JP4682200B2 - Ｉｌ−１７拮抗性抗体 - Google Patents

Ｉｌ−１７拮抗性抗体 Download PDF

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Publication number
JP4682200B2
JP4682200B2 JP2007524286A JP2007524286A JP4682200B2 JP 4682200 B2 JP4682200 B2 JP 4682200B2 JP 2007524286 A JP2007524286 A JP 2007524286A JP 2007524286 A JP2007524286 A JP 2007524286A JP 4682200 B2 JP4682200 B2 JP 4682200B2
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amino acid
seq
acid sequence
antibody
cdr3
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JP2008507988A (ja
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フランコ・エ・ディ・パドヴァ
ヘルマン・グラム
ハンス・ホーフシュテッター
マルギット・イェシュケ
ジャン−ミシェル・ロンドー
ウィム・ファン・デン・ベルフ
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2007524286A 2004-08-05 2005-08-04 Ｉｌ−１７拮抗性抗体 Expired - Lifetime JP4682200B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0417487.6A GB0417487D0 (en) 2004-08-05 2004-08-05 Organic compound
PCT/EP2005/008470 WO2006013107A1 (en) 2004-08-05 2005-08-04 Il-17 antagonistic antibodies

Publications (2)

Publication Number Publication Date
JP2008507988A JP2008507988A (ja) 2008-03-21
JP4682200B2 true JP4682200B2 (ja) 2011-05-11

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ID=32982602

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Application Number Title Priority Date Filing Date
JP2007524286A Expired - Lifetime JP4682200B2 (ja) 2004-08-05 2005-08-04 Ｉｌ−１７拮抗性抗体

Country Status (40)

Country Link
US (9) US7807155B2 (enExample)
EP (5) EP2364729B3 (enExample)
JP (1) JP4682200B2 (enExample)
KR (2) KR20080029018A (enExample)
CN (1) CN101001645B (enExample)
AR (1) AR050200A1 (enExample)
AT (1) ATE517924T1 (enExample)
AU (2) AU2005268857C1 (enExample)
BE (1) BE2015C041I2 (enExample)
BR (3) BRPI0513078C1 (enExample)
CA (1) CA2573586C (enExample)
CY (6) CY1111963T1 (enExample)
DK (4) DK2364729T6 (enExample)
EC (1) ECSP077198A (enExample)
ES (4) ES2487533T7 (enExample)
FR (1) FR15C0048I2 (enExample)
GB (1) GB0417487D0 (enExample)
HK (1) HK1256639A1 (enExample)
HR (3) HRP20110758T4 (enExample)
HU (4) HUE038187T2 (enExample)
IL (1) IL180717A (enExample)
LT (3) LT2902039T (enExample)
LU (2) LU92768I2 (enExample)
MA (1) MA28982B1 (enExample)
MX (1) MX2007001338A (enExample)
MY (1) MY144925A (enExample)
NL (1) NL300749I2 (enExample)
NO (9) NO336279B1 (enExample)
NZ (1) NZ552658A (enExample)
PE (1) PE20060418A1 (enExample)
PL (4) PL2364729T6 (enExample)
PT (4) PT2902039T (enExample)
RU (2) RU2426741C3 (enExample)
SG (1) SG155186A1 (enExample)
SI (4) SI2902039T1 (enExample)
TN (1) TNSN07034A1 (enExample)
TR (1) TR201808057T4 (enExample)
TW (1) TWI359153B (enExample)
WO (1) WO2006013107A1 (enExample)
ZA (1) ZA200700242B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009525349A (ja) * 2006-01-31 2009-07-09 ノバルティス アクチエンゲゼルシャフト 癌を処置するためのｉｌ−１７アンタゴニスト抗体

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* Cited by examiner, † Cited by third party
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MX2007001338A (es) 2008-03-11
DK2364729T6 (en) 2015-07-06
NO2015023I2 (no) 2015-10-26
NO337286B1 (no) 2016-02-29
TWI359153B (en) 2012-03-01
ES2487533T3 (es) 2014-08-21
US8617552B2 (en) 2013-12-31
PL2902039T3 (pl) 2018-09-28
HK1256639A1 (en) 2019-09-27
US7807155B2 (en) 2010-10-05
PT2366405E (pt) 2015-06-30
LT2902039T (lt) 2018-06-25
PL1776142T4 (pl) 2018-04-30
AU2010201689A1 (en) 2010-05-20
HRP20181069T1 (hr) 2018-09-07
SI1776142T1 (sl) 2011-11-30
CY2015030I1 (el) 2015-11-04
US20170355762A1 (en) 2017-12-14
US20120107325A1 (en) 2012-05-03
NO20070985L (no) 2007-03-30
EP1776142B1 (en) 2011-07-27
NZ552658A (en) 2009-11-27
SI2366405T1 (sl) 2015-07-31
HK1101277A1 (en) 2007-10-12
RU2426741C2 (ru) 2011-08-20
CY1116256T1 (el) 2017-02-08
RU2011113153A (ru) 2012-10-20
US20150152178A1 (en) 2015-06-04
US9765140B2 (en) 2017-09-19
NO20171697A1 (no) 2007-03-30
EP2366405A2 (en) 2011-09-21
ECSP077198A (es) 2007-02-28
HUS1800040I1 (hu) 2018-11-28
EP1776142A1 (en) 2007-04-25
ES2677245T3 (es) 2018-07-31
CY1111963T1 (el) 2015-11-04
NO20151787L (no) 2006-02-06
NO2018007I1 (no) 2018-02-14
LTC1776142I2 (lt) 2022-07-11
EP3409288A1 (en) 2018-12-05
AU2010201689B2 (en) 2011-09-29
TW200617025A (en) 2006-06-01
LUC00088I2 (enExample) 2018-12-17
BR122017009404B1 (pt) 2022-02-22
NO336279B1 (no) 2015-07-06
TNSN07034A1 (en) 2008-06-02
CY1120723T1 (el) 2019-12-11
GB0417487D0 (en) 2004-09-08
FR15C0048I2 (fr) 2015-11-20
PT1776142E (pt) 2011-10-06
CA2573586C (en) 2013-06-25
NO2022026I1 (no) 2022-06-24
RU2007108067A (ru) 2008-09-10
EP1776142B9 (en) 2016-09-07
ATE517924T1 (de) 2011-08-15
CY2015030I2 (el) 2017-11-14
EP2364729A3 (en) 2012-01-18
AU2005268857B2 (en) 2010-01-28
HUE025815T2 (en) 2016-04-28
AR050200A1 (es) 2006-10-04
SI2364729T1 (sl) 2014-08-29
JP2008507988A (ja) 2008-03-21
DK1776142T6 (en) 2015-07-06
NO20150064L (no) 2007-03-30
NO341384B1 (no) 2017-10-30
EP2902039B1 (en) 2018-04-11
EP2366405B1 (en) 2015-02-25
AU2005268857B8 (en) 2010-05-27
NO2016017I1 (no) 2016-08-23
PE20060418A1 (es) 2006-06-15
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CN101001645B (zh) 2012-09-05

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