2004-08-05 | 2018-07-11 | Ανταγωνιστικα αντισωματα il-17 |
CY2018027C CY2018027I1 (el) | 2004-08-05 | 2018-10-10 | Ανταγωνιστικα αντισωματα il-17 |
Country Status (40)
Country | Link |
---|---|
US (8) | US7807155B2 (el) |
EP (5) | EP1776142B9 (el) |
JP (1) | JP4682200B2 (el) |
KR (2) | KR100852523B1 (el) |
CN (1) | CN101001645B (el) |
AR (1) | AR050200A1 (el) |
AT (1) | ATE517924T1 (el) |
AU (2) | AU2005268857C1 (el) |
BE (1) | BE2015C041I2 (el) |
BR (3) | BR122018075556B1 (el) |
CA (1) | CA2573586C (el) |
CY (6) | CY1111963T1 (el) |
DK (4) | DK1776142T6 (el) |
EC (1) | ECSP077198A (el) |
ES (4) | ES2536228T3 (el) |
FR (1) | FR15C0048I2 (el) |
GB (1) | GB0417487D0 (el) |
HK (3) | HK1101277A1 (el) |
HR (3) | HRP20110758T4 (el) |
HU (4) | HUE025815T2 (el) |
IL (1) | IL180717A (el) |
LT (3) | LT2902039T (el) |
LU (2) | LU92768I2 (el) |
MA (1) | MA28982B1 (el) |
MX (1) | MX2007001338A (el) |
MY (1) | MY144925A (el) |
NL (1) | NL300749I2 (el) |
NO (9) | NO336279B1 (el) |
NZ (1) | NZ552658A (el) |
PE (1) | PE20060418A1 (el) |
PL (4) | PL2364729T6 (el) |
PT (4) | PT2366405E (el) |
RU (2) | RU2426741C3 (el) |
SG (1) | SG155186A1 (el) |
SI (4) | SI2902039T1 (el) |
TN (1) | TNSN07034A1 (el) |
TR (1) | TR201808057T4 (el) |
TW (1) | TWI359153B (el) |
WO (1) | WO2006013107A1 (el) |
ZA (1) | ZA200700242B (el) |
Families Citing this family (154)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
GB0417487D0 (en) * | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
GB0425569D0 (en) | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Biological products |
ATE445415T1 (de) * | 2005-09-01 | 2009-10-15 | Schering Corp | Verwendung von il-23 und il-17-antagonisten zur behandlung von autoimmuner entzündlicher augenerkrankung |
EP2481753B1 (en) * | 2005-12-13 | 2018-04-18 | Eli Lilly and Company | Anti-IL-17 Antibodies |
SG170749A1 (en) | 2005-12-20 | 2011-05-30 | Sbi Biotech Co Ltd | Anti-ilt7 antibody |
AR060017A1 (es) | 2006-01-13 | 2008-05-21 | Novartis Ag | Composiciones y metodos de uso para anticuerpos de dickkopf -1 |
US8012477B2 (en) | 2006-01-31 | 2011-09-06 | Novartis Ag | Methods of treating multiple myeloma using IL-17 binding molecules |
US7910703B2 (en) | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
EP2044118A2 (en) | 2006-06-13 | 2009-04-08 | Zymogenetics, Inc. | Il-17 and il-23 antagonists and methods of using the same |
TW200815469A (en) | 2006-06-23 | 2008-04-01 | Astrazeneca Ab | Compounds |
GB0612928D0 (en) | 2006-06-29 | 2006-08-09 | Ucb Sa | Biological products |
AR063683A1 (es) * | 2006-08-11 | 2009-02-11 | Schering Corp | Anticuerpos para il-17a |
GB0620729D0 (en) | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
TWI426918B (zh) | 2007-02-12 | 2014-02-21 | Merck Sharp & Dohme | Il-23拮抗劑於治療感染之用途 |
EP2417974A1 (en) | 2007-02-28 | 2012-02-15 | Schering Corporation | Combination therapy for treatment of immune disorders |
MX2009012948A (es) | 2007-05-29 | 2009-12-14 | Novartis Ag | Nuevas indicaciones para la terapia anti-il-1-beta. |
EP2171449A2 (en) * | 2007-06-20 | 2010-04-07 | Schering Corporation | Joint destruction biomarkers for anti-il-17a therapy of inflammatory joint disease |
WO2009015063A2 (en) * | 2007-07-23 | 2009-01-29 | Centocor | Methods and compositions for treating fibrosis related disorders using il-17 antagonists |
US20110195509A1 (en) * | 2007-09-06 | 2011-08-11 | Drew Pardoll | Treatment of th17-mediated autoimmune disease via inhibition of stat 3 |
WO2009072802A2 (en) * | 2007-12-03 | 2009-06-11 | Amorepacific Corporation | Composition for slimming |
WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
CA3069576A1 (en) * | 2008-01-09 | 2009-07-16 | The Schepens Eye Research Institute, Inc. | Therapeutic compositions for treatment of ocular inflammatory disorders |
GB0807413D0 (en) | 2008-04-23 | 2008-05-28 | Ucb Pharma Sa | Biological products |
UA102097C2 (ru) * | 2008-04-29 | 2013-06-10 | Амген Рисерч (Мюнхен) ГмбХ | Способ лечения воспалительного заболевания с применением соединения, которое нейтрализует gm-csf, и соединения, которое нейтрализует il-17 |
BRPI0910482A2 (pt) | 2008-04-29 | 2019-09-24 | Abbott Lab | imunoglobinas de domínio variável duplo e usos das mesmas |
KR101711798B1 (ko) | 2008-05-05 | 2017-03-02 | 노비뮨 에스 에이 | 항-il-17a/il-17f 교차-반응성 항체 및 그의 사용 방법 |
JP2011523853A (ja) | 2008-06-03 | 2011-08-25 | アボット・ラボラトリーズ | 二重可変ドメイン免疫グロブリン及びその使用 |
NZ589436A (en) | 2008-06-03 | 2012-12-21 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
JP5674654B2 (ja) | 2008-07-08 | 2015-02-25 | アッヴィ・インコーポレイテッド | プロスタグランジンe2二重可変ドメイン免疫グロブリンおよびその使用 |
MY153893A (en) * | 2008-09-29 | 2015-04-15 | Roche Glycart Ag | Antibodies against human il17 and uses thereof |
PE20160653A1 (es) | 2009-03-05 | 2016-07-24 | Abbvie Inc | Proteinas de union a il-17 |
WO2010125003A1 (en) * | 2009-04-27 | 2010-11-04 | Novartis Ag | Compositions and methods for increasing muscle growth |
US8137671B2 (en) | 2009-05-05 | 2012-03-20 | Genentech, Inc. | Anti-IL-17F antibodies |
UY32870A (es) | 2009-09-01 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
KR20120093932A (ko) * | 2009-10-10 | 2012-08-23 | 일레븐 바이오테라피틱스, 아이엔씨. | Il-17 패밀리 사이토카인 조성물들 및 용도들 |
BR112012008833A2 (pt) | 2009-10-15 | 2015-09-08 | Abbott Lab | imunoglobulinas de dominio variavel duplo e usos das mesmas |
UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
JP5922025B2 (ja) | 2009-10-30 | 2016-05-25 | ヤンセン バイオテツク,インコーポレーテツド | Il−17a拮抗物質 |
EP3546483A1 (en) | 2010-05-20 | 2019-10-02 | Ablynx N.V. | Biological materials related to her3 |
US8735546B2 (en) | 2010-08-03 | 2014-05-27 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
NZ607615A (en) * | 2010-08-05 | 2015-03-27 | Anaptysbio Inc | Antibodies directed against il-17 |
EP2600901B1 (en) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
CA2809433A1 (en) | 2010-08-26 | 2012-03-01 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
DE19177059T1 (de) | 2010-10-01 | 2021-10-07 | Modernatx, Inc. | N1-methyl-pseudouracile enthältendes ribonucleinsäuren sowie ihre verwendungen |
LT2625199T (lt) * | 2010-10-08 | 2018-03-12 | Novartis Ag | Psoriazės gydymo būdai panaudojant il-17 antagonistus |
AU2014259523B2 (en) * | 2010-11-05 | 2016-02-04 | Novartis Ag | Methods of treating psoriatic arthritis using IL-17 antagonists |
ES2804624T1 (es) * | 2010-11-05 | 2021-02-08 | Novartis Ag | Métodos de tratamiento de artritis psoriásica usando antagonistas de IL-17 |
TW201307845A (zh) | 2010-12-13 | 2013-02-16 | Novartis Ag | 預測方法及利用il-17拮抗劑治療關節炎的方法 |
GB201100282D0 (en) | 2011-01-07 | 2011-02-23 | Ucb Pharma Sa | Biological methods |
JP5947041B2 (ja) * | 2011-01-07 | 2016-07-06 | 第一三共ヘルスケア株式会社 | 安全なil−17産生抑制剤 |
US10208349B2 (en) | 2011-01-07 | 2019-02-19 | Ucb Biopharma Sprl | Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy |
US20140004540A1 (en) * | 2011-01-13 | 2014-01-02 | Universite Paris Descartes | Methods and kits for predicting the risk of having a cardiovascular event in a subject |
CN103384682B (zh) | 2011-01-14 | 2017-04-12 | Ucb医药有限公司 | 结合il‑17a和il‑17f的抗体分子 |
WO2012125680A1 (en) | 2011-03-16 | 2012-09-20 | Novartis Ag | Methods of treating vasculitis using an il-17 binding molecule |
WO2012135415A1 (en) | 2011-03-29 | 2012-10-04 | Glaxosmithkline Llc | Buffer system for protein purification |
WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
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KR20140097178A (ko) * | 2011-11-21 | 2014-08-06 | 노파르티스 아게 | IL-17 길항제 및 건선성 관절염 (PsA) 반응 또는 비-반응 대립유전자를 이용하여 PsA를 치료하는 방법 |
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EP2791170A1 (en) | 2011-12-16 | 2014-10-22 | Synthon Biopharmaceuticals B.V. | Compounds and methods for treating inflammatory diseases |
US9120870B2 (en) | 2011-12-30 | 2015-09-01 | Abbvie Inc. | Dual specific binding proteins directed against IL-13 and IL-17 |
EP2809660B1 (en) | 2012-02-02 | 2016-01-20 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating il-17 |
DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
CN104245738B (zh) | 2012-04-05 | 2018-02-02 | 弗·哈夫曼-拉罗切有限公司 | 针对人tweak和人il17的双特异性抗体及其用途 |
KR20150010709A (ko) | 2012-04-20 | 2015-01-28 | 노파르티스 아게 | Il-17 길항제를 사용하는 강직성 척추염의 치료 방법 |
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